Tuberculosis& its management

Tuberculosis www.freelivedoctor.com

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Transmission ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Classification of Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Isoniazid ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Mechanism of action ,[object Object],[object Object],www.freelivedoctor.com

Resistance ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Excretion ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Excretion cont. ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Adverse Effects ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Age dependency www.freelivedoctor.com % incidence age 0.13 25 .59 35 1.09 45 1.75 55 2.5 >60

Drug Interaction ,[object Object],www.freelivedoctor.com

Rifampin ,[object Object],[object Object],www.freelivedoctor.com

Resistance: ,[object Object],www.freelivedoctor.com

Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Adverse Effects: ,[object Object],[object Object],www.freelivedoctor.com

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WARNING! Rifampin and Isoniazid are the most effective drugs for the treatment of TB, The drug enjoys high patient compliance and acceptability. But these 2 drugs should never be given alone! They are always used in combination because resistance occurs to one drug alone very rapidly. They are used in combination with each other initially as well as other drugs. Bacilli must become resistant to two drugs in order to remain viable. Statistically, the chances are verv small of the bacilli becoming resistant to both. . Prophylaxis is with one drug usually isoniazid. www.freelivedoctor.com

2nd Line Drugs: Not as effective and have more toxicity ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

para- Aminosalicylic Acid ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Adverse effects ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Third Line Drug s - least effective and most toxic ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Adverse effects ,[object Object],www.freelivedoctor.com

Cycloserine ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Chemoprophylaxis of TB Used only in high risk groups ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Chemotherapy of TB ,[object Object],[object Object],www.freelivedoctor.com

Treatment ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Antitubercular Agents ,[object Object],[object Object],[object Object]

Mycobacterium Infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Mycobacterium Infections ,[object Object],[object Object],[object Object],[object Object],[object Object]

Mycobacterium Infections ,[object Object],[object Object],[object Object],[object Object]

Antitubercular Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antitubercular Agents: Mechanism of Action ,[object Object],[object Object],[object Object],[object Object]

Antitubercular Agents: Mechanism of Action isoniazid (INH) ,[object Object],[object Object],[object Object]

Used for the prophylaxis or treatment of TB Antitubercular Agents: Therapeutic Uses

Antitubercular Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antitubercular Agents: Side Effects ,[object Object],[object Object],[object Object]

Antitubercular Agents: Nursing Implications ,[object Object],[object Object],[object Object]

Antitubercular Agents: Nursing Implications ,[object Object],[object Object],[object Object],[object Object]

Antitubercular Agents: Nursing Implications ,[object Object],[object Object]

Tuberculosis& its management

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