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FIRST. TRANSFORMATIVE. PROVEN.

TRANSFORMING THE FUTURE
NASDAQ : TINY

1	
  
SAFE HARBOR STATEMENT

This presentation may contain statements of a forward-looking nature relating to
future events. Statements contained in this presentation that are forwardlooking statements are intended to be made pursuant to the Safe Harbor
Provisions of the Private Securities Litigation Reform Act of 1995. These
forward-looking statements are subject to the inherent uncertainties in
predicting future results and conditions.
These statements reflect the
Company’s current beliefs, and a number of important factors could cause actual
results to differ materially from those expressed herein. 


Please see the Company’s Annual Report on Form 10-K, as well as subsequent
filings, filed with the Securities and Exchange Commission for a more detailed
discussion of the risks and uncertainties associated with the Company’s business,
including but not limited to the risks and uncertainties associated with venture
capital investing and other significant factors that could affect the Company’s
actual results. Except as otherwise required by Federal securities laws, Harris &
Harris Group, Inc. undertakes no obligation to update or revise these forwardlooking statements to reflect new events or uncertainties.

2	
  
CORPORATE HIGHLIGHTS
History


-  1983: Completed IPO

-  1992: Became an investment company
-  1995: Became a BDC
-  2002: Focused on nanotechnology
-  Today: Leading investor in transformative
companies

Financial Highlights2

-  Net Assets: $132.0 million
-  Total Liquidity: $49.2 million3
-  Net Asset Value Per Share: $4.24



Stock Highlights1
-  Symbol: NASDAQ:TINY
-  Shares Outstanding: 31.2 million
-  ADTV: 87,000 shares
-  Stock Price: $3.06
-  Market Capitalization: $95.7 million

Portfolio Highlights


-  Recent liquidity events generated net
gains on invested capital.
-  26 current portfolio companies, a portion
of which could drive near-term growth.
-  Robust pipeline of new investment
opportunities to drive long-term growth.

1) Data as of September 10, 2013. 2) Data as of June 30, 2013. 3) Total liquidity is amount as of
June 30, 2013, plus $12.8 million in cash received in July 2013, from the sale of Xradia to Carl Zeiss.

3	
  
HIGHLIGHTS
NAV / Share
$135.3

$150 
$100 
$50 

$24.3

$- 
12/31/01

25
20
15
10
5
0

6/30/13

$5.00 
$4.00 
$3.00 
$2.00 
$1.00 
$- 

Total Liquidity
$4.24 

$2.75 

Millions

Millions

Net Assets

$36.4

$40 
$30 
$20 

$13.5

$10 
$- 
12/31/01

6/30/13

TINY Stock Price History

12/31/01

6/30/13
HARRIS & HARRIS GROUP

Harris & Harris Group 
builds transformative companies
from disruptive science.
	
  

5	
  
HARRIS & HARRIS GROUP HIGHLIGHTS

•  We have significant equity stakes in companies

bringing transformative products to the market.

•  The value in our portfolio has not yet been
realized.
•  We have refined our strategy.
•  We have a strong interdisciplinary team.
•  We have the resources necessary to execute.
BUSINESS MODEL

Invest

•  NAV	
  Growth	
  
•  Deemed	
  Dividends	
  
and	
  Dividends	
  

Return

•  Early	
  Stage	
  
•  BIOLOGY+	
  

Build
Value

•  Company	
  Building	
  
•  Board	
  Involvement	
  
•  Partnerships	
  

Our evergreen structure facilitates growth 
and is a competitive advantage.
HARRIS & HARRIS GROUP

Our Four-Part Plan


Realize
Invest
Partner
Return

8	
  
HARRIS & HARRIS GROUP

Our Four-Part Plan


Realize
Invest
Partner
Return

9	
  
BIOVEX (ACQ. BY AMGEN)
TINY	
  recognized	
  that	
  BioVex	
  would	
  be	
  the	
  first	
  to	
  commercialize	
  oncolyNc	
  virus	
  cancer	
  therapy	
  
•  Initial investment: At first signs of
clinical efficacy (Series E)
•  Initial Market: Melanoma with plans
for other solid tumors
•  Initial involvement: Board Observer

Acquired by Amgen in 2011
$1	
  Billion	
  in	
  total	
  payouts	
  
Acquired	
  at	
  Start	
  of	
  Phase	
  3	
  Trials	
  

MARKET: Solid Tumor Cancer Therapy
Melanoma Therapeutics: $1.4Billion by 2017
Head & Neck Therapeutics: $1.7Billion by 2016 

BioVex engineered oncolytic viruses to preferentially attack tumor cells, 
leaving healthy cells unharmed
* Market size estimates by GlobalData

10	
  
SOLAZYME (IPO IN 2011; NASDAQ:SZYM)
TINY identified impact potential, invested, and grew the company from the earliest stage
•  Initial investment: Seed round
•  Employees @ initial investment: 2
•  Initial involvement: Board seat
Investors / Corporate Partners 
Since Our Initial Investment
Roda	
  Group	
  
Braemar	
  Energy	
  Ventures	
  
Morgan	
  Stanley	
  
Lightspeed	
  
VantagePoint	
  

Chevron	
  
Unilever	
  
Mitsui	
  
Sephora	
  
Bunge	
  
San-­‐Ei	
  Gen	
  

MARKET: Tailored Oils
Chemicals and Fuels: $1 Trillion*
Nutrition: $100 Billion*
Skin & Personal Care: $50 Billion*

Solazyme harnesses the power of microalgae to transform 
low-cost sugars into high-value renewable oils.
* Market size estimates by Solazyme

11	
  
XRADIA (ACQ. BY CARL ZEISS IN 2013)
As 1st institutional investor, TINY helped position Xradia for future growth in new markets
• 

Initial investment: Series D; First Institutional
round of investment

• 

Revenue @ initial investment: $7 million

• 

Initial market focus: Electronics

• 

Involvement: Board seat

• 

Recruited new management team and members of
board of directors.

• 

Helped build business strategy for expansion into
new growth markets.

• 

Active involvement in sale process.

Proprietary 
X-Ray Lenses

Life Sciences

Electronics

Harris & Harris Group Contributions

Materials Science

Natural Resources

3D High Resolution
Imaging Tools

MARKET: X-Ray Microscopy
$1.2B in 2013*
Growth driven by 
Life sciences, materials, oil/gas, mining

Xradia’s proprietary technology enables high-resolution, 3D imaging 
of samples of interest to multiple high-growth industries.
12	
  
WE HAVE A PIPELINE THAT
INCLUDES HIGH-QUALITY INVESTMENTS
OVER THE NEXT THREE YEARS WE EXPECT TO REALIZE PROCEEDS FROM
THE MAJORITY OF OUR MID STAGE AND LATE STAGE COMPANIES.
Energy

Early Stage

Mid Stage

Late Stage

Life Sciences

ABSMaterials (2010)
Contour Energy (2007)
Produced Water Absorbents (2011)
Ultora (2010)

Electronics

AgBiome (2012)
Ancora (2007)
EchoPixel (2013)
Enumeral (2009)
Senova (2011)

Cobalt (2008)
Laser Light Engines (2008)

Mersana (2002)
OpGen (2012)

Cambrios (2004)
HzO (2011)
Kovio (2005)
Nantero (2001)
SiOnyx (2006)

Bridgelux (2005)
Nanosys (2003)

Champions Oncology 
(OTC:CSBR; 2011)
Ensemble (2007)
Metabolon (2006)

Adesto (2007)
D-Wave Systems (2006)
Molecular Imprints (2004)

Note: 
Equity-focused portfolio companies, year of first investment and stage classifications as of June 30, 2013, not including 1) our publicly traded shares
of Solazyme, 2) the recently acquired portfolio company Xradia; and 3) our rights to milestone payments from Amgen, Inc. associated with the acquisition of
BioVex Group, Inc. and Laird Technologies, Inc. associated with the acquisition of Nextreme Thermal Solutions, Inc.

13	
  
METABOLON


INITIAL INVESTMENT: Q1 2006

TINY	
  recognized	
  metabolomics	
  as	
  the	
  future	
  of	
  biological	
  understanding	
  
•  Initial investment: Series B, lead investor

O
H
O

•  Current Milestones: 2 Diagnostic tests
released
Investors / Corporate Partners 
Aurora

Charles River Discovery
Services

Syngenta Ventures

Top 10 Pharma companies

Fletcher Spaght

DHMRI

Sevin Rosen Funds

Health Diagnostics
Laboratory

O
H
N
H
2

O
H

glucose

•  Involvement: Board observer

	
  
	
  
	
  
	
  
	
  
	
  
	
  

O

H
O

H
O

•  Initial market focus: Testing & service

O
H

O
H

cholesterol

L-threonine

MARKET: 
Diagnostics & Drug Discovery
Diabetes Diagnostics: $3 Billion & Growing
PSA Diagnostics: $12 Billion & Growing
$20 Million revenue in services

TINY	
  Impact:	
  Exit	
  at	
  8-­‐12%	
  ownership	
  

Metabolon is the leader in measuring biological pathways and is positioned to disrupt
billion dollar diagnostic markets with its novel solutions.
14
D-WAVE SYSTEMS


INITIAL INVESTMENT: Q2 2006

TINY	
  recognized	
  the	
  criNcal	
  importance	
  of	
  increased	
  compuNng	
  power	
  to	
  the	
  Internet-­‐age	
  
•  Initial investment: Lead Series B
•  Target Market: High Performance
Computing
•  Business Model: Quantum Cloud
Computing
•  Initial involvement: Board Member
Investors / Corporate Partners 

Bezos	
  ExpediNons	
  
In-­‐Q-­‐Tel	
  
Draper	
  Fisher	
  Jurvetson	
  
Goldman	
  Sachs	
  

Google	
  
NASA	
  Ames	
  
Lockheed	
  MarNn	
  

MARKET: High Performance Computing
High Performance Computing: $44 Billion by 2020 
Cloud Computing: $33 Billion by 2016

TINY Impact: Exit at 2.5-5% ownership 

D-Wave harnesses quantum mechanical phenomena to solve some of the most
computationally intensive problems known to humankind
* Market size estimates by Gartner and Market Research Media

15	
  
SIONYX


INITIAL INVESTMENT: Q2 2006

TINY	
  idenNfied	
  the	
  potenNal	
  of	
  the	
  technology	
  &	
  helped	
  found	
  SiOnyx	
  
• 

Initial investment: Seed, 1st Institutional Investor

• 

Initial market focus: Unknown – TINY helped
develop the first focus

• 

Involvement: Board Seat

• 

	
  	
  	
  	
  	
  	
  SiOnyx	
  Solu;on:	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  Compe;;on:	
  

Current Milestones: 2 Diagnostic tests released
Comparable Companies:

Image Sensors

Cameras &
Camera
Modules

Omnivision (NASDAQ:OVTI)
Aptina, Pixim (Private)
FLIR Systems (NASDAQ:FLIR), Ambarella
(NASDAQ:AMBA), Pelco (Sub. of Scheinder
Elec.), Axis (STO:AXIS), Mobotix (ETR:MBQ)
Everfocus (TPE:5484)

	
  
	
  
	
  
	
  
	
  
	
  
	
  

MARKET: Infrared Cameras
$7B in 2013 è $25B in 2017*
Growth driven by 
Security/Surveillance (Night Vision) and 
Gesture User Interface (ex: Microsoft Kinect™)

TINY	
  Impact:	
  	
  Exit	
  at	
  10-­‐20%	
  	
  ownership	
  

SiOnyx is bringing disruptive performance and silicon economics to the multi-billion dollar
night vision, security & surveillance, and gesture user interface markets
* Sources: SiOnyx estimates and IMS Research. 

16
HZO, INC. 
INITIAL INVESTMENT: Q3 2011
TINY	
  idenNfied	
  submersion	
  water	
  protecNon	
  as	
  a	
  criNcal	
  feature	
  in	
  future	
  electronic	
  devices	
  
•  Initial investment: Lead Series A
•  Initial Market: Water protection for
electronic devices
•  Initial involvement: Board Member
TINY’s Contribution

•  Established	
  an	
  experienced	
  management	
  team	
  
•  Seeded	
  company	
  with	
  outside	
  experNse	
  
•  Connected	
  company	
  to	
  strategic	
  partners	
  and	
  
customers	
  

MARKET: Electronic Device Market

Consumer Electronics: $3.3 Billion
Life Sciences: $3.1 Billion
Industrial Electronics: $0.7 Billion
TINY	
  Impact:	
  	
  Exit	
  at	
  15-­‐20%	
  	
  ownership	
  

HzO combines high-volume manufacturing with innovative coating technology to add
critical submersion protection to electronic devices
* Market size estimates by HzO, Inc.

17	
  
ADESTO


INITIAL INVESTMENT: Q1 2007

TINY	
  idenNfied	
  major	
  scaling	
  challenges	
  in	
  front	
  of	
  tradiNonal	
  NVM	
  computer	
  memory	
  	
  
•  Initial investment: Lead Series A
•  Target Market: Non-volatile memory
•  Initial involvement: Board Member
•  Acquisition: Atmel’s flash memory
business
Investors / Corporate Partners 

Arch	
  Ventures	
  
Applied	
  Ventures	
  
(Applied	
  Materials)	
  
ATA	
  Ventures	
  

AlNs	
  Semiconductor	
  
Microchip	
  
Altera	
  

MARKET: Nonvolatile Memory (NVM)

NVM: $80 Billion/year in 2013
TINY Impact: Exit at 8-12% ownership 

Adesto is addressing the need for ultra low-power, low-cost, high-speed, scalable 
non-volatile memory (NVM) for stand-alone and embedded applications
* Market size estimates by Adesto

18	
  
GROWTH IN AVERAGE OWNERSHIP
Sources of 
Future Returns

Sources of 
Recent Returns
16.00%

14%

14.00%
12.00%
10.00%

9%

8.00%
6.00%

5%

4.00%
2.00%
0.00%
2001-2004

2005-2008

2009-2013

Notes: Average ownership data includes investment-weighted ownership percentages on a fully diluted basis as of June 30, 2013, for
unrealized investments. Many of our current portfolio companies may raise additional capital, and depending on many factors our
ownership could increase or decrease in these companies as a result of these financings. The data for 2005-2008 does not include
ownership in Ancora Pharmaceuticals Inc. If this investment was included, the investment-weighted average ownership would be 15
percent.

19	
  
HARRIS & HARRIS GROUP

Our Four-Part Plan


Realize

Invest
Partner
Return

20	
  
EXPERIENCED EARLY-STAGE INVESTORS

First Institutional Investor or Part of First Institutional Syndicate(1)
•  ABSMaterials
•  Adesto
•  AgBiome
•  Ancora
•  Bridgelux
•  Contour Energy
•  Enumeral
•  HzO
•  Laser Light Eng.
•  Mersana
•  Nantero
•  PWA
•  Senova
•  SiOnyx
•  Ultora

Adaptive Web Tech. (Exited Position in 2001)
Ag Services of America (Exited Position in 1993)
Agile Materials (Exited Position in 2005)
Alliance Pharmaceutical (Exited Position in 1990)
American Equine Prod. (Exited Position in 1990)
Chlorogen (Exited Position in 2008)
CMA Group (Exited Position in 1995)
CORDEX Petroleums (Exited Position in 1998)
Crystal IS (Exited Position in 2011)
Cswitch (Exited Position in 2009)
Dynecology (Exited Position in 1997)
Evolved Nanomater. Sci. (Exited Position in 2008)
Experion Systems (Exited Position in 2005)
Exponential (Exited Position in 2009)
Genomica (Exited Position in 2001)
Harber Brothers (Exited Position in 1997)
Harris Newco (Exited Position in 2001) 
Highline Capital (Exited Position in 1997) 
Informio (Exited Position in 2002)

Molten Metal Tech. (Exited Position in 1993)
MultiTarget (Exited Position in 1998)

NanoGram (Exited Position in 2010) 
NanoGram Devices (Exited Position in 2005)




Nassim & Nicolovius (Exited Position in 1994)
NBX (Exited Position in 1999)

NeoPhotonics (Exited Position in 2012) 
NeuroMetrix (Exited Position in 2005) 
Nextreme (Exited Position in 2013)

nFX (Exited Position in 1997)

Pharm. Peptides (Exited Position in 1993)
Phoenix Molecular (Exited Position in 2008)
PHZ Capital Partners (Exited Position in 2003)
Princeton Video Image (Exited Position in 1999)
Questech (Exited Position in 2011)

Re Capital (Exited Position in 1989)

SciQuest (Exited Position in 2000)

InSite Marketing (Exited Position in 2001)
Siluria (Exited Position in 2011)

(2)
Solazyme (IPO in 2011)
Sonex (Exited Position in 1996)

Starfire Systems (Exited Position in 2009)
Sundial Marketplace (Exited Position in 2001)
Voice Control Systems (Exited Position in 1999)
Xradia (Exited Position in 2013)
Zia Laser (Exited Position in 2008)

(1)  Includes initial investments made prior to 2002. The first member of the current
investment team joined Harris & Harris Group in 2002.
(2)  A portion of our shares of Solazyme remained unrealized as of June 30, 2013.

21	
  
EVOLUTION OF OUR INVESTMENT FOCUS
Nanotechnology
Opportunity Space

Energy

Electronics

Electronics
Energy

Electronics
BIOLOGY

Life 
Sciences

2002-2007

Energy

BIOLOGY

Life 
Sciences

BIOLOGY

Life 
Sciences

2008-2013

Future

We are Positioned to take Advantage of Many of the Exciting
Trends in Growing Life Science Markets
22	
  
OUR EXPERTISE IS INTERDISCIPLINARY
Our	
  interdisciplinary	
  team	
  has	
  the	
  ability	
  	
  
to	
  iden;fy	
  and	
  diligence	
  cross-­‐discipline	
  deals.	
  	
  

Physics	
  
Engineering	
  

Materials	
  
Science	
  

Medicine	
  
Biology	
  
Chemistry	
  

5	
  Ph.D.	
  level	
  investment	
  professionals:	
  	
  
Chemistry,	
  Physics,	
  Biochemical	
  Engineering,	
  Gene;cs	
  and	
  Materials	
  Science	
  
23	
  
H&H APPROACH YIELDS A UNIQUE PORTFOLIO

???	
  
Quantum	
  Compu;ng	
  
Imaging	
  and	
  Visualiza;on	
  
Synthe;c	
  Biology	
  
Cancer	
  Therapeu;cs	
  

Separa;ons	
  
Solid-­‐State	
  Sensors	
  
Single	
  Cell	
  Analysis	
  
Molecular	
  Engineering	
  

3D	
  Biology	
  

Omics	
  

Molecular	
  Diagnos;cs	
  

Structural	
  Varia;on	
  

Drug	
  Delivery	
  
Vaccines	
  

Water	
  
Microbiome	
  

This	
  yields	
  a	
  unique	
  and	
  diversified	
  life	
  science	
  porZolio	
  at	
  the	
  
intersec;on	
  of	
  biology	
  and	
  other	
  disciplines.	
  
24	
  
OUR DISTINCTIVE APPROACH
Interdisciplinary innovation is required to address
these life science challenges. 

BIOLOGY

Electronics
Physics
Materials Science
Chemistry
IT 
Engineering

LIFE SCIENCE
SOLUTIONS

Mathematics

25	
  
EXAMPLES OF BIOLOGY 

DNA SEQUENCING

SEMICONDUCTORS

PERSONALIZED 
GENOMICS

PROTEIN 
BIOCHEMISTRY

INFORMATION 
TECHNOLOGY

NOVEL THERAPEUTIC
TARGETS

ONCOLOGY

PHYSICS

3D NON-INVASIVE 
IMAGING AND DIAGNOSTICS
26	
  
A DECADE OF BIOLOGY
BIOLOGY

INVESTMENTS

ENABLES

Engineering

Single Cell Analysis

Physics

Non-Invasive, HighResolution Imaging

Electronics

Personal Genomics

IT

Protein Structure Analysis

Mathematics

High-Quality
Molecular Diagnostics

Material Science

H&H PORTFOLIO COMPANY

Targeted 
Bio-Compatible
Drug Delivery
27	
  
DisrupNve	
  
Science	
  

OUR COMPETITIVE POSITION – 
EARLY STAGE AND DISRUPTIVE SCIENCE

SFE	
  

Internet	
  /	
  	
  
Social	
  Media	
  

KIPO	
  
GSVC	
  

SVVC	
  

Late-­‐Stage	
  
Passive	
  Involvement	
  

Early-­‐Stage,	
  
AcNve	
  Involvement	
  

Harris & Harris Group Uniquely Addresses an Underserved Market
Amongst Publicly Traded Equity-Focused Investment Companies
Liquid	
  

OUR COMPETITIVE POSITION – 
EARLY STAGE AND LIQUIDITY

GSVC	
  

SVVC	
   KIPO	
  
SFE	
  

KPCB	
  

Illiquid	
  

Venrock	
  
Polaris	
  
Khosla	
  
ARCH	
  Ventures	
  

Late-­‐Stage	
  
Passive	
  Involvement	
  

Early-­‐Stage,	
  
AcNve	
  Involvement	
  

Harris & Harris Group is a Liquid Vehicle for Early-Stage Investing
HARRIS & HARRIS GROUP

Our Four-Part Plan


Realize
Invest

Partner
Return

30	
  
PARTNERING TO INCREASE RETURNS

Return	
  

Return	
  

Return	
  

Cost	
  

Cost	
  

R&D	
  

Seed	
  Stage	
  

Early-­‐Stage	
   Later-­‐stage	
  
VC	
  
VC	
  

Time	
  

Return	
  

R&D	
  

Seed	
  Stage	
  

Early-­‐Stage	
   Later-­‐stage	
  
VC	
  
VC	
  

Time	
  
EARLY-STAGE EXPERTISE AND CORPORATE EXPERTISE IS 
CRITICAL FOR BRINGING NEW TECHNOLOGY TO MARKET
	
  	
  
EARLY-STAGE
DEVELOPMENT

Company formation,
Management Team
Identification, University IP
Negotiation, Initial Funding
and Performance Metrics

SCALE AND
MANUFACTURING
Manufacturing Scale,
Factory Integration, 
Pilot Facilities, 
Clinical Trials

Value Creation

$$

Cumulative Cost

REVENUE GROWTH

Introduction and Access to the
Market and Customers

TIME
Corporate involvement is critical to providing scale and distribution. Understanding the
optimal transition point is quintessential to build capital efficient businesses. 
32	
  
PARTNERING EARLY IS BENEFICIAL

Corporate	
  Partner(s)	
  
Scale	
  &	
  
Manufacturing	
  
Technology	
  	
  
Plaeorms	
  

Company	
  
Building	
  

Market	
  
Access	
  

Corporate	
  Partner(s)	
  
Scale	
  &	
  
Manufacturing	
  

Market	
  
Access	
  

Technology	
  	
  
Plaeorms	
  

Company	
  
Building	
  

Opportunity	
  Space	
  

We believe the skillsets of Harris & Harris Group and
corporate partners are highly complementary.
33	
  
OUR PARTNERING STRATEGY
Our two paths to working with corporations.
Corporate	
  Partner(s)	
  

• 
• 
• 
• 
• 

Investment
Development Programs
Commercialization/
Purchase Agreements
Licensing
Expertise

• 
• 
• 

Investment
Strategic Insights
Management Fees and
Carried Interest

H&H Portfolio Companies

Corporations are an important part of 
Harris & Harris Group’s current and future strategies.
34	
  
CURRENT EXAMPLE OF OUR PARTNERING STRATEGY
Three Large Corporate Partners

Investment in Initial Round of Funding
+
Development Programs

Corporations currently add value to Harris & Harris Group
and our portfolio companies in multiple ways.
35	
  
HARRIS & HARRIS GROUP

Our Four-Part Plan


Realize
Invest
Partner

Return
36	
  
RETURNING VALUE FOR SHAREHOLDERS
We seek to create value for shareholders by: 
•  Increasing net asset value per share (NAV) through:
-  Gains on our investments
-  Reduction of number of shares outstanding

•  Distributing a portion of net capital gains on investments
to shareholders through:
-  Present: deemed dividends
-  Future: deemed and actual dividends

We believe execution on our four-part plan 
will generate meaningful returns to shareholders.
37	
  
HARRIS & HARRIS GROUP

Harris & Harris Group 
builds transformative companies
from disruptive science.
	
  

38	
  
39	
  

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Tiny 102013

  • 1. FIRST. TRANSFORMATIVE. PROVEN. TRANSFORMING THE FUTURE NASDAQ : TINY 1  
  • 2. SAFE HARBOR STATEMENT This presentation may contain statements of a forward-looking nature relating to future events. Statements contained in this presentation that are forwardlooking statements are intended to be made pursuant to the Safe Harbor Provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking statements are subject to the inherent uncertainties in predicting future results and conditions. These statements reflect the Company’s current beliefs, and a number of important factors could cause actual results to differ materially from those expressed herein. Please see the Company’s Annual Report on Form 10-K, as well as subsequent filings, filed with the Securities and Exchange Commission for a more detailed discussion of the risks and uncertainties associated with the Company’s business, including but not limited to the risks and uncertainties associated with venture capital investing and other significant factors that could affect the Company’s actual results. Except as otherwise required by Federal securities laws, Harris & Harris Group, Inc. undertakes no obligation to update or revise these forwardlooking statements to reflect new events or uncertainties. 2  
  • 3. CORPORATE HIGHLIGHTS History -  1983: Completed IPO -  1992: Became an investment company -  1995: Became a BDC -  2002: Focused on nanotechnology -  Today: Leading investor in transformative companies Financial Highlights2 -  Net Assets: $132.0 million -  Total Liquidity: $49.2 million3 -  Net Asset Value Per Share: $4.24 Stock Highlights1 -  Symbol: NASDAQ:TINY -  Shares Outstanding: 31.2 million -  ADTV: 87,000 shares -  Stock Price: $3.06 -  Market Capitalization: $95.7 million Portfolio Highlights -  Recent liquidity events generated net gains on invested capital. -  26 current portfolio companies, a portion of which could drive near-term growth. -  Robust pipeline of new investment opportunities to drive long-term growth. 1) Data as of September 10, 2013. 2) Data as of June 30, 2013. 3) Total liquidity is amount as of June 30, 2013, plus $12.8 million in cash received in July 2013, from the sale of Xradia to Carl Zeiss. 3  
  • 4. HIGHLIGHTS NAV / Share $135.3 $150 $100 $50 $24.3 $- 12/31/01 25 20 15 10 5 0 6/30/13 $5.00 $4.00 $3.00 $2.00 $1.00 $- Total Liquidity $4.24 $2.75 Millions Millions Net Assets $36.4 $40 $30 $20 $13.5 $10 $- 12/31/01 6/30/13 TINY Stock Price History 12/31/01 6/30/13
  • 5. HARRIS & HARRIS GROUP Harris & Harris Group builds transformative companies from disruptive science.   5  
  • 6. HARRIS & HARRIS GROUP HIGHLIGHTS •  We have significant equity stakes in companies bringing transformative products to the market. •  The value in our portfolio has not yet been realized. •  We have refined our strategy. •  We have a strong interdisciplinary team. •  We have the resources necessary to execute.
  • 7. BUSINESS MODEL Invest •  NAV  Growth   •  Deemed  Dividends   and  Dividends   Return •  Early  Stage   •  BIOLOGY+   Build Value •  Company  Building   •  Board  Involvement   •  Partnerships   Our evergreen structure facilitates growth and is a competitive advantage.
  • 8. HARRIS & HARRIS GROUP Our Four-Part Plan Realize Invest Partner Return 8  
  • 9. HARRIS & HARRIS GROUP Our Four-Part Plan Realize Invest Partner Return 9  
  • 10. BIOVEX (ACQ. BY AMGEN) TINY  recognized  that  BioVex  would  be  the  first  to  commercialize  oncolyNc  virus  cancer  therapy   •  Initial investment: At first signs of clinical efficacy (Series E) •  Initial Market: Melanoma with plans for other solid tumors •  Initial involvement: Board Observer Acquired by Amgen in 2011 $1  Billion  in  total  payouts   Acquired  at  Start  of  Phase  3  Trials   MARKET: Solid Tumor Cancer Therapy Melanoma Therapeutics: $1.4Billion by 2017 Head & Neck Therapeutics: $1.7Billion by 2016 BioVex engineered oncolytic viruses to preferentially attack tumor cells, leaving healthy cells unharmed * Market size estimates by GlobalData 10  
  • 11. SOLAZYME (IPO IN 2011; NASDAQ:SZYM) TINY identified impact potential, invested, and grew the company from the earliest stage •  Initial investment: Seed round •  Employees @ initial investment: 2 •  Initial involvement: Board seat Investors / Corporate Partners Since Our Initial Investment Roda  Group   Braemar  Energy  Ventures   Morgan  Stanley   Lightspeed   VantagePoint   Chevron   Unilever   Mitsui   Sephora   Bunge   San-­‐Ei  Gen   MARKET: Tailored Oils Chemicals and Fuels: $1 Trillion* Nutrition: $100 Billion* Skin & Personal Care: $50 Billion* Solazyme harnesses the power of microalgae to transform low-cost sugars into high-value renewable oils. * Market size estimates by Solazyme 11  
  • 12. XRADIA (ACQ. BY CARL ZEISS IN 2013) As 1st institutional investor, TINY helped position Xradia for future growth in new markets •  Initial investment: Series D; First Institutional round of investment •  Revenue @ initial investment: $7 million •  Initial market focus: Electronics •  Involvement: Board seat •  Recruited new management team and members of board of directors. •  Helped build business strategy for expansion into new growth markets. •  Active involvement in sale process. Proprietary X-Ray Lenses Life Sciences Electronics Harris & Harris Group Contributions Materials Science Natural Resources 3D High Resolution Imaging Tools MARKET: X-Ray Microscopy $1.2B in 2013* Growth driven by Life sciences, materials, oil/gas, mining Xradia’s proprietary technology enables high-resolution, 3D imaging of samples of interest to multiple high-growth industries. 12  
  • 13. WE HAVE A PIPELINE THAT INCLUDES HIGH-QUALITY INVESTMENTS OVER THE NEXT THREE YEARS WE EXPECT TO REALIZE PROCEEDS FROM THE MAJORITY OF OUR MID STAGE AND LATE STAGE COMPANIES. Energy Early Stage Mid Stage Late Stage Life Sciences ABSMaterials (2010) Contour Energy (2007) Produced Water Absorbents (2011) Ultora (2010) Electronics AgBiome (2012) Ancora (2007) EchoPixel (2013) Enumeral (2009) Senova (2011) Cobalt (2008) Laser Light Engines (2008) Mersana (2002) OpGen (2012) Cambrios (2004) HzO (2011) Kovio (2005) Nantero (2001) SiOnyx (2006) Bridgelux (2005) Nanosys (2003) Champions Oncology (OTC:CSBR; 2011) Ensemble (2007) Metabolon (2006) Adesto (2007) D-Wave Systems (2006) Molecular Imprints (2004) Note: Equity-focused portfolio companies, year of first investment and stage classifications as of June 30, 2013, not including 1) our publicly traded shares of Solazyme, 2) the recently acquired portfolio company Xradia; and 3) our rights to milestone payments from Amgen, Inc. associated with the acquisition of BioVex Group, Inc. and Laird Technologies, Inc. associated with the acquisition of Nextreme Thermal Solutions, Inc. 13  
  • 14. METABOLON INITIAL INVESTMENT: Q1 2006 TINY  recognized  metabolomics  as  the  future  of  biological  understanding   •  Initial investment: Series B, lead investor O H O •  Current Milestones: 2 Diagnostic tests released Investors / Corporate Partners Aurora Charles River Discovery Services Syngenta Ventures Top 10 Pharma companies Fletcher Spaght DHMRI Sevin Rosen Funds Health Diagnostics Laboratory O H N H 2 O H glucose •  Involvement: Board observer               O H O H O •  Initial market focus: Testing & service O H O H cholesterol L-threonine MARKET: Diagnostics & Drug Discovery Diabetes Diagnostics: $3 Billion & Growing PSA Diagnostics: $12 Billion & Growing $20 Million revenue in services TINY  Impact:  Exit  at  8-­‐12%  ownership   Metabolon is the leader in measuring biological pathways and is positioned to disrupt billion dollar diagnostic markets with its novel solutions. 14
  • 15. D-WAVE SYSTEMS INITIAL INVESTMENT: Q2 2006 TINY  recognized  the  criNcal  importance  of  increased  compuNng  power  to  the  Internet-­‐age   •  Initial investment: Lead Series B •  Target Market: High Performance Computing •  Business Model: Quantum Cloud Computing •  Initial involvement: Board Member Investors / Corporate Partners Bezos  ExpediNons   In-­‐Q-­‐Tel   Draper  Fisher  Jurvetson   Goldman  Sachs   Google   NASA  Ames   Lockheed  MarNn   MARKET: High Performance Computing High Performance Computing: $44 Billion by 2020 Cloud Computing: $33 Billion by 2016 TINY Impact: Exit at 2.5-5% ownership D-Wave harnesses quantum mechanical phenomena to solve some of the most computationally intensive problems known to humankind * Market size estimates by Gartner and Market Research Media 15  
  • 16. SIONYX INITIAL INVESTMENT: Q2 2006 TINY  idenNfied  the  potenNal  of  the  technology  &  helped  found  SiOnyx   •  Initial investment: Seed, 1st Institutional Investor •  Initial market focus: Unknown – TINY helped develop the first focus •  Involvement: Board Seat •             SiOnyx  Solu;on:                            Compe;;on:   Current Milestones: 2 Diagnostic tests released Comparable Companies: Image Sensors Cameras & Camera Modules Omnivision (NASDAQ:OVTI) Aptina, Pixim (Private) FLIR Systems (NASDAQ:FLIR), Ambarella (NASDAQ:AMBA), Pelco (Sub. of Scheinder Elec.), Axis (STO:AXIS), Mobotix (ETR:MBQ) Everfocus (TPE:5484)               MARKET: Infrared Cameras $7B in 2013 è $25B in 2017* Growth driven by Security/Surveillance (Night Vision) and Gesture User Interface (ex: Microsoft Kinect™) TINY  Impact:    Exit  at  10-­‐20%    ownership   SiOnyx is bringing disruptive performance and silicon economics to the multi-billion dollar night vision, security & surveillance, and gesture user interface markets * Sources: SiOnyx estimates and IMS Research. 16
  • 17. HZO, INC. INITIAL INVESTMENT: Q3 2011 TINY  idenNfied  submersion  water  protecNon  as  a  criNcal  feature  in  future  electronic  devices   •  Initial investment: Lead Series A •  Initial Market: Water protection for electronic devices •  Initial involvement: Board Member TINY’s Contribution •  Established  an  experienced  management  team   •  Seeded  company  with  outside  experNse   •  Connected  company  to  strategic  partners  and   customers   MARKET: Electronic Device Market Consumer Electronics: $3.3 Billion Life Sciences: $3.1 Billion Industrial Electronics: $0.7 Billion TINY  Impact:    Exit  at  15-­‐20%    ownership   HzO combines high-volume manufacturing with innovative coating technology to add critical submersion protection to electronic devices * Market size estimates by HzO, Inc. 17  
  • 18. ADESTO INITIAL INVESTMENT: Q1 2007 TINY  idenNfied  major  scaling  challenges  in  front  of  tradiNonal  NVM  computer  memory     •  Initial investment: Lead Series A •  Target Market: Non-volatile memory •  Initial involvement: Board Member •  Acquisition: Atmel’s flash memory business Investors / Corporate Partners Arch  Ventures   Applied  Ventures   (Applied  Materials)   ATA  Ventures   AlNs  Semiconductor   Microchip   Altera   MARKET: Nonvolatile Memory (NVM) NVM: $80 Billion/year in 2013 TINY Impact: Exit at 8-12% ownership Adesto is addressing the need for ultra low-power, low-cost, high-speed, scalable non-volatile memory (NVM) for stand-alone and embedded applications * Market size estimates by Adesto 18  
  • 19. GROWTH IN AVERAGE OWNERSHIP Sources of Future Returns Sources of Recent Returns 16.00% 14% 14.00% 12.00% 10.00% 9% 8.00% 6.00% 5% 4.00% 2.00% 0.00% 2001-2004 2005-2008 2009-2013 Notes: Average ownership data includes investment-weighted ownership percentages on a fully diluted basis as of June 30, 2013, for unrealized investments. Many of our current portfolio companies may raise additional capital, and depending on many factors our ownership could increase or decrease in these companies as a result of these financings. The data for 2005-2008 does not include ownership in Ancora Pharmaceuticals Inc. If this investment was included, the investment-weighted average ownership would be 15 percent. 19  
  • 20. HARRIS & HARRIS GROUP Our Four-Part Plan Realize Invest Partner Return 20  
  • 21. EXPERIENCED EARLY-STAGE INVESTORS First Institutional Investor or Part of First Institutional Syndicate(1) •  ABSMaterials •  Adesto •  AgBiome •  Ancora •  Bridgelux •  Contour Energy •  Enumeral •  HzO •  Laser Light Eng. •  Mersana •  Nantero •  PWA •  Senova •  SiOnyx •  Ultora Adaptive Web Tech. (Exited Position in 2001) Ag Services of America (Exited Position in 1993) Agile Materials (Exited Position in 2005) Alliance Pharmaceutical (Exited Position in 1990) American Equine Prod. (Exited Position in 1990) Chlorogen (Exited Position in 2008) CMA Group (Exited Position in 1995) CORDEX Petroleums (Exited Position in 1998) Crystal IS (Exited Position in 2011) Cswitch (Exited Position in 2009) Dynecology (Exited Position in 1997) Evolved Nanomater. Sci. (Exited Position in 2008) Experion Systems (Exited Position in 2005) Exponential (Exited Position in 2009) Genomica (Exited Position in 2001) Harber Brothers (Exited Position in 1997) Harris Newco (Exited Position in 2001) Highline Capital (Exited Position in 1997) Informio (Exited Position in 2002) Molten Metal Tech. (Exited Position in 1993) MultiTarget (Exited Position in 1998) NanoGram (Exited Position in 2010) NanoGram Devices (Exited Position in 2005) Nassim & Nicolovius (Exited Position in 1994) NBX (Exited Position in 1999) NeoPhotonics (Exited Position in 2012) NeuroMetrix (Exited Position in 2005) Nextreme (Exited Position in 2013) nFX (Exited Position in 1997) Pharm. Peptides (Exited Position in 1993) Phoenix Molecular (Exited Position in 2008) PHZ Capital Partners (Exited Position in 2003) Princeton Video Image (Exited Position in 1999) Questech (Exited Position in 2011) Re Capital (Exited Position in 1989) SciQuest (Exited Position in 2000) InSite Marketing (Exited Position in 2001) Siluria (Exited Position in 2011) (2) Solazyme (IPO in 2011) Sonex (Exited Position in 1996) Starfire Systems (Exited Position in 2009) Sundial Marketplace (Exited Position in 2001) Voice Control Systems (Exited Position in 1999) Xradia (Exited Position in 2013) Zia Laser (Exited Position in 2008) (1)  Includes initial investments made prior to 2002. The first member of the current investment team joined Harris & Harris Group in 2002. (2)  A portion of our shares of Solazyme remained unrealized as of June 30, 2013. 21  
  • 22. EVOLUTION OF OUR INVESTMENT FOCUS Nanotechnology Opportunity Space Energy Electronics Electronics Energy Electronics BIOLOGY Life Sciences 2002-2007 Energy BIOLOGY Life Sciences BIOLOGY Life Sciences 2008-2013 Future We are Positioned to take Advantage of Many of the Exciting Trends in Growing Life Science Markets 22  
  • 23. OUR EXPERTISE IS INTERDISCIPLINARY Our  interdisciplinary  team  has  the  ability     to  iden;fy  and  diligence  cross-­‐discipline  deals.     Physics   Engineering   Materials   Science   Medicine   Biology   Chemistry   5  Ph.D.  level  investment  professionals:     Chemistry,  Physics,  Biochemical  Engineering,  Gene;cs  and  Materials  Science   23  
  • 24. H&H APPROACH YIELDS A UNIQUE PORTFOLIO ???   Quantum  Compu;ng   Imaging  and  Visualiza;on   Synthe;c  Biology   Cancer  Therapeu;cs   Separa;ons   Solid-­‐State  Sensors   Single  Cell  Analysis   Molecular  Engineering   3D  Biology   Omics   Molecular  Diagnos;cs   Structural  Varia;on   Drug  Delivery   Vaccines   Water   Microbiome   This  yields  a  unique  and  diversified  life  science  porZolio  at  the   intersec;on  of  biology  and  other  disciplines.   24  
  • 25. OUR DISTINCTIVE APPROACH Interdisciplinary innovation is required to address these life science challenges. BIOLOGY Electronics Physics Materials Science Chemistry IT Engineering LIFE SCIENCE SOLUTIONS Mathematics 25  
  • 26. EXAMPLES OF BIOLOGY DNA SEQUENCING SEMICONDUCTORS PERSONALIZED GENOMICS PROTEIN BIOCHEMISTRY INFORMATION TECHNOLOGY NOVEL THERAPEUTIC TARGETS ONCOLOGY PHYSICS 3D NON-INVASIVE IMAGING AND DIAGNOSTICS 26  
  • 27. A DECADE OF BIOLOGY BIOLOGY INVESTMENTS ENABLES Engineering Single Cell Analysis Physics Non-Invasive, HighResolution Imaging Electronics Personal Genomics IT Protein Structure Analysis Mathematics High-Quality Molecular Diagnostics Material Science H&H PORTFOLIO COMPANY Targeted Bio-Compatible Drug Delivery 27  
  • 28. DisrupNve   Science   OUR COMPETITIVE POSITION – EARLY STAGE AND DISRUPTIVE SCIENCE SFE   Internet  /     Social  Media   KIPO   GSVC   SVVC   Late-­‐Stage   Passive  Involvement   Early-­‐Stage,   AcNve  Involvement   Harris & Harris Group Uniquely Addresses an Underserved Market Amongst Publicly Traded Equity-Focused Investment Companies
  • 29. Liquid   OUR COMPETITIVE POSITION – EARLY STAGE AND LIQUIDITY GSVC   SVVC   KIPO   SFE   KPCB   Illiquid   Venrock   Polaris   Khosla   ARCH  Ventures   Late-­‐Stage   Passive  Involvement   Early-­‐Stage,   AcNve  Involvement   Harris & Harris Group is a Liquid Vehicle for Early-Stage Investing
  • 30. HARRIS & HARRIS GROUP Our Four-Part Plan Realize Invest Partner Return 30  
  • 31. PARTNERING TO INCREASE RETURNS Return   Return   Return   Cost   Cost   R&D   Seed  Stage   Early-­‐Stage   Later-­‐stage   VC   VC   Time   Return   R&D   Seed  Stage   Early-­‐Stage   Later-­‐stage   VC   VC   Time  
  • 32. EARLY-STAGE EXPERTISE AND CORPORATE EXPERTISE IS CRITICAL FOR BRINGING NEW TECHNOLOGY TO MARKET     EARLY-STAGE DEVELOPMENT Company formation, Management Team Identification, University IP Negotiation, Initial Funding and Performance Metrics SCALE AND MANUFACTURING Manufacturing Scale, Factory Integration, Pilot Facilities, Clinical Trials Value Creation $$ Cumulative Cost REVENUE GROWTH Introduction and Access to the Market and Customers TIME Corporate involvement is critical to providing scale and distribution. Understanding the optimal transition point is quintessential to build capital efficient businesses. 32  
  • 33. PARTNERING EARLY IS BENEFICIAL Corporate  Partner(s)   Scale  &   Manufacturing   Technology     Plaeorms   Company   Building   Market   Access   Corporate  Partner(s)   Scale  &   Manufacturing   Market   Access   Technology     Plaeorms   Company   Building   Opportunity  Space   We believe the skillsets of Harris & Harris Group and corporate partners are highly complementary. 33  
  • 34. OUR PARTNERING STRATEGY Our two paths to working with corporations. Corporate  Partner(s)   •  •  •  •  •  Investment Development Programs Commercialization/ Purchase Agreements Licensing Expertise •  •  •  Investment Strategic Insights Management Fees and Carried Interest H&H Portfolio Companies Corporations are an important part of Harris & Harris Group’s current and future strategies. 34  
  • 35. CURRENT EXAMPLE OF OUR PARTNERING STRATEGY Three Large Corporate Partners Investment in Initial Round of Funding + Development Programs Corporations currently add value to Harris & Harris Group and our portfolio companies in multiple ways. 35  
  • 36. HARRIS & HARRIS GROUP Our Four-Part Plan Realize Invest Partner Return 36  
  • 37. RETURNING VALUE FOR SHAREHOLDERS We seek to create value for shareholders by: •  Increasing net asset value per share (NAV) through: -  Gains on our investments -  Reduction of number of shares outstanding •  Distributing a portion of net capital gains on investments to shareholders through: -  Present: deemed dividends -  Future: deemed and actual dividends We believe execution on our four-part plan will generate meaningful returns to shareholders. 37  
  • 38. HARRIS & HARRIS GROUP Harris & Harris Group builds transformative companies from disruptive science.   38  
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