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IMPORTANT ASPECTS OF
   ANTENATAL CARE
  CME Conducted by
  ATLAS HOSPITAL, RUWI
  MUSCAT
NICE/RCOG GUIDELINES – JUNE
            2010
 Pregnancy is a normal physiological
 process & any interventions offered should
 have known benefits & be acceptable to the
 pregnant women
 Current models of ante-natal care originated in
  the early 20th century.
 The pattern of visits recommended at that time
  (monthly until 30 wks, then fortnightly to 36 wks
  and then weekly until delivery) is still
  recognisable today
AIMS OF ANTENATAL CARE
   Monitoring the progress of pregnancy
    with minimum interference
   Guidance to the expectant mother
   Early detection of any deviation from
    normal
   Institution of corrective measures
    wherever possible
   Preparation of the mother for labour &
    delivery
PRENATAL CARE
   The ideal initial prenatal care visit occurs before
    conception with a pre-conceptive visit.

   A pre-conceptive visit allows modification of
    behavioral choices, medication, and optimizing
    medical concerns before conception.
FIRST VISIT – 10 WEEKS

ANC BEGINS AS SOON AS PREGNANCY IS
CONFIRMED
 CONFIRMATION OF PREGNANCY – UPT

 HISTORY TAKING

 GENERAL & SYSTEMIC EXAMINATION

 INVESTIGATIONS – Hb, RBS, Ur, Blood Group, HIV,
  VDRL, HbsAg , Sickling Test
 USG –Confirming viability & number

        Estimation of GA & EDD (10–13wks)
Advice - Do’s And Dont’s
   DIET
   WORK & EXERCISE – Continue working till the end & moderate
    exercise
   COMMON SYMPTOMS – Morning
    sickness, Heartburn, LBA, Frequency, Vg Discharge, Constipation
   SEXUAL INTERCOURSE – safe
   MEDICATIONS – Folic acid & calcium
   ALCOHOL INTAKE - <1-2 UK units/wk (1 u= half a pint of ordinary
    strength lager/beer, or one shot [25 ml] of spirits. One small [125
    ml] glass of wine =1.5 UK units)
   SMOKING – Quit-LBW, IUGR
   DRIVING & TRAVEL – Car (seat belts) & Air travel (36wks), travel
    abroad & related vaccinations
Seat Belt in pregnant lady – the right
                 way!
SCREENING FOR MATERNAL
            DISEASES
   ANEMIA – Booking – 11 gm%
                28wks – 10.5 gm%
    No need for routine Iron supplements
   SICKLE CELL DISEASE - Sickling test
   ALLO-ANTIBODIES - ICT - Routine anti-D
    prophylaxis at 28 & 36 wks to all non-sensitised
    pregnant women
   Women should be screened for atypical red cell
    allo antibodies (Kidd, Duffy, Anti-C) in early
    pregnancy & at 28 weeks, regardless of their
    rhesus D status
SCREENING FOR FETAL ANOMALIES
    DOWN’S SYNDROME- Nuchal Thickness -
     performed end of first trimester (13w0d-13w6d) –
     increased >6 mm
    COMBINED TEST – NT + HCG + PAPP-A (11w-
     13w6d)
    TRIPLE/QUADRUPLE TEST 15-20wks.
    CONTINGENT SCREENING measuring free β-
     hCG & PAPP-A in all pts at 10 wks -those with low
     risk are screened negative- remainder NT - 13 wks -
     low risk are screened negative-others offered marker
     assays & diagnostic tests.
    ANOMALY SCAN - 18w 0d-20w 6d – Optional
TRIPLE MARKER TEST
   Performed between the 15th & 18th wk.

   AFP (fetus), HCG (placenta), and Estriol
    (both)

   High AFP levels - neural tube defects,
    anencephaly, mistaken dates.

   Low AFP & Estriol & High HCG -Trisomy 21
    (Down) Trisomy 18 (Edwards) or any other type
    of chromosome abnormality.
QUADRUPLE TEST
   Pts registering in late 2nd trimester-22wks
   AFP (fetal liver), Estriol (placenta+fetal
    liver),HCG (placenta),Inhibin-A (placenta)
   High AFP levels - open neural tube defect,
    mistaken dates or twins.
   Low AFP levels - high risk for Down syndrome.
   High HCG and Inhibin-A levels - increased
    risk Down syndrome.
   Low Estriol - high risk for Down syndrome
SCREENING FOR INFECTIONS
   Asymptomatic bacteriuria - persistent bacterial
    colonisation of the urinary tract without symptoms.
   After the initial screening, patients only need to be
    screened for UTI infections if they are symptomatic
   HIV – MTCT- more than 35% reduced to 5% with
    ART with ZT(300mg)+NVP(200mg)+3TC(150mg)
    twice daily-14 wks till BF & 6wks for infant after BF
   The combination of ART, LSCS and avoiding breast
    feeding can further reduce the transmission to 1%.
   Latest guidelines – Continue ART + Breast feeding
SCREENING FOR INFECTIONS
 HEPATITIS–B - Screening for HBsAg, new
  sample-confirmatory testing & testing for e-markers
  to know if baby will need Ig along with vaccine
  postnatally
 RUBELLA - susceptibility screening offered early to
  identify women at risk of contracting rubella
  infection and vaccinate in the postnatal period.
 SYPHILLIS- TPHA if VDRL is positive

 Mother-to-child transmission is associated with
 neonatal death, congenital syphilis, stillbirth and
 preterm birth
SCREENING FOR CLINICAL
          CONDITIONS
GESTATIONAL DIABETES
 RBS at booking - less than 130 mg/dl or 7.2 mmol/l
 OGCT - 1 hr after 50 gm of glucose - 24wks – h/o
  GDM–16wks-< 140mg/dl or 7.8 mmol/l
 GTT– 75 gm of glucose and 03 days of diet rich in
  carbohydrates.
 Fasting – 104 mg/dl or 5.8 mmol/l
 2 hr after glucose – 140 mg/dl or 7.8 mmol/l
 A 2 hr 75 g OGTT is used as the gold standard
  diagnostic test and is assumed to be 100%
  sensitive and specific
PRE-ECLAMPSIA
   Pre-eclampsia is a complex disorder with
    widespread endothelial damage in all organs, thus
    presenting signs and symptoms may be more varied
    than just high BP & proteinuria
   Blood pressure measurement and urinalysis
    for protein–each visit.
   Hypertension single diastolic BP of 110 mmHg or
    any consecutive readings of 90 mmHg on more than
    one occasion at least 4 hours apart.
   Proteinuria 02 clean catch samples-4 hours apart
    with 2+ proteinuria by dipstick are significant.
   300 mg protein in a 24 hour sample
PLACENTA PREVIA
   Low-lying placentae - not an uncommon finding
    on early trimester scans
   Most low-lying placentae detected at the routine
    scan generally resolve by the time the baby is
    born.
   Only a woman whose placenta extends over the
    internal cervical os should be offered another
    trans-abdominal scan at 32 weeks.
    If the trans-abdominal scan is unclear, a trans-
    vaginal scan should be performed.
MONITORING FETAL WELL BEING
   Clinical Examination – Symphysis-Fundal height
    – after 24wks (difference of more than 2 cms is
    significant)
   Daily Fetal Movement Count – DFMC–10/12 hrs
    or 3 in one hr – one hr post meals.
   Ultrasound – not accurate in assessing fetal growth
    in later trimesters
   Doppler Studies - in suspected IUGR
   CTG/NST– valid only after 32 weeks
   Biophysical Profile – Movement, tone, HR (NST),
    Breathing, AFI – Normal score 8 or more
   Modified Biophysical Profile – NST + AFI
VACCINATIONS
   Tetanus Toxoid - 02 doses
   Killed/Inactivated/Toxoids can be given .
   Live vaccines are contraindicated
   Not Given - BCG, Cholera, Japanese Encephalitis,
    Measles , Mumps, Rubella, Typhoid, Varicella
   Give only if essential as safety in pregnancy has
    not been documented -         Hepatitis A & E
                           Influenza
                           Meningococcal
                           OPV
                           Rabies
                           Diphtheria
                           Yellow fever
MANAGEMENT OF COMMON
      SYMPTOMS IN PREGNANCY
               NAUSEA & VOMITTING

   More in primigravidas & multiple pregnancies
   Cause - First/Increased exposure to HCG
   No harm to fetus - Generally settles by 16-20wks
   Diet - Avoid oily & spicy food
          Small frequent meals
   Home remedies – Ginger & lemon
   Medications - T. Pyridoxine - twice daily
                    Severe cases – Inj. Metoclopramide
HEARTBURN
   Effect of progesterone - reduced tone of
    lower esophageal sphincter
   Diet modifications – reduce spicy food & eat
    small and frequent meals at short intervals
   Postural modifications – avoid bending &
    lying down immediately after meals
   Medications–H2 receptor blockers - Ranitidine
                  Proton Pump Inhibitors - Omez ®
                  Antacids - Gelusil®
CONSTIPATION
   Effect of Progesterone – Relaxes musculature
    reduces tone & motility of smooth muscles
   Diet modification – High fibre diet
                         Plenty of water
                         More fruits & vegetables
   Medications – Mild Laxatives–Lactulose
                                   Herbolax ®
                                   Liquid Paraffin
VAGINAL DISCHARGE
 Due to vascular congestion & increased activity
  of cervical mucus secreting glands
 No treatment required

 Watch for – Change of colour

               Foul Smell
               Associated Pruritis
               Painful or burning micturition
Above signs indicate infection in which case the
 same will have to be treated accordingly
BACKACHE
   Initially due to pelvic organ congestion & later
    due to strained pelvic supports & exaggerated
    lumbar lordosis
   Lifestyle – as active as possible
   Support- Lower back when sitting
             Abdominal bump when lying down
   Non-pharmacological - Back massage
                             - Hot fomentation
   Drugs - Unrelenting cases - Analgesics
                               - Balms/gels for LA
HAEMORRHOIDS & VARICOSE
            VEINS
   Due to vascular congestion
   Effect of Progesterone
   No effective treatment in pregnancy
   Avoid constipation
   Diet advice – high fibre, plenty of water
   Leg elevation & avoid prolonged periods of
    standing
   Compression stockings
   Medications – Laxatives, creams & Flavinoids
                    Hirudoid cream
POST-DATISM
   At 40 wks of gestation, only 58% of women had
    delivered, 74% by 41 wks and 82% by 42 wks
   Perinatal mortality & morbidity is increased if
    duration of pregnancy is more than 42 wks.
   Sweeping/Stripping of membranes – 41 wks –
    likelihood of spontaneous onset of labour in 48
    hrs
   41-42 weeks – Twice weekly NST, USG for AFI
   42 weeks – Induction of labour & delivery
INTERVENTIONS NOT ROUTINELY
           RECOMMENDED
   Repeated maternal weighing.
   Breast or pelvic examination.
   Iron or vitamin A supplements.
   Routine Doppler ultrasound in low-risk pregnancies.
   Ultrasound estimation of fetal size for suspected LGA
   Routine screening for preterm labour.
   Routine screening for cardiac anomalies using NT.
   Routine fetal-movement counting.
   Routine auscultation of the fetal heart.
   Routine antenatal electronic cardio-tocography.
   Routine ultrasound scanning after 24 weeks
THANKS

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Important aspects of antenatal care

  • 1. IMPORTANT ASPECTS OF ANTENATAL CARE CME Conducted by ATLAS HOSPITAL, RUWI MUSCAT
  • 2. NICE/RCOG GUIDELINES – JUNE 2010 Pregnancy is a normal physiological process & any interventions offered should have known benefits & be acceptable to the pregnant women  Current models of ante-natal care originated in the early 20th century.  The pattern of visits recommended at that time (monthly until 30 wks, then fortnightly to 36 wks and then weekly until delivery) is still recognisable today
  • 3. AIMS OF ANTENATAL CARE  Monitoring the progress of pregnancy with minimum interference  Guidance to the expectant mother  Early detection of any deviation from normal  Institution of corrective measures wherever possible  Preparation of the mother for labour & delivery
  • 4. PRENATAL CARE  The ideal initial prenatal care visit occurs before conception with a pre-conceptive visit.  A pre-conceptive visit allows modification of behavioral choices, medication, and optimizing medical concerns before conception.
  • 5. FIRST VISIT – 10 WEEKS ANC BEGINS AS SOON AS PREGNANCY IS CONFIRMED  CONFIRMATION OF PREGNANCY – UPT  HISTORY TAKING  GENERAL & SYSTEMIC EXAMINATION  INVESTIGATIONS – Hb, RBS, Ur, Blood Group, HIV, VDRL, HbsAg , Sickling Test  USG –Confirming viability & number Estimation of GA & EDD (10–13wks)
  • 6. Advice - Do’s And Dont’s  DIET  WORK & EXERCISE – Continue working till the end & moderate exercise  COMMON SYMPTOMS – Morning sickness, Heartburn, LBA, Frequency, Vg Discharge, Constipation  SEXUAL INTERCOURSE – safe  MEDICATIONS – Folic acid & calcium  ALCOHOL INTAKE - <1-2 UK units/wk (1 u= half a pint of ordinary strength lager/beer, or one shot [25 ml] of spirits. One small [125 ml] glass of wine =1.5 UK units)  SMOKING – Quit-LBW, IUGR  DRIVING & TRAVEL – Car (seat belts) & Air travel (36wks), travel abroad & related vaccinations
  • 7. Seat Belt in pregnant lady – the right way!
  • 8. SCREENING FOR MATERNAL DISEASES  ANEMIA – Booking – 11 gm% 28wks – 10.5 gm%  No need for routine Iron supplements  SICKLE CELL DISEASE - Sickling test  ALLO-ANTIBODIES - ICT - Routine anti-D prophylaxis at 28 & 36 wks to all non-sensitised pregnant women  Women should be screened for atypical red cell allo antibodies (Kidd, Duffy, Anti-C) in early pregnancy & at 28 weeks, regardless of their rhesus D status
  • 9. SCREENING FOR FETAL ANOMALIES  DOWN’S SYNDROME- Nuchal Thickness - performed end of first trimester (13w0d-13w6d) – increased >6 mm  COMBINED TEST – NT + HCG + PAPP-A (11w- 13w6d)  TRIPLE/QUADRUPLE TEST 15-20wks.  CONTINGENT SCREENING measuring free β- hCG & PAPP-A in all pts at 10 wks -those with low risk are screened negative- remainder NT - 13 wks - low risk are screened negative-others offered marker assays & diagnostic tests.  ANOMALY SCAN - 18w 0d-20w 6d – Optional
  • 10. TRIPLE MARKER TEST  Performed between the 15th & 18th wk.  AFP (fetus), HCG (placenta), and Estriol (both)  High AFP levels - neural tube defects, anencephaly, mistaken dates.  Low AFP & Estriol & High HCG -Trisomy 21 (Down) Trisomy 18 (Edwards) or any other type of chromosome abnormality.
  • 11. QUADRUPLE TEST  Pts registering in late 2nd trimester-22wks  AFP (fetal liver), Estriol (placenta+fetal liver),HCG (placenta),Inhibin-A (placenta)  High AFP levels - open neural tube defect, mistaken dates or twins.  Low AFP levels - high risk for Down syndrome.  High HCG and Inhibin-A levels - increased risk Down syndrome.  Low Estriol - high risk for Down syndrome
  • 12. SCREENING FOR INFECTIONS  Asymptomatic bacteriuria - persistent bacterial colonisation of the urinary tract without symptoms.  After the initial screening, patients only need to be screened for UTI infections if they are symptomatic  HIV – MTCT- more than 35% reduced to 5% with ART with ZT(300mg)+NVP(200mg)+3TC(150mg) twice daily-14 wks till BF & 6wks for infant after BF  The combination of ART, LSCS and avoiding breast feeding can further reduce the transmission to 1%.  Latest guidelines – Continue ART + Breast feeding
  • 13. SCREENING FOR INFECTIONS  HEPATITIS–B - Screening for HBsAg, new sample-confirmatory testing & testing for e-markers to know if baby will need Ig along with vaccine postnatally  RUBELLA - susceptibility screening offered early to identify women at risk of contracting rubella infection and vaccinate in the postnatal period.  SYPHILLIS- TPHA if VDRL is positive Mother-to-child transmission is associated with neonatal death, congenital syphilis, stillbirth and preterm birth
  • 14. SCREENING FOR CLINICAL CONDITIONS GESTATIONAL DIABETES  RBS at booking - less than 130 mg/dl or 7.2 mmol/l  OGCT - 1 hr after 50 gm of glucose - 24wks – h/o GDM–16wks-< 140mg/dl or 7.8 mmol/l  GTT– 75 gm of glucose and 03 days of diet rich in carbohydrates.  Fasting – 104 mg/dl or 5.8 mmol/l  2 hr after glucose – 140 mg/dl or 7.8 mmol/l  A 2 hr 75 g OGTT is used as the gold standard diagnostic test and is assumed to be 100% sensitive and specific
  • 15. PRE-ECLAMPSIA  Pre-eclampsia is a complex disorder with widespread endothelial damage in all organs, thus presenting signs and symptoms may be more varied than just high BP & proteinuria  Blood pressure measurement and urinalysis for protein–each visit.  Hypertension single diastolic BP of 110 mmHg or any consecutive readings of 90 mmHg on more than one occasion at least 4 hours apart.  Proteinuria 02 clean catch samples-4 hours apart with 2+ proteinuria by dipstick are significant.  300 mg protein in a 24 hour sample
  • 16. PLACENTA PREVIA  Low-lying placentae - not an uncommon finding on early trimester scans  Most low-lying placentae detected at the routine scan generally resolve by the time the baby is born.  Only a woman whose placenta extends over the internal cervical os should be offered another trans-abdominal scan at 32 weeks.  If the trans-abdominal scan is unclear, a trans- vaginal scan should be performed.
  • 17. MONITORING FETAL WELL BEING  Clinical Examination – Symphysis-Fundal height – after 24wks (difference of more than 2 cms is significant)  Daily Fetal Movement Count – DFMC–10/12 hrs or 3 in one hr – one hr post meals.  Ultrasound – not accurate in assessing fetal growth in later trimesters  Doppler Studies - in suspected IUGR  CTG/NST– valid only after 32 weeks  Biophysical Profile – Movement, tone, HR (NST), Breathing, AFI – Normal score 8 or more  Modified Biophysical Profile – NST + AFI
  • 18. VACCINATIONS  Tetanus Toxoid - 02 doses  Killed/Inactivated/Toxoids can be given .  Live vaccines are contraindicated  Not Given - BCG, Cholera, Japanese Encephalitis, Measles , Mumps, Rubella, Typhoid, Varicella  Give only if essential as safety in pregnancy has not been documented - Hepatitis A & E Influenza Meningococcal OPV Rabies Diphtheria Yellow fever
  • 19. MANAGEMENT OF COMMON SYMPTOMS IN PREGNANCY NAUSEA & VOMITTING  More in primigravidas & multiple pregnancies  Cause - First/Increased exposure to HCG  No harm to fetus - Generally settles by 16-20wks  Diet - Avoid oily & spicy food Small frequent meals  Home remedies – Ginger & lemon  Medications - T. Pyridoxine - twice daily Severe cases – Inj. Metoclopramide
  • 20. HEARTBURN  Effect of progesterone - reduced tone of lower esophageal sphincter  Diet modifications – reduce spicy food & eat small and frequent meals at short intervals  Postural modifications – avoid bending & lying down immediately after meals  Medications–H2 receptor blockers - Ranitidine Proton Pump Inhibitors - Omez ® Antacids - Gelusil®
  • 21. CONSTIPATION  Effect of Progesterone – Relaxes musculature reduces tone & motility of smooth muscles  Diet modification – High fibre diet Plenty of water More fruits & vegetables  Medications – Mild Laxatives–Lactulose Herbolax ® Liquid Paraffin
  • 22. VAGINAL DISCHARGE  Due to vascular congestion & increased activity of cervical mucus secreting glands  No treatment required  Watch for – Change of colour Foul Smell Associated Pruritis Painful or burning micturition Above signs indicate infection in which case the same will have to be treated accordingly
  • 23. BACKACHE  Initially due to pelvic organ congestion & later due to strained pelvic supports & exaggerated lumbar lordosis  Lifestyle – as active as possible  Support- Lower back when sitting Abdominal bump when lying down  Non-pharmacological - Back massage - Hot fomentation  Drugs - Unrelenting cases - Analgesics - Balms/gels for LA
  • 24. HAEMORRHOIDS & VARICOSE VEINS  Due to vascular congestion  Effect of Progesterone  No effective treatment in pregnancy  Avoid constipation  Diet advice – high fibre, plenty of water  Leg elevation & avoid prolonged periods of standing  Compression stockings  Medications – Laxatives, creams & Flavinoids Hirudoid cream
  • 25. POST-DATISM  At 40 wks of gestation, only 58% of women had delivered, 74% by 41 wks and 82% by 42 wks  Perinatal mortality & morbidity is increased if duration of pregnancy is more than 42 wks.  Sweeping/Stripping of membranes – 41 wks – likelihood of spontaneous onset of labour in 48 hrs  41-42 weeks – Twice weekly NST, USG for AFI  42 weeks – Induction of labour & delivery
  • 26. INTERVENTIONS NOT ROUTINELY RECOMMENDED  Repeated maternal weighing.  Breast or pelvic examination.  Iron or vitamin A supplements.  Routine Doppler ultrasound in low-risk pregnancies.  Ultrasound estimation of fetal size for suspected LGA  Routine screening for preterm labour.  Routine screening for cardiac anomalies using NT.  Routine fetal-movement counting.  Routine auscultation of the fetal heart.  Routine antenatal electronic cardio-tocography.  Routine ultrasound scanning after 24 weeks
  • 27.