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Bioinformatics of cellular processes

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Lars Juhl Jensen
Lars Juhl Jensen

EMBO Practical Course on Methods in Cell Biology: Exploring the Dynamics of Cellular Organization, European Molecular Biology Laboratory, Heidelberg, Germany, August 23-31, 2007

Technologie
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Bioinformatics of cellular processes Protein networks, signaling and regulation Lars Juhl Jensen EMBL Heidelberg
functional networks
data integration
protein interactions
 
genetic interactions
 
gene coexpression
 
genomic context methods
gene neighborhood
 
gene fusion
 
phylogenetic profiles
 
literature mining
 
curated knowledge
 
variable quality
benchmarking
 
probabilistic network
 
signaling networks
phosphoproteomics
 
in vivo phosphosites
kinases are unknown
computational methods
 
overprediction
context
scaffolders
interaction networks
 
NetworKIN
 
 
benchmarking
 
DNA damage response
 
experimental validation
dynamic networks
the cell cycle
 
microarrays
 
expression profiles
 
cell-cycle-regulated genes
protein interactions
 
temporal network
 
global observations
dynamic and static subunits
 
consistent timing
 
phosphorylation by CDK
27% of dynamic proteins
8% of static proteins
targeted degradation
44% of dynamic proteins
29% of static proteins
just-in-time assembly
 
summary
networks
data integration
highly specific predictions
new biological principles
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