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Discovery of Cells
 The first observations of cells were made in 1665 by
 English scientist Robert Hooke, who used a crude
 microscope of his own invention to examine a variety
 of objects, including a thin piece of cork.
 While Hooke was the first to observe and describe
 cells, he did not comprehend their significance.

 At about the same time, the Dutch maker of
 microscopes Anton Van Leeuwenhoek pioneered the
 invention of one of the best microscopes of the time.
 Using his invention, Leeuwenhoek was the first to
 observe, draw, and describe a variety of living
 organisms, including bacteria gliding in saliva, one-
 celled organisms cavorting in pond water, and sperm
 swimming in semen.
The cell is the structural and
  functional unit of all known
      living organisms. It is the
  smallest unit of an organism
that is classified as living, and
   is often called the building
 brick of life.Some organisms,
     such as most bacteria, are
unicellular (consist of a single
  cell). Other organisms, such
 as humans, are multicellular.
Major components of the Cell
Theory
a. All living things/ organisms are composed of one or
    more cells and cell products

b. All living cells come from other living cells by the
    process of cell division
Cell Functions
 1. Nutrition – process by which cells obtain food
  molecules to support their other activities.
 2. Digestion- food particles are broken down into
  smaller soluble units suitable for cell use with the help
  of the ENZYMES
 3. Absorption- is the process by which cells absorb
  water, minerals & other matl’s essential to life
 4. Biosynthesis- process by which cells organize
  complex chemicals from simple building units to
  complex
 5. Excretion- process by which by products of all cell
  activities which are not needed for further cell fxning
  are eliminated
 6. Egestion-insoluble, non digested particles are
  eliminated by the cell
 7. Secretion- process by which substances that are
  synthesized by the cells are expelled from the
  membrane (e.g Hormones)
 8. Movement- process by which includes the
  locomotion of cells by means of special structures like
  cilia of flagella
 9. Irritability- process by which cells respond or
  react to external factors.

 10. Respiration- is the process of breaking down
  food molecules into chemical energy needed by all
  cells in order to fxn

11. Reproduction- process by which cells copy or
  replicates its DNA and increases its number by cell
  division.
Anatomy of cells

 There are two types of cells: eukaryotic and prokaryotic.


 Prokaryotic cells are usually independent, while
  eukaryotic cells are often found in multicellular
  organisms.
Prokaryotic cells
 prokaryote cell is simpler
  than a eukaryote cell,
  lacking a nucleus and
  most of the other
  organelles of eukaryotes.
  There are two kinds of
  prokaryotes: bacteria
  and archaea; these share
  a similar overall
  structure.
 A prokaryotic cell has three architectural regions:


 on the outside, flagella and pili project from the
  cell's surface. These are structures (not present in
  all prokaryotes) made of proteins that facilitate
  movement and communication between cells;
 Eukaryotic cells
Eukaryotic cells are about 10 times the size of a typical
prokaryote and can be as much as 1000 times greater in
volume. The major difference between prokaryotes and
eukaryotes is that eukaryotic cells contain membrane-
bound compartments in which specific metabolic
activities take place. Most important among these is the
presence of a cell nucleus, a membrane-delineated
compartment that houses the eukaryotic cell's DNA. It is
this nucleus that gives the eukaryote its name, which
means "true nucleus."
Animal Cell
 An animal cell typically contains several types of
  membrane-bound organs, or organelles. The nucleus
  directs activities of the cell and carries genetic
  information from generation to generation. The
  mitochondria generate energy for the cell. Proteins
  are manufactured by ribosomes, which are bound to
  the rough endoplasmic reticulum or float free in the
  cytoplasm. The Golgi apparatus modifies, packages,
  and distributes proteins while lysosomes store
  enzymes for digesting food. The entire cell is
  wrapped in a lipid membrane that selectively permits
  materials to pass in and out of the cytoplasm.
Table 1: Comparison of features of prokaryotic and eukaryotic cells
                            Prokaryotes                        Eukaryotes
 Typical organisms          bacteria, archaea                  protists, fungi, plants, animals
                                                               ~ 10-100 µm (sperm cells, apart from
 Typical size               ~ 1-10 µm
                                                               the tail, are smaller)
 Type of nucleus            nucleoid region; no real nucleus   real nucleus with double membrane
                                                               linear molecules (chromosomes) with
 DNA                        circular (usually)
                                                               histone proteins
                                                               RNA-synthesis inside the nucleus
 RNA-/protein-synthesis     coupled in cytoplasm
                                                               protein synthesis in cytoplasm
 Ribosomes                  50S+30S                            60S+40S
                                                               highly structured by endomembranes
 Cytoplasmatic structure    very few structures
                                                               and a cytoskeleton

                                                               flagella and cilia containing
 Cell movement              flagella made of flagellin         microtubules; lamellipodia and
                                                               filopodia containing actin

                                                               one to several thousand (though some
 Mitochondria               none
                                                               lack mitochondria)
 Chloroplasts               none                               in algae and plants
                                                               single cells, colonies, higher
 Organization               usually single cells               multicellular organisms with
                                                               specialized cells
                                                               Mitosis (fission or budding)
 Cell division              Binary fission (simple division)
                                                               Meiosis
Comparison of structures between animal and plant cells
                       Typical animal cell   Typical plant cell
 Organelles            •Nucleus              •Nucleus
                       •Nucleolus (within    •Nucleolus (within
                       nucleus)              nucleus)
                       •Rough endoplasmic    •Rough ER
                       reticulum (ER)        •Smooth ER
                       •Ribosomes            •Ribosomes
                       •Cytoskeleton         •Cytoskeleton
                       •Golgi apparatus      •Golgi apparatus
                       •Cytoplasm            (dictiosomes)
                       •Mitochondria         •Cytoplasm
                       •Vesicles             •Mitochondria
                       •Lysosomes
                       •Centrosome
                       •Centrioles
                       •Vacuoles

                       •Smooth ER
 The Plasma Membrane—A Cell's Protective Coat
 The outer lining of a eukaryotic cell is called the
  plasma membrane. This membrane serves to
  separate and protect a cell from its surrounding
  environment and is made mostly from a double layer
  of proteins and lipids, fat-like molecules. Embedded
  within this membrane are a variety of other molecules
  that act as channels and pumps, moving different
  molecules into and out of the cell. A form of plasma
  membrane is also found in prokaryotes, but in this
  organism it is usually referred to as the cell
  membrane.
 The plasma membrane
  (cell membrane) is
  made of two layers of
  phospholipids. The
  membrane has many
  proteins embedded in
  it.
 The plasma membrane
  regulates what enters
  and leaves the cell.
  Many molecules cross
  the cell membrane by
  diffusion and osmosis.
The Cytoskeleton—A Cell's
Scaffold
The cytoskeleton is an
important, complex, and dynamic
cell component. It acts to organize
and maintain the cell's shape;
anchors organelles in place; helps
during endocytosis, the uptake
of external materials by a cell; and
moves parts of the cell in
processes of growth and motility.
There are a great number of
proteins associated with the
cytoskeleton, each controlling a
cell’s structure by directing,
bundling, and aligning filaments.
 The Cytoplasm—A Cell's Inner Space

 Inside the cell there is a large fluid-filled
  space called the cytoplasm, sometimes
  called the cytosol. In prokaryotes, this
  space is relatively free of compartments.
  In eukaryotes, the cytosol is the "soup"
  within which all of the cell's organelles
  reside. It is also the home of the
  cytoskeleton. The cytosol contains
  dissolved nutrients, helps break down
  waste products, and moves material
  around the cell through a process called
  cytoplasmic streaming. The nucleus
  often flows with the cytoplasm changing
   its shape as it moves. The cytoplasm also
   contains many salts and is an excellent
   conductor of electricity, creating the
   perfect environment for the mechanics
   of the cell. The function of the
   cytoplasm, and the organelles which
   reside in it, are critical for a cell's
   survival.
 Genetic Material
 Two different kinds of
 genetic material exist:
 deoxyribonucleic acid
 (DNA) and ribonucleic
 acid (RNA). Most
 organisms are made of
 DNA, but a few viruses have
 RNA as their genetic
 material. The biological
 information contained in an
 organism is encoded in its
 DNA or RNA sequence.
 The Nucleus—A Cell's Center

 The nucleus is the most
  conspicuous organelle found in a
  eukaryotic cell. It houses the cell's
  chromosomes and is the place
  where almost all DNA replication
  and RNA synthesis occur. The
  nucleus is spheroid in shape and
  separated from the cytoplasm by a
  membrane called the nuclear
  envelope. The nuclear envelope
  isolates and protects a cell's DNA
  from various molecules that could
  accidentally damage its structure or
  interfere with its processing.
  During processing, DNA is
  transcribed, or synthesized, into a
  special RNA, called mRNA. This
  mRNA is then transported out of
  the nucleus, where it is translated
  into a specific protein molecule. In
  prokaryotes, DNA processing takes
  place in the cytoplasm.
 The Ribosome—The
  Protein Production
  Machine
 Ribosomes are found in
  both prokaryotes and
  eukaryotes. The ribosome
  is a large complex
  composed of many
  molecules, including RNAs
  and proteins, and is
  responsible for processing
  the genetic instructions
  carried by an mRNA
 The mitochondria are
 specialised for energy
 production (respiration).
 Chloroplasts are organelles
 found in plant cells which
 produce sugar using light.
 Light is the ultimate source of
 energy for almost all life on
 Earth. The area of the cell
 outside the nucleus and the
 organelles is called the
 cytoplasm. Membranes are
 complex structures and they
 are an effective barrier to the
 environment, and regulate the
 flow of food, energy and
 information in and out of the
 cell
Transport, "intracellular highway".
Ribosomes are positioned along the rough
ER, protein made by the ribosomes enter the
ER for transport.




 Processes, packages and secretes proteins.
 Like a factory.
Animal cell
Plant cell

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Cells.

  • 1.
  • 2. Discovery of Cells  The first observations of cells were made in 1665 by English scientist Robert Hooke, who used a crude microscope of his own invention to examine a variety of objects, including a thin piece of cork.
  • 3.  While Hooke was the first to observe and describe cells, he did not comprehend their significance.  At about the same time, the Dutch maker of microscopes Anton Van Leeuwenhoek pioneered the invention of one of the best microscopes of the time. Using his invention, Leeuwenhoek was the first to observe, draw, and describe a variety of living organisms, including bacteria gliding in saliva, one- celled organisms cavorting in pond water, and sperm swimming in semen.
  • 4. The cell is the structural and functional unit of all known living organisms. It is the smallest unit of an organism that is classified as living, and is often called the building brick of life.Some organisms, such as most bacteria, are unicellular (consist of a single cell). Other organisms, such as humans, are multicellular.
  • 5. Major components of the Cell Theory a. All living things/ organisms are composed of one or more cells and cell products b. All living cells come from other living cells by the process of cell division
  • 6. Cell Functions  1. Nutrition – process by which cells obtain food molecules to support their other activities.  2. Digestion- food particles are broken down into smaller soluble units suitable for cell use with the help of the ENZYMES  3. Absorption- is the process by which cells absorb water, minerals & other matl’s essential to life  4. Biosynthesis- process by which cells organize complex chemicals from simple building units to complex
  • 7.  5. Excretion- process by which by products of all cell activities which are not needed for further cell fxning are eliminated  6. Egestion-insoluble, non digested particles are eliminated by the cell  7. Secretion- process by which substances that are synthesized by the cells are expelled from the membrane (e.g Hormones)  8. Movement- process by which includes the locomotion of cells by means of special structures like cilia of flagella
  • 8.
  • 9.  9. Irritability- process by which cells respond or react to external factors.  10. Respiration- is the process of breaking down food molecules into chemical energy needed by all cells in order to fxn 11. Reproduction- process by which cells copy or replicates its DNA and increases its number by cell division.
  • 10. Anatomy of cells  There are two types of cells: eukaryotic and prokaryotic.  Prokaryotic cells are usually independent, while eukaryotic cells are often found in multicellular organisms.
  • 11. Prokaryotic cells  prokaryote cell is simpler than a eukaryote cell, lacking a nucleus and most of the other organelles of eukaryotes. There are two kinds of prokaryotes: bacteria and archaea; these share a similar overall structure.
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  • 13.  A prokaryotic cell has three architectural regions: on the outside, flagella and pili project from the cell's surface. These are structures (not present in all prokaryotes) made of proteins that facilitate movement and communication between cells;
  • 14.  Eukaryotic cells Eukaryotic cells are about 10 times the size of a typical prokaryote and can be as much as 1000 times greater in volume. The major difference between prokaryotes and eukaryotes is that eukaryotic cells contain membrane- bound compartments in which specific metabolic activities take place. Most important among these is the presence of a cell nucleus, a membrane-delineated compartment that houses the eukaryotic cell's DNA. It is this nucleus that gives the eukaryote its name, which means "true nucleus."
  • 16.  An animal cell typically contains several types of membrane-bound organs, or organelles. The nucleus directs activities of the cell and carries genetic information from generation to generation. The mitochondria generate energy for the cell. Proteins are manufactured by ribosomes, which are bound to the rough endoplasmic reticulum or float free in the cytoplasm. The Golgi apparatus modifies, packages, and distributes proteins while lysosomes store enzymes for digesting food. The entire cell is wrapped in a lipid membrane that selectively permits materials to pass in and out of the cytoplasm.
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  • 19. Table 1: Comparison of features of prokaryotic and eukaryotic cells Prokaryotes Eukaryotes Typical organisms bacteria, archaea protists, fungi, plants, animals ~ 10-100 µm (sperm cells, apart from Typical size ~ 1-10 µm the tail, are smaller) Type of nucleus nucleoid region; no real nucleus real nucleus with double membrane linear molecules (chromosomes) with DNA circular (usually) histone proteins RNA-synthesis inside the nucleus RNA-/protein-synthesis coupled in cytoplasm protein synthesis in cytoplasm Ribosomes 50S+30S 60S+40S highly structured by endomembranes Cytoplasmatic structure very few structures and a cytoskeleton flagella and cilia containing Cell movement flagella made of flagellin microtubules; lamellipodia and filopodia containing actin one to several thousand (though some Mitochondria none lack mitochondria) Chloroplasts none in algae and plants single cells, colonies, higher Organization usually single cells multicellular organisms with specialized cells Mitosis (fission or budding) Cell division Binary fission (simple division) Meiosis
  • 20. Comparison of structures between animal and plant cells Typical animal cell Typical plant cell Organelles •Nucleus •Nucleus •Nucleolus (within •Nucleolus (within nucleus) nucleus) •Rough endoplasmic •Rough ER reticulum (ER) •Smooth ER •Ribosomes •Ribosomes •Cytoskeleton •Cytoskeleton •Golgi apparatus •Golgi apparatus •Cytoplasm (dictiosomes) •Mitochondria •Cytoplasm •Vesicles •Mitochondria •Lysosomes •Centrosome •Centrioles •Vacuoles •Smooth ER
  • 21.  The Plasma Membrane—A Cell's Protective Coat  The outer lining of a eukaryotic cell is called the plasma membrane. This membrane serves to separate and protect a cell from its surrounding environment and is made mostly from a double layer of proteins and lipids, fat-like molecules. Embedded within this membrane are a variety of other molecules that act as channels and pumps, moving different molecules into and out of the cell. A form of plasma membrane is also found in prokaryotes, but in this organism it is usually referred to as the cell membrane.
  • 22.  The plasma membrane (cell membrane) is made of two layers of phospholipids. The membrane has many proteins embedded in it.  The plasma membrane regulates what enters and leaves the cell. Many molecules cross the cell membrane by diffusion and osmosis.
  • 23. The Cytoskeleton—A Cell's Scaffold The cytoskeleton is an important, complex, and dynamic cell component. It acts to organize and maintain the cell's shape; anchors organelles in place; helps during endocytosis, the uptake of external materials by a cell; and moves parts of the cell in processes of growth and motility. There are a great number of proteins associated with the cytoskeleton, each controlling a cell’s structure by directing, bundling, and aligning filaments.
  • 24.  The Cytoplasm—A Cell's Inner Space  Inside the cell there is a large fluid-filled space called the cytoplasm, sometimes called the cytosol. In prokaryotes, this space is relatively free of compartments. In eukaryotes, the cytosol is the "soup" within which all of the cell's organelles reside. It is also the home of the cytoskeleton. The cytosol contains dissolved nutrients, helps break down waste products, and moves material around the cell through a process called cytoplasmic streaming. The nucleus often flows with the cytoplasm changing its shape as it moves. The cytoplasm also contains many salts and is an excellent conductor of electricity, creating the perfect environment for the mechanics of the cell. The function of the cytoplasm, and the organelles which reside in it, are critical for a cell's survival.
  • 25.  Genetic Material  Two different kinds of genetic material exist: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Most organisms are made of DNA, but a few viruses have RNA as their genetic material. The biological information contained in an organism is encoded in its DNA or RNA sequence.
  • 26.  The Nucleus—A Cell's Center  The nucleus is the most conspicuous organelle found in a eukaryotic cell. It houses the cell's chromosomes and is the place where almost all DNA replication and RNA synthesis occur. The nucleus is spheroid in shape and separated from the cytoplasm by a membrane called the nuclear envelope. The nuclear envelope isolates and protects a cell's DNA from various molecules that could accidentally damage its structure or interfere with its processing. During processing, DNA is transcribed, or synthesized, into a special RNA, called mRNA. This mRNA is then transported out of the nucleus, where it is translated into a specific protein molecule. In prokaryotes, DNA processing takes place in the cytoplasm.
  • 27.  The Ribosome—The Protein Production Machine  Ribosomes are found in both prokaryotes and eukaryotes. The ribosome is a large complex composed of many molecules, including RNAs and proteins, and is responsible for processing the genetic instructions carried by an mRNA
  • 28.  The mitochondria are specialised for energy production (respiration). Chloroplasts are organelles found in plant cells which produce sugar using light. Light is the ultimate source of energy for almost all life on Earth. The area of the cell outside the nucleus and the organelles is called the cytoplasm. Membranes are complex structures and they are an effective barrier to the environment, and regulate the flow of food, energy and information in and out of the cell
  • 29. Transport, "intracellular highway". Ribosomes are positioned along the rough ER, protein made by the ribosomes enter the ER for transport. Processes, packages and secretes proteins. Like a factory.