Lead Time Bias
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The document compares late referral versus early referral for patients needing dialysis, showing that early referral results in longer survival on dialysis. It initially concludes that early referral has a large effect on survival on dialysis. However, it then presents additional information showing that while early referral leads to earlier initiation of dialysis and prolonged survival on dialysis, it does not ultimately change overall patient survival.
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Lead Time Bias
- 1. Late referral Early referral Survival (months) Initiation of dialysis Conclusion: early referral has a large effect on the survival on dialysis Wednesday, March 11, 2009
- 2. Late referral Early referral Survival (months) GFR of 10 mL/min Wednesday, March 11, 2009
- 3. Initiation of dialysis for late referrals Late referral Early referral Survival (months) Initiation of dialysis for early referrals GFR of 10 mL/min Wednesday, March 11, 2009
- 4. Survival time off dialysis gained by Initiation of dialysis for late referrals the late initiation of dialysis Late referral Early referral Survival (months) Initiation of dialysis for early referrals GFR of 10 mL/min New conclusion: early referral results in earlier initiation of dialysis and prolonged survival on dialysis but does not change patient survival. Wednesday, March 11, 2009