This is Dr. Cady's third presentation to health care professionals in California, this time with updated news from the peer reviewed literature and a wide-ranging discussion of Pharmanex supplements and products: not just for "antioxidant" benefit, but for a complete, balance, systems-focused approach toward wellness.

1. A Review of the Pharmanex Biophotonic Scanner,
Supplementation and the “Cady White Paper”
Newport Beach, California – June 2, 2012
Louis B. Cady, MD – CEO & Founder – Cady Wellness Institute
Adjunct Professor – University of Southern Indiana
Adjunct Clinical Lecturer – Indiana University School of Medicine
Department of Psychiatry
Child, Adolescent, Adult & Forensic Psychiatry – Evansville, Indiana
This presentation is © Louis B. Cady M.D. and may not be reproduced in
part or whole, in any form, or used without permission.

2. Disclaimer: Pharmanex
supplementation and the
BioPhotonic Scanner are not
FDA approved for the diagnosis,
treatment, prevention, or cure of
ANY disease or “medical
condition.”
They ARE appropriate to support the structure
and function of the human body.

3. Tech Rules…. Please turn
your phones ON (just
silenced).
• Shoot photos!
• Tweet! ( @LouisCadyMD )

4. Cady Wellness Institute – July 2005
The Reasons:
• Conventional medical practice had failed me twice.
• A lot of “psychiatric cases” WEREN’T “psychiatric.”
• Nobody was integrated.
• Nobody was looking at ALL of the peer-reviewed
literature.

7. CURRENT PRACTICE OF MEDICINE:
What a patient had to say about her “specialists”:
“They just monitor my
degeneration.”

9. A TALE OF THREE WOMEN

11. Evansville Courier & Press: May 29,
2006

15. As of 5/31/2012

16. Could it happen to you?

17. What causes oxidative stress?
• Environmental Toxins
– Heavy metals – including Mercury (fillings!)
– Pesticides/herbicides
– Preservatives
– PCB’s, Dioxins, Phthalates
• Toxins produced in the body
– Yeast and bacteria
– Products of cellular metabolism
• Emotional Stress
– Anxiety/Tension
– Fear
– Anger

19. Oxidative stress in the BRAIN

20. Why is the brain so
susceptible to oxidative stress?
• Burns glucose – generates free radicals.
• Uses 20% of total oxygen and energy consumed
by the body.
• ½ of this is for electrochemical nerve
transmission.
• Contains IRON
• Contains essential fatty acids, which can be
OXIDIZED (“rancid fat”)
• Limited supply of own antioxidants
• Limited ability to regenerate/repair damage

21. What are some consequences of
oxidative stress?
• Impaired cognitive function
• Decreased memory
• Depressed immune system
• Increased inflammation
• DNA damage
• cancer
• Behavioral deterioration

22. Center for Biomedical Optics – Dixon
Laser Institute, University of Utah
• Werner Gellermann, Ph.D. – Research
Professor
• Colleague – Igor Ermakov, Ph.D., et al.
• Technologies – “Novel Raman Spectroscopy
and Raman Imaging.”
• Funding:
– National Institutes of Health
– State of Utah
– Spectrotek, LLC

24. “A method and apparatus are provided
for the determination of levels of
carotenoids and similar chemical
compounds in biological tissue such
as living skin.”

25. Scientific Validation: Peer-reviewed by the
medical & research communities
• Society of Investigative Dermatology, May 25, 2000.
– Non-Invasive Raman Spectroscopic
Detection of Carotenoids in Human Skin.
• Arch Biochem Biophys. 2010 Dec 1;504(1):40-9. Epub
2010 Aug 1.
– Validation model for Raman based skin
carotenoid detection
• J Eur Acad Dermatol Ven. 2011 Aug;25(8):945-9.
– Skin carotenoid levels in adult patients with
psoriasis.

26. “RSS spectroscopy is a reliable
method for non-invasive
measurement of B-carotene
levels in skin, and may be used
as an important biomarker of
antioxidant status in nutritional
and health studies in humans.”
Ramirez-Velez, et al. Endocrinol Nutr. 2012 April

27. Where to read more…

29. “The Complete Idiot’s Guide to the
“Cady White Paper”
• Pp 1-3 Patent claim synthesis: assessing
the overall antioxidant status in human
tissue via Raman spectroscopy via
measuring carotenoids
– Carotenoids are antioxidants
• Identified in 1992
• Potent antioxidants
• Lycopenes and carotenoids appear to diminish risk of
prostate CA.
• P 4 Further discussion of prostate CA

30. Carotenoid correlation with other
antioxidants (pp 4-6)
• Cited: carotenoids as chemopreventive agents*
• Carotenoids as first line of defense, associated
with “antioxidant network” – with Vitamins C, E,
Coenzyme Q10, ALA, and SE. **
• Yeum et al: need to measure water AND fat
soluble vitamins identified.***
*Peng YM et al. Concentrations and plasma-tissue-diet relationships of carotenoids,
retinoids, and tocopherols in humans. Nutr Cancer. 1995;23(3):233-46.
** Packet, Lester. The Antioxidant Miracle. John Wiley & Sons, Inc. © 1999
***Yeum et al. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic
compartments of human plasma. Arch Biochem Biophys. 2004 Oct 1; 430(1):97-103.

31. Relationships of carotenoids to other more
conventionally measured antioxidants (p 6 -7)
• Svilaas et al (2004):
– 2, 670 adults studied with serum carotenoids
measured and correlated with vitamin
consumption
– serum carotenoids were stronger predictors of
other antioxidants than were alpha, beta, delta,
and gamma tocopherols, as well as
glutathione.*
* Svilaas A, et al. Intakes of antioxidants in coffee, wine, and
vegetables are correlated with plasma carotenoids in humans. J
Nutr. 2004 Mar;134(3):562-7.

32. Convenience of carotenoids as antioxidant
measurement: from the eye to the skin (pp7-11)
• Bernstein P et al (1998) - Carotenoids useful as
measure of antioxidant status in human retina*
• Hata, et al (2000) – correlated skin carotenoids
(Raman) with carotenoid levels from skin from
abdominoplasty patients (HPLC).
– “Our technique can be used…for assessing antioxidant
status and the risk for diseases related to oxidative
stress.”
– Previous use in skin, retina, oral cavity and other tissues
cited. Palm of skin = highest carotenoid location
*Bernstein P et al. Raman detection of macular carotenoids pigments in intact human
retina. Invest Opthalmol Vis Sc. 1998 Oct;39(11):2003-11.
**Hata et al. Non-invasive Raman spectroscopic detection of carotenoids in human
skin. J Invest Dermatol. 2000 Sep; 115(3):441-8.

33. The Svilaas/Hata Syllogism:
• Hata (2000) – Raman measurements of
carotenoid == HPLC skin measurements
• Svilaas (2004) – skin carotenoids = better
predictor of antioxidant status than mixed
tocopherols and glutathione
• THEREFORE [Cady]: Raman spectroscopy
is a better measure of antioxidant status
than mixed tocopherols and glutathione.

34. Dissolved carotenoids in stratum corneum
27 days

35. BTW – what does that “SCS” actually
mean in REAL LAB MEASUREMENTS?
• Y = 12703 * X + 5891.7
– Where Y is the SCS, and X is the carotenoid
concentration in MICROgrams/ml, viz:
• 25,000 = 12703X + 5891.7
• 25,000 – 5891.7 = 12703 * X
• 19,108.3 = 12703 * X
• 19,108.3 /12703 = X
• X = 1.50 MICROgrams /ml
• Rule of thumb: 1,000 on SCS = .06 ug carotenoid/
ml blood serum
• (e.g., SCS of 40,000 = 2.4 ug carotenoid/ml)
Source: NuSkin/Pharmanex

36. Original study Skin carotenoid score
distribution
• N=1,375
April 2012 -
– SCS ranges:
Columbia
• 1500 –
cancer
patient
• 73,000 –
two month
old baby.
– Mean: 19,281
Smidt, C. Clinical screening study: use of the Pharmanex ® Biophotonic scanner to
assess skin carotenoids as a marker of antioxidant status. 2002

37. How are we doing? 2006 Data Histogram:
N =2,591,667 Skin Carotenoid Score
Source: data reported by Pharmanex Mean SCS = 26,673
Obesity
Smokers
Average (2-3 Fruits & Vegetables)
Frequency
5-9 Fruits & Vegetables
LifePak
LifePak +
5-9 Fruits & Vegetables

38. 16,103 people – 1994 – 1996.
ZERO got 100% of all required vitamins and
nutrients
- Highest – B12 =- 82.8% got enough
- 66.8% - had adequate folate
- Lowest – Zinc – only 26.6% got enough.

39. What’s New since the “cady
report” (2006 & 2008)?

40. Lipid peroxidation, antioxidant status
& survival in institutionalized elderly
• Plasma MDA
predicted mortality
independently of all
other variables.
• B-carotene and
alpha tocopherol
were independently
associated with
survival. Huerta JM et al. Free Radical Research
2006, vol 40, no 6. pp 571-578.

41. Angela Mastaloudis Ph.D.
Senior Scientist, Global Research &
Development, Pharmanex

42. “RS accurately measures total carotenoids in human skin
with less intra-individual variability than measurement of
serum carotenoids by HPLC analysis. RS technology
is a valid and reliable noninvasive method
to rapidly assess carotenoid nutritional
status in humans.” (J Am. Coll Nutr 2009)

43. Epidemiology of Vascular Aging (EVA)
• Study population:
– N=1,389; age range {59-71 yoa}
– 9 year study
• Relative risks:
– all cause mortality at 2.94X in men in lowest
quintile (95% CI, P=0.03)
– cancer 1.72X in men (95% CI, P=0.01
• “Total plasma carotenoids levels
were independently associated
with mortality risk in men.”

44. Vitamin/mineral supplementation & cancer,
cardiovascular, and all-cause mortality
(EPIC-Heidelberg) Li K, Kaaks R., et al. Eur J Nutri July 2011
• Purpose: evaluate vitamin/mineral
supplementation with CA, CV dz, and mortality
• Methods:
– 23,943 healthy participants, followed x 11 years
– Baseline and “new-use” supplementation noted
• Results: 513 CA deaths, 264 CV deaths
– “No MVI supplement had any significant effect”
– Baseline users of antioxidant supplements
had significantly reduced risk of cancer [HR
0.52] and all cause mortality [0.58]
• “sick user” phenomenon discussed.

45. Antioxidants and brain tumors?
• “free radicals are another etiological factor
of brain tumor and are removed by cellular
antioxidants in the human body.”
• Inverse correlation between:
– antioxidant levels and oxidative DNA damage
– Grades of malignancy
• Decrease in antioxidants are associated
with severity of malignancy

46. Conclusions
• “It is concluded that
administration of antioxidants
could reduce the incidence of
brain tumors and probably other
types of cancer.”
• - Shewelta SA , Sheikh, BY Curr Drug Metab. 2011
Jul;12(6):587-93. (Dept.of Biosciences & Technology,
Alexandria University, Egypt.)

47. Oxidative damage in DNA in lymphocytes:
correlation with CA and CV disease
• 8-oxodeoxyguanosine (8-
oxo-dG) concentration
measured in lymphocytes
• Vitamin C in plasma
• Vitamin E & carotenoids by
HPLC
• Mortality correlations with
oxidative damage:
– Heart dz, males (r= 0.95)
– Colorectal CA, males
Collin AR , et al. FASEB J.
1998 Oct;12(13):1397-400. (r=0.91)

48. The GREAT news about a BAD study
Conclusions: “In older women, several
commonly used dietary vitamin and mineral
supplements may be associated with
increased total mortality risk; this association
is strongest with supplemental iron.”

49. Not so fast!
• 18 year duration; 38,000 “older” white
women in Iowa
• Supplements: MVI’s, A, D, E, Beta-
carotene, B –vitamins, iron, calcium,
copper, magnesium selenium, and zinc.
• The real results:
– Early results showed women who used C, D,
E, and Calcium had significantly lower rates
of death
– Iron supplementation was highly correlated to
death rates (but these results were mixed in)

50. A real hatchet job on MVI’s
• Study measured “who dies over 18 years?”
– Average age at start – 61 yoa
– Average age at end of study 82 yoa
– Average mortality for all women – 80 yoa in
2003 (during the study)
• Conclusion: Over 50% of the women in the
Iowa study lived longer than the average life
expectancy.
Mursu, Harnack et al – Dietary supplements and mortality rate in
older women…. Arch Intern Med 2011 Oct 10;171(18):1625-33.

51. More hatcheting – poor controls
• Hormones (Premarin/provera) Nearly
– 13.5% of supplement users 2X as
– 7.2% of non-supplement users
many!!
• No explanation as to why so many women
were taking iron.
• Excess levels of vitamin A in some MVI
brands
• No evaluation of the quality or potency of
the supplements
Mursu, Harnack et al – Dietary supplements and mortality rate in
older women…. Arch Intern Med 2011 Oct 10;171(18):1625-33.

52. “Pending strong evidence …from randomized trials, it
appears prudent for all adults to take vitamin
supplements.” Fletcher & Fairfield, JAMA 2002

53. So why do you need a
SYSTEM in your vitamin
supplement/mineral
complex?? And what’s a
‘nano’?

54. What does “Nano” mean?
• Cylcodextrin ring – benign, digestable
• Feeds the gut microflora

55. How do nano-nutrients work?
Fat-soluble nutrients like Nano-encapsulated nutrients do
carotenoids and coenzyme Q10 not clump; they DISPERSE.
CLUMP in watery milieu.

56. The Nanotechnology Difference
5-fold increase in absorption!
pmol/mg protein
γ-cyclodextrin
Adapted from Craft et al, FASEB Journal. 2005; 19(4): Abstract #281.6, A449.
complex

57. The train has left the station…

58. what about other
things besides carotenoids
and “Antioxidants”??
B12, Magnesium, Selenium, Zinc, fish
oil…

59. 3
ega - s
O m c id
fa tty a
nts
mi ns onu
trie
vita P hyt
s nts
ine ral xid
a
m ntio
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hea
(b one

60. Symptoms of B12 Deficiency
Mental Physical
• Irritability
• • Diminished sense
Apathy
of touch and pain
• Personality changes
• Clumsiness
• Depression
• Weakness
• Memory loss
• Pernicious anemia
• Dementia
• Chronic fatigue
• Hallucinations
• Tremors
• Violent behavior
• GI problems
• Anxiety

61. LifePak Nano factoids - % RDA in 2
packets
• B12 - 1,000% (as 60 MICROgrams
cyanocobalamin)
• Magnesium 76% (as 300 Mg amino acid
chelate)
• Zinc 100% (15 mg as zinc chelate)
• Selenium 200% (L-selenomethionine &
NaSeO3)

62. Magnesium mementos
• One of the first minerals to disappear with:
– Processed food
– Stress
• Decreased by EtOH, caffeine, sodas, meds
• Considered “anti-stress” mineral
– Decreases cortisol (rel to sleep disruption)
– Relaxes muscles, prevents cramps (sleep
disruption)
– Decreases anxiety; improves sleep

63. Symptoms of Magnesium Deficiency
PSYCHIATRIC ISSUES: Health Conditions Associated
•Difficulty with memory with Magnesium Deficiency
and concentration  Migraine headaches
•Depression, apathy  PMS
•Emotional lability  Dysmenorrhea
•Irritability, nervousness,  Fibromyalgia
anxiety  Fatigue
•Insomnia
 CONSTIPATION
Autism
ADHD

64. SELENIUM DEFICIENCY in FASEB:
• “Adaptive dysfunction of
selenoproteins from the
perspective of the ‘triage’
theory: why modest
selenium deficiency
may increase risk
of diseases of
aging.”
Foundation of American McCann, J, Ames BM. FASEB J.
Societies for Experimental 2011 Jun;25(6):1793-814.
Biology

65. Negative downstream effects from
selenium deficiency:
“…cancer, heart disease, and
immune dysfunction are
prospectively associated with
modest selenium deficiency….
suggesting that Se deficiency could
be a CAUSATIVE factor”
McCann, J, Ames BM. FASEB J. 2011 Jun;25(6):1793-814.

66. Se+

“the foot soldier”
LifePak Nano has 200% of
RDA of selenium.

68. Fast food (low Zn) is bad for you.
• Fast food = high energy density = low essential
micronutrient density, ESPECIALLY ZINC
• Antioxidant processes are dependent on Zinc
• Fast food = severe decrease in antioxidant
vitamins and zinc, correlating with
inflammation in testicular tissue – with
underdevelopment of testicular tissue and
decreased testosterone levels

69. Special needs - Zinc
• Low Zinc- associated with low testosterone
– Per USDA, 60% of US men between 20 – 49
years of age do not get enough.
– N.B.: Do not supplement with > 50 mg daily
(can interfere with Cu+ metabolism)
• Tsai, E.C., Boyko, E.J., Leonetti, D.L., & Fujimoto,
W.Y. (2000). Low serum testosterone level as a
predictor of increased visceral fat in Japanese-
American men.
International Journal of Obesity and Related Metabolic Dis
24, 485-491

70. Essential Fatty Acids – relevant for:
“Psych” “Medical”
• Depression • Seizures
• Bipolar depression • Rheumatoid arthritis
• Schizophrenia (& anything with
• Autism inflammation)
• • Coronary heart
AD(H)D
disease (or health
• Learning disabilities maintenance)

71. Do YOU Need Fish Oil?
5X reduction

72. What happens with biotin
deficiency?
Two LifePak Nano packets have
100% of recommended daily
requirements of Biotin.
“Our results suggest that biotin deficiency
promotes hyperglycemic mechanisms…and
decreased insulin secretion and sensitivity to
compensate for reduced blood glucose
concentrations.”

73. Putting it all together…

74. LifePak Nano Contains
60+ Antioxidants, plus complete nutritional system
• All 8 forms of natural vitamin E
• Buffered vitamin C, Alpha lipoic acid
• Nano Carotenoids:
– as found in 5-10 fruits & vegetables per day
• Over 20 Flavonoids:
– green tea catechins, quercetin, citrus bioflavonoids,
grape seed polyphenols, resveratrol
• Selenium, Copper, Zinc, Mg++, Mb++
• B-vitamins complex, Biotin, D3 (150%)
• 4 GRAMS fish oil (incl. 600mg EPA/400 mg DHA)

75. The Effects of high dose B vitamins
on stress at work
Strough C et al. The effect of 90 day administration of a high dose vitamin B-
coplex on work stress. Hum Psyhopharmacol. 2011 Sept 8. doi
10.1002/hup.1229 (Swinburne University of Techbnology – Hawhorn, Victoria,
Australia.)

76. The Effects of high dose B vitamins
on stress at work
• “Occupational stress is increasing in Western societies.”
• 3 month, double blind, placebo control, randomized study
• Measured: Personality, work demands, mood, anxiety, and
strain
• After variances in personality and work demands were
controlled,
the vitamin B complex treated
group reported significantly lower personal
strain and a reduction in confusion and
depressed/dejected mood after 12 weeks.
Strough C et al. The effect of 90 day administration of a high dose vitamin B-
coplex on work stress. Hum Psychopharmacol. 2011 Sept 8. doi
10.1002/hup.1229 (Swinburne University of Techbnology – Hawhorn, Victoria,
Australia.)

77. Erectile dysfunction
& antioxidants with
MVI’s??

78. Way to improve erectile quality
(LP Nano concentrations in parentheses)
• Holistic: physical exercise, improved nutrition,
weight control
• Supplements: adequate intake
– Omega 3 fatty acids ( ~4 grams/ day in LP Nano)
– Antioxidants {+++}
– Calcium (600 mg = 60%)
– Folic acid (folate – 600 ug = 150%)
• RX: Replacement of any T deficiency
Meldrum DR et al. The link between erectile and cardiovascular health: the
canary in the coal mine. Am J Cardiol. 2011 Aug 15;108(4):599-606

79. Contact information:
Louis B. Cady, M.D.
www.cadywellness.com
www.indianaTMS-cadywellness.com
Office: 812-429-0772
E-mail: lcady@cadywellness.com
4727 Rosebud Lane – Suite F
Interstate Office Park
Newburgh, IN 47630 (USA)
Download from
iTunes or Android App stores
now!

81. Two thinkers:
- Yoshida Kenko – (1283?-1350?)
“Life Frail & Fleeting” • Risk reversal
• “USP”
• Defining the buying criteria

84. How do you want to age?

85. Success and Failure (Jim Rohn)
What about you? You’ve only got one body.
• “Errors in judgement” - High glycemic eating,
no exercise, poor nutrition, lousy or no
supplementation, high stress lifestyle.
- “Good disciplines” – appropriate diet,
supplementation, exercise, hormones. Stress
management. Decent lifestyle.

86. Perhaps the ability not only to acquire
the confidence of the patient, but to
deserve it, to see what the patient
desires and needs, comes through the
sixth sense we call intuition, which in
turn comes from wide experience and
deep sympathy for and devotion to
the patient, giving to the possessor
remarkable ability to achieve results.
...William J. Mayo, 1935