Osteoarthritis is a disorder of movable joints characterized by cartilage degeneration and joint damage. Risk factors include age, genetics, obesity, injury, and repetitive joint use. Glucosamine and chondroitin help rebuild cartilage as key components of cartilage tissue. Omega-3 fatty acids reduce inflammation and slow cartilage breakdown. Seven Seas JointCare products combine these ingredients to support joint health, with options for mild, moderate, or severe osteoarthritis providing different levels of glucosamine, chondroitin, collagen, and omega-3.

1. Natural approaches to joint care
With glucosamine and omega-3

2. Healthy Joint Arthritic Joint

3. What is osteoarthritis (OA)?
- the complicated text book definition!
• Osteoarthritis is primarily a disorder of
movable joints characterized by an
imbalance between the synthesis and
degradation of the articular cartilage,
leading to joint damage, pain &
inflammation

4. Risk factors for OA
Body build
Arthritis in
the family Difficult
pregnancy/birth
Smoking
Trauma
Misshapen joints
Repetitive use:
-occupational
-leisure
What makesWhat makes
you moreyou more
susceptible?susceptible?
MechanicalMechanical
FactorsFactors
Age
Overweight

5. Osteoarthritis
• As lifespan increases, the pressure
on load bearing joints also increases
• Arthritis can affect any joint but hips,
knees and lower spine are most
commonly affected

6. Osteoarthritis
No longer a disease of old age
• Osteoarthritis - No longer a
disease of old age
– Begins in our 30’s, 20’s or even
younger
– Tell tale twinges not felt till 40’s
and 50’s
• Professional sports players
may be at more risk of early
joint changes
– Repetitive use of certain joints
increases risk

7. The healthy joint
• Movable joints are made up of bone, connective tissue (cartilage,
tendons, muscles and ligaments) and synovial tissue
Cartilage
Synovial
fluid Muscles
Tibia Fibula
Ligament

8. Osteoarthritis
The symptoms
• Cartilage degeneration
• Pain and inflammation
• Muscle weakening
• Bone weakening and
fragmentation
• Loss of mobility and quality
of life
• Eventual need for joint
replacement surgery

9. The osteoarthritic joint
• Doctors used to think that failing cartilage caused osteoarthritis.
Now they know it’s a complex process involving muscles, tendons,
bones - even genetics
Cartilage wears
away & body
comes less
capable of
replacing it
Synovial fluid
can become
depleted
making joint
less capble of
absorbing
shocks
Muscles
weakened with
old age, causing
greater strain on
joints
Eroding
cartilage causes
bones to grind
and flake
producing bone
spurs
Ligaments
damaged &
weakened

10. Osteoarthritis
The main symptoms
• Inflammation and swelling
around the synovial joints
• Cartilage degradation

11. How glucosamine works
CHONDROCYTES
(THE BUILDERS OF
CARTILAGE)
CARTILAGE
(A WALL/BARRIER AT
THE ENDS OF BONES
THAT ACTS AS SHOCK
ABORBER)
GLUCOSAMINE
(HELPS FORM
PROTEOGLYCANS)
. . used by
. . to create

12. Chondroitin
• Chondroitin is present in cartilage and
connective tissue and is involved in
the attraction of fluid that lubricates the
joint
• Connective tissues are continuously
being remodelled as they wear away
during activity and are them reformed
afterwards
• As we age, we become less efficient at
renewing these tissues (especially
cartilage)
• Like glucosamine, chondroitin is a
building block of proteoglycans (one
of the main structural components of
cartilage)
• Hyaluronic acid is a major
component of synovial fluid which is
the lubricating fluid in joints
• Whilst chondroitin is a natural amino
sugar already present in the body, it
can not be easily obtained from diet
as it is found in only a small number
of foods

13. Glucosamine
Clinical support
• Glucosamine lays the foundation for the everyday
building of connective tissues around the joints including
tendons, ligaments and cartilage, important for the
smooth working of joints.
• “The results of a recent study has proven that glucosamine
treatment significantly slows or may even prevent total joint
replacement for patients with knee osteoarthritis”
O Bruyere, K Pavelka, L C Rovati, et al. Total joint replacement after glucosamine sulphate
treatment in knee osteoarthritis: result of a mean 8-year observation of patients from two previous
3-year, randomised, placebo-controlled trials. Osteoarthritis and Cartilage 2008; 16:254-260.

14. Glucosamine
Further clinical support
• “Long-term treatment with glucosamine sulfate retarded the progression of knee
osteoarthritis”
Karel Pavelka, Jindriska Gatterova, Marta Olejarova et al. Glucosamine Sulfate Use and Delay of Progression of Knee
Osteoarthritis. A 3 year, randomised, placebo-controlled, double-blind study. Arch Intern Med. 2002;162:2113-2123
• “The long-term combined structure-modifying and symptom modifying effects of
glucosamine sulphate suggest that it could be a disease modifying agent in osteoarthritis”
Jean Yves Reginster, Rita Deroisy, Lucio C Rovati et al. Long-term effects of glucosamine suplhate on osteoarthritis
progression: a randomised, placebo-controlled clinical trial. The Lancet 2001;357:251-56
• “The result suggest that glucosamine supplementation can provide some degree of pain
relief and improved function in persons who experience regular knee pain, which may be
caused by prior cartilage injury and/or osteoarthritis”
R Braham, B Dawson, C Goodman. The effect of glucosamine supplementation on people experiencing regular knee pain.
Br J Sports Med 2003;37:45-49
• “The findings of this study indicate that glucosamine sulfate at the oral once-daily dosage
of 1,500mg is more effective than placebo in treating OA symptoms”
Gabriel Herrero-Beaumont, Jose Andres Roman Ivorra, Maria del Carmen Trabado et al. Glucosamine Sulfate in the
Treatment of Knee Osteoarthritis Symptoms. A randomised, double-blind, placebo-controlled study using Acetaminophen as
a side comparator. Arthritis and Rheumatism. Vol. 56, no 2, February 2007, pp 555-567

15. How omega-3 works
REDUCE
INFLAMMATION
(BY ACTING AS A
NATURAL ANTI -
INFLAMMATORY)
OMEGA 3’s
(IN COD LIVER OIL
& FISH OIL)
STOP
DESTRUCTIVE
ENZYMES
(THAT BREAKDOWN
THE CARTILAGE)
. . both
. . and

16. Cod Liver Oil / Omega-3
Clinical support
• Cod Liver Oil / Omega-3 helps to keep joints and
muscles flexible by slowing down cartilage degradation
and reducing joint pain and inflammation
• “The results of a five-year study show that cod liver oil can reduce
the amount of anti-inflammatory drugs taken by Rheumatoid Arthritis
(RA) patients by over 30%.”
B Galarraga, M Ho, H M Youssef, et al. Cod liver oil (n-3 fatty acids) as an NSAID-
sparing agent in RA. Rheumatology. doi;10.1093/rheumatology/ken024

17. Omega-3 / Cod Liver Oil
Further clinical support
• “Fish oil supplements containing EPA and DHA reduces the requirement for NSAID usage
in patients with mild Rheumatoid Arthritis.”
CS Lau, KD Morley and JJF Belch. Effects of fish oil supplementation on non-steroidal anti-inflammatory drug requirement in patients
with mild rheumatoid arthritis – a double-blind placebo controlled study. British Journal of Rheumatology 1993;32:982-989
• “The results suggest that Omega-3 PUFAs are an attractive adjunctive treatment for joint
pain associated with rheumatoid arthritis”
Robert J. Goldberg and Joel Katz. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid
supplementation for inflammatory joint pain. Pain. 129 (2007) 210-223
Kremer J M, Lawrence D A, Jubiz W et al (1990). Dietary fish oil and olive oil supplementation in patients with Rheumatoid
Arthritis. Arthritis and Rheumatism 33:810-820
Kremer J M, Jubiz W, Michalek A et al (1987). Fish oil fatty acid supplementation in active rheumatoid arthritis. Ann Intern
med 106:497-503

18. Working in synergy
Omega-3 and glucosamine
Cod liver
Oil/omega 3
slows down
cartilage
degradation and
reduces
inflammation
Glucosamine
helps rebuild
new cartilage
and connective
tissues

19. Seven Seas JointCare
GlucOmega®
• Seven Seas JointCare is the ONLY
joint care supplement that contains
GlucOmega® a powerful formula
for healthy, supple and flexible
joints.

20. Choosing the right Seven Seas
JointCare product
Provides strength, resilience and support
to connective tissue.
Collagen
Essential for building and maintaining
strong healthy bones
Projoint Formula
(containing Vitamins, Calcium,
Hyaluronic Acid & Minerals)
Involved in keeping joints supple and
flexible
Omega-3
Involved in keeping joints and muscles
supple and flexible
Cod Liver Oil
Involve in the attraction of fluid that
lubricates the joints
Chondroitin
Lays the foundations for the rebuilding of
connective tissue
Glucosamine
IMPORTANCE OF
INGREDIENT
INGREDIENT
Moderate Severe

21. JointCare Original
• Contains 615mg Cod
Liver Oil providing 200mg
Omega-3 per capsule
• Contains 200mg
Glucosamine Sulphate
per capsule
• Helps to maintain
supple and flexible
joints

22. JointCare Advanced
• Contains 250mg
Glucosamine Sulphate per
capsule
• Contains 200mg Chondroitin
Sulphate per capsule
• Chondroitin is present in
cartilage and connective
tissue and is involved in the
attraction of fluid that
lubricates the joints
• Advanced nutritional
support for joints

23. JointCare Projoint
• Seven Seas JointCare Projoint formula
contains Glucosamine, Omega-3
Chondroitin, Vitamins, Calcium,
Hyaluronic Acid and Minerals
• The Projoint formula contains calcium
and vitamins D and K which are
essential for building and maintaining
strong healthy bones. Vitamin D helps
the body absorb calcium and helps to
ensure the optimal functioning of
muscles
• Contains 478mg Cod Liver Oil
providing 200mg Omega-3 per capsule
• Contains 250mg Glucosamine
Sulphate and 50mg Chondroitin
Sulphate per capsule
• Triple action formula helps to
maintain healthy joints, muscles and
bones

24. JointCare Max
• Highest potency product in the
range
• Contains 1500mg Glucosamine
Sulphate per tablet, the same
level as used in trials
• Contains 975mg Cod Liver Oil
providing 400mg Omega-3 per
capsule
• Contains 100mg Collagen per
capsule. Collagen is a natural
protein that provide strength,
resilience and support to
connective tissues.
• Max strength helps to maintain
mobility of joints

25. Notes: