The document discusses drugs that affect the cardiovascular system, including their classification and mechanisms of action. It covers antihypertensive drugs, drugs for cardiac function and electrophysiology, as well as antiplatelet and anticoagulant drugs. Key topics include the Vaughn-Williams classification system for antiarrhythmics, calcium channel blockers, beta blockers, ACE inhibitors, diuretics, and drugs for hemostasis including aspirin, heparin, warfarin, and thrombolytics.
36. BP = CO x PVR Key: CCB = calcium channel blockers CA Adrenergics = central-acting adrenergics ACEi’s = angiotensin-converting enzyme inhibitors cardiac factors circulating volume heart rate contractility 1. Beta Blockers 2. CCB’s 3. C.A. Adrenergics salt aldosterone ACEi’s Diuretics
37. BP = CO x PVR Peripheral Sympathetic Receptors alpha beta 1. alpha blockers 2. beta blockers Local Acting 1. Peripheral-Acting Adrenergics Hormones 1. vasodilators 2. ACEI’s 3. CCB’s Central Nervous System 1. CA Adrenergics
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42. ACE Inhibitors Angiotensin I ACE Angiotensin II 1. potent vasoconstrictor - increases BP 2. stimulates Aldosterone - Na + & H 2 O reabsorbtion . RAAS
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47. CCB Site of Action diltiazem & verapamil nifedipine (and other dihydropyridines )
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51. Diuretic Site of Action . loop of Henle proximal tubule Distal tubule Collecting duct