This presentation was delivered at the 25th Annual Meeting of the British Organic Geochemical Society (BOGS), which Markes was delighted to have sponsored. The meeting was held at the School of Natural Sciences and Psychology at Liverpool John Moores University, UK. The meeting featured presentations from across the field of organic geochemistry, including tracing of soil pollution and petroleum geochemistry. This is an excerpt from the original presentation. The full presentation can be downloaded from the Markes website: http://www.markes.com/Resources/Scientific- publications/Conference-presentations.aspx

1. Select-eV:
Increasing dimensionality in GC×GC–TOF MS
Laura McGregor
lmcgregor@markes.com
BOGS 2014, 10th July; Liverpool

2. Outline
• Introduction to the BenchTOF
• Select-eV ion-source technology
– What, why and how?
• Case studies:
– GC×GC–TOF MS of a vacuum oil distillate
– Monitoring bio-accumulative substances

3. What is the BenchTOF?
• A reflectron time-of-flight mass spectrometer
• Platform-neutral
• Innovative design
Mass spectrometry at Markes

4. BenchTOF technology
Innovative design
High
accelerating
voltage
Differentially pumped source
and analyser chambers
Direct extraction optimises
sensitivity
Multi-stage reflectron
optimises resolution

5. Ion source technology

6. Historically…
Variable-energy electron ionisation
70 eV mass spectrum of p-cymene 14 eV mass spectrum of p-cymene

7. Water Framework Directive (WFD)
• Lower detection limits
• New monitoring methods and analytical
techniques are now necessary
• Focus is on “priority” substances, but what
about those of emerging concern?

8. GC×GC–TOF MS with Select-eV
River water extract
BPX5
BPX50

9. Emerging contaminants
O
O
O
O
O
P
O
O
O
CH3
CH3

10. 70 eV
10 eV
14 eV
12 eV
Match factor = 879
Polycyclic Musks
Galaxolide (HHCB)

11. Implant extract
PCBs
Chloro-pesticides
Amgard TCMP (flame retardant)
Octocrylene (UV filter)
Tetrabromobenzene
Pharmaceuticals

12. Oxychlordane
PCB 44
Trans-nonachlor

13. Summary
• Hassle-free soft ionisation
• Improved sensitivity and selectivity
• Reduced matrix impact
• Lower detection limits

14. The full presentation can be
downloaded from the
Markes website
http://www.markes.com/Resources/Scientific-
publications/Conference-presentations.aspx

15. Contact Markes
www.markes.com
enquiries@markes.com