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Neuroanatomy of an Spinal Cord
Injury and a study for cure
C 2
C 3
C 4
C 5
C 6
LesionLesion
Longitudinal C6
Cervical plexus
Horizontal C6
Horizontal Cervical
Titanium Fixation place
One hope from neurobiology
Astrocyte types and
neuroregeneration
Kevin Everett's case
- Lesion C3/C4
- Complete function loss
- Colling iniciated immediatly after
trauma
Colling neuroprotection
Sensation and
motor recovery
For more knowledge
• https://www.youtube.com/watch?
v=48U5T0uKV2w
• https://www.youtube.com/watch?v=QnBsnhzy1Ug
• https://www.youtube.com/watch?v=ERO8_DXiwz0
• https://www.youtube.com/watch?v=h5-
O4wmxX6Q
• https://www.youtube.com/watch?v=3rEtvTY2MsU
• https://www.youtube.com/watch?
v=mYH_2Wre9r4

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Nbel final project - n euroanatomy of spinal cord injury - mario oliveira

Hinweis der Redaktion

  1. Contagem de nível de lesão
  2. Contagem de vértebra e acunhamento de vértebra C7
  3. Experimento – Ratos adultos (3 meses de idade), transição em C1/C2. Como os axônios atravessam a área da lesão ? Eles serão eficientes em construir pontes ?
  4. Transplantamos os GDAsBMP para a área da lesão e uma molécula de rastreamento (BDA), para acompanhar o caminho das células
  5. Transplantando GDAs na lesão medular, promove regeneração do axônio ? Promove recuperação funcional ?
  6. Com a estratégia de utilizar GDAsBMP, o resultado foi de 39% em 8 dias
  7. Se utilizar o GRP nativo, antes de transformá-lo em astrocito, eles se transformam em um tipo de astrocito que cria cicatriz. NSC - NEUROEPITHELIAL STEM CELL ESC – EMBRYONIC STEM CELL GRP – GLIAL RESTRICTED PRECURSOR GDA – GLIAL DERIVED ASTROCYTE BMP – BONE MORPHOGENIC 4 MOLECULE CNTF - CSPG - chondroitin sulfate proteoglycan
  8. Quadro comparativo com GRP (experiência de 2004)
  9. Recuperação funcional
  10. Indice de redução de fatores inibidores na presença de DECORIN injetado na lesão em paciente agudo em 4 dias.
  11. DECORIN pode quebrar a cicatriz já formada ? A enzima PLASMIN è usada pelo organismo para alterar a cicatriz, houve aumento de 17 vezes dessa enzima quando injetado o DECORIN
  12. Além de suprimir as moléculas inibidoras (CSPGs), DECORIN potencializou a capacidade dos neurônios de crescer axônios.