The document discusses stem cell therapies and the body's ability to regenerate and heal itself. It summarizes that adult cells have been shown to be able to differentiate into different cell types, contradicting the standard paradigm of embryology. Low level engraftment of stem cells in the body has been shown to be vital for healing and regeneration after injuries. The document also discusses using stem cell therapies to treat conditions like emphysema, chronic wounds, liver disease and diabetes.

1. Stem Cell Therapies and Regeneration: Your Body as a Self-Healing Ecosystem Neil Theise, MD Departments of Pathology and Medicine Beth Israel Medical Center - Albert Einstein College of Medicine New York City www.neiltheise.com this talk: Posted on slideshare.net (search “theise”)

2. December ‘99

3. January ’00 December ‘99

4. Lethal Irradiation Male Bone Marrow Transplant FISH for Y-Chromosome

6. July ’00 January ’00 December ‘99

7. Controversy!!!

17. MESODERM ENDODERM ECTODERM One Adult Cell

18. Adult cells can do whatever embryonic cells can do! MESODERM ENDODERM ECTODERM One Adult Cell

19. The Standard Paradigm of Embryology & Adult Tissue Repair

20. The Revised Paradigm

21. Proof of Principle

22. Controversy!!!

23. trivial... vs. ROBUST!!!

29. Meanwhile, back at the stem cell debates… trivial vs. robust...?

30. Conversations with Jane Prophet New Media Artist and Professor, Interdisciplinary Studies University of Westminster, London UK SciArt Award, Wellcome Trust 2002

31. Date: 9th May 2002 Location: Neil's office, New York Jane says: “Ideas about pathways are interesting. A lot of people who are involved in digital biology are interested in things like swarming people and so called ’soup organism’ behaviour. And one of the useful models to take forward is about ant colonies…”

32. Complex Adaptive Systems: Lewin R, Complexity: Life at the Edge of Chaos. 2nd ed. Chicago IL: University of Chicago Press; 2002. Johnson S, Emergence. New York NY: Scribner; 2001.

33. … Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures

34. Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures that appear planned from the top, downward ,

35. Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures that appear planned from the top, downward, BUT ARE NOT!

36. Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures that appear planned from the top, downward, BUT ARE NOT! These self organizing structures are ADAPTIVE.

37. Complex Adaptive Systems: Rise and Fall of Economic Markets Urban Development Immune Systems Beatlemania Rise and Fall of Civilizations Coral Reefs Evolution and Speciation

45. Low level engraftment is not only NOT trivial, but it is VITAL – literally so. 1-3 1 Theise ND. Exp Hematology 2003 2 D’Inverno M, Theise ND. BCMD 2004 3 D’Inverno M, Theise ND, Prophet J. In: Potten C, Wilson J, Clarke R, Renahan A: Tissue stem cells: Biology and applications

49. Hierarchies of complex systems… thing vs. phenomenon depends on scale of observation

52. How does this relate to disease and injury?

55. HEART ATTACK!!!

56. STEM CELLS

57. STEM CELLS

58. STEM CELLS

60. Stem Cells!

61. Stem Cells!

62. Here at Beth Israel (in collaboration with NeoStem, Inc) The Team: Drs. Theise, Karpeh, and Bodenheimer

72. More…

73. 2006 Conference: Longevity & Optimal Health Integrating Eastern & Western Perspectives

76. GLOBAL mind/body interventions e.g. YOGA, MEDITATION, etc….

77. GLOBAL mind/body interventions Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking e.g. YOGA, MEDITATION, etc….

78. GLOBAL mind/body interventions LOCAL effects Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking Site Specific, Tissue Regeneration e.g. YOGA, MEDITATION, etc….

79. Still more…

80. Communities Bodies Cells

81. e.g. cities, cultures, ecosystems, Gaia Bodies Cells

83. If our parks are the lungs of the city…?

84. Are our hospitals its organs of healing and regeneration?