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Dr. Rameswar Panda
Teaching Asst.
College of Veterinary Science, Hyderabad
Advances in Vitamin & Mineral
Nutrition in Livestock
Mineral
s
Function Cause of deficiency
Cu Transport of Iron in the body, synthesis of
collagen, myelin sheath formation, component
of cytochrome oxidase,
superoxidase,ceruloplasmin, tyrosinase,
stability to DNA/RNA.
High Mo, Cu:Mo ratio below
3:1,
Fe Component of catalase, oXidase, peroxidase,
Myoglobin, transferrin, ferittin
Parasitic infestation, raw
cotton seed meal feeding
Zn Component of 70 enzymes like alcoholic
dehydrogenase, carbonic anhydrase, carboxy
peptidase,DNA-RNApolymerase,
spermatogenesis, helps in Vit-A utilisation,
integrity of immune system, prostaglandin
metabolism,
Over cultivation of soil.
Mn Constituent of arginase, carboxylase,
transferase, hydrolase, mucoploysaccharide
synthesis, glycoprotein synthesis, maintains
membrane integrity, regulate CL
Prolonged intake of dry
fodder, in poultry Mn
deficiency occures due to
deficiency of Ca,P.
Co Recycling of methionine, purine and pyrimidine
synthesis
Legumes are superior in Ca, Cu, Zn,
Fe, and Co than the grasses.
Grasses has higher content of Mn and
Mo than the legumes.
Straw and Stover contains excess tannin,
silica and oxalates.
Straws are the major roughage source for
animal feeding.
With increased soil PH, there has been
drastic decrease in Mn level.
The soil in tropical climate is deficient in P.
Requirement of minerals for Ruminants
Major
Minerals
(% of diet)
Young
stock
Lactating
animals
Sheep and goat Maximum
tolerable limit
Ca 0.50 0.70 0.50 2.0
P 0.31 0.48 0.27 1.0
Mg 0.16 0.20 0.15 0.50
S 0.16 0.25 0.26 0.40
Na 0.10 0.18 0.18 1.5
K 0.65 1.0 0.70 3.0
Trace minerals
(mg/kg DM)
Young stock Lactating animal Sheep and Goat
Co 0.10 0.10 0.10
Cu 10.0 10.0 10.0
Fe 50.0 50.0 50.0
Mn 40.0 40.0 40.0
Zn 40.0 40.0 40.0
Calcium
1. Forages are
good source of
Ca.
2. Ca in feed
stuff is present
in the form of
oxalate and
phytate.
3. Addition of
lactose and
casein increase
the absorption
and retention of
Ca in both
ruminants and
non ruminants.
4.The descending
order of Ca
bioavailabilty
*Ca gluconate>Mono
calciumphosphate>Dicalciu
m phosphate>Ca Chloride>
bone meal> egg shell>lime
stone>oyster shell>Ca
sulphate> Ca Carbonate
Phosphorous
Known as
master mineral
Naturally
occuring phytic
acid is
hydrolysed by
ruminants,
except poultry
and swine
Worldwide P is
the most
deficient
mineral.
In plants, available as Phytic acid,
which should be degraded to
Phosphoric acid by phytase to
make it available to animals.
Cereal grains
and oil seed
contain
moderate to
high amount of
P.
Magnesium
Most Mg occurs in bones
and muscles.
Grass tetany happens
due to deficiency of Mg in
serum and CSF caused
by feeding of lush grass
high in K and low in Ca
and Mg.
Apparent absorption of
Mg from plant is 20-45%.
Supplimentation of
readily formentable
carbohydrate increase
the Mg absorption.
Mg in sulphate form is
better absorbed.
Potassium
The third most
abundant mineral in
the body, the
measure cation in
the intracellular fluid
a. Forage contain K
@ 1-4%
b. Average
absorption of K from
plants is 87-94%.
c.K is excreted from
the body primiarily in
the form of urine.
d.Bioavaolability of K
in the order of
KCl>Kbicarbonate>K
sulphate/carbonate
Sulphur
1. Sulphur is the component of Methionine,
Cystine, Cysteine, Thiamine and Biotin.
2. Inorganic S rumen microbes Organic Sulphur
S. Amino acids synthesized from
Sulphides oxidised sulphates
K.Sulphate> Mg
sulphate>Na
Sulphate>Ca sulphate
Sorghum deficient in
S.
Chromium
a.Glucose Tolerance
Factor
b. 0.02-1mg/kg Cr
stressed animals
Produce meat
animals with less
fat and more fat
Cobalt
3-13% of Co is
converted to
VitB12
Copper
Cu is available
more from
concentrate diets.
The requirement
is increased by
both S and Mo.
React to
thiomolybdeates
to form insolube
complex.
S cu sulphide
Cu
Storage-liver
Excretion-bile
Well absorbed
form- Cu
Sulphate &Cupric
carbonate
T3
T4
Iodine
Thyroxine
Energy metabolism
Goiterogenic substances
Thiocyanate
glucosinolates
Example-
Soyabean meal &
cotton seed meal
Brassica
Thiouracil goitrogen
Iodination of Tyrosine molecules
Fe
Oxygen Transport
>50% Iron (HB)
Deficiency is secondary
Cereal grains (30-60mg/kg)
Oil seeds (100-200mg/kg)
Meat and fish meal (400-500mg/kg)
Forage (70-500mg/kg)
Milk deficient
Animal protein high in Fe
Iron variation in forage is due to soil
contamination
Ca/P Fe
Manganese
Component of
Arginase,
carboxylase ,
Superoxide
dismutase
Cereal grains-
5-40mg/kg
Forage-30-
50mg/kg
Animal protein-
5-15mg/kg
Molybdenum
Component of Xanthine oxidase
Deficiency not common in cattle
Sulphate and Molybdenum have common
transport system
The conditions favouring Mo uptake in forages are
a. High moisture
b. Alkaline/neutral PH
c. High organic content
SELENIUM
Glutathione peroxidase-
1st selenium
metalloenzyme
G.Peroxidase reduces
hydrogen peroxide,
prevents oxidative
damage to the body
Iodothyronine 5’-
deiodinase- deiodination
of thyroxine to
triiodothyronine
(metabolically active)
Selenium toxicity
1. Blind staggers
2. Alkali disease/degnala
Vit-E and Se are
intercorrelated.
Zn
A. strong role in immune system
B. Every phase of growth requires Zn.
C. a role in steroid genesis, vit-A metabolism
D. Zn & Vit-A have synergestic action.
A. Role in reproductive status of the females.
B. Relative bioavailability of Zn is 60-70%.
Curtailing of menace of
Mineral deficiency
A.Enrichment of
soil
B. Mineral
biofortification
of plants
C.Direct
method of
mineral
supplimentation
D.
Supplimentation
of area specific
mineral mixture
NEWER TRACE ELEMENTS
Boran increase Ca & Mg
retention
Li-> effective in recovery of
bovine spastic paresis
Si- helps in
glycosamine
and collagen
synthesis.
Supplimentation of Vanadium
at 0.1ppm increase growth
rate, RBC and hameoglobin
level and helped in bone
formation in jaw defect.
Present in plants in the
form of carotenes and
carotenoids.
Deficiency associated
with vision, bone
development, epithelial
structure and
maintenance.
Supplementation of Zn
reduces the deficiency
of Vit A
10 times dietary level of
Vit A depress Vit E
utilisation.
Vitamin A
Vitamin D
Comprised of antirachitic
compounds
Two forms
a. Ergocalciferol(D2), derived
from ergosterol
b. Cholecalciferol(D3),derived
from 7-dehydrocholesterol, found
in animals
a. absorbed in intestine
along with lipid and bile
salts.
b. Requirement in cattle-
250IU/kg DM
Deficiency vit D- Rickets (young)-
>failure to utilise Ca,P
Osteomalacia (adults)-> Bone
weaken,fracture
Vitamin E
Occures in feed as ὰ-tocopherol,stored in liver Adipose tissue
Vit-E requirement in calf is 60IU/kg DM.
Vit-E deficiency can be precipitated by the intake of unsaturated fats.
Muscular dystrophy, white muscle disease
Prevents mastitis during periparturient
period
Vitamin K
Vit K
Antihaemorrhagic
Phylloquinone(K1)-
>plants
Menaquinone(K2)-
>fbacterial flora
Sweet clover disease
Antagonist to dicumarol
Ruminants-
>VitK2
Vit K1->
abundant
Water soluble vitamins (Vit B)
 Abundant in milk.
 Synthesized by rumen organisms.
Vitamin B12
4.5%Co
Metabolism of nucleic acid,
protein, carbohydrate,fat
Adenosylcobalamine
Methylcobalamine
Propionate metabolism
B1
Cocarboxylase
Role in TCA
cycle
Glucose
metabolism
Nervous disorder
Glucose
supply to
the brain
Synthesis by
rumen organisms
Liver detoxification
of blood NH3 to
urea and liver
metabolism of
ketone in ketosis
Coenzyme of NAD &
NADP
a. Dietary niacin
b. Tryptophan to
niacin
c. Ruminal
synthensis
Scaly dermatitis
Young animals
Microcytic anemia
Choline
 Essential for maintaining cell structure and
formation of acetyl choline.
 All naturally occurring fats contain choline.
 Calves fed a synthetic milk diet containing 15%
caesin exhibited signs of choline deficiency.
 It is recommended to add 0.26% choline in milk
replacers.

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Advances in vitamin & mineral nutrition in livestock

  • 1. Dr. Rameswar Panda Teaching Asst. College of Veterinary Science, Hyderabad Advances in Vitamin & Mineral Nutrition in Livestock
  • 2. Mineral s Function Cause of deficiency Cu Transport of Iron in the body, synthesis of collagen, myelin sheath formation, component of cytochrome oxidase, superoxidase,ceruloplasmin, tyrosinase, stability to DNA/RNA. High Mo, Cu:Mo ratio below 3:1, Fe Component of catalase, oXidase, peroxidase, Myoglobin, transferrin, ferittin Parasitic infestation, raw cotton seed meal feeding Zn Component of 70 enzymes like alcoholic dehydrogenase, carbonic anhydrase, carboxy peptidase,DNA-RNApolymerase, spermatogenesis, helps in Vit-A utilisation, integrity of immune system, prostaglandin metabolism, Over cultivation of soil. Mn Constituent of arginase, carboxylase, transferase, hydrolase, mucoploysaccharide synthesis, glycoprotein synthesis, maintains membrane integrity, regulate CL Prolonged intake of dry fodder, in poultry Mn deficiency occures due to deficiency of Ca,P. Co Recycling of methionine, purine and pyrimidine synthesis
  • 3. Legumes are superior in Ca, Cu, Zn, Fe, and Co than the grasses. Grasses has higher content of Mn and Mo than the legumes. Straw and Stover contains excess tannin, silica and oxalates. Straws are the major roughage source for animal feeding. With increased soil PH, there has been drastic decrease in Mn level. The soil in tropical climate is deficient in P.
  • 4. Requirement of minerals for Ruminants Major Minerals (% of diet) Young stock Lactating animals Sheep and goat Maximum tolerable limit Ca 0.50 0.70 0.50 2.0 P 0.31 0.48 0.27 1.0 Mg 0.16 0.20 0.15 0.50 S 0.16 0.25 0.26 0.40 Na 0.10 0.18 0.18 1.5 K 0.65 1.0 0.70 3.0
  • 5. Trace minerals (mg/kg DM) Young stock Lactating animal Sheep and Goat Co 0.10 0.10 0.10 Cu 10.0 10.0 10.0 Fe 50.0 50.0 50.0 Mn 40.0 40.0 40.0 Zn 40.0 40.0 40.0
  • 6. Calcium 1. Forages are good source of Ca. 2. Ca in feed stuff is present in the form of oxalate and phytate. 3. Addition of lactose and casein increase the absorption and retention of Ca in both ruminants and non ruminants. 4.The descending order of Ca bioavailabilty *Ca gluconate>Mono calciumphosphate>Dicalciu m phosphate>Ca Chloride> bone meal> egg shell>lime stone>oyster shell>Ca sulphate> Ca Carbonate
  • 7. Phosphorous Known as master mineral Naturally occuring phytic acid is hydrolysed by ruminants, except poultry and swine Worldwide P is the most deficient mineral. In plants, available as Phytic acid, which should be degraded to Phosphoric acid by phytase to make it available to animals. Cereal grains and oil seed contain moderate to high amount of P.
  • 8. Magnesium Most Mg occurs in bones and muscles. Grass tetany happens due to deficiency of Mg in serum and CSF caused by feeding of lush grass high in K and low in Ca and Mg. Apparent absorption of Mg from plant is 20-45%. Supplimentation of readily formentable carbohydrate increase the Mg absorption. Mg in sulphate form is better absorbed.
  • 9. Potassium The third most abundant mineral in the body, the measure cation in the intracellular fluid a. Forage contain K @ 1-4% b. Average absorption of K from plants is 87-94%. c.K is excreted from the body primiarily in the form of urine. d.Bioavaolability of K in the order of KCl>Kbicarbonate>K sulphate/carbonate
  • 10. Sulphur 1. Sulphur is the component of Methionine, Cystine, Cysteine, Thiamine and Biotin. 2. Inorganic S rumen microbes Organic Sulphur S. Amino acids synthesized from Sulphides oxidised sulphates K.Sulphate> Mg sulphate>Na Sulphate>Ca sulphate Sorghum deficient in S.
  • 11. Chromium a.Glucose Tolerance Factor b. 0.02-1mg/kg Cr stressed animals Produce meat animals with less fat and more fat Cobalt 3-13% of Co is converted to VitB12
  • 12. Copper Cu is available more from concentrate diets. The requirement is increased by both S and Mo. React to thiomolybdeates to form insolube complex. S cu sulphide Cu Storage-liver Excretion-bile Well absorbed form- Cu Sulphate &Cupric carbonate
  • 13. T3 T4 Iodine Thyroxine Energy metabolism Goiterogenic substances Thiocyanate glucosinolates Example- Soyabean meal & cotton seed meal Brassica Thiouracil goitrogen Iodination of Tyrosine molecules
  • 14. Fe Oxygen Transport >50% Iron (HB) Deficiency is secondary Cereal grains (30-60mg/kg) Oil seeds (100-200mg/kg) Meat and fish meal (400-500mg/kg) Forage (70-500mg/kg) Milk deficient Animal protein high in Fe Iron variation in forage is due to soil contamination Ca/P Fe
  • 15. Manganese Component of Arginase, carboxylase , Superoxide dismutase Cereal grains- 5-40mg/kg Forage-30- 50mg/kg Animal protein- 5-15mg/kg
  • 16. Molybdenum Component of Xanthine oxidase Deficiency not common in cattle Sulphate and Molybdenum have common transport system The conditions favouring Mo uptake in forages are a. High moisture b. Alkaline/neutral PH c. High organic content
  • 17. SELENIUM Glutathione peroxidase- 1st selenium metalloenzyme G.Peroxidase reduces hydrogen peroxide, prevents oxidative damage to the body Iodothyronine 5’- deiodinase- deiodination of thyroxine to triiodothyronine (metabolically active) Selenium toxicity 1. Blind staggers 2. Alkali disease/degnala Vit-E and Se are intercorrelated.
  • 18. Zn A. strong role in immune system B. Every phase of growth requires Zn. C. a role in steroid genesis, vit-A metabolism D. Zn & Vit-A have synergestic action. A. Role in reproductive status of the females. B. Relative bioavailability of Zn is 60-70%.
  • 19. Curtailing of menace of Mineral deficiency A.Enrichment of soil B. Mineral biofortification of plants C.Direct method of mineral supplimentation D. Supplimentation of area specific mineral mixture
  • 20. NEWER TRACE ELEMENTS Boran increase Ca & Mg retention Li-> effective in recovery of bovine spastic paresis Si- helps in glycosamine and collagen synthesis. Supplimentation of Vanadium at 0.1ppm increase growth rate, RBC and hameoglobin level and helped in bone formation in jaw defect.
  • 21. Present in plants in the form of carotenes and carotenoids. Deficiency associated with vision, bone development, epithelial structure and maintenance. Supplementation of Zn reduces the deficiency of Vit A 10 times dietary level of Vit A depress Vit E utilisation. Vitamin A
  • 22. Vitamin D Comprised of antirachitic compounds Two forms a. Ergocalciferol(D2), derived from ergosterol b. Cholecalciferol(D3),derived from 7-dehydrocholesterol, found in animals a. absorbed in intestine along with lipid and bile salts. b. Requirement in cattle- 250IU/kg DM Deficiency vit D- Rickets (young)- >failure to utilise Ca,P Osteomalacia (adults)-> Bone weaken,fracture
  • 23. Vitamin E Occures in feed as ὰ-tocopherol,stored in liver Adipose tissue Vit-E requirement in calf is 60IU/kg DM. Vit-E deficiency can be precipitated by the intake of unsaturated fats. Muscular dystrophy, white muscle disease Prevents mastitis during periparturient period
  • 24. Vitamin K Vit K Antihaemorrhagic Phylloquinone(K1)- >plants Menaquinone(K2)- >fbacterial flora Sweet clover disease Antagonist to dicumarol Ruminants- >VitK2 Vit K1-> abundant
  • 25. Water soluble vitamins (Vit B)  Abundant in milk.  Synthesized by rumen organisms.
  • 26. Vitamin B12 4.5%Co Metabolism of nucleic acid, protein, carbohydrate,fat Adenosylcobalamine Methylcobalamine Propionate metabolism
  • 27. B1 Cocarboxylase Role in TCA cycle Glucose metabolism Nervous disorder Glucose supply to the brain Synthesis by rumen organisms
  • 28. Liver detoxification of blood NH3 to urea and liver metabolism of ketone in ketosis Coenzyme of NAD & NADP a. Dietary niacin b. Tryptophan to niacin c. Ruminal synthensis Scaly dermatitis Young animals Microcytic anemia
  • 29. Choline  Essential for maintaining cell structure and formation of acetyl choline.  All naturally occurring fats contain choline.  Calves fed a synthetic milk diet containing 15% caesin exhibited signs of choline deficiency.  It is recommended to add 0.26% choline in milk replacers.