![Thiazide Diuretics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Bendroflumethiazide 1.25-2.5 mg once daily Chlorthalidone 12.5-25 mg once daily Hydrochlorothiazide 12.5-25 mg once daily Indapamide 2.5 mg once daily or 1.5 mg of sustained release (SR) preparation For Internal Use Only Lip G and Bakris G. Handbook Hypertension Management. CMG 2006](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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Diureticos
- 1. The 3 Classes of Diuretics and Their Primary Sites of Action in the Nephron For Internal Use Only Adapted from: Oparil S and Weber MA. Hypertension.Elsevier/Sanders 2nd ed. 2005; L ip G and Bakris G. Handbook Hypertension Management. CMG 2006
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- GLB.IRB.06.12.01 Thiazide/thiazide-like diuretics : They promote diuresis by inhibiting sodium and chloride ion reabsorption at the beginning of the distal convoluted tubule . This results in an increase in excretion of sodium and chloride ions, which in turn promotes water loss. A reduction in blood volume reduces cardiac preload, cardiac output and consequently blood pressure. 2. Loop diuretics : They act on the ascending limb of Henle’s loop , increasing the excretion of sodium, potassium, calcium and chloride ions. As a result, reabsorption of water from the collecting system is virtually abolished and large volumes of water are excreted. 3. Potassium-sparing diuretics : They inhibit the exchange of sodium for potassium ions in the distal convoluted tubule of the nephron. They bring about this effect in one of two ways: * triamterene/amiloride: decreases the permeability of the distal luminal membrane to sodium ions spironolactone (aldosterone antagonist): inhibits the effects of aldosterone on the kidneys. This leads to an increased excretion of sodium ions and water, but a decreased loss of potassium ions. References: Adapted from Oparil S and Weber MA. Hypertension.Elsevier/Sanders 2nd ed. 2005 L ip G and Bakris G. Handbook Hypertension Management. CMG 2006