This document discusses several trends affecting the refrigeration and air conditioning sector including increasing population, urbanization, energy demand, and cooling needs. It notes that the Montreal Protocol is on target for phasing out ozone-depleting substances but that hydrofluorocarbon emissions are rising and projected to contribute significantly to global warming. Several policy developments aim to control hydrofluorocarbons including proposed amendments to the Montreal Protocol and regional regulations. Challenges in the transition to low-global warming potential alternatives are also covered.