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Cyclacel Pharmaceuticals Pipeline Review Q2 2011

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This report provides a summary of Cyclacel Pharmaceuticals Inc.'s product pipeline as of the second quarter of 2011. It details the company's focus on developing treatments for cancer and inflammatory diseases. The pipeline includes several drugs in clinical trials, including sapacitabine for blood cancers. The report is based on information from Cyclacel as well as third party sources, and provides profiles of pipeline drugs with details on development status and mechanisms of action. It is intended to help evaluate Cyclacel's strategic position and identify partnership or licensing opportunities.

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Cyclacel Pharmaceuticals Inc. – Product Pipeline Review – Q2 2011 Report Summary Global Market Direct’s pharmaceuticals report, “Cyclacel Pharmaceuticals Inc. - Product Pipeline Review - Q2 2011” provides data on the Cyclacel Pharmaceuticals Inc.’s research and development focus. The report includes information on current developmental pipeline, complete with latest updates, and features on discontinued and dormant projects. This report is built using data and information sourced from Global Markets Direct’s proprietary databases, Cyclacel Pharmaceuticals Inc.’s corporate website, SEC filings, investor presentations and featured press releases, both from Cyclacel Pharmaceuticals Inc. and industry-specific third party sources, put together by Global Markets Direct’s team. Scope • Cyclacel Pharmaceuticals Inc. - Brief Cyclacel Pharmaceuticals Inc. overview including business description, key information and facts, and its locations and subsidiaries. • Review of current pipeline of Cyclacel Pharmaceuticals Inc. human therapeutic division. • Overview of pipeline therapeutics across various therapy areas. • Coverage of current pipeline molecules in various stages of drug development, including the combination treatment modalities, across the globe. • Product profiles for late stage and clinical stage products of Cyclacel Pharmaceuticals Inc. with complete description of the product’s developmental history, mechanism of action, therapeutic class, target and major milestones. • Recent updates of the Cyclacel Pharmaceuticals Inc.’s market pipeline in the last quarter. • Key discontinued and dormant projects. • Latest news and deals relating to the products. Browse All Pharmaceuticals Market Research Reports Reasons to buy • Evaluate Cyclacel Pharmaceuticals Inc.’s strategic position with total access to detailed information on its product pipeline. • Assess the growth potential of Cyclacel Pharmaceuticals Inc. in its therapy areas of focus. • Identify new drug targets and therapeutic classes in the Cyclacel Pharmaceuticals Inc.’s R&D portfolio and develop key strategic initiatives to reinforce pipeline in those areas. • Exploit in-licensing opportunities by identifying windows of opportunity to fill portfolio gaps. • Exploit collaboration and partnership opportunities with Cyclacel Pharmaceuticals Inc.. • Avoid Intellectual Property Rights related issues. • Explore the dormant and discontinued projects of Cyclacel Pharmaceuticals Inc. and identify potential opportunities in those areas. Table of Contents Table of Contents 2 List of Tables 4 List of Figures 4 Cyclacel Pharmaceuticals Inc. Snapshot 5
Cyclacel Pharmaceuticals Inc. Overview 5 Key Information 5 Key Facts 5 Cyclacel Pharmaceuticals Inc. – Research and Development Overview 6 Key Therapeutic Areas 6 Cyclacel Pharmaceuticals Inc. – Pipeline Review 9 Pipeline Products by Stage of Development 9 Pipeline Products – Monotherapy 10 Pipeline Products – Combination Treatment Modalities 11 Cyclacel Pharmaceuticals Inc. – Pipeline Products Glance 12 Cyclacel Pharmaceuticals Inc. – Late Stage Pipeline 12 Phase III Products/Combination Treatment Modalities 12 Cyclacel Pharmaceuticals Inc. Clinical Stage Pipeline Products 13 Phase II Products/Combination Treatment Modalities 13 Phase I Products/Combination Treatment Modalities 14 Cyclacel Pharmaceuticals Inc.–Early Stage Pipeline Products 15 Pre-Clinical Products/Combination Treatment Modalities 15 Discovery Products/Combination Treatment Modalities 16 Cyclacel Pharmaceuticals Inc. – Drug Profiles 17 Sapacitabine 17 Product Description 17 Mechanism of Action 17 R&D Progress 17 Sapacitabine + Decitabine 19 Product Description 19 Mechanism of Action 19 R&D Progress 19 Sapacitabine 20 Product Description 20 Mechanism of Action 20 R&D Progress 20 Seliciclib 22 Product Description 22 Mechanism of Action 22 R&D Progress 22 Cell Cycle Inhibitors Program 23 Product Description 23 Mechanism of Action 23 R&D Progress 23 CYC116 24 Product Description 24 Mechanism of Action 24 R&D Progress 24 Sapacitabine + Seliciclib 25 Product Description 25 Mechanism of Action 25 R&D Progress 25 CDK Inhibitors Program 26 Product Description 26 Mechanism of Action 26 R&D Progress 26
CYC065 27 Product Description 27 Mechanism of Action 27 R&D Progress 27 GSK-3 Inhibitors Program 28 Product Description 28 Mechanism of Action 28 R&D Progress 28 PLK1 Inhibitor Program 29 Product Description 29 Mechanism of Action 29 R&D Progress 29 GSK-3 Inhibitors Program 30 Product Description 30 Mechanism of Action 30 R&D Progress 30 Cyclacel Pharmaceuticals Inc. – Pipeline Analysis 31 Cyclacel Pharmaceuticals Inc. – Pipeline Products by Therapeutic Class 31 Cyclacel Pharmaceuticals Inc. - Pipeline Products By Target 33 Cyclacel Pharmaceuticals Inc. – Pipeline Products by Route of Administration 34 Cyclacel Pharmaceuticals Inc. – Pipeline Products by Molecule Type 35 Cyclacel Pharmaceuticals Inc. – Recent Pipeline Updates 36 Cyclacel Pharmaceuticals Inc. - Dormant Projects 39 Cyclacel Pharmaceuticals Inc. - Discontinued Pipeline Products 40 Discontinued Pipeline Product Profiles 40 Cell Cycle Inhibitors Program 40 Cyclin Binding Groove Inhibitors 41 Hdm2 Inhibitor Program 41 Cyclacel Pharmaceuticals Inc. – Locations And Subsidiaries 42 Head Office 42 Other Locations & Subsidiaries 42 Appendix 43 Methodology 43 Coverage 43 Secondary Research 43 Primary Research 43 Expert Panel Validation 44 Contact Us 44 Disclaimer 44 List of Tables Cyclacel Pharmaceuticals Inc. - Pipeline by Therapy Area and Indication, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline by Stage of Development, 2011 Cyclacel Pharmaceuticals Inc. - Monotherapy Products in Pipeline, 2011 Cyclacel Pharmaceuticals Inc. - Combination Treatment Modalities in Pipeline, 2011 Cyclacel Pharmaceuticals Inc. - Phase III, 2011 Cyclacel Pharmaceuticals Inc. - Phase II, 2011 Cyclacel Pharmaceuticals Inc. - Phase I, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Therapeutic Class, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Target, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Route of Administration, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Molecule Type, 2011
Cyclacel Pharmaceuticals Inc. - Recent Pipeline Updates, 2011 Cyclacel Pharmaceuticals Inc. - Dormant Developmental Projects, 2010 Cyclacel Pharmaceuticals Inc. - Discontinued Pipeline Products, 2010 Cyclacel Pharmaceuticals Inc., Other Locations Cyclacel Pharmaceuticals Inc., Subsidiaries List of Figures Cyclacel Pharmaceuticals Inc. - Pipeline by Therapy Area and Indication, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline by Stage of Development, 2011 Cyclacel Pharmaceuticals Inc. - Monotherapy Products in Pipeline, 2011 Cyclacel Pharmaceuticals Inc. - Combination Treatment Modalities in Pipeline, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Therapeutic Class, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Target, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Molecule Type, 2011 About Us: ReportsnReports is an online library of over 100,000+ market research reports and in-depth market research studies & analysis of over 5000 micro markets. We provide 24/7 online and offline support to our customers. Get in touch with us for your needs of market research reports. Follow us on Twitter: http://twitter.com/marketsreports Our Facebook Pagehttp://www.facebook.com/pages/ReportsnReports/191441427571689 Contact: Mr.Priyank 7557 Rambler road, Suite727,Dallas,TX75231 Tel: +1-888-989-8004 E-mail: sales@reportsnreports.com http://www.reportsnreports.com Visit our Market Research Blog

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Cyclacel Pharmaceuticals Pipeline Review Q2 2011

  • 1. Cyclacel Pharmaceuticals Inc. – Product Pipeline Review – Q2 2011 Report Summary Global Market Direct’s pharmaceuticals report, “Cyclacel Pharmaceuticals Inc. - Product Pipeline Review - Q2 2011” provides data on the Cyclacel Pharmaceuticals Inc.’s research and development focus. The report includes information on current developmental pipeline, complete with latest updates, and features on discontinued and dormant projects. This report is built using data and information sourced from Global Markets Direct’s proprietary databases, Cyclacel Pharmaceuticals Inc.’s corporate website, SEC filings, investor presentations and featured press releases, both from Cyclacel Pharmaceuticals Inc. and industry-specific third party sources, put together by Global Markets Direct’s team. Scope • Cyclacel Pharmaceuticals Inc. - Brief Cyclacel Pharmaceuticals Inc. overview including business description, key information and facts, and its locations and subsidiaries. • Review of current pipeline of Cyclacel Pharmaceuticals Inc. human therapeutic division. • Overview of pipeline therapeutics across various therapy areas. • Coverage of current pipeline molecules in various stages of drug development, including the combination treatment modalities, across the globe. • Product profiles for late stage and clinical stage products of Cyclacel Pharmaceuticals Inc. with complete description of the product’s developmental history, mechanism of action, therapeutic class, target and major milestones. • Recent updates of the Cyclacel Pharmaceuticals Inc.’s market pipeline in the last quarter. • Key discontinued and dormant projects. • Latest news and deals relating to the products. Browse All Pharmaceuticals Market Research Reports Reasons to buy • Evaluate Cyclacel Pharmaceuticals Inc.’s strategic position with total access to detailed information on its product pipeline. • Assess the growth potential of Cyclacel Pharmaceuticals Inc. in its therapy areas of focus. • Identify new drug targets and therapeutic classes in the Cyclacel Pharmaceuticals Inc.’s R&D portfolio and develop key strategic initiatives to reinforce pipeline in those areas. • Exploit in-licensing opportunities by identifying windows of opportunity to fill portfolio gaps. • Exploit collaboration and partnership opportunities with Cyclacel Pharmaceuticals Inc.. • Avoid Intellectual Property Rights related issues. • Explore the dormant and discontinued projects of Cyclacel Pharmaceuticals Inc. and identify potential opportunities in those areas. Table of Contents Table of Contents 2 List of Tables 4 List of Figures 4 Cyclacel Pharmaceuticals Inc. Snapshot 5
  • 2. Cyclacel Pharmaceuticals Inc. Overview 5 Key Information 5 Key Facts 5 Cyclacel Pharmaceuticals Inc. – Research and Development Overview 6 Key Therapeutic Areas 6 Cyclacel Pharmaceuticals Inc. – Pipeline Review 9 Pipeline Products by Stage of Development 9 Pipeline Products – Monotherapy 10 Pipeline Products – Combination Treatment Modalities 11 Cyclacel Pharmaceuticals Inc. – Pipeline Products Glance 12 Cyclacel Pharmaceuticals Inc. – Late Stage Pipeline 12 Phase III Products/Combination Treatment Modalities 12 Cyclacel Pharmaceuticals Inc. Clinical Stage Pipeline Products 13 Phase II Products/Combination Treatment Modalities 13 Phase I Products/Combination Treatment Modalities 14 Cyclacel Pharmaceuticals Inc.–Early Stage Pipeline Products 15 Pre-Clinical Products/Combination Treatment Modalities 15 Discovery Products/Combination Treatment Modalities 16 Cyclacel Pharmaceuticals Inc. – Drug Profiles 17 Sapacitabine 17 Product Description 17 Mechanism of Action 17 R&D Progress 17 Sapacitabine + Decitabine 19 Product Description 19 Mechanism of Action 19 R&D Progress 19 Sapacitabine 20 Product Description 20 Mechanism of Action 20 R&D Progress 20 Seliciclib 22 Product Description 22 Mechanism of Action 22 R&D Progress 22 Cell Cycle Inhibitors Program 23 Product Description 23 Mechanism of Action 23 R&D Progress 23 CYC116 24 Product Description 24 Mechanism of Action 24 R&D Progress 24 Sapacitabine + Seliciclib 25 Product Description 25 Mechanism of Action 25 R&D Progress 25 CDK Inhibitors Program 26 Product Description 26 Mechanism of Action 26 R&D Progress 26
  • 3. CYC065 27 Product Description 27 Mechanism of Action 27 R&D Progress 27 GSK-3 Inhibitors Program 28 Product Description 28 Mechanism of Action 28 R&D Progress 28 PLK1 Inhibitor Program 29 Product Description 29 Mechanism of Action 29 R&D Progress 29 GSK-3 Inhibitors Program 30 Product Description 30 Mechanism of Action 30 R&D Progress 30 Cyclacel Pharmaceuticals Inc. – Pipeline Analysis 31 Cyclacel Pharmaceuticals Inc. – Pipeline Products by Therapeutic Class 31 Cyclacel Pharmaceuticals Inc. - Pipeline Products By Target 33 Cyclacel Pharmaceuticals Inc. – Pipeline Products by Route of Administration 34 Cyclacel Pharmaceuticals Inc. – Pipeline Products by Molecule Type 35 Cyclacel Pharmaceuticals Inc. – Recent Pipeline Updates 36 Cyclacel Pharmaceuticals Inc. - Dormant Projects 39 Cyclacel Pharmaceuticals Inc. - Discontinued Pipeline Products 40 Discontinued Pipeline Product Profiles 40 Cell Cycle Inhibitors Program 40 Cyclin Binding Groove Inhibitors 41 Hdm2 Inhibitor Program 41 Cyclacel Pharmaceuticals Inc. – Locations And Subsidiaries 42 Head Office 42 Other Locations & Subsidiaries 42 Appendix 43 Methodology 43 Coverage 43 Secondary Research 43 Primary Research 43 Expert Panel Validation 44 Contact Us 44 Disclaimer 44 List of Tables Cyclacel Pharmaceuticals Inc. - Pipeline by Therapy Area and Indication, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline by Stage of Development, 2011 Cyclacel Pharmaceuticals Inc. - Monotherapy Products in Pipeline, 2011 Cyclacel Pharmaceuticals Inc. - Combination Treatment Modalities in Pipeline, 2011 Cyclacel Pharmaceuticals Inc. - Phase III, 2011 Cyclacel Pharmaceuticals Inc. - Phase II, 2011 Cyclacel Pharmaceuticals Inc. - Phase I, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Therapeutic Class, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Target, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Route of Administration, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Molecule Type, 2011
  • 4. Cyclacel Pharmaceuticals Inc. - Recent Pipeline Updates, 2011 Cyclacel Pharmaceuticals Inc. - Dormant Developmental Projects, 2010 Cyclacel Pharmaceuticals Inc. - Discontinued Pipeline Products, 2010 Cyclacel Pharmaceuticals Inc., Other Locations Cyclacel Pharmaceuticals Inc., Subsidiaries List of Figures Cyclacel Pharmaceuticals Inc. - Pipeline by Therapy Area and Indication, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline by Stage of Development, 2011 Cyclacel Pharmaceuticals Inc. - Monotherapy Products in Pipeline, 2011 Cyclacel Pharmaceuticals Inc. - Combination Treatment Modalities in Pipeline, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Therapeutic Class, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Target, 2011 Cyclacel Pharmaceuticals Inc. - Pipeline By Molecule Type, 2011 About Us: ReportsnReports is an online library of over 100,000+ market research reports and in-depth market research studies & analysis of over 5000 micro markets. We provide 24/7 online and offline support to our customers. Get in touch with us for your needs of market research reports. Follow us on Twitter: http://twitter.com/marketsreports Our Facebook Pagehttp://www.facebook.com/pages/ReportsnReports/191441427571689 Contact: Mr.Priyank 7557 Rambler road, Suite727,Dallas,TX75231 Tel: +1-888-989-8004 E-mail: sales@reportsnreports.com http://www.reportsnreports.com Visit our Market Research Blog