Slideshow is from the University of Michigan Medical School's M1 Patients and Populations: Medical Genetics Sequence. View additional course materials on Open.Michigan: openmi.ch/med-M1PatientsPopulations

1. Author(s): Gerald Abrams, M.D., 2009
License: Unless otherwise noted, this material is made available under the terms
of the Creative Commons Attribution–Non-commercial–Share Alike 3.0
License: http://creativecommons.org/licenses/by-nc-sa/3.0/
We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your
ability to use, share, and adapt it. The citation key on the following slide provides information about how you
may share and adapt this material.
Copyright holders of content included in this material should contact open.michigan@umich.edu with any
questions, corrections, or clarification regarding the use of content.
For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use.
Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis
or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please
speak to your physician if you have questions about your medical condition.
Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.

2. Citation Key
for more information see: http://open.umich.edu/wiki/CitationPolicy
Use + Share + Adapt
{ Content the copyright holder, author, or law permits you to use, share and adapt. }
Public Domain – Government: Works that are produced by the U.S. Government. (USC 17 §105)
Public Domain – Expired: Works that are no longer protected due to an expired copyright term.
Public Domain – Self Dedicated: Works that a copyright holder has dedicated to the public domain.
Creative Commons – Zero Waiver
Creative Commons – Attribution License
Creative Commons – Attribution Share Alike License
Creative Commons – Attribution Noncommercial License
Creative Commons – Attribution Noncommercial Share Alike License
GNU – Free Documentation License
Make Your Own Assessment
{ Content Open.Michigan believes can be used, shared, and adapted because it is ineligible for copyright. }
Public Domain – Ineligible: Works that are ineligible for copyright protection in the U.S. (USC 17 § 102(b)) *laws in
your jurisdiction may differ
{ Content Open.Michigan has used under a Fair Use determination. }
Fair Use: Use of works that is determined to be Fair consistent with the U.S. Copyright Act. (USC 17 § 107) *laws in your
jurisdiction may differ
Our determination DOES NOT mean that all uses of this 3rd-party content are Fair Uses and we DO NOT guarantee that
your use of the content is Fair.
To use this content you should do your own independent analysis to determine whether or not your use will be Fair.

3. M1 Patients and Populations:
DISTURBANCES OF GROWTH
NEOPLASIA I
Gerald D. Abrams MD
Fall 2008

4. ORGANS/TISSUES SMALLER
THAN NORMAL
• DEVELOPMENTAL
AGENESIS
APLASIA
HYPOPLASIA
ATRESIA
• ACQUIRED
ATROPHY

5. UNILATERAL RENAL AGENESIS
Department of Pathology, University of Michigan

6. UNILATERAL RENAL
HYPOPLASIA
Department of Pathology, University of Michigan

7. LIVER, BROWN ATROPHY
G.D. Abrams, University of Michigan Medical School

8. ORGANS / TISSUES LARGER
THAN NORMAL
• HYPERTROPHY
INCREASE IN CELL SIZE
• HYPERPLASIA
INCREASE IN CELL NUMBER

9. HEART, NORMAL
Department of Pathology, University of Michigan

10. HEART, HYPERTROPHY
Department of Pathology, University of Michigan

11. MYOCARDIUM, NORMAL
G.D. Abrams, University of Michigan Medical School

12. MYOCARDIUM, HYPERTROPHY
G.D. Abrams, University of Michigan Medical School

13. SKIN, NORMAL
G.D. Abrams, University of Michigan Medical School

14. SKIN, HYPERPLASIA
G.D. Abrams, University of Michigan Medical School

15. SKIN, HYPERKERATOSIS
G.D. Abrams, University of Michigan Medical School

16. MAMMARY GLAND
G.D. Abrams, University of Michigan Medical School

17. MAMMARY GLAND, LACTATING
G.D. Abrams, University of Michigan Medical School

18. PROSTATE, HYPERPLASIA
Source Undetermined

19. BREAST- FIBROCYSTIC
CHANGE
Source Undetermined

20. NORMAL BREAST
G.D. Abrams, University of Michigan Medical School

21. BREAST
FIBROCYSTIC CHANGE
G.D. Abrams, University of Michigan Medical School

22. ABNORMAL PATTERNS OF CELL
GROWTH / DIFFERENTIATION
• METAPLASIA
• DYSPLASIA

23. ENDOCERVIX, SQUAMOUS
METAPLASIA
G.D. Abrams, University of Michigan Medical School

24. ENDOCERVIX, SQUAMOUS
METAPLASIA
G.D. Abrams, University of Michigan Medical School

25. SQUAMOUS EPITHELIUM,
NORMAL
G.D. Abrams, University of Michigan Medical School

26. SQUAMOUS EPITHELIUM,
MODERATE DYSPLASIA
G.D. Abrams, University of Michigan Medical School

27. SQUAMOUS EPITHELIUM,
SEVERE DYSPLASIA
G.D. Abrams, University of Michigan Medical School

28. NEOPLASM / TUMOR
• MASS ( NEW GROWTH ) –
PROLIFERATING CELLS
• AUTONOMOUS
• NON-EQUILIBRIUM, UNCOORDINATED
GROWTH
• PERSISTENT / IRREVERSIBLE

29. NEOPLASTIC
TRANSFORMATION
• SERIES OF GENETIC EVENTS
• CLONAL CHARACTERISTICS

30. Benign Tumor: growth by expansion
Malignant Tumor: growth by invasion
Regents of The University of Michigan

31. BENIGN AND MALIGNANT
GROWTH
• BENIGN
COHESIVE /EXPANSILE
CIRCUMSCRIBED / LOCALIZED
• MALIGNANT
POORLY CIRCUMSCRIBED /
INVASIVE….METASTASIZING

32. UTERUS, LEIOMYOMA
Department of Pathology, University of Michigan

33. UTERUS, LEIOMYOMA
G.D. Abrams, University of Michigan Medical School

34. BREAST CANCER
Department of Pathology, University of Michigan

35. COLON CANCER
Department of Pathology, University of Michigan

36. COLON CANCER
Department of Pathology, University of Michigan

37. CANCER INVADING COLONIC
WALL
G.D. Abrams, University of Michigan Medical School

38. METASTASIS
• A COMPLEX CASCADE OF EVENTS
• VIA BLOOD
• VIA LYMPH
• DIRECT

39. CANCER CELLS WITHIN BLOOD
VESSEL
G.D. Abrams, University of Michigan Medical School

40. CANCER CELLS WITHIN
LYMPHATIC
G.D. Abrams, University of Michigan Medical School

41. PERITONEUM,
CARCINOMATOSIS
Department of Pathology, University of Michigan

42. PERITONEAL METASTASES
Department of Pathology, University of Michigan

43. LIVER, METASTASES
Department of Pathology, University of Michigan

44. EYE, PRIMARY MALIGNANT
MELANOMA
Department of Pathology, University of Michigan

45. LUNG, METASTASES
Department of Pathology, University of Michigan

46. VERTEBRAE, METASTASES
Department of Pathology, University of Michigan

47. VERTEBRA, METASTASIS
Department of Pathology, University of Michigan

48. BRAIN, METASTASIS
Department of Pathology, University of Michigan

49. LIVER, METASTASES
Department of Pathology, University of Michigan

50. Additional Source Information
for more information see: http://open.umich.edu/wiki/CitationPolicy
Slide 5: Department of Pathology, University of Michigan
Slide 6: Department of Pathology, University of Michigan
Slide 7: G.D. Abrams, University of Michigan Medical School
Slide 9: Department of Pathology, University of Michigan
Slide 10: Department of Pathology, University of Michigan
Slide 11: G.D. Abrams, University of Michigan Medical School
Slide 12: G.D. Abrams, University of Michigan Medical School
Slide 13: G.D. Abrams, University of Michigan Medical School
Slide 14: G.D. Abrams, University of Michigan Medical School
Slide 15: G.D. Abrams, University of Michigan Medical School
Slide 16: G.D. Abrams, University of Michigan Medical School
Slide 17: G.D. Abrams, University of Michigan Medical School
Slide 18: Source Undetermined
Slide 19: Source Undetermined
Slide 20: G.D. Abrams, University of Michigan Medical School
Slide 21: G.D. Abrams, University of Michigan Medical School
Slide 23: G.D. Abrams, University of Michigan Medical School
Slide 24: G.D. Abrams, University of Michigan Medical School
Slide 25: G.D. Abrams, University of Michigan Medical School
Slide 26: G.D. Abrams, University of Michigan Medical School
Slide 27: G.D. Abrams, University of Michigan Medical School
Slide 30: Regents of the University of Michigan
Slide 32: Department of Pathology, University of Michigan
Slide 33: G.D. Abrams, University of Michigan Medical School
Slide 34: Department of Pathology, University of Michigan
Slide 35: Department of Pathology, University of Michigan
Slide 36: Department of Pathology, University of Michigan
Slide 37: G.D. Abrams, University of Michigan Medical School
Slide 39: G.D. Abrams, University of Michigan Medical School
Slide 40: G.D. Abrams, University of Michigan Medical School
Slide 41: Department of Pathology, University of Michigan
Slide 42: Department of Pathology, University of Michigan
Slide 43: Department of Pathology, University of Michigan
Slide 44: Department of Pathology, University of Michigan
Slide 45: Department of Pathology, University of Michigan
Slide 46: Department of Pathology, University of Michigan
Slide 47: Department of Pathology, University of Michigan
Slide 48: Department of Pathology, University of Michigan
Slide 49: Department of Pathology, University of Michigan