Ketamine Treatment of Acute and Chronic Pain

S(+)-ketamine Treatment of Acute and Chronic Pain Marnix Sigtermans, MD Department of Anesthesiology

Chronic pain ,[object Object],[object Object],[object Object],[object Object]

Introduction: NMDA receptor antagonists ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Study objectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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CRPS-1: International Association for the Study of Pain ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Time course of analgetic effect P <0.001

Side effects during treatment ,[object Object],[object Object],[object Object],P < 0.001 P = 0.004 P < 0.001 P = 0.78

CRPS acute and chronic pain Infusion phase Elimination phase

CRPS Experimental pain CRPS pain

Conclusion ,[object Object],[object Object],[object Object]

Ketamine Treatment of Acute and Chronic Pain

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