1. Cortical spreading depolarizations are a novel mechanism independently associated with unfavorable clinical outcome in TBI Jed Hartings, PhD Department of Neurosurgery University of Cincinnati [email_address] 513-558-3567 COSBID

6. Electrocorticography (ECoG) Methods

12. Results No differences in recording durations (p>0.50), timing of surgery (p>0.50), or prognostic scores (p=0.34). Significant difference in outcome between depolarization categories χ 2 , p<0.01 Poor outcome (dead, VS, severe disability) ISD CSD None Poor outcome More likely Less likely Prognostic scores

13. Results *p=0.26 ^p<0.001 Multivariate ordinal regression analysis Estimated common odds ratio 95% confidence interval p-value Prognostic Score 1.76 1.26 to 2.46 <0.001 Depolarization None 1.0 reference <0.001 CSD 1.56* 0.72 to 3.37 ISD 7.58^ 2.64 to 21.8 Depolarization No 1.0 reference 0.01 Yes 2.55 1.25 to 5.20

16. Acknowledgments Ross Bullock – Miami, FL David Okonkwo – Pittsburgh, PA Lilian Murray – Glasgow, Scotland Gordon Murray – Glasgow, Scotland Martin Fabricius – Copenhagen, Denmark Andrew Maas – Edegem, Belgium Johannes Woitzik – Berlin, Germany Oliver Sakowitz – Heidelberg, Germany Bruce Mathern – Richmond, VA Bob Roozenbeek – Rotterdam, Netherlands Hester Lingsma – Rotterdam, Netherlands Jens Dreier – Berlin, Germany Ava Puccio – Pittsburgh, PA Lori Shutter – Cincinnati, OH Clemens Pahl – London, UK Anthony Strong – London, UK COSBID U.S. Army CDMRP PH/TBI Research Program, Contract No. W81XWH-08-2-0016