Business Description

1. 1/23/2011 C2 BioTechnologies, LLC 1 By Larry Cosenza

2. 1/23/2011 C2 BioTechnologies, LLC 2 Business Overview R&D: Design enzymes for industry. Goal: Manufacture enzymes for production of renewable energy. Technology: Fusion Enzyme. Seeking: Licensing and Commercial Partner.

3. What We Do Design enzymes for industrial process. Design and construct more robust enzymes. Design and construct enzymes to consolidate industrial bio-process. 1/23/2011 C2 BioTechnologies, LLC 3

4. How Does This Help? Robust enzymes can reduce variability in process… increasing product yield. Consolidating bio-process reduces operating and consumables costs. Each prototype fusion enzyme can be re-engineered: result in families of products. 1/23/2011 C2 BioTechnologies, LLC 4

5. 1/23/2011 C2 BioTechnologies, LLC 5 Renewable Feedstock Where does C2 Biotechnologies fit in? Energy

6. 1/23/2011 C2 BioTechnologies, LLC 6 What are Enzymes? Enzymes are proteins, which are produced by all living organisms. Enzymes are responsible for a number of biological activities in plants, animals, human beings and microorganisms. Enzymes are distinguishable from other proteins because of their catalytic activity. Enzymes work by making or breaking chemical bonds.

7. 1/23/2011 C2 BioTechnologies, LLC 7 How Do Enzymes Work? Gluco-amylase a - Amylase

8. First Product Prototype Amylase Fusion Enzyme More robust Active over wide range temperature Actively converts starch into glucose Simple bacterial production system Target markets: ethanol, corn sweetener, fermentation. 1/23/2011 C2 Biotechnologies, LLC 8

9. Second Technology in Development Cellulase Fusion Enzyme Consolidate bio-process SBIR funded by Department of Energy Target market: cellulosic ethanol 1/23/2011 C2 BioTechnologies, LLC 9

10. 1/23/2011 C2 BioTechnologies, LLC 10 Industrial Enzymes Market Current Enzyme Market $3.3 billion. Currently ~13 billion gallons ethanol produced in U.S. nearly all from corn. Global market expected to grow. Amylase market ~20% of total or ~$660 million. Cellulase market: growing…

11. 1/23/2011 C2 BioTechnologies, LLC 11 Industrial Enzyme Pain Points C2 BioTechnologies Fits in here.

12. 1/23/2011 C2 BioTechnologies, LLC 12 C2BioTechnologies:Right Time Right Place Federal & State legislation mandating use of bio-fuels. Current enzyme market growing. New technology / new products. New markets. Fusion technology addresses industry pain points.

13. Summary R&D : Design and Construct Fusion Enzyme Technology for Industrial Use. Products: Amylase & Cellulase Fusion Technologies Target Markets: Energy, Food, Fermentation. Goal: Manufacture Enzymes. Seeking: Licensing and Commercial Partner. 1/23/2011 C2 BioTechnologies, LLC 13