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Physiology of the Autonomic Nervous System  Anatomy and Physiology  L | E | C | O | M  Mathew J. Bateman, Ph.D., D.H.Ed.
Definitions  ,[object Object],[object Object],[object Object],[object Object]
Somatic vs. Autonomic
Receptors
Nicotinic Cholinergic Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nicotinic Synapse
Parasympathetic
Muscarinic Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Muscarinic Synapse Ach Ach Receptor Choline + Acetate Post synaptic Heart (M 2  receptor) Or Gland/Smooth Muscle (M 3 ) Reuptake Ach + Ach Esterase G Protein  cyclic AMP (M 2 )     Calcium (M 3 ) Diet AchE Inhibitors Muscarinic Blockers Muscarine & other Agonists
Parasympathetic Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Sympathetic Receptors
Sympathetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Synapse N.E. N.E, Receptor Post synaptic   1 ,   2  (smooth muscle)  1  (Heart)   2  (smooth muscle) or   3  (adipocytes) Reuptake + G Protein L-DOPA Dopamine N.E. N.E.    cyclic AMP (  )  cyclic AMP (  2 )     Calcium (  1 ) COMT & MAO Homovanillic Acid  (HVA) uptake Urine N.E. Adrenergic Blockers Adrenergic Agonists MAO or COMT Inhibitors Reserpine
Adrenergic Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Receptors ,[object Object],[object Object],[object Object],[object Object]
Adrenal Medulla  ,[object Object],[object Object],[object Object],[object Object]
“ Fight or Flight” Sympathetic Defense Response  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Parasympathetic Response  (DEM B 2 LUES 3 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dual Innervation

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  • 1. Physiology of the Autonomic Nervous System Anatomy and Physiology L | E | C | O | M Mathew J. Bateman, Ph.D., D.H.Ed.
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  • 9. Muscarinic Synapse Ach Ach Receptor Choline + Acetate Post synaptic Heart (M 2 receptor) Or Gland/Smooth Muscle (M 3 ) Reuptake Ach + Ach Esterase G Protein  cyclic AMP (M 2 )  Calcium (M 3 ) Diet AchE Inhibitors Muscarinic Blockers Muscarine & other Agonists
  • 10.
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  • 14. Adrenergic Synapse N.E. N.E, Receptor Post synaptic  1 ,  2 (smooth muscle)  1 (Heart)  2 (smooth muscle) or  3 (adipocytes) Reuptake + G Protein L-DOPA Dopamine N.E. N.E.  cyclic AMP (  )  cyclic AMP (  2 )  Calcium (  1 ) COMT & MAO Homovanillic Acid (HVA) uptake Urine N.E. Adrenergic Blockers Adrenergic Agonists MAO or COMT Inhibitors Reserpine
  • 15.
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  • 19.