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Dypyridamole (cas 58-32-2) MSDS

      1.    IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
      1.1   Product identifiers
            Product name                     :   Dipyridamole
            Product Number                   :   D9766
            Brand                            :
            CAS-No.                          :   58-32-2
      1.2   Relevant identified uses of the substance or mixture and uses advised against
            Identified uses                  :   Laboratory chemicals, Manufacture of substances
      2.    HAZARDS IDENTIFICATION
      2.1   Classification of the substance or mixture
            Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
            Skin irritation (Category 2)
            Eye irritation (Category 2)
            Specific target organ toxicity - single exposure (Category 3)
            Classification according to EU Directives 67/548/EEC or 1999/45/EC
            Irritating to eyes, respiratory system and skin.
      2.2   Label elements
            Labelling according Regulation (EC) No 1272/2008 [CLP]
            Pictogram

            Signal word                          Warning
            Hazard statement(s)
            H315                                 Causes skin irritation.
            H319                                 Causes serious eye irritation.
            H335                                 May cause respiratory irritation.
            Precautionary statement(s)
            P261                                 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
            P305 + P351 + P338                   IF IN EYES: Rinse cautiously with water for several minutes. Remove
                                                 contact lenses, if present and easy to do. Continue rinsing.
            Supplemental Hazard                   none
            Statements
            Safety data sheet available on request.
            According to European Directive 67/548/EEC as amended.
            Hazard symbol(s)


            R-phrase(s)
            R36/37/38                            Irritating to eyes, respiratory system and skin.
            S-phrase(s)
            S26                                  In case of contact with eyes, rinse immediately with plenty of water and
                                                 seek medical advice.
            S36                                  Wear suitable protective clothing.
      2.3   Other hazards - none
      3.    COMPOSITION/INFORMATION ON INGREDIENTS
      3.1   Substances
            Formula                          :   C24H40N8O4
            Molecular Weight                 :   504,63 g/mol
            Component                                                                                       Concentration
            Dipyridamole
                  CAS-No.                        58-32-2                                                     -
                  EC-No.                         200-374-7
4.    FIRST AID MEASURES
4.1   Description of first aid measures
      General advice
      Consult a physician. Show this safety data sheet to the doctor in attendance.
      If inhaled
      If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
      In case of skin contact
      Wash off with soap and plenty of water. Consult a physician.
      In case of eye contact
      Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
      If swallowed
      Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2   Most important symptoms and effects, both acute and delayed
      To the best of our knowledge, the chemical, physical, and toxicological properties have not been
      thoroughly investigated.
4.3   Indication of any immediate medical attention and special treatment needed
      no data available

5.    FIREFIGHTING MEASURES
5.1   Extinguishing media
      Suitable extinguishing media
      Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2   Special hazards arising from the substance or mixture
      Carbon oxides, nitrogen oxides (NOx)
5.3   Advice for firefighters
      Wear self contained breathing apparatus for fire fighting if necessary.

5.4   Further information
      no data available

6.    ACCIDENTAL RELEASE MEASURES
6.1   Personal precautions, protective equipment and emergency procedures
      Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
      adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
6.2   Environmental precautions
      Do not let product enter drains.
6.3   Methods and materials for containment and cleaning up
      Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
      containers for disposal.
6.4   Reference to other sections
      For disposal see section 13.

7.    HANDLING AND STORAGE
7.1   Precautions for safe handling
      Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
      Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
      protection.
7.2   Conditions for safe storage, including any incompatibilities
      Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
      room temperature
7.3   Specific end uses
      no data available

8.    EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1   Control parameters
      Components with workplace control parameters
8.2   Exposure controls
      Appropriate engineering controls
      Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
      at the end of workday.
      Personal protective equipment
Eye/face protection
            Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
            and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
            Skin protection
            Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
            (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
            contaminated gloves after use in accordance with applicable laws and good laboratory practices.
            Wash and dry hands.
            The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
            the standard EN 374 derived from it.
            Body Protection
            impervious clothing, The type of protective equipment must be selected according to the
            concentration and amount of the dangerous substance at the specific workplace.
            Respiratory protection
            For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
            level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.


            Use respirators and components tested and approved under appropriate government standards
            such as NIOSH (US) or CEN (EU).

9.    PHYSICAL AND CHEMICAL PROPERTIES
9.1   Information on basic physical and chemical properties
      a) Appearance                  Form: powder
                                     Colour: yellow, green
      b) Odour                       no data available
      c) Odour Threshold             no data available
      d) pH                          no data available
      e) Melting point/freezing      Melting point/range: 165 - 166 °C - lit.
         point
      f) Initial boiling point and  no data available
         boiling range
      g) Flash point                no data available
      h) Evaporation rate           no data available
      i) Flammability (solid, gas) no data available
      j) Upper/lower                no data available
         flammability or
         explosive limits
      k) Vapour pressure            no data available
      l) Vapour density             no data available
      m) Relative density            no data available
      n) Water solubility            no data available
      o) Partition coefficient: n-   no data available
          octanol/water
      p) Autoignition                no data available
          temperature
      q) Decomposition               no data available
          temperature
      r) Viscosity                   no data available
      s) Explosive properties        no data available
      t) Oxidizing properties        no data available
9.2   Other safety information
      no data available

10. STABILITY AND REACTIVITY
10.1 Reactivity
      no data available
10.2 Chemical stability
      no data available
10.3 Possibility of hazardous reactions
      no data available
10.4 Conditions to avoid
Light.
10.5 Incompatible materials
      Strong oxidizing agents

10.6 Hazardous decomposition products
      Other decomposition products - no data available

11. TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
     Acute toxicity
      LD50 Oral - rat - 8.400 mg/kg
      Remarks: Behavioral:Altered sleep time (including change in righting reflex). Behavioral:Somnolence
      (general depressed activity). Behavioral:Irritability.
      LD50 Subcutaneous - rat - 1.650 mg/kg
      Remarks: Behavioral:Somnolence (general depressed activity). Respiratory disorder Behavioral:Ataxia.
      LD50 Subcutaneous - mouse - 2.700 mg/kg
      Skin corrosion/irritation
      no data available
      Serious eye damage/eye irritation
      no data available
      Respiratory or skin sensitization
      no data available
      Germ cell mutagenicity
      Genotoxicity in vitro - rat - liver
      DNA inhibition
      Genotoxicity in vitro - rat - Liver
      Other mutation test systems
      Genotoxicity in vitro - mouse - Ascites tumor
      Other mutation test systems
      Genotoxicity in vivo - rat - Intravenous
      DNA inhibition
      Carcinogenicity
      IARC:         No component of this product present at levels greater than or equal to 0.1% is identified as
                    probable, possible or confirmed human carcinogen by IARC.
      Reproductive toxicity
      no data available
      Specific target organ toxicity - single exposure
      Inhalation - May cause respiratory irritation.
      Specific target organ toxicity - repeated exposure
      no data available
      Aspiration hazard
      no data available
      Potential health effects
           Inhalation          May be harmful if inhaled. Causes respiratory tract irritation.
           Ingestion           May be harmful if swallowed.
           Skin                May be harmful if absorbed through skin. Causes skin irritation.
           Eyes                Causes serious eye irritation.
      Signs and Symptoms of Exposure
      To the best of our knowledge, the chemical, physical, and toxicological properties have not been
      thoroughly investigated.
      Additional Information
      RTECS: KK7450000



12. ECOLOGICAL INFORMATION
12.1 Toxicity
      no data available
12.2 Persistence and degradability
      no data available
12.3 Bioaccumulative potential
      no data available
12.4 Mobility in soil
      no data available
12.5 Results of PBT and vPvB assessment
      no data available
12.6 Other adverse effects
      no data available

13. DISPOSAL CONSIDERATIONS
13.1 Waste treatment methods
     Product
      Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
      professional waste disposal service to dispose of this material. Dissolve or mix the material with a
      combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
      Contaminated packaging
      Dispose of as unused product.

14. TRANSPORT INFORMATION
14.1 UN number
      ADR/RID: -                           IMDG: -                              IATA: -
14.2 UN proper shipping name
      ADR/RID: Not dangerous goods
      IMDG:    Not dangerous goods
      IATA:    Not dangerous goods
14.3 Transport hazard class(es)
      ADR/RID: -                           IMDG: -                              IATA: -
14.4 Packaging group
      ADR/RID: -                           IMDG: -                              IATA: -
14.5 Environmental hazards
      ADR/RID: no                          IMDG Marine pollutant: no            IATA: no
14.6 Special precautions for user
      no data available

15.   REGULATORY INFORMATION
      This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
      no data available
15.2 Chemical Safety Assessment
      no data available

16.   OTHER INFORMATION
      Further information
      The above information is believed to be correct but does not purport to be all inclusive and
      shall be used only as a guide. The information this document is based on the resent state
      The above informationis applicable to the product with regardpurport to be all safety precautions.be
      of our knowledge and is believed to be correct but does not to appropriate inclusive and shall
      used only as a guide.any guarantee ofin this document is based on the present state of our knowledge
      It does not represent The information the properties of the product. guidechem shall not be
      held liable for any damage resulting from handling or from contact with the above product.
      See reverse side of invoice or packing slip for additional terms and conditions of sale.

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58 32-2

  • 1. Click http://www.guidechem.com/cas-58/58-32-2.html for suppliers of this product Dypyridamole (cas 58-32-2) MSDS 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Dipyridamole Product Number : D9766 Brand : CAS-No. : 58-32-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 2. HAZARDS IDENTIFICATION 2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Skin irritation (Category 2) Eye irritation (Category 2) Specific target organ toxicity - single exposure (Category 3) Classification according to EU Directives 67/548/EEC or 1999/45/EC Irritating to eyes, respiratory system and skin. 2.2 Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal word Warning Hazard statement(s) H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s) P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard none Statements Safety data sheet available on request. According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R36/37/38 Irritating to eyes, respiratory system and skin. S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 Wear suitable protective clothing. 2.3 Other hazards - none 3. COMPOSITION/INFORMATION ON INGREDIENTS 3.1 Substances Formula : C24H40N8O4 Molecular Weight : 504,63 g/mol Component Concentration Dipyridamole CAS-No. 58-32-2 - EC-No. 200-374-7
  • 2. 4. FIRST AID MEASURES 4.1 Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. 4.3 Indication of any immediate medical attention and special treatment needed no data available 5. FIREFIGHTING MEASURES 5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx) 5.3 Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. 5.4 Further information no data available 6. ACCIDENTAL RELEASE MEASURES 6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. 6.2 Environmental precautions Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. 6.4 Reference to other sections For disposal see section 13. 7. HANDLING AND STORAGE 7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. 7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. room temperature 7.3 Specific end uses no data available 8. EXPOSURE CONTROLS/PERSONAL PROTECTION 8.1 Control parameters Components with workplace control parameters 8.2 Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment
  • 3. Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). 9. PHYSICAL AND CHEMICAL PROPERTIES 9.1 Information on basic physical and chemical properties a) Appearance Form: powder Colour: yellow, green b) Odour no data available c) Odour Threshold no data available d) pH no data available e) Melting point/freezing Melting point/range: 165 - 166 °C - lit. point f) Initial boiling point and no data available boiling range g) Flash point no data available h) Evaporation rate no data available i) Flammability (solid, gas) no data available j) Upper/lower no data available flammability or explosive limits k) Vapour pressure no data available l) Vapour density no data available m) Relative density no data available n) Water solubility no data available o) Partition coefficient: n- no data available octanol/water p) Autoignition no data available temperature q) Decomposition no data available temperature r) Viscosity no data available s) Explosive properties no data available t) Oxidizing properties no data available 9.2 Other safety information no data available 10. STABILITY AND REACTIVITY 10.1 Reactivity no data available 10.2 Chemical stability no data available 10.3 Possibility of hazardous reactions no data available 10.4 Conditions to avoid
  • 4. Light. 10.5 Incompatible materials Strong oxidizing agents 10.6 Hazardous decomposition products Other decomposition products - no data available 11. TOXICOLOGICAL INFORMATION 11.1 Information on toxicological effects Acute toxicity LD50 Oral - rat - 8.400 mg/kg Remarks: Behavioral:Altered sleep time (including change in righting reflex). Behavioral:Somnolence (general depressed activity). Behavioral:Irritability. LD50 Subcutaneous - rat - 1.650 mg/kg Remarks: Behavioral:Somnolence (general depressed activity). Respiratory disorder Behavioral:Ataxia. LD50 Subcutaneous - mouse - 2.700 mg/kg Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity Genotoxicity in vitro - rat - liver DNA inhibition Genotoxicity in vitro - rat - Liver Other mutation test systems Genotoxicity in vitro - mouse - Ascites tumor Other mutation test systems Genotoxicity in vivo - rat - Intravenous DNA inhibition Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity no data available Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation. Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects Inhalation May be harmful if inhaled. Causes respiratory tract irritation. Ingestion May be harmful if swallowed. Skin May be harmful if absorbed through skin. Causes skin irritation. Eyes Causes serious eye irritation. Signs and Symptoms of Exposure To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Additional Information RTECS: KK7450000 12. ECOLOGICAL INFORMATION 12.1 Toxicity no data available 12.2 Persistence and degradability no data available 12.3 Bioaccumulative potential no data available
  • 5. 12.4 Mobility in soil no data available 12.5 Results of PBT and vPvB assessment no data available 12.6 Other adverse effects no data available 13. DISPOSAL CONSIDERATIONS 13.1 Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. 14. TRANSPORT INFORMATION 14.1 UN number ADR/RID: - IMDG: - IATA: - 14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods 14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: - 14.4 Packaging group ADR/RID: - IMDG: - IATA: - 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user no data available 15. REGULATORY INFORMATION This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture no data available 15.2 Chemical Safety Assessment no data available 16. OTHER INFORMATION Further information The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information this document is based on the resent state The above informationis applicable to the product with regardpurport to be all safety precautions.be of our knowledge and is believed to be correct but does not to appropriate inclusive and shall used only as a guide.any guarantee ofin this document is based on the present state of our knowledge It does not represent The information the properties of the product. guidechem shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.