remember: many undifferentiated stem cells, can mature into both lymphoid or myeloid. Make both RBC and WBC. \nMyeloid -> monoblast -> monocyte -> macrophage. \nLymph -> B, T, and NKC\n
Epo stimulates marrow to make RBCs and Hb production. \n\n
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Lab serum feritin low - know there is low iron. Iron hard to absorb.\n
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Many disorders show issue with bili.\nLiver failure - elevation of things, RBC’s hemolyze, failure, obstructions. \n
RBC described by size and color\nnormal: normocutic/chromic\nPoikilocytosis - variabile shape: target, tear drop, etc.\nAnisocytosis - variation in size\n
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MCV - volume\nMCH - amt Hb. \nMCHC - how concentrated the Hb is\nRetic count - helpful for watching tx (put on iron, should see change in month, should increase). No response, worry about bone marrow\n\n
small pale cells\ndue to deficiency of iron (infants). Cows milk is much lower. #1 cause of fe efficiency is too much milk. \nDue to loss\n
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unable to make Hb, so see small cells, pale,\nTIBC - transferrin, protein carrier. Hi, lots of empty train cars, lots of ability to bind fe. \n
pale RBC’s\n
Retics in a week, \nNeed to take Fe TIB = constipation --> take cholase, fiber, etc.\n\n\n
microcytic and homochromic\n\n
Free alpha chains, cause hemoluis\n
Mediteranian and Asian descent.\nSee Hb lab not matching presentation. \n
Fe in granules around nucleus, waiting to be taken up by Hb. \n
WHat to do. \nTHalasemia when HbA is less than 2\n
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probably b12 or folate\n
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triggared by hypoxia, decreased temperature, sometimes fever due to infection. \nJoint pain, abdominal pain. \n
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Scicle celss only leave a short time or can be sequestered in spleen. Can get into an aplastic crisis. \n
see malignant plasma cells arise from b cell line, see an increased release on non-specific Ig. \nM protein, associated with Ig.\nBence Jones proteins in urine. \n
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there are two paths: intrinsic and extrinsic\n
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fibrin is the end product\n
Important in DIC tx\n
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Ab mediated destruction.\nSometimes is limited, sometimes reoccurs.\n
nomal plt ct-200,000\n
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Global clotting, followed by global bleeding.\n
increased degredation product.\nUnderlying problem is clotting, clinical manifestation is bleeding. \n