Session 3: Agriculture & Nutrition Title : Doubling Crop Productivity And Ensuring Nutritional Security Dr Daphne Preuss, Chromatin

1. Chromatin, Inc.
Redesigning crops for agriculture and bioenergy
CEO’s Life Science Conference – Kuala Lumpur
October 6, 2009
Daphne Preuss
Chromatin, Inc.

2. Chromatin overview
!! Developed a leading innovation for modifying crops
!!Allows addition of multiple genes to a plant in a single step
!! Market access via the world’s premier agricultural companies
!!Corn, soybean, canola, cotton and sugarcane
!! Financing raised in Q4 2008 to improve energy crops
Chromatin, Inc.

3. Market for gene stacks
Biotech crop sales Stacked Traits
8.0 40
% Stacked Traits
Sales ($Billion)
6.0 30
4.0 20
3 genes
2.0 10
1-2 genes
0.0
0.0
00 01 02 03 04 05 06 07 08 00 01 02 03 04 05 06 07 08
By 2010, Monsanto & Dow will use breeding to stack 8 different pest and herbicide
resistance genes in corn (Smartstax™)
1 x 2 x 3 x 4 X 5 x 6 x 7 x 8
Chromatin, Inc.

4. Chromatin’s Gene Stacking Technology
Gene Stack Assembled Mini-chromosome Improved Crop
Higher yield
More nutritious
A B C D E F G H I J K L + More biomass
Higher value products
Benefits Validation
•! Accelerates product •! Peer-review publications:
development pipelines PLoS Genetics, (2007)
Carlson et al.
•! Any crop
Chromosoma, (2009)
•! Faster development, Ananiev et al.
lower costs Mini-chromosomes
•! 15 issued patents;
Single-step gene >35 applications pending
•! Streamlined regulatory
stack delivery into
process
plants
4 Chromatin, Inc.

5. Chromatin’s licenses to industry leaders
•! Non-exclusive: corn, soybean, cotton, canola
•! Exclusive: sugarcane (+ others under discussion)
•! Chromatin retains rights to improvements
•! Payments:
-! Fees
-! Milestones
- Royalties
Chromatin, Inc.

6. Crop-specific market strategy
Mini- Crops &
+ Genes + + End User
Chromosomes Feedstocks
Non-exclusive
Partnerships in traditional agriculture
traditional crop Chromatin (corn, soy, cotton, canola)
licenses
Exclusive co- Owned / licensed
development Chromatin by Chromatin Partner Partner
relationships and / or partners
Proprietary Owned /
Owned / licensed
product Chromatin by Chromatin
licensed by Partner
development Chromatin
Chromatin, Inc.

7. Energy crops
!! Most significant cost of biofuel production
!! ~70% of biorefinery costs
!! Most have not been optimized through breeding
!! Agronomic yields are suboptimal
!! Crop cultivation (planting, harvesting, seed / pest treatment) is undeveloped
!! Most have not been bred for “energy” traits
!! Inconsistent quality reduces yield
Chromatin, Inc.

8. Optimizing energy crops requires many genetic changes
Genes on the market today: Energy traits:
•! Insect resistance
•! Herbicide resistance •! Improved feedstock conversion
-! Biomass yield
Genes in industry pipelines: -! Cellulose recalcitrance
•! Better insect / herbicide resistance
•! Increased seed yield -! Enzymes
•! Reduced nitrogen use
•! Optimized product selectivity
•! Drought tolerance
•! Healthy oils -! Minimized by-product (CO2)
•! Amylase
•! Optimized processing efficiencies
Other agronomic traits: •! Feedstock + yeast + enzymes
•! Viral / bacterial resistance •! Lower energy / chemicals use
•! Cold / heat / salt tolerance
•! Water and nutrient use •! Faster fermentation cycles
Chromatin, Inc.

9. Chromatin’s Energy Crop Improvement Platform
Feedstock Molecular Transgenic Value-added
Traits Breeding Breeding Hybrids
Feedstock
Products
Production
Proprietary Technology partners
Ethanol
Butanol
Hydrocarbons
Monomers
Polymers
9 Chromatin, Inc.

10. Management Team
Over 100 years expertise spanning agriculture, biotech & energy
Daphne Preuss •! Co-Founder & CEO
Jeff Scheib •! VP Biofuels (Previously BP and Cilion)
Ken Davenport •! VP Strategic Development (Previously Bayer and ArborGen)
Ken Moonie •! Business Development
10 Chromatin, Inc.

11. Investors and operations
Raised $24M total
Chicago Champaign-Urbana
+ Field sites
Chromatin, Inc.

12. Chromatin, Inc.
Redesigning crops for agriculture and bioenergy
•! Disruptive technology platform
•! Strategic alliances to bring
technology to existing markets
•! Expanding platform to improve
energy crops
Chromatin, Inc.