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The breathless patient


Adapted from Lichtenstein's BLUE
             protocol
        (with permission)
                               1
Summary
1 (Ongoing resus) Clinical assessment:
  formulate the question
2 Rapid screen
3 Form a working diagnosis
4 Continue resuscitation
5 Re-scan / monitor progress / further
  investigations

                                         2
1. Formulate the question
1. Formulate the question
 Why is the patient breathless?




                                  4
Why is the patient breathless?
• Pneumothorax (PTX)
• Pneumonia
• Acute cardiogenic pulmonary oedema
  (APO)
• Pulmonary embolism (PE)
• Asthma / COPD
• (Other: rare)
                                       5
2. The BLUE protocol
Curved probe, abdominal preset
• Machine settings: as for arrest screen




                                           7
A 3-step scan
1. Anterior lung fields: 2 points
2. If A profile: scan the upper & lower limb
  veins for DVT
3. If no DVT: PLAPS points




                                         8
The BLUE protocol scan




                         9
The BLUE protocol scan




                         9
Step 1: anterior chest: upper & lower
            BLUE points




                                  10
Step 1: anterior chest: upper & lower
              BLUE points
• Probe sagittal, midclavicular line
• 2 spots on each side
• i.e. upper chest & lower chest




                                       11
Recall: upper & lower BLUE points




             1      1

         2              2




                              12
Step 1 findings
      One lung not                       Both lungs sliding
          sliding



A’ profile   B’ profile      A profile     B profile    A/B or C
                                                         profile
Step 1 findings
        One lung not                       Both lungs slidng
            sliding



A’ profile:    B’ profile:     A profile    B profile: A/B or C
  PTX?         Pneumonia                    Pulmonary profile:
 Look for        Treat.                      Oedema Pneumonia
lung point,                                   Treat.    Treat.
 consider
  DDX.                          Step 2
   Treat
Step 2: the veins




                    15
Step 2 (if dry lungs)
    Compression scans UL & LL veins

          Upper limb: IJV, SCV

Lower limb: femoral confluence, lower SFV,
                calf veins!
Step 2: scan the veins

      Scan the veins     DVT seen = PE
                             Treat.



      DVT not seen:
     Proceed to step 3
Step 2 note


This is rule-in, not rule-out. Even with 81%
 sensitivity in the hands of an expert, you’ll
      still miss 19% of patients with PE.
Step 3: the PLAPS points




                           19
What are the PLAPS points?

= the most dependent part of the lungs
As far behind & as low as you can scan
  without hitting the diaphragm
‘The Morison’s Pouch of the lung’ [thanks Dr
  Chris Wong]
Recall: PLAPS

Posterolateral alveolar &/or pleural syndrome
           Not as bad as it sounds!
Posterolateral alveolar &/or pleural
                syndrome
If you see effusion or   If you see anything
   consolidation at         else (A lines, B
   PLAPS points it's        lines), it's 'PLAPS-
   'PLAPS positive’         negative'
PLAPS-positive?
PLAPS-positive?
PLAPS-positive?
PLAPS-positive?
PLAPS-positive?
Step 3: the PLAPS points

        PLAPS points            PLAPS seen:
                                  Pneumonia
                             (PE still possible but
                                much less likely)
      PLAPS not seen:               Treat.
            COPD
           Asthma
      PE is still possible
      Reassess patient;
        consider other
             tests.
Now what?
     You’ve reached the end of the scan
              Patient still breathless
 You’ve ruled out APO, PTX, pneumonia
                  …but not PE.
If it’s still on your list, you need a different
                         test.



                                           27
The BLUE protocol
        One lung not sliding                                 Both lungs slidng


  A’ profile:       B’ profile:               A profile       B profile:          A/B or C
    PTX?            Pneumonia                                 Pulmonary            profile:
   Look for                                                    Oedema            Pneumonia
  lung point,                                  Step 2
consider DDX.                                 Scan the
                                               Veins



                               DVT not seen               DVT seen: PE


    PLAPS seen:                   Step 3                    PLAPS not seen:
     Pneumonia                 PLAPS points                COPD / asthma / PE
BLUE protocol: important notes




                             29
BLUE protocol: notes
• Controversial eg for DVT:
     • Scans below the knee
     • Scans the upper limbs (increases sensitivity for PE by 4%)
• Does not make use of cardiac / IVC windows (and misses 19% PE in
  the hands of an expert)
• Accurate in hands of expert lung sonologist. Not yet validated in
  multicentre trials of all comers with breathlessness, by non-experts




                                                               30
Suggestions
1. Add cardiac/IVC scan to the protocol to increase
  sensitivity for PE (Rule-in, not rule –out: if cardiac/
  IVC scan negative, could still be PE)
• E.G. as step 4 (PTO)
• Or as step 3 (before veins)
2. Include upper limb & below knee in your DVT
  scan? Leave to operator discretion
3. Perform validation studies & review this advice



                                                  31
Step 4: heart / IVC
                      Dry lungs, no DVT,
                            no PLAPS:


High pressure RV         Heart / IVC          Grossly normal:
+ distended IVC:                                   COPD
  Massive PE                                      Asthma
                                             PE is still possible
                       Inadequate view:
                                             Reassess patient;
                       Get help, or finish     consider other
                            the scan &              tests.
                           arrange other
                               tests
Modified BLUE protocol
                                        Step 1
      One lung not sliding            The lungs               Both lungs sliding


  A’ profile:       B’ profile:                  A profile       B profile:         A/B or C
    PTX?            Pneumonia                                    Pulmonary           profile:
   Look for                                                       Oedema           Pneumonia
  lung point,                                   Step 2
consider DDX.
                                               The veins

                               DVT not seen                  DVT seen: PE


    PLAPS seen:                   Step 3                       PLAPS not seen:
     Pneumonia                 PLAPS points                    Step 4 heart /IVC


                      Grossly normal: COPD / Asthma                      High pressure RV
                               PE is still possible                      + distended IVC:
                    Reassess patient; consider other tests.                 Massive PE
Modified BLUE protocol scan




                         34
Modified BLUE protocol scan




                         34
Oustanding issues
• Does RV/IVC distension occur in status asthmaticus / severe COPD?
  If so, this could limit its use as a discriminator for massive PE (and is
  the reason Lichtenstein does not include it on the BLUE protocol)
• BUT realistically a sensible dr can pick asthma/COPD clinically, so
  this should not be an issue
• Scanning for DVT
     • Include upper limb? Only adds 4% sensitivity
     • Include below knee? This will be controversial for many
     • Details less important than the understanding that this is ‘rule-
       in’, not ‘rule-out’
• Validation studies by non-experts are needed



                                                                  35
Summary: the modified BLUE protocol

   Step 1: anterior lungs
   Step 2: the veins
   Step 3: the PLAPS points
   Step 4: heart & IVC




                               36

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12 breathless algorithm

  • 1. The breathless patient Adapted from Lichtenstein's BLUE protocol (with permission) 1
  • 2. Summary 1 (Ongoing resus) Clinical assessment: formulate the question 2 Rapid screen 3 Form a working diagnosis 4 Continue resuscitation 5 Re-scan / monitor progress / further investigations 2
  • 3. 1. Formulate the question
  • 4. 1. Formulate the question Why is the patient breathless? 4
  • 5. Why is the patient breathless? • Pneumothorax (PTX) • Pneumonia • Acute cardiogenic pulmonary oedema (APO) • Pulmonary embolism (PE) • Asthma / COPD • (Other: rare) 5
  • 6. 2. The BLUE protocol
  • 7. Curved probe, abdominal preset • Machine settings: as for arrest screen 7
  • 8. A 3-step scan 1. Anterior lung fields: 2 points 2. If A profile: scan the upper & lower limb veins for DVT 3. If no DVT: PLAPS points 8
  • 11. Step 1: anterior chest: upper & lower BLUE points 10
  • 12. Step 1: anterior chest: upper & lower BLUE points • Probe sagittal, midclavicular line • 2 spots on each side • i.e. upper chest & lower chest 11
  • 13. Recall: upper & lower BLUE points 1 1 2 2 12
  • 14. Step 1 findings One lung not Both lungs sliding sliding A’ profile B’ profile A profile B profile A/B or C profile
  • 15. Step 1 findings One lung not Both lungs slidng sliding A’ profile: B’ profile: A profile B profile: A/B or C PTX? Pneumonia Pulmonary profile: Look for Treat. Oedema Pneumonia lung point, Treat. Treat. consider DDX. Step 2 Treat
  • 16. Step 2: the veins 15
  • 17. Step 2 (if dry lungs) Compression scans UL & LL veins Upper limb: IJV, SCV Lower limb: femoral confluence, lower SFV, calf veins!
  • 18. Step 2: scan the veins Scan the veins DVT seen = PE Treat. DVT not seen: Proceed to step 3
  • 19. Step 2 note This is rule-in, not rule-out. Even with 81% sensitivity in the hands of an expert, you’ll still miss 19% of patients with PE.
  • 20. Step 3: the PLAPS points 19
  • 21. What are the PLAPS points? = the most dependent part of the lungs As far behind & as low as you can scan without hitting the diaphragm ‘The Morison’s Pouch of the lung’ [thanks Dr Chris Wong]
  • 22. Recall: PLAPS Posterolateral alveolar &/or pleural syndrome Not as bad as it sounds!
  • 23. Posterolateral alveolar &/or pleural syndrome If you see effusion or If you see anything consolidation at else (A lines, B PLAPS points it's lines), it's 'PLAPS- 'PLAPS positive’ negative'
  • 29. Step 3: the PLAPS points PLAPS points PLAPS seen: Pneumonia (PE still possible but much less likely) PLAPS not seen: Treat. COPD Asthma PE is still possible Reassess patient; consider other tests.
  • 30. Now what? You’ve reached the end of the scan Patient still breathless You’ve ruled out APO, PTX, pneumonia …but not PE. If it’s still on your list, you need a different test. 27
  • 31. The BLUE protocol One lung not sliding Both lungs slidng A’ profile: B’ profile: A profile B profile: A/B or C PTX? Pneumonia Pulmonary profile: Look for Oedema Pneumonia lung point, Step 2 consider DDX. Scan the Veins DVT not seen DVT seen: PE PLAPS seen: Step 3 PLAPS not seen: Pneumonia PLAPS points COPD / asthma / PE
  • 33. BLUE protocol: notes • Controversial eg for DVT: • Scans below the knee • Scans the upper limbs (increases sensitivity for PE by 4%) • Does not make use of cardiac / IVC windows (and misses 19% PE in the hands of an expert) • Accurate in hands of expert lung sonologist. Not yet validated in multicentre trials of all comers with breathlessness, by non-experts 30
  • 34. Suggestions 1. Add cardiac/IVC scan to the protocol to increase sensitivity for PE (Rule-in, not rule –out: if cardiac/ IVC scan negative, could still be PE) • E.G. as step 4 (PTO) • Or as step 3 (before veins) 2. Include upper limb & below knee in your DVT scan? Leave to operator discretion 3. Perform validation studies & review this advice 31
  • 35. Step 4: heart / IVC Dry lungs, no DVT, no PLAPS: High pressure RV Heart / IVC Grossly normal: + distended IVC: COPD Massive PE Asthma PE is still possible Inadequate view: Reassess patient; Get help, or finish consider other the scan & tests. arrange other tests
  • 36. Modified BLUE protocol Step 1 One lung not sliding The lungs Both lungs sliding A’ profile: B’ profile: A profile B profile: A/B or C PTX? Pneumonia Pulmonary profile: Look for Oedema Pneumonia lung point, Step 2 consider DDX. The veins DVT not seen DVT seen: PE PLAPS seen: Step 3 PLAPS not seen: Pneumonia PLAPS points Step 4 heart /IVC Grossly normal: COPD / Asthma High pressure RV PE is still possible + distended IVC: Reassess patient; consider other tests. Massive PE
  • 39. Oustanding issues • Does RV/IVC distension occur in status asthmaticus / severe COPD? If so, this could limit its use as a discriminator for massive PE (and is the reason Lichtenstein does not include it on the BLUE protocol) • BUT realistically a sensible dr can pick asthma/COPD clinically, so this should not be an issue • Scanning for DVT • Include upper limb? Only adds 4% sensitivity • Include below knee? This will be controversial for many • Details less important than the understanding that this is ‘rule- in’, not ‘rule-out’ • Validation studies by non-experts are needed 35
  • 40. Summary: the modified BLUE protocol Step 1: anterior lungs Step 2: the veins Step 3: the PLAPS points Step 4: heart & IVC 36