1. WELCOME

2. Seminar on PHARMACOGENOMICS A promise of personalized medicine

3. UNDER GUIDENCE OF Mrs. M sandhya M.pharm Assistant professor

5. Definition

6. Gene index

7. Need for pharmacogenomics

8. Expression studies

9. Recent research promise

10. Single nucleotide polymorphism

11. Pharmacogenomics in drug development

12. Challenges posed by pharmacogenomics

13. Scientific hurdles

14. Positional cloning

15. Polymorphism

16. Enzyme polymorphism

17. Success so far

18. Benefits

20. DEFINITION Pharmacogenomics refers to the use of DNA-based genotyping in order to target pharmaceutical agents to specific patient population in the design of drugs.

22. 15,000 known genes – 17,000 gene prediction.

24. They represent the advent personalized medicine.

25. Treatment according to his genotype.

26. Increase the safety and efficiency of drug.

29. DNA array technology allows the expression monitoring of thousand of genes.

35. Lead to patient stratification and these new targets and as well as existing targets will be divided into subsets.

38. Responsible for many diseases.

45. I-form expresses ACE lower than D-form.

48. 5 fluoro- uracilbased chemotherapy first line treatment is very poor.

49. Combination with irinotican is effective but produces adverse effects.

50. Polymorphism in enzyme system is identified by pharmacogenomic studies.

52. To over come the resistance to drug is one of many challenge of current cancer.

53. To identify patients more likely benefits to identify which chemotherapy regimen to use.

54. DNA micro array but gene expression of different cancer in human.

56. Identification of genetic markers of drug response for better control of blood pressure.

58. Pharmacogenomics have great impact on statin therapy.

60. Inter individual variability is ten fold to obtain therapeutic response.

61. Low dose- no effect.

62. High dose- rise of over bleeding.

64. Increase the probability that the drug might be success with particular population.

67. THANK YOU