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              Skin Cancer is on the Rise
Skin Cancer is the most common form of cancer, with more than
3.5 million cases per year. Early detection and treatment are key
to prevention and survival. It’s critical to pay attention to moles
and other marks on your skin and get a skin exam once a year.
                                               Who Gets It?
•   1 in 5 Americans
•   1 in 3 Caucasians
•   Increasing incidence with age
•   Higher rate in older men & young women
•   Higher rate among people with family history of skin cancer
•   Higher rate among people with high sun exposure & tanning bed use
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               Do You Have Skin Cancer?
•   Basal cell carcinoma-most common cancer
•   Squamous cell carcinoma
•   Melanoma-one of most lethal forms of cancer
•   Pre-cancers
•   Others (e.g., lymphoma)

    The following photos show typical skin lesions that may be
    or develop into one of the top three forms of skin cancer.

      Photos from KDL Pathology and The Skin Cancer Foundation. Slide show adapted from www.cbsnews.com/2300-
      204_162-10006772-5.html#ixzz1l4eJhlHU
Dedicated to Providing Superior Diagnostics



        Actinic Keratosis, All May Develop into Cancer
                                              Classic actinic keratosis - flat, pink and scaly.
                                              Although you might be able to pick this crusty
                                              lesion off with your fingers, it would grow back.
                                              • rough
                                              • sometimes bleed
                                              • tend to occur on sun-exposed skin, including
                                                  the ears, face, scalp, backs of hands, neck.




                                                                        Actinic keratosis, marked
                                                                        with ink - in preparation
                                                                        for its removal.
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                        Treat Precancerous Lesions

These red, scaly patches are
Actinic keratoses. These back-
of-the-hand lesions are
common in older golfers and
others who spend a lot of time
outdoors.

Without treatment, actinic
keratoses can turn into a form
of cancer known as squamous
cell carcinoma.
Dedicated to Providing Superior Diagnostics




          Actinic Keratosis or Cancer?
This could be an actinic
keratosis or squamous cell
carcinoma. It should be
removed and sent to the lab
to determine.

In general, the prognosis is
good for people with
squamous cell carcinoma.
But a squamous cell
carcinoma that develops on
the lips or another mucous
membrane is more likely to
spread (metastasize) - and in
rare cases, proves deadly.
Dedicated to Providing Superior Diagnostics




                 Basal Cell Carcinoma
                                              Classic basal cell carcinoma - the
                                              least dangerous form of skin
                                              cancer. Note the red color and the
                                              almost pearlescent look. These
                                              cancers seldom metastasize but can
                                              grow larger - and so should be
                                              removed.




   This basal cell carcinoma has turned
   into a bloody, oozy mess. Any lesion
   that bleeds and doesn't heal is suspect
   and should be examined right away.
Dedicated to Providing Superior Diagnostics




              Results of Sun Exposure
                                              Basal cell carcinomas
                                              like these and other
                                              cancers are common
                                              on the face because it
                                              gets so much sun
                                              exposure over the
                                              years.


                                                                       Mohs surgery can be
                                                                       performed on an
                                              Some basal cell
                                                                       outpatient basis to
                                              carcinomas, like
                                                                       minimizes scarring and
                                              this one, have a
                                                                       prevent disfigurement.
                                              raised border.
                                                                       Others not on the face can
                                                                       simply be burned off.
Dedicated to Providing Superior Diagnostics




                                              Scar?

                                                      No, it’s basal cell carcinoma
                                                      that looks like a scar.
                                                      Atypical lesions like these
                                                      can be tricky to diagnose. If
                                                      it's not the aftermath of a
                                                      wound, it should likely be
                                                      removed.
Dedicated to Providing Superior Diagnostics



        Squamous Cell Carcinoma
                     This nodular ear lesion is a squamous cell
                     carcinoma. These lesions are seldom fatal but
                     can be disfiguring.



                                Squamous cell carcinoma
                                on the back of the hand.




                                                             Squamous cell carcinoma of
                                                             the nail.
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           It’s Deeper than it Looks
                                       Just a scab? No--this is a squamous cell carcinoma.

                                       Because skin cancers often extend deeper into tissue
                                       than they appear, the surgery required to remove this
                                       lesion is likely to be very extensive - and potentially
                                       disfiguring.

                                       Lesions should be removed before they get so big.
Dedicated to Providing Superior Diagnostics



                                           Is it a Mole?
                                             This isn't skin cancer but a dysplastic nevus (mole).
                                             These types of moles and lesions that appear
                                             irregular but are generally benign. If you have a lot
                                             of them, you may be more likely to develop skin
                                             cancer.




Another dysplastic
nevus. The
irregular border
and different
shades of color                                                       This close-up shot shows another
can be signs of                                                       dysplastic nevus, but the dark color
melanoma - but                                                        is more typical of a melanoma and
not in this case.                                                     should be biopsied right away.
Dedicated to Providing Superior Diagnostics



Melanoma-One of the Deadliest Cancers

                                               Melanoma:
                                               • color - dark, almost black
                                               • irregular, scalloped border




       Over time, melanomas grow and
       thicken. The thicker the lesion, the
       worse the prognosis.
       This one should have been removed
       long ago.
Dedicated to Providing Superior Diagnostics



    Melanomas Can Occur Anywhere, Don’t
               Ignore Them

                                             Looks like a black-and-
                                             blue nail? No. It's a
                                             melanoma, and lesions
                                             like this can be deadly.


This melanoma has been
growing for years. Lesions                                              Melanomas on the foot are
this extensive generally                                                rare but sometimes deadly -
cannot be successfully                                                  because people may mistake
treated - which is why early                                            them for warts, delaying
removal is so essential                                                 treatment by a doctor.
Dedicated to Providing Superior Diagnostics




                        Advancing Melanoma
                                    Classic melanoma with
                                    typical very dark coloration
                                    and varied (variegated)
                                    color. In addition, it's highly
                                    asymmetrical.




                                                                      This melanoma is fairly advanced
                                                                      - as evidenced by the raised
A melanoma                                                            portion. As melanomas grow and
this thick is                                                         thicken, they become harder to
almost certain                                                        treat successfully
to prove lethal.
Dedicated to Providing Superior Diagnostics




       Melanoma Color Variation
                                         Here's a bluish-black
                                         melanoma. Sometimes
                                         melanomas start out as
                                         one color and slowly
                                         change

                                                                   The pink area next to this
                                                                   melanoma may be the
                                                                   result of regression,
                                                                   shrinking as the body tries
                                         This blackish lesion is
                                                                   to fight back. But the body
                                         a melanoma. But
                                                                   can't deal with a deadly
                                         melanomas can also
                                                                   lesion like this. It should be
                                         look reddish, or even
                                                                   removed promptly.
                                         bluish
Dedicated to Providing Superior Diagnostics




Larger Melanoma is more Deadly
                                               People sometimes put off
                                               going to the doctor even
                                               when they suspect they have
                                               a problem.

                                               In other cases, melanomas
                                               are allowed to grow big
                                               because they develop on a
                                               hard-to-see part of the body

                                               Check your skin monthly and
                                               don’t put off getting
                                               suspicious lesion checked.
Dedicated to Providing Superior Diagnostics




                The ABCD’s of Melanomas




• Usually begin as small, flat colored lesion that spreads and thickens over time
• May begin in pre-existing tumor (nevus) or as a new tumor in sun-damaged skin
Dedicated to Providing Superior Diagnostics




                      Skin Cancer Detection
The single most important sign of skin cancer is change in
                 appearance of the lesion.
   •   Have all suspicious lesions biopsied immediately
   •   Skin biopsy typically covered by insurance plans
   •   Clinical history may be misleading
   •   Contact KDL for more information at clientservices@kdlpathology.com

Who finds them?
   •   Patients- 50%
   •   Practitioners- 25%
   •   Family members – 20%
   •   Melanomas are identified sooner by medical practitioners than
       patients
Dedicated to Providing Superior Diagnostics




                    Keep a “WATCHFull Eye”
• Whites
•   Adults
•   Tanning bed/ sun exposure
•   Changing lesions
•   History- personal or family history of skin cancer
•   Full skin examination
•   Eye – look for lesions which have features of skin
    cancer
Dedicated to Providing Superior Diagnostics

                     KDL Pathology                       Accreditations & Licenses:
                                                           CAP, CLIA, State of TN
• Founded in 1997 by Dr. Paul B. Googe as
  Knoxville Dermatopathology Laboratory, a                 Staff Board-Certified:
  regional laboratory with national recognition           Dermatopathologists,
                                                         Ophthalmic and Anatomic
• Only laboratory in East TN specializing in
                                                                Pathologists
  pathology and diagnostic testing for diseases of
  the skin, nail and eye                                        Affiliations:
• Laboratory diagnostic reports correlate                   KDL Pathologists have
  histologic findings, ancillary testing and clinical   teaching appointments at UT
  features                                              Graduate School of Medicine
                                                          and Vanderbilt University
• Reports include therapeutic recommendation
  when warranted or requested                              Active member of TN
                                                          Comprehensive Cancer
• RapidResults biopsy testing services available
                TM
                                                             Control Coalition

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Do i have skin cancer?

  • 1. Dedicated to Providing Superior Diagnostics Skin Cancer is on the Rise Skin Cancer is the most common form of cancer, with more than 3.5 million cases per year. Early detection and treatment are key to prevention and survival. It’s critical to pay attention to moles and other marks on your skin and get a skin exam once a year. Who Gets It? • 1 in 5 Americans • 1 in 3 Caucasians • Increasing incidence with age • Higher rate in older men & young women • Higher rate among people with family history of skin cancer • Higher rate among people with high sun exposure & tanning bed use
  • 2. Dedicated to Providing Superior Diagnostics Do You Have Skin Cancer? • Basal cell carcinoma-most common cancer • Squamous cell carcinoma • Melanoma-one of most lethal forms of cancer • Pre-cancers • Others (e.g., lymphoma) The following photos show typical skin lesions that may be or develop into one of the top three forms of skin cancer. Photos from KDL Pathology and The Skin Cancer Foundation. Slide show adapted from www.cbsnews.com/2300- 204_162-10006772-5.html#ixzz1l4eJhlHU
  • 3. Dedicated to Providing Superior Diagnostics Actinic Keratosis, All May Develop into Cancer Classic actinic keratosis - flat, pink and scaly. Although you might be able to pick this crusty lesion off with your fingers, it would grow back. • rough • sometimes bleed • tend to occur on sun-exposed skin, including the ears, face, scalp, backs of hands, neck. Actinic keratosis, marked with ink - in preparation for its removal.
  • 4. Dedicated to Providing Superior Diagnostics Treat Precancerous Lesions These red, scaly patches are Actinic keratoses. These back- of-the-hand lesions are common in older golfers and others who spend a lot of time outdoors. Without treatment, actinic keratoses can turn into a form of cancer known as squamous cell carcinoma.
  • 5. Dedicated to Providing Superior Diagnostics Actinic Keratosis or Cancer? This could be an actinic keratosis or squamous cell carcinoma. It should be removed and sent to the lab to determine. In general, the prognosis is good for people with squamous cell carcinoma. But a squamous cell carcinoma that develops on the lips or another mucous membrane is more likely to spread (metastasize) - and in rare cases, proves deadly.
  • 6. Dedicated to Providing Superior Diagnostics Basal Cell Carcinoma Classic basal cell carcinoma - the least dangerous form of skin cancer. Note the red color and the almost pearlescent look. These cancers seldom metastasize but can grow larger - and so should be removed. This basal cell carcinoma has turned into a bloody, oozy mess. Any lesion that bleeds and doesn't heal is suspect and should be examined right away.
  • 7. Dedicated to Providing Superior Diagnostics Results of Sun Exposure Basal cell carcinomas like these and other cancers are common on the face because it gets so much sun exposure over the years. Mohs surgery can be performed on an Some basal cell outpatient basis to carcinomas, like minimizes scarring and this one, have a prevent disfigurement. raised border. Others not on the face can simply be burned off.
  • 8. Dedicated to Providing Superior Diagnostics Scar? No, it’s basal cell carcinoma that looks like a scar. Atypical lesions like these can be tricky to diagnose. If it's not the aftermath of a wound, it should likely be removed.
  • 9. Dedicated to Providing Superior Diagnostics Squamous Cell Carcinoma This nodular ear lesion is a squamous cell carcinoma. These lesions are seldom fatal but can be disfiguring. Squamous cell carcinoma on the back of the hand. Squamous cell carcinoma of the nail.
  • 10. Dedicated to Providing Superior Diagnostics It’s Deeper than it Looks Just a scab? No--this is a squamous cell carcinoma. Because skin cancers often extend deeper into tissue than they appear, the surgery required to remove this lesion is likely to be very extensive - and potentially disfiguring. Lesions should be removed before they get so big.
  • 11. Dedicated to Providing Superior Diagnostics Is it a Mole? This isn't skin cancer but a dysplastic nevus (mole). These types of moles and lesions that appear irregular but are generally benign. If you have a lot of them, you may be more likely to develop skin cancer. Another dysplastic nevus. The irregular border and different shades of color This close-up shot shows another can be signs of dysplastic nevus, but the dark color melanoma - but is more typical of a melanoma and not in this case. should be biopsied right away.
  • 12. Dedicated to Providing Superior Diagnostics Melanoma-One of the Deadliest Cancers Melanoma: • color - dark, almost black • irregular, scalloped border Over time, melanomas grow and thicken. The thicker the lesion, the worse the prognosis. This one should have been removed long ago.
  • 13. Dedicated to Providing Superior Diagnostics Melanomas Can Occur Anywhere, Don’t Ignore Them Looks like a black-and- blue nail? No. It's a melanoma, and lesions like this can be deadly. This melanoma has been growing for years. Lesions Melanomas on the foot are this extensive generally rare but sometimes deadly - cannot be successfully because people may mistake treated - which is why early them for warts, delaying removal is so essential treatment by a doctor.
  • 14. Dedicated to Providing Superior Diagnostics Advancing Melanoma Classic melanoma with typical very dark coloration and varied (variegated) color. In addition, it's highly asymmetrical. This melanoma is fairly advanced - as evidenced by the raised A melanoma portion. As melanomas grow and this thick is thicken, they become harder to almost certain treat successfully to prove lethal.
  • 15. Dedicated to Providing Superior Diagnostics Melanoma Color Variation Here's a bluish-black melanoma. Sometimes melanomas start out as one color and slowly change The pink area next to this melanoma may be the result of regression, shrinking as the body tries This blackish lesion is to fight back. But the body a melanoma. But can't deal with a deadly melanomas can also lesion like this. It should be look reddish, or even removed promptly. bluish
  • 16. Dedicated to Providing Superior Diagnostics Larger Melanoma is more Deadly People sometimes put off going to the doctor even when they suspect they have a problem. In other cases, melanomas are allowed to grow big because they develop on a hard-to-see part of the body Check your skin monthly and don’t put off getting suspicious lesion checked.
  • 17. Dedicated to Providing Superior Diagnostics The ABCD’s of Melanomas • Usually begin as small, flat colored lesion that spreads and thickens over time • May begin in pre-existing tumor (nevus) or as a new tumor in sun-damaged skin
  • 18. Dedicated to Providing Superior Diagnostics Skin Cancer Detection The single most important sign of skin cancer is change in appearance of the lesion. • Have all suspicious lesions biopsied immediately • Skin biopsy typically covered by insurance plans • Clinical history may be misleading • Contact KDL for more information at clientservices@kdlpathology.com Who finds them? • Patients- 50% • Practitioners- 25% • Family members – 20% • Melanomas are identified sooner by medical practitioners than patients
  • 19. Dedicated to Providing Superior Diagnostics Keep a “WATCHFull Eye” • Whites • Adults • Tanning bed/ sun exposure • Changing lesions • History- personal or family history of skin cancer • Full skin examination • Eye – look for lesions which have features of skin cancer
  • 20. Dedicated to Providing Superior Diagnostics KDL Pathology Accreditations & Licenses: CAP, CLIA, State of TN • Founded in 1997 by Dr. Paul B. Googe as Knoxville Dermatopathology Laboratory, a Staff Board-Certified: regional laboratory with national recognition Dermatopathologists, Ophthalmic and Anatomic • Only laboratory in East TN specializing in Pathologists pathology and diagnostic testing for diseases of the skin, nail and eye Affiliations: • Laboratory diagnostic reports correlate KDL Pathologists have histologic findings, ancillary testing and clinical teaching appointments at UT features Graduate School of Medicine and Vanderbilt University • Reports include therapeutic recommendation when warranted or requested Active member of TN Comprehensive Cancer • RapidResults biopsy testing services available TM Control Coalition