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» Empirical Awakening: The New Science
  on 12-step Treatment and Related
  Addiction Mutual-Help Organization
  Participation

                             John F. Kelly, Ph.D.
 President Elect, Society of Addiction Psychology, American Psychological Association
                            Associate Professor in Psychiatry
                                Harvard Medical School
              Program Director Addiction Recovery Management Service
                Associate Director MGH Center for Addiction Medicine



Awakening to the New Science of Mutual Help for Drug Addiction Recovery
                San Juan, Puerto Rico, March 15th, 2013
» Substance Use Disorders: massive medical, social, and
  economic burden
» Mutual-help groups (MHGs) can help offset burden
» MHGs work for many different types of individuals and
  produce additional benefit over and above formal
  treatment
» MHGs work through mechanisms similar to those
  operating in formal treatment
» MHGs can reduce costs by reducing patients’ reliance on
  professional services without any detriment to
  outcomes, and may even enhance outcomes
» Empirically-supported clinical interventions can increase
  patients’ participation in MHGs and enhance treatment
  outcomes
• #1 public health problem (Institute for Health
                  Policy, 2011); notably youth (CASA, 2011)
Public health   • Of all DALYs lost due to all psychiatric
                  conditions, alcohol use disorder alone = 36%

                • $425 billion in US each year (lost
                  productivity, criminal justice, medical costs)
 Economic       • Excessive alcohol consumption costs society $2 per
                  drink

                • SUD leading cause of mortality -alcohol leading risk
                  factor among males 15-59 yrs worldwide
 Mortality      • Opiate overdose – leading cause of accidental death
                  nationwide

                • Onset of long-term problems occur during
                  adolescence/young adulthood
 Prevention     • 90% adults with dependence start using before age 18
                • 50% of adults start using before age 15
$450


     $400


     $350


     $300


     $250

                                                                                                  Economic cost (in billions)
     $200


     $150


     $100


      $50


       $0
            Alcohol/drugs Heart disease   Alcohol   Drugs      Diabetes    Smoking      Obesity




Source: Bouchery, Harwood, Sacks, Simon, & Brewer (2011); US Department of Justice (2011)
Typical Clinical Course for Substance Dependence and Recovery



Addiction     Help                 Full Sustained                Relapse Risk
                                     Remission                   drops below
 Onset       Seeking                                                 15%




      4-5 years          8 years                      5 years



       Self-              4-5
                       Treatment                    Continuing
     initiated         episodes/                      care/
     cessation          mutual-                      mutual-
     attempts             help                         help
» SUDs: massive health, social, and economic burden
» Mutual-help groups (MHGs) can offset that burden
» MHGs work for many different types of individuals over
  and above formal treatment
» MHGs work through mechanisms similar to those
  operating in formal treatment
» MHGs can reduce costs by reducing patients’ reliance
  on professional services without any detriment to
  outcomes, and may even enhance outcomes
» Empirically-supported clinical interventions increase
  patients’ participation in MHGs and enhance treatment
  outcomes
» Past 40 years increase in quality and
  quantity of SUD treatment in US and
  developed countries

» However, professional resources alone
  cannot cope; stigma and cost present
  further barriers to access

» Addiction often has chronic course (8 yrs
  from 1 st tx to achieve FSR; Dennis et
  al, 2005); 4-5 yrs before risk of relapse
  <15%

» In tacit recognition, most societies seen
  increases in MHGs during past 70 yrs
  (Kelly & Yeterian, 2008)
» Cost-effective -free; attend as intensively, as long as desired
» Focused on addiction recovery over the long haul
» Widely available, easily accessible, flexible
» Access to fellowship/broad support network
» Entry threshold (no paperwork, insurance); anonymous
  (stigma)
» Adaptive community based system that is responsive to
  undulating relapse risk
 1950’s “Minnesota Model”

 >90% of private SUD treatment in US base tx on the 12-step
  principles (Roman & Blum, 1998)

 About 80% of VA SUD patients are referred to 12-step groups
  (Humphreys et al., 1997)

 84% of youth are referred to AA/NA post-discharge (Knudsen
  et al, 2008; Kelly et al, 2008)
Substance Focused Mutual-help Groups
                               Year of                                                                                              Evidence base*
          Name                                                                       Location of groups in U.S.
                               Origin      Number of groups in U.S.                                                                      (0-3)
 Alcoholics Anonymous                                52,651
                                                                                               all 50 States                            1, 2, 3
          (AA)                  1935
  Narcotics Anonymous                            Approx. 15,000
                                                                                               all 50 States                             1, 2
          (NA)                 1940s
  Cocaine Anonymous                           Approx. 2000 groups                 most States; 6 online meetings at
                                                                                                                                          0
         (CA)                   1982                                                    www.ca-online.org
 Methadone Anonymous                                                                25 States; online meetings at
                                               Approx. 100 groups                                                                        1, 2
        (MA)                   1990s                                        http://methadone-anonymous.org/chat.html
 Marijuana Anonymous                                                                 24 States; online meetings at
                                               Approx. 200 groups                                                                         0
        (MA)                    1989                                                     www.ma-online.org
                                          No group meetings or mutual
                                1988        helping; emphasis is on
 Rational Recovery (RR)                                                     -----------------------------------------------------        1, 2
                                             individual control and
                                                 responsibility

  Self-Management and                                                           40 States; 19 online meetings at
   Recovery Training            1994           Approx. 250 groups          www.smartrecovery.org/meetings/olschedule                     1, 3
 (S.M.A.R.T. Recovery)                                                                        .htm

Secular Organization for
                                                                                   all 50 States; Online chat at
  Sobriety, a.k.a. Save         1986           Approx. 480 groups                                                                         1
                                                                                 www.sossobriety.org/sos/chat.htm
    Ourselves (SOS)
  Women for Sobriety                                                                    Online meetings at
                                                 150-300 groups                                                                           1
      (WFS)                     1976                                        http://groups.msn.com/ WomenforSobriety
Moderation Management                        Approx.16 face-to-face            12 States; Most meetings are online at
                                                                                                                                          1
        (MM)                    1994               meetings                     www.angelfire.com/trek/mmchat/;

*0= None 1=Descriptive studies only 2 = Observational (correlational, longitudinal) 3= Experimental (random assignment, controlled).

Source: Kelly & Yeterian, 2008
» SUDs: massive health, social, and economic burden
» Mutual-help groups (MHGs) can offset that burden
» MHGs work for many different types of individuals
  over and above formal treatment
» MHGs work through mechanisms similar to those
  operating in formal treatment
» MHGs can reduce costs by reducing patients’ reliance
  on professional services without any detriment to
  outcomes, and may even enhance outcomes
» Empirically-supported clinical interventions increase
  patients’ participation in MHGs and enhance treatment
  outcomes
 Emrick et al. 1993 - 107 studies. AA attendance and involvement modest
  beneficial effect on drinking behavior

 Tonigan et al., 1996 - 74 studies. Examined moderators of effectiveness (i.e.
  outpatient vs. inpatient; study quality)
   Studies generally, were “methodological poor” and underpowered

 Kownacki & Shadish, 1999 – 21 studies. Examined controlled trials only
     - Randomization confounded with coerced status (justice system required)
     - Coerced individuals fared worse than individuals in other treatment or no
treatment
     - Coerced individuals may have better outcomes if coerced into other kinds
of treatment
     - Found support for 12-step-based tx and non-coerced AA attendance
» Attempted to examine RCTs of AA or TSF
» 8 trials involving 3417 people were included.
» Findings:
   ˃ AA may help patients to accept treatment and keep patients in treatment
       more than alternative treatments
   ˃ AA had similar retention rates
   ˃ 3 studies compared AA combined with other interventions against other
       treatments and found few differences in the amount of drinks and
       percentage of drinking days
   ˃ Peer-led AA participation found to be as effective as other comparison
       professionally-delivered interventions to which it was compared
       (e.g., CBT)
 Clinical concerns member-group fit with 12-step mutual-
  help organizations.

    1. Dual-diagnosed (DD)
       Medications
       Clinical syndromes vs. “not working the program”

    2. Non-religious people
       Barriers to 12-step

    3. Women
       “Powerlessness”

    4. Young People
       Developmental barriers
Setting
Authors                         Year    N      Follow-up (Months)      % Female   M Age
                                                                                               (No. of sites)

Alford, Koehler, Leonard        1991   157          6, 12, 24            38%       16          Inpatient (1)

Brown                           1993   140              12               42%       16          Inpatient (2)

Kennedy & Minami                1993    91              12               23%      16.5         Inpatient (1)

Hsieh, Hoffman, Hollister       1998   2,317          6, 12              35%      17-19        Inpatient (24)

Kelly, Myers, Brown             2000    99              6                60%       16          Inpatient (2)

Kelly, Myers, Brown             2002    74              6                62%       16          Inpatient (2)

Mason and Luckey                2003    95            3, 12              32%       22          Inpatient (2)

                                2004   810              12               30%       16     Residential (8),STI (6),
Grella, Joshi, Hser
                                                                                              Outpatient (9)
Kelly, Myers, Brown             2005    74              6                62%       16          Inpatient (2)

Kelly, Brown et al              2008   160     6, 12, 24, 48, 72, 96     34%      13-18        Inpatient (2)

Chi, Kaskutas, Sterling et al   2009   419          6, 12, 36            34%      13-18   Intensive outpatient (4)

Kelly, Dow, Yeterian            2010   127             3, 6              24%      16.7        Outpatient (1)

Chi, Sterling, Campbell,        2012   419      12, 36, 60, 72, 84       34%      13-18   Intensive outpatient(4)
Weisner
Kelly and Urbanoski             2012   127           3, 6, 12            24%      16.7        Outpatient (1)

Kelly, Stout, Slaymaker         2012   303          1, 3, 6, 12          27%       20         Residential (1)
Any, Monthy, and Weekly AA/NA Attendance across 8 Years
                                                             Following Inpatient Treatment
                                        100%

                                        90%

                                        80%
                    % Attending AA/NA




                                        70%
                                                                                                         Any
                                        60%                                                              Monthly
                                        50%                                                              Weekly

                                        40%

                                        30%
                                        20%

                                        10%
                                         0%
                                               0-6m   6m-1yr    1-2yr    2-4yr    4-6yr    6-8yr
                                                                  Follow-Up




Source: Kelly, J.F., Brown, S. A., Abrantes, A., Kahler, C. H., & Myers, M. (2008) Social Recovery Model: An 8-
year Investigation of adolescent 12-step group participation following inpatient treatment. Alcoholism:
Clinical and Experimental Research.
Percent of Youth in Each Trajectory Outcome Group attending AA/NA at least Weekly
                                                                    across 8 Years




                           100
% Attending AA/NA weekly




                            90

                            80

                            70
                                                                                                             Abstainers
                            60
                                                                                                             Infrequent User
                            50
                                                                                                             worse with time
                            40
                                                                                                             Frequent User
                            30

                            20

                            10

                             0
                                   6m         12m        24m          48m      72m         96m


                                                               Time
Parameter                  Estimate        Standard Error    95% Confidence      Z        P
                                                                        Limits


            Intercept                  37.3071         6.9601           23.6656    50.9486   5.36    <.0001

            Time                       1.4424          0.8693           -0.2614    3.1462    1.66    0.0971

            Gender                     -9.3380         2.6605           -14.5526   -4.1234   -3.51   0.0004

            Pre-treatment PDA          -0.0811         0.0490           -0.1772    0.0150    -1.65   0.0980

            Moderate use               -1.8816         0.9646           -3.7722    0.0090    -1.95   0.0511

            Aftercare1 6m              0.4349          0.5158           -0.5761    1.4460    0.84    0.3991

            Formal Treatment2          5.5669          3.2856           -0.8727    12.0065   1.69    0.0902

            AA/NA2                     1.9517          0.4512           1.0674     2.8360    4.33    <.0001

            PDA2                       0.5030          0.0371           0.4304     0.5757    13.56   <.0001



       1= Sq root transformed; 2= Time varying covariate

Kelly JF, Brown SA, Abrantes, A. et al. Social Recovery Model: An 8-Year Investigation of Youth Treatment Outcome in
Relation to 12-step Group Involvement. Alcoholism: Clinical and Experimental Research, 2008, 32, 8 1468-1478.
20
Kelly JF, Brown SA, Abrantes, A. et al. Social Recovery Model: An 8-Year Investigation of Youth
Treatment Outcome in Relation to 12-step Group Involvement. Alcoholism: Clinical and Experimental
Research, 2008, 32, 8 1468-1478.
Moderators: Might Age Composition of AA/NA meetings
              100
                  moderate participation and derived benefits?

                  95


                  90


                  85


                  80


                  75


                  70


                  65


                  60


                  55                                                                               Days Abstinent (3m)

                  50                                                                               Days Abstinent (6m)
                         All adults   Mostly adults   Even mix    Mostly teens   All teens



Kelly JF, Myers, MG Brown SA (2005). The effect of age composition of 12-step meetings on adolescent attendance and outcomes
Journal of Child and Adolescent Chemical Dependency.
» SUDs: massive health, social, and economic burden
» Mutual-help groups (MHGs) can offset that burden
» MHGs work for many different types of individuals over
  and above formal treatment
» MHGs work through mechanisms similar to those
  operating in formal treatment
» MHGs can reduce costs by reducing patients’ reliance
  on professional services without any detriment to
  outcomes, and may even enhance outcomes
» Empirically-supported clinical interventions increase
  patients’ participation in MHGs and enhance treatment
  outcomes
» Studies of treatment are often theory-based
  (e.g, Longabaugh and Morgenstern, 2002;
  Moos, 2007)

» However, studies of SUD remission and recovery
  are very seldom theory-based

» But, there are empirically supported theories that
  help explain the onset of substance use and SUD

» These same theories may be useful in helping
  explain SUD remission and recovery…
Parallels in the onset and offset of SUD

      People want to use
      substances for 4 main
      reasons (NIDA, 2005):
           To feel good
           To feel better
           To do better
           Because others are
           doing it
Parallels in the onset and offset of SUD

      People want to use        People want to stop using
      substances for 4 main     substances and recover for
      reasons (NIDA, 2005):     the same 4 main reasons:
           To feel good                To feel good
           To feel better              To feel better
           To do better                To do better
           Because others are          Because others are
           doing it                    doing it
Theory                                    Key process mechanisms for…
                                Substance use                                        Recovery
    Social          Lack of strong bonds with family,              Goal-direction, structure and monitoring,
    Control         friends, work, religion, other aspects         shaping behavior to adaptive social bonds
                    traditional society

    Social          Modeling and observation and                   Social network composed of individuals
    Learning        imitation of substance use, social             who espouse abstinence, reinforce negative
                    reinforcement for and expectations             expectations about effects of substances,
                    of positive consequences from use;             provide models of effective sober living
                    positive norms for use

    Stress and      life stressors (e.g.,                          Effective coping enhances self-confidence
    coping          social/work/financial problems,                and self-esteem
                    phys/sex abuse) lead to substance
                    use especially those lacking coping
                    and avoid problems; substance use
                    form of avoidance coping, self-
                    medication

    Behavioral      Lack of alternative rewards provided           Effective access to alternative, competing,
    economics       by activities other than substance             rewards through involvement in
                    use                                            educational, work, religious,
                                                                   social/recreational pursuits



Source: Moos, RH (2011) Processes the promote recovery from addictive disorders.
Theory                                    Key process mechanisms for…
                               Substance use                                        Recovery
   Social          Lack of strong bonds with family,              Goal-direction, structure and monitoring,
   Control         friends, work, religion, other aspects         shaping behavior to adaptive social bonds
                   traditional society

   Social          Modeling and observation and                   Social network composed of individuals
   Learning        imitation of substance use, social             who espouse abstinence, reinforce negative
                   reinforcement for and expectations             expectations about effects of substances,
                   of positive consequences from use;             provide models of effective sober living
                   positive norms for use

   Stress and      life stressors (e.g.,                          Effective coping enhances self-confidence
   coping          social/work/financial problems,                and self-esteem
                   phys/sex abuse) lead to substance
                   use especially those lacking coping
                   and avoid problems; substance use
                   form of avoidance coping, self-
                   medication

   Behavioral      Lack of alternative rewards provided           Effective access to alternative, competing,
   economics       by activities other than substance             rewards through involvement in
                   use                                            educational, work, religious,
                                                                  social/recreational pursuits

Source: Moos, RH (2011) Processes the promote recovery from addictive disorders.
How might MHGs like AA reduce relapse risk and sustain the
                                 recovery process?
                    Cue Induced




                 Stress Induced                                                                                              RELAPSE




                  Drug Induced


  AA-related social network changes may
  help avoid cues, reduce and tolerate
  distress, and maintain abstinence
  minimizing drug-induced relapse risks
                                                                                                                       AA



Kelly JF, Yeterian, JD, (In 28
                            press). Mutual help groups. In McCrady and Epstein. Comprehensive Textbook on Substance Abuse.
(15-mo) Alcohol Outcomes
                                         (3-mo) AA attendance
                                                                                                                    (PDA or DDD)


   Baseline (BL) Covariates
  Age
  Race
  Sex
  Marital Status
  Employment Status

  Prior Alcohol Treatment
  MATCH Treatment group
  MATCH study site

  Alcohol Outcomes (PDA/DDD)


  (BL) Self-efficacy                                                      (9-mo) Self-efficacy
         Negative Affect                                                         Negative Affect

  (BL) Self-efficacy                                                      (9-mo) Self-efficacy
         Positive Social                                                         Positive Social

  (BL) Religious/Spiritual                                                (9-mo) Religious/Spiritual
         Practices                                                               Practices

  (BL) Depression                                                         (9-mo) Depression

  (BL) Social Network                                                     (9-mo) Social Network
         “pro-abstinence”                                                        “pro-abstinence”

  (BL) Social Network                                                     (9-mo) Social Network
         “pro-drinking”                                                          pro-drinking”




Source: Kelly, Hoeppner, Stout, Pagano (2012) , Determining the relative importance of the mechanisms of behavior change within Alcoholics
Anonymous: A multiple mediator analysis. Addiction 107(2):289-99
Aftercare (PDA)                                 effect of AA on                    Aftercare (DDD)
                                             Self-efficacy
                                                                                 alcohol use for
                                                 (NA)              Depression    AC was explained
                                                  5%                  3%
                                                                                 by social factors
                                                                                 but also by S/R
                                                                                                                                        Self-efficacy
                                                                                 and through                       SocNet: pro-drk.
                                                                                                                                            (NA)
                             SocNet: pro-drk.                                                                           16%
                                  24%
                                                                                 negative affect               SocNet:
                                                                                                                                            20%
                                                             Spirit/Relig
                                                                23%
                                                                                 (DDD only)                   pro-abst.
                                                                                                                11%                            Depression
                             SocNet: pro-                                                                                                         11%
                                abst.
                                                                                                               Self-efficacy
                                16%              Self-efficacy                                                     (Soc)
                                                     (Soc)                                                                            Spirit/Relig
                                                                                                                   21%
                                                     34%                                                                                 21%




                                                                                 Majority of effect
                               Outpatient (PDA)                                  of AA on alcohol                  Outpatient (DDD)
                                                                                                        Self-efficacy
                        Self-efficacy           Depression                       use for OP was             (NA)                            Depression
                            (NA)                   2%      Spirit/Relig
                                                               6%                explained by                1%                                5%
                             1%
                                                                                 social factors
                                                                                                                                          Spirit/Relig
                                                                                                                                              9%
                                                                                                                  SocNet: pro-drk.
                                                                                                                       29%
                          SocNet: pro-drk.                    Self-efficacy
                               33%                                (Soc)
                                                                  27%
                                                                                                                                       Self-efficacy
                                                                                                                    SocNet: pro-           (Soc)
                                            SocNet: pro-                                                               abst.               39%
                                               abst.                                                                   17%
                                               31%




Source: Kelly, Hoeppner, Stout, Pagano (2012) , Determining the relative importance of the mechanisms of behavior change within Alcoholics Anonymous:
                                                                                                                                                            30
A multiple mediator analysis. Addiction 107(2):289-99
effect of AA on
                            Aftercare (PDA)                                                                     Aftercare (DDD)
                                                                                 alcohol use for
                                         Self-efficacy
                                             (NA)              Depression        AC was explained
                                              5%                  3%             by social factors
                                                                                 but also by S/R
                                                                                                                                    Self-efficacy
                                                                                 and through                   SocNet: pro-drk.
                                                                                                                                        (NA)
                                                                                                                    16%
                        SocNet: pro-drk.                                         negative affect                                        20%
                             24%                                                                            SocNet:
                                                         Spirit/Relig            (DDD only)                pro-abst.
                                                            23%
                                                                                                             11%                           Depression
                        SocNet: pro-                                                                                                          11%
                           abst.
                                                                                                            Self-efficacy
                           16%               Self-efficacy                                                      (Soc)
                                                 (Soc)                                                                            Spirit/Relig
                                                                                                                21%
                                                 34%                                                                                 21%




                                                                                 Majority of effect
                          Outpatient (PDA)                                       of AA on alcohol          Outpatient                (DDD)
                   Self-efficacy            Depression                           use for OP was Self-efficacy
                                                                                                    (NA)                                Depression
                       (NA)                    2%      Spirit/Relig
                        1%                                 6%                    explained by        1%                                    5%

                                                                                 social factors
                                                                                                                                      Spirit/Relig
                                                                                                                                          9%
                                                                                                              SocNet: pro-drk.
                                                                                                                   29%
                      SocNet: pro-drk.                    Self-efficacy
                           33%                                (Soc)
                                                              27%
                                                                                                                                    Self-efficacy
                                                                                                                SocNet: pro-            (Soc)
                                       SocNet: pro-                                                                abst.                39%
                                          abst.                                                                    17%
                                          31%                                                                                                           31



Source: Kelly, Hoeppner, Stout, Pagano (2012) , Determining the relative importance of the mechanisms of behavior change within Alcoholics Anonymous:
A multiple mediator analysis. Addiction 107(2):289-99
32
CONCLUSIONS
    ˃ Recovery benefits derived from AA differ in nature and magnitude between
      more severely alcohol involved/impaired and less severely alcohol
      involved/impaired; and between men and women

    ˃ These differences reflect differing needs based on recovery challenges related
      to differing symptom profiles, degree of subjective suffering and perceived
      severity/threat, recovery challenges, and gender-based social roles & drinking
      contexts

    ˃ Similar to psychotherapy literature (Bohart & Tollman, 1999) rather than
      thinking about how AA or similar organizations work, better to think how
      individuals use or make these organizations work for them – to meet their
      most urgent needs at any given phase of recovery
» SUDs: massive health, social, and economic burden
» Mutual-help groups (MHGs) can offset that burden
» MHGs work for many different types of individuals over
  and above formal treatment
» MHGs work through mechanisms similar to those
  operating in formal treatment
» MHGs can reduce costs by reducing patients’ reliance
  on professional services without any detriment to
  outcomes, and may even enhance outcomes
» Empirically-supported clinical interventions increase
  patients’ participation in MHGs and enhance treatment
  outcomes
HEALTH CARE COST OFFSET POTENTIAL OF MHGS (1)
               CBT VS 12-STEP RESIDENTIAL TREATMENT
                                  Cost per patient over 1 year *
                                                Cost per patient over 1 year *
CBT Resulted
in $4,729                          $12,129.00

greater costs
                                                                              $7,400.00
per patient with
sig. worse
outcomes
                                      CBT                                        TSF
                                                                                                   Compared to CBT-
                                                                                                   treated
                                    Cost per patient over 1-2 year                                 patients, 12-step
CBT Resulted in                                                                                    treated patients
                                                           Cost per patient
$3,295 greater                                                                                     more likely to be in
costs per patient
                                   $5,735.00                                                       recovery, at a
with sig. worse                                                                                    $8,000 lower cost
outcomes in Yr 2                                                                                   per pt over 2 yrs
                                                                                       $2,440.00
Follow up                                                                                          (about $15M for
                                                                                                   entire sample)

                                     CBT                                                  TSF
Source: Humphreys & Moos (2001; 2007) Alcoholism: Clinical Experimental Research
» The first study to examine how 12-Step participation affects
  medical costs in adolescents with SUD
» 4 intensive outpatient programs
» N = 403 adolescents, age 13-18
    66% male; mean age 16.1; 49% White
    Comorbid ADHD: 17%, depression: 36%
» Follow-up: 6 months, 1, 3, 5, and 7 years
» Difference-in-difference model was used




    Source: Mundt, Parthasarathy, Chi, Sterling, Campbell (2012)
» Avg annual medical costs for all participants
  over 7 years: $3085 per person per year
» 4.7% decrease in medical costs with each
  additional 12-step meeting attended = $145
  annual savings per 12-step meetings attended




Source: Mundt, Parthasarathy, Chi, Sterling, Campbell (2012)
» SUDs: massive health, social, and economic burden
» Mutual-help groups (MHGs) can offset that burden
» MHGs work for many different types of individuals over
  and above formal treatment
» MHGs work through mechanisms similar to those
  operating in formal treatment
» MHGs can reduce costs by reducing patients’ reliance
  on professional services without any detriment to
  outcomes, and may even enhance outcomes
» Empirically-supported clinical interventions increase
  patients’ participation in MHGs and enhance
  treatment outcomes
Risk             Treatment Settings          High Supportive Treatment           Low supportive Treatment
   Factors              Combined                         milieu                             milieu
                    n       Dropout Rate           n         Dropout Rate                  n       Dropout Rate
   0               261      30 % (77)             151         30 % (45)                   110       29 % (32)
   1               548      30 % (163)            274         29 % (79)                   274       31% (84)
   2               582      38 % (221)            269         38 %(103)                   313       38 % (118)
   3               512      43 % (218)            176         40 % (70)                   336       44% (148)
   4               381      51 % (193)            119         42 % (50)                   262       55% (143)
   5               150      54 % (81)              36         47 % (17)                   114       56% (64)
   6-7              78      65 % (51)              16         50 % (8)                     62       70% (43)

  •Dropout rate = 40%
  •AA dropouts had 3x higher odds of relapse to alcohol/drug use




Source: Kelly & Moos (2003) Dropout from 12-Step Groups: Prevalence, Predictors and Counteracting Treatment
Influences, Journal of Substance Abuse Treatment,24, 241-250
Source: Kelly & Moos (2003) Dropout from 12-Step Groups: Prevalence, Predictors and Counteracting Treatment
Influences, Journal of Substance Abuse Treatment,24, 241-250
» 20 patients randomly selected from outpatient tx
  program for alcohol use disorder
» Randomly assigned to:
   ˃1: Standard referral
      - given information about AA including time, date, location of
      meetings, encouraged to attend meetings
   ˃2: Systematic encouragement and community access
      - In addition to standard procedure, clients had phone conversation with AA
      member during a session - client and AA member met before first
      meeting, member provided client with ride; client also received a reminder
      phone call from the member
» Results:
   ˃0% clients in standard referral attended a meeting during the
    target week

   ˃100% clients in systematic encouragement and community
    access group attended meeting during target week

   ˃Mean AA meeting attendance rate for 4 week period:
      + 0 for standard referral group vs 2.3 for systematic encouragement
        group
T     O
S     T
F     H




Stand alone           Integrated into an existing   Component of a treatment
Independent therapy           therapy                     package (e.g., an
                                                          additional group)




As Modular add-on
linkage component
» Multisite randomized clinical trial of alcohol dependent
  individuals
   2 arms
       • Aftercare (n=774)- recently finished inpatient treatment
       • Outpatient (n=952)
   3 conditions, all with ultimate goal of abstinence
       • Twelve Step Facilitation
        - Therapist took firm stance against any drinking
       • Cognitive Behavioral Therapy
         - Therapist assisted in building skill set to maintain abstinence
       • Motivational Enhancement Therapy
        - Therapist aimed to build clients motivation to accept abstinence as
       objective
» Individuals randomly assigned to TSF attended AA more frequently and had
  higher rates of continuous abstinence (71% more) 1yr following tx
  (TSF=24%, CBT=15%, MET=14%) than those assigned to CBT or MET; similar
  on continuous outcomes (PDA/DDD)
» Social support for drinking
   ˃ 3 yrs post treatment, clients whose social networks were more
      supportive of drinking prior to treatment had higher abstinence and
      lower drinks per drinking day in TSF than in MET (clients in CBT did not
      show a significant advantage over those in MET)
 Effects mediated by ongoing AA attendance
 Across txs, those who attended AA groups had better outcomes (Tonigan
  et al, 2002)
 AA valuable adjunct to SUD treatment - even when not formally
  emphasized
T     O
S     T
F     H




Stand alone           Integrated into an existing   Component of a treatment
Independent therapy           therapy                     package (e.g., an
                                                          additional group)




As Modular add-on
linkage component
» Approaches to assist in involvement in AA

» 169 adult alcoholic outpatients randomly assigned to
  one of three treatment conditions

» All clients received treatment that included:
   ˃12 sessions
   ˃Focus on problem-solving, drink refusal, relaxation
   ˃Recommendation to attend AA meetings
»   Treatment varied between 3 conditions in terms of how the therapist discussed AA and how
    much information about AA was shared
     ˃ Condition 1: Directive approach
          - Therapist directed
          - Client signed contract describing goals to attend AA meetings
          - Therapist encouraged client to keep a journal about meetings
          - Reading material about AA provided to client
          - Therapist informs client about skills to use during meetings and about using a
          sponsor
          - 38% total material covered in sessions was about AA
     ˃ Condition 2: motivational enhancement approach (more client centered)
          - Therapist obtains clients feelings and attitudes about AA
          - Therapist describes positive aspects of AA, but states that it is up to the client how
          much they will be involved
          - Therapist intends to assist the client in making a decision in favor of AA
          - 20% total material covered in sessions about AA
     ˃ Condition 3: CBT treatment as usual, no special emphasis on AA
          - Throughout treatment, therapist briefly inquires about AA and encourages client to
          attend AA
          - 8% total material covered in sessions about AA


                                                      Walitzer, Dermen & Barrick, 2009
» Participants exposed to the Directive TSF approach reported
  significantly more:
   ˃attendance of AA meetings
   ˃more active involvement in AA
   ˃higher percent days abstinent in comparison to the
      motivational and treatment as usual groups
» Evidence suggests AA involvement partially mediated the
  effects of the directive approach
T     O
S     T
F     H




Stand alone           Integrated into an existing   Component of a treatment
Independent therapy           therapy                     package (e.g., an
                                                          additional group)




As Modular add-on
linkage component
» Making AA Easier- manual guided - designed to help clients prepare for AA

» Goal: to prepare for AA (encourage participation in AA, minimize resistance
  to AA, and educate about AA)
   ˃ MAAEZ intervention is conducted in a group format to help prepare for
      group dynamic of AA

» Facilitator goal: to inform clients about AA and facilitate group interaction
   ˃ Facilitator recommended to be an active member of AA, NA, or CA

» Discussion format: MAAEZ allows and encourages feedback (referred to as
  “cross-talk” in MAAEZ), unlike AA which does not allow feedback
» Structure of Program:

» Six, weekly, 90-minute sessions
   ˃Homework assigned at the end of each session
       - List of texts for reading assignments provided in
       manual
       - List of articles that discuss effectiveness of AA
       provided in manual
       - Each homework assignment includes going to at least
       one AA meeting in the 7 days following that
       session, making connections with other people in
       AA, and completing reading assignments
» Spirituality: provides clients with range of “spirituality” definitions that do
  not all require religious orientation. The homework assignment after that
  session is to talk to someone longer sober, after a meeting.

» Principles Not Personalities: deals with AA myths, types of
  meetings/etiquette. Homework- ask someone for phone number and
  speak on the phone before next session.

» Sponsorship: explains function of AA sponsor, offers guidelines for picking
  someone, and includes role-playing to practice asking for a sponsor and
  overcoming a rejection. Homework that week is to get a temporary
  sponsor.

» Living Sober, tools for staying sober are tackled: relapse
  triggers, service, and avoiding “slippery” people, places, and things.
  Homework for this session is to socialize with someone in AA who has
  more sobriety.
» Abstinence:
   ˃ TSF participants significantly more past 30 day alcohol
     abstinence, drug abstinence, and both alcohol and drug abstinence at
     12 month time period
   ˃ Increased odds of continuous abstinence in general and for each
     additional MAAEZ session attended

» Prior AA Exposure:
   ˃ MAAEZ found to be more effective in participants with AA previous
      experience (differs from outcomes found in Project MATCH), possibly
      because MAAEZ gives clients new perspective of AA




                                                    Kaskutas et al 2009
T     O
S     T
F     H




Stand alone           Integrated into an existing   Component of a treatment
Independent therapy           therapy                     package (e.g., an
                                                          additional group)




As Modular add-on
linkage component
 Evaluation of procedures to effectively refer patients to 12-step meetings

 Individuals with SUDs entering a new outpatient treatment program randomly assigned
  to a treatment condition and provided self reports on meeting attendance and
  substance use

     Condition 1: standard referral
         • Patients given locations and schedules of meetings and encouraged to attend

     Condition 2: intensive referral
         • Patients give locations and schedules of meetings, with the meetings
            preferred by previous clients indicated

          • Therapist reviews a handout about program including introduction to 12-step
            philosophy and common concerns

          • Therapist arranged a meeting with a current member and client had a phone
            conversation with this member during a session

          • Therapist and client agreed on which meetings client will attend and client
            kept a journal of meetings attended and experiences
» At 6m, patients in intensive referral who had relatively less
  previous 12-Step experience had:

   ˃higher meeting attendance
   ˃better substance use outcomes

» At both the 6 and 12 month follow up, patients in intensive
  referral:

   ˃more likely to attend at least one meeting per week
   ˃had higher rates of attendance and had higher rates of
    abstinence
» Timko et al. (2011; N=287): standard vs. intensive referral
  condition
» Patients in the intensive referral group were more likely to
  attend and be involved in dual-focused mutual-help groups
  (DFGs) and substance-focused mutual-help groups
  (SFGs), and had less drug use and better psychiatric
  outcomes at follow-up
» Only 23% of patients in the intensive-referral group
  attended a DFG meeting during the six-month follow-up
  period, while 85% attended a SFG
San Juan talk, empirical awakening (fri march 15 2013) - John Francis Kelly

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San Juan talk, empirical awakening (fri march 15 2013) - John Francis Kelly

  • 1. » Empirical Awakening: The New Science on 12-step Treatment and Related Addiction Mutual-Help Organization Participation John F. Kelly, Ph.D. President Elect, Society of Addiction Psychology, American Psychological Association Associate Professor in Psychiatry Harvard Medical School Program Director Addiction Recovery Management Service Associate Director MGH Center for Addiction Medicine Awakening to the New Science of Mutual Help for Drug Addiction Recovery San Juan, Puerto Rico, March 15th, 2013
  • 2. » Substance Use Disorders: massive medical, social, and economic burden » Mutual-help groups (MHGs) can help offset burden » MHGs work for many different types of individuals and produce additional benefit over and above formal treatment » MHGs work through mechanisms similar to those operating in formal treatment » MHGs can reduce costs by reducing patients’ reliance on professional services without any detriment to outcomes, and may even enhance outcomes » Empirically-supported clinical interventions can increase patients’ participation in MHGs and enhance treatment outcomes
  • 3. • #1 public health problem (Institute for Health Policy, 2011); notably youth (CASA, 2011) Public health • Of all DALYs lost due to all psychiatric conditions, alcohol use disorder alone = 36% • $425 billion in US each year (lost productivity, criminal justice, medical costs) Economic • Excessive alcohol consumption costs society $2 per drink • SUD leading cause of mortality -alcohol leading risk factor among males 15-59 yrs worldwide Mortality • Opiate overdose – leading cause of accidental death nationwide • Onset of long-term problems occur during adolescence/young adulthood Prevention • 90% adults with dependence start using before age 18 • 50% of adults start using before age 15
  • 4. $450 $400 $350 $300 $250 Economic cost (in billions) $200 $150 $100 $50 $0 Alcohol/drugs Heart disease Alcohol Drugs Diabetes Smoking Obesity Source: Bouchery, Harwood, Sacks, Simon, & Brewer (2011); US Department of Justice (2011)
  • 5. Typical Clinical Course for Substance Dependence and Recovery Addiction Help Full Sustained Relapse Risk Remission drops below Onset Seeking 15% 4-5 years 8 years 5 years Self- 4-5 Treatment Continuing initiated episodes/ care/ cessation mutual- mutual- attempts help help
  • 6. » SUDs: massive health, social, and economic burden » Mutual-help groups (MHGs) can offset that burden » MHGs work for many different types of individuals over and above formal treatment » MHGs work through mechanisms similar to those operating in formal treatment » MHGs can reduce costs by reducing patients’ reliance on professional services without any detriment to outcomes, and may even enhance outcomes » Empirically-supported clinical interventions increase patients’ participation in MHGs and enhance treatment outcomes
  • 7. » Past 40 years increase in quality and quantity of SUD treatment in US and developed countries » However, professional resources alone cannot cope; stigma and cost present further barriers to access » Addiction often has chronic course (8 yrs from 1 st tx to achieve FSR; Dennis et al, 2005); 4-5 yrs before risk of relapse <15% » In tacit recognition, most societies seen increases in MHGs during past 70 yrs (Kelly & Yeterian, 2008)
  • 8. » Cost-effective -free; attend as intensively, as long as desired » Focused on addiction recovery over the long haul » Widely available, easily accessible, flexible » Access to fellowship/broad support network » Entry threshold (no paperwork, insurance); anonymous (stigma) » Adaptive community based system that is responsive to undulating relapse risk
  • 9.  1950’s “Minnesota Model”  >90% of private SUD treatment in US base tx on the 12-step principles (Roman & Blum, 1998)  About 80% of VA SUD patients are referred to 12-step groups (Humphreys et al., 1997)  84% of youth are referred to AA/NA post-discharge (Knudsen et al, 2008; Kelly et al, 2008)
  • 10. Substance Focused Mutual-help Groups Year of Evidence base* Name Location of groups in U.S. Origin Number of groups in U.S. (0-3) Alcoholics Anonymous 52,651 all 50 States 1, 2, 3 (AA) 1935 Narcotics Anonymous Approx. 15,000 all 50 States 1, 2 (NA) 1940s Cocaine Anonymous Approx. 2000 groups most States; 6 online meetings at 0 (CA) 1982 www.ca-online.org Methadone Anonymous 25 States; online meetings at Approx. 100 groups 1, 2 (MA) 1990s http://methadone-anonymous.org/chat.html Marijuana Anonymous 24 States; online meetings at Approx. 200 groups 0 (MA) 1989 www.ma-online.org No group meetings or mutual 1988 helping; emphasis is on Rational Recovery (RR) ----------------------------------------------------- 1, 2 individual control and responsibility Self-Management and 40 States; 19 online meetings at Recovery Training 1994 Approx. 250 groups www.smartrecovery.org/meetings/olschedule 1, 3 (S.M.A.R.T. Recovery) .htm Secular Organization for all 50 States; Online chat at Sobriety, a.k.a. Save 1986 Approx. 480 groups 1 www.sossobriety.org/sos/chat.htm Ourselves (SOS) Women for Sobriety Online meetings at 150-300 groups 1 (WFS) 1976 http://groups.msn.com/ WomenforSobriety Moderation Management Approx.16 face-to-face 12 States; Most meetings are online at 1 (MM) 1994 meetings www.angelfire.com/trek/mmchat/; *0= None 1=Descriptive studies only 2 = Observational (correlational, longitudinal) 3= Experimental (random assignment, controlled). Source: Kelly & Yeterian, 2008
  • 11. » SUDs: massive health, social, and economic burden » Mutual-help groups (MHGs) can offset that burden » MHGs work for many different types of individuals over and above formal treatment » MHGs work through mechanisms similar to those operating in formal treatment » MHGs can reduce costs by reducing patients’ reliance on professional services without any detriment to outcomes, and may even enhance outcomes » Empirically-supported clinical interventions increase patients’ participation in MHGs and enhance treatment outcomes
  • 12.
  • 13.  Emrick et al. 1993 - 107 studies. AA attendance and involvement modest beneficial effect on drinking behavior  Tonigan et al., 1996 - 74 studies. Examined moderators of effectiveness (i.e. outpatient vs. inpatient; study quality) Studies generally, were “methodological poor” and underpowered  Kownacki & Shadish, 1999 – 21 studies. Examined controlled trials only - Randomization confounded with coerced status (justice system required) - Coerced individuals fared worse than individuals in other treatment or no treatment - Coerced individuals may have better outcomes if coerced into other kinds of treatment - Found support for 12-step-based tx and non-coerced AA attendance
  • 14. » Attempted to examine RCTs of AA or TSF » 8 trials involving 3417 people were included. » Findings: ˃ AA may help patients to accept treatment and keep patients in treatment more than alternative treatments ˃ AA had similar retention rates ˃ 3 studies compared AA combined with other interventions against other treatments and found few differences in the amount of drinks and percentage of drinking days ˃ Peer-led AA participation found to be as effective as other comparison professionally-delivered interventions to which it was compared (e.g., CBT)
  • 15.  Clinical concerns member-group fit with 12-step mutual- help organizations.  1. Dual-diagnosed (DD)  Medications  Clinical syndromes vs. “not working the program”  2. Non-religious people  Barriers to 12-step  3. Women  “Powerlessness”  4. Young People  Developmental barriers
  • 16. Setting Authors Year N Follow-up (Months) % Female M Age (No. of sites) Alford, Koehler, Leonard 1991 157 6, 12, 24 38% 16 Inpatient (1) Brown 1993 140 12 42% 16 Inpatient (2) Kennedy & Minami 1993 91 12 23% 16.5 Inpatient (1) Hsieh, Hoffman, Hollister 1998 2,317 6, 12 35% 17-19 Inpatient (24) Kelly, Myers, Brown 2000 99 6 60% 16 Inpatient (2) Kelly, Myers, Brown 2002 74 6 62% 16 Inpatient (2) Mason and Luckey 2003 95 3, 12 32% 22 Inpatient (2) 2004 810 12 30% 16 Residential (8),STI (6), Grella, Joshi, Hser Outpatient (9) Kelly, Myers, Brown 2005 74 6 62% 16 Inpatient (2) Kelly, Brown et al 2008 160 6, 12, 24, 48, 72, 96 34% 13-18 Inpatient (2) Chi, Kaskutas, Sterling et al 2009 419 6, 12, 36 34% 13-18 Intensive outpatient (4) Kelly, Dow, Yeterian 2010 127 3, 6 24% 16.7 Outpatient (1) Chi, Sterling, Campbell, 2012 419 12, 36, 60, 72, 84 34% 13-18 Intensive outpatient(4) Weisner Kelly and Urbanoski 2012 127 3, 6, 12 24% 16.7 Outpatient (1) Kelly, Stout, Slaymaker 2012 303 1, 3, 6, 12 27% 20 Residential (1)
  • 17. Any, Monthy, and Weekly AA/NA Attendance across 8 Years Following Inpatient Treatment 100% 90% 80% % Attending AA/NA 70% Any 60% Monthly 50% Weekly 40% 30% 20% 10% 0% 0-6m 6m-1yr 1-2yr 2-4yr 4-6yr 6-8yr Follow-Up Source: Kelly, J.F., Brown, S. A., Abrantes, A., Kahler, C. H., & Myers, M. (2008) Social Recovery Model: An 8- year Investigation of adolescent 12-step group participation following inpatient treatment. Alcoholism: Clinical and Experimental Research.
  • 18. Percent of Youth in Each Trajectory Outcome Group attending AA/NA at least Weekly across 8 Years 100 % Attending AA/NA weekly 90 80 70 Abstainers 60 Infrequent User 50 worse with time 40 Frequent User 30 20 10 0 6m 12m 24m 48m 72m 96m Time
  • 19. Parameter Estimate Standard Error 95% Confidence Z P Limits Intercept 37.3071 6.9601 23.6656 50.9486 5.36 <.0001 Time 1.4424 0.8693 -0.2614 3.1462 1.66 0.0971 Gender -9.3380 2.6605 -14.5526 -4.1234 -3.51 0.0004 Pre-treatment PDA -0.0811 0.0490 -0.1772 0.0150 -1.65 0.0980 Moderate use -1.8816 0.9646 -3.7722 0.0090 -1.95 0.0511 Aftercare1 6m 0.4349 0.5158 -0.5761 1.4460 0.84 0.3991 Formal Treatment2 5.5669 3.2856 -0.8727 12.0065 1.69 0.0902 AA/NA2 1.9517 0.4512 1.0674 2.8360 4.33 <.0001 PDA2 0.5030 0.0371 0.4304 0.5757 13.56 <.0001 1= Sq root transformed; 2= Time varying covariate Kelly JF, Brown SA, Abrantes, A. et al. Social Recovery Model: An 8-Year Investigation of Youth Treatment Outcome in Relation to 12-step Group Involvement. Alcoholism: Clinical and Experimental Research, 2008, 32, 8 1468-1478.
  • 20. 20 Kelly JF, Brown SA, Abrantes, A. et al. Social Recovery Model: An 8-Year Investigation of Youth Treatment Outcome in Relation to 12-step Group Involvement. Alcoholism: Clinical and Experimental Research, 2008, 32, 8 1468-1478.
  • 21. Moderators: Might Age Composition of AA/NA meetings 100 moderate participation and derived benefits? 95 90 85 80 75 70 65 60 55 Days Abstinent (3m) 50 Days Abstinent (6m) All adults Mostly adults Even mix Mostly teens All teens Kelly JF, Myers, MG Brown SA (2005). The effect of age composition of 12-step meetings on adolescent attendance and outcomes Journal of Child and Adolescent Chemical Dependency.
  • 22. » SUDs: massive health, social, and economic burden » Mutual-help groups (MHGs) can offset that burden » MHGs work for many different types of individuals over and above formal treatment » MHGs work through mechanisms similar to those operating in formal treatment » MHGs can reduce costs by reducing patients’ reliance on professional services without any detriment to outcomes, and may even enhance outcomes » Empirically-supported clinical interventions increase patients’ participation in MHGs and enhance treatment outcomes
  • 23. » Studies of treatment are often theory-based (e.g, Longabaugh and Morgenstern, 2002; Moos, 2007) » However, studies of SUD remission and recovery are very seldom theory-based » But, there are empirically supported theories that help explain the onset of substance use and SUD » These same theories may be useful in helping explain SUD remission and recovery…
  • 24. Parallels in the onset and offset of SUD People want to use substances for 4 main reasons (NIDA, 2005): To feel good To feel better To do better Because others are doing it
  • 25. Parallels in the onset and offset of SUD People want to use People want to stop using substances for 4 main substances and recover for reasons (NIDA, 2005): the same 4 main reasons: To feel good To feel good To feel better To feel better To do better To do better Because others are Because others are doing it doing it
  • 26. Theory Key process mechanisms for… Substance use Recovery Social Lack of strong bonds with family, Goal-direction, structure and monitoring, Control friends, work, religion, other aspects shaping behavior to adaptive social bonds traditional society Social Modeling and observation and Social network composed of individuals Learning imitation of substance use, social who espouse abstinence, reinforce negative reinforcement for and expectations expectations about effects of substances, of positive consequences from use; provide models of effective sober living positive norms for use Stress and life stressors (e.g., Effective coping enhances self-confidence coping social/work/financial problems, and self-esteem phys/sex abuse) lead to substance use especially those lacking coping and avoid problems; substance use form of avoidance coping, self- medication Behavioral Lack of alternative rewards provided Effective access to alternative, competing, economics by activities other than substance rewards through involvement in use educational, work, religious, social/recreational pursuits Source: Moos, RH (2011) Processes the promote recovery from addictive disorders.
  • 27. Theory Key process mechanisms for… Substance use Recovery Social Lack of strong bonds with family, Goal-direction, structure and monitoring, Control friends, work, religion, other aspects shaping behavior to adaptive social bonds traditional society Social Modeling and observation and Social network composed of individuals Learning imitation of substance use, social who espouse abstinence, reinforce negative reinforcement for and expectations expectations about effects of substances, of positive consequences from use; provide models of effective sober living positive norms for use Stress and life stressors (e.g., Effective coping enhances self-confidence coping social/work/financial problems, and self-esteem phys/sex abuse) lead to substance use especially those lacking coping and avoid problems; substance use form of avoidance coping, self- medication Behavioral Lack of alternative rewards provided Effective access to alternative, competing, economics by activities other than substance rewards through involvement in use educational, work, religious, social/recreational pursuits Source: Moos, RH (2011) Processes the promote recovery from addictive disorders.
  • 28. How might MHGs like AA reduce relapse risk and sustain the recovery process? Cue Induced Stress Induced RELAPSE Drug Induced AA-related social network changes may help avoid cues, reduce and tolerate distress, and maintain abstinence minimizing drug-induced relapse risks AA Kelly JF, Yeterian, JD, (In 28 press). Mutual help groups. In McCrady and Epstein. Comprehensive Textbook on Substance Abuse.
  • 29. (15-mo) Alcohol Outcomes (3-mo) AA attendance (PDA or DDD) Baseline (BL) Covariates Age Race Sex Marital Status Employment Status Prior Alcohol Treatment MATCH Treatment group MATCH study site Alcohol Outcomes (PDA/DDD) (BL) Self-efficacy (9-mo) Self-efficacy Negative Affect Negative Affect (BL) Self-efficacy (9-mo) Self-efficacy Positive Social Positive Social (BL) Religious/Spiritual (9-mo) Religious/Spiritual Practices Practices (BL) Depression (9-mo) Depression (BL) Social Network (9-mo) Social Network “pro-abstinence” “pro-abstinence” (BL) Social Network (9-mo) Social Network “pro-drinking” pro-drinking” Source: Kelly, Hoeppner, Stout, Pagano (2012) , Determining the relative importance of the mechanisms of behavior change within Alcoholics Anonymous: A multiple mediator analysis. Addiction 107(2):289-99
  • 30. Aftercare (PDA) effect of AA on Aftercare (DDD) Self-efficacy alcohol use for (NA) Depression AC was explained 5% 3% by social factors but also by S/R Self-efficacy and through SocNet: pro-drk. (NA) SocNet: pro-drk. 16% 24% negative affect SocNet: 20% Spirit/Relig 23% (DDD only) pro-abst. 11% Depression SocNet: pro- 11% abst. Self-efficacy 16% Self-efficacy (Soc) (Soc) Spirit/Relig 21% 34% 21% Majority of effect Outpatient (PDA) of AA on alcohol Outpatient (DDD) Self-efficacy Self-efficacy Depression use for OP was (NA) Depression (NA) 2% Spirit/Relig 6% explained by 1% 5% 1% social factors Spirit/Relig 9% SocNet: pro-drk. 29% SocNet: pro-drk. Self-efficacy 33% (Soc) 27% Self-efficacy SocNet: pro- (Soc) SocNet: pro- abst. 39% abst. 17% 31% Source: Kelly, Hoeppner, Stout, Pagano (2012) , Determining the relative importance of the mechanisms of behavior change within Alcoholics Anonymous: 30 A multiple mediator analysis. Addiction 107(2):289-99
  • 31. effect of AA on Aftercare (PDA) Aftercare (DDD) alcohol use for Self-efficacy (NA) Depression AC was explained 5% 3% by social factors but also by S/R Self-efficacy and through SocNet: pro-drk. (NA) 16% SocNet: pro-drk. negative affect 20% 24% SocNet: Spirit/Relig (DDD only) pro-abst. 23% 11% Depression SocNet: pro- 11% abst. Self-efficacy 16% Self-efficacy (Soc) (Soc) Spirit/Relig 21% 34% 21% Majority of effect Outpatient (PDA) of AA on alcohol Outpatient (DDD) Self-efficacy Depression use for OP was Self-efficacy (NA) Depression (NA) 2% Spirit/Relig 1% 6% explained by 1% 5% social factors Spirit/Relig 9% SocNet: pro-drk. 29% SocNet: pro-drk. Self-efficacy 33% (Soc) 27% Self-efficacy SocNet: pro- (Soc) SocNet: pro- abst. 39% abst. 17% 31% 31 Source: Kelly, Hoeppner, Stout, Pagano (2012) , Determining the relative importance of the mechanisms of behavior change within Alcoholics Anonymous: A multiple mediator analysis. Addiction 107(2):289-99
  • 32. 32
  • 33. CONCLUSIONS ˃ Recovery benefits derived from AA differ in nature and magnitude between more severely alcohol involved/impaired and less severely alcohol involved/impaired; and between men and women ˃ These differences reflect differing needs based on recovery challenges related to differing symptom profiles, degree of subjective suffering and perceived severity/threat, recovery challenges, and gender-based social roles & drinking contexts ˃ Similar to psychotherapy literature (Bohart & Tollman, 1999) rather than thinking about how AA or similar organizations work, better to think how individuals use or make these organizations work for them – to meet their most urgent needs at any given phase of recovery
  • 34. » SUDs: massive health, social, and economic burden » Mutual-help groups (MHGs) can offset that burden » MHGs work for many different types of individuals over and above formal treatment » MHGs work through mechanisms similar to those operating in formal treatment » MHGs can reduce costs by reducing patients’ reliance on professional services without any detriment to outcomes, and may even enhance outcomes » Empirically-supported clinical interventions increase patients’ participation in MHGs and enhance treatment outcomes
  • 35.
  • 36.
  • 37.
  • 38.
  • 39. HEALTH CARE COST OFFSET POTENTIAL OF MHGS (1) CBT VS 12-STEP RESIDENTIAL TREATMENT Cost per patient over 1 year * Cost per patient over 1 year * CBT Resulted in $4,729 $12,129.00 greater costs $7,400.00 per patient with sig. worse outcomes CBT TSF Compared to CBT- treated Cost per patient over 1-2 year patients, 12-step CBT Resulted in treated patients Cost per patient $3,295 greater more likely to be in costs per patient $5,735.00 recovery, at a with sig. worse $8,000 lower cost outcomes in Yr 2 per pt over 2 yrs $2,440.00 Follow up (about $15M for entire sample) CBT TSF Source: Humphreys & Moos (2001; 2007) Alcoholism: Clinical Experimental Research
  • 40. » The first study to examine how 12-Step participation affects medical costs in adolescents with SUD » 4 intensive outpatient programs » N = 403 adolescents, age 13-18  66% male; mean age 16.1; 49% White  Comorbid ADHD: 17%, depression: 36% » Follow-up: 6 months, 1, 3, 5, and 7 years » Difference-in-difference model was used Source: Mundt, Parthasarathy, Chi, Sterling, Campbell (2012)
  • 41. » Avg annual medical costs for all participants over 7 years: $3085 per person per year » 4.7% decrease in medical costs with each additional 12-step meeting attended = $145 annual savings per 12-step meetings attended Source: Mundt, Parthasarathy, Chi, Sterling, Campbell (2012)
  • 42. » SUDs: massive health, social, and economic burden » Mutual-help groups (MHGs) can offset that burden » MHGs work for many different types of individuals over and above formal treatment » MHGs work through mechanisms similar to those operating in formal treatment » MHGs can reduce costs by reducing patients’ reliance on professional services without any detriment to outcomes, and may even enhance outcomes » Empirically-supported clinical interventions increase patients’ participation in MHGs and enhance treatment outcomes
  • 43. Risk Treatment Settings High Supportive Treatment Low supportive Treatment Factors Combined milieu milieu n Dropout Rate n Dropout Rate n Dropout Rate 0 261 30 % (77) 151 30 % (45) 110 29 % (32) 1 548 30 % (163) 274 29 % (79) 274 31% (84) 2 582 38 % (221) 269 38 %(103) 313 38 % (118) 3 512 43 % (218) 176 40 % (70) 336 44% (148) 4 381 51 % (193) 119 42 % (50) 262 55% (143) 5 150 54 % (81) 36 47 % (17) 114 56% (64) 6-7 78 65 % (51) 16 50 % (8) 62 70% (43) •Dropout rate = 40% •AA dropouts had 3x higher odds of relapse to alcohol/drug use Source: Kelly & Moos (2003) Dropout from 12-Step Groups: Prevalence, Predictors and Counteracting Treatment Influences, Journal of Substance Abuse Treatment,24, 241-250
  • 44. Source: Kelly & Moos (2003) Dropout from 12-Step Groups: Prevalence, Predictors and Counteracting Treatment Influences, Journal of Substance Abuse Treatment,24, 241-250
  • 45. » 20 patients randomly selected from outpatient tx program for alcohol use disorder » Randomly assigned to: ˃1: Standard referral - given information about AA including time, date, location of meetings, encouraged to attend meetings ˃2: Systematic encouragement and community access - In addition to standard procedure, clients had phone conversation with AA member during a session - client and AA member met before first meeting, member provided client with ride; client also received a reminder phone call from the member
  • 46. » Results: ˃0% clients in standard referral attended a meeting during the target week ˃100% clients in systematic encouragement and community access group attended meeting during target week ˃Mean AA meeting attendance rate for 4 week period: + 0 for standard referral group vs 2.3 for systematic encouragement group
  • 47. T O S T F H Stand alone Integrated into an existing Component of a treatment Independent therapy therapy package (e.g., an additional group) As Modular add-on linkage component
  • 48. » Multisite randomized clinical trial of alcohol dependent individuals  2 arms • Aftercare (n=774)- recently finished inpatient treatment • Outpatient (n=952)  3 conditions, all with ultimate goal of abstinence • Twelve Step Facilitation - Therapist took firm stance against any drinking • Cognitive Behavioral Therapy - Therapist assisted in building skill set to maintain abstinence • Motivational Enhancement Therapy - Therapist aimed to build clients motivation to accept abstinence as objective
  • 49. » Individuals randomly assigned to TSF attended AA more frequently and had higher rates of continuous abstinence (71% more) 1yr following tx (TSF=24%, CBT=15%, MET=14%) than those assigned to CBT or MET; similar on continuous outcomes (PDA/DDD) » Social support for drinking ˃ 3 yrs post treatment, clients whose social networks were more supportive of drinking prior to treatment had higher abstinence and lower drinks per drinking day in TSF than in MET (clients in CBT did not show a significant advantage over those in MET)
  • 50.  Effects mediated by ongoing AA attendance  Across txs, those who attended AA groups had better outcomes (Tonigan et al, 2002)  AA valuable adjunct to SUD treatment - even when not formally emphasized
  • 51. T O S T F H Stand alone Integrated into an existing Component of a treatment Independent therapy therapy package (e.g., an additional group) As Modular add-on linkage component
  • 52. » Approaches to assist in involvement in AA » 169 adult alcoholic outpatients randomly assigned to one of three treatment conditions » All clients received treatment that included: ˃12 sessions ˃Focus on problem-solving, drink refusal, relaxation ˃Recommendation to attend AA meetings
  • 53. » Treatment varied between 3 conditions in terms of how the therapist discussed AA and how much information about AA was shared ˃ Condition 1: Directive approach - Therapist directed - Client signed contract describing goals to attend AA meetings - Therapist encouraged client to keep a journal about meetings - Reading material about AA provided to client - Therapist informs client about skills to use during meetings and about using a sponsor - 38% total material covered in sessions was about AA ˃ Condition 2: motivational enhancement approach (more client centered) - Therapist obtains clients feelings and attitudes about AA - Therapist describes positive aspects of AA, but states that it is up to the client how much they will be involved - Therapist intends to assist the client in making a decision in favor of AA - 20% total material covered in sessions about AA ˃ Condition 3: CBT treatment as usual, no special emphasis on AA - Throughout treatment, therapist briefly inquires about AA and encourages client to attend AA - 8% total material covered in sessions about AA Walitzer, Dermen & Barrick, 2009
  • 54. » Participants exposed to the Directive TSF approach reported significantly more: ˃attendance of AA meetings ˃more active involvement in AA ˃higher percent days abstinent in comparison to the motivational and treatment as usual groups » Evidence suggests AA involvement partially mediated the effects of the directive approach
  • 55. T O S T F H Stand alone Integrated into an existing Component of a treatment Independent therapy therapy package (e.g., an additional group) As Modular add-on linkage component
  • 56. » Making AA Easier- manual guided - designed to help clients prepare for AA » Goal: to prepare for AA (encourage participation in AA, minimize resistance to AA, and educate about AA) ˃ MAAEZ intervention is conducted in a group format to help prepare for group dynamic of AA » Facilitator goal: to inform clients about AA and facilitate group interaction ˃ Facilitator recommended to be an active member of AA, NA, or CA » Discussion format: MAAEZ allows and encourages feedback (referred to as “cross-talk” in MAAEZ), unlike AA which does not allow feedback
  • 57. » Structure of Program: » Six, weekly, 90-minute sessions ˃Homework assigned at the end of each session - List of texts for reading assignments provided in manual - List of articles that discuss effectiveness of AA provided in manual - Each homework assignment includes going to at least one AA meeting in the 7 days following that session, making connections with other people in AA, and completing reading assignments
  • 58. » Spirituality: provides clients with range of “spirituality” definitions that do not all require religious orientation. The homework assignment after that session is to talk to someone longer sober, after a meeting. » Principles Not Personalities: deals with AA myths, types of meetings/etiquette. Homework- ask someone for phone number and speak on the phone before next session. » Sponsorship: explains function of AA sponsor, offers guidelines for picking someone, and includes role-playing to practice asking for a sponsor and overcoming a rejection. Homework that week is to get a temporary sponsor. » Living Sober, tools for staying sober are tackled: relapse triggers, service, and avoiding “slippery” people, places, and things. Homework for this session is to socialize with someone in AA who has more sobriety.
  • 59. » Abstinence: ˃ TSF participants significantly more past 30 day alcohol abstinence, drug abstinence, and both alcohol and drug abstinence at 12 month time period ˃ Increased odds of continuous abstinence in general and for each additional MAAEZ session attended » Prior AA Exposure: ˃ MAAEZ found to be more effective in participants with AA previous experience (differs from outcomes found in Project MATCH), possibly because MAAEZ gives clients new perspective of AA Kaskutas et al 2009
  • 60.
  • 61. T O S T F H Stand alone Integrated into an existing Component of a treatment Independent therapy therapy package (e.g., an additional group) As Modular add-on linkage component
  • 62.
  • 63.
  • 64.  Evaluation of procedures to effectively refer patients to 12-step meetings  Individuals with SUDs entering a new outpatient treatment program randomly assigned to a treatment condition and provided self reports on meeting attendance and substance use  Condition 1: standard referral • Patients given locations and schedules of meetings and encouraged to attend  Condition 2: intensive referral • Patients give locations and schedules of meetings, with the meetings preferred by previous clients indicated • Therapist reviews a handout about program including introduction to 12-step philosophy and common concerns • Therapist arranged a meeting with a current member and client had a phone conversation with this member during a session • Therapist and client agreed on which meetings client will attend and client kept a journal of meetings attended and experiences
  • 65. » At 6m, patients in intensive referral who had relatively less previous 12-Step experience had: ˃higher meeting attendance ˃better substance use outcomes » At both the 6 and 12 month follow up, patients in intensive referral: ˃more likely to attend at least one meeting per week ˃had higher rates of attendance and had higher rates of abstinence
  • 66. » Timko et al. (2011; N=287): standard vs. intensive referral condition » Patients in the intensive referral group were more likely to attend and be involved in dual-focused mutual-help groups (DFGs) and substance-focused mutual-help groups (SFGs), and had less drug use and better psychiatric outcomes at follow-up » Only 23% of patients in the intensive-referral group attended a DFG meeting during the six-month follow-up period, while 85% attended a SFG

Hinweis der Redaktion

  1. More than 400 disorders in the DSM IV AUD alone confers 36% of DALYS attributable to psychiatric disorders!!!!
  2. I left some extra spaces in case you had some more articles in mind – you can send them to me and I can plug in the information
  3. Some young people, particularly those who have received formal treatment, do participate in AA/NA….Dropout rate of about 40% at 1 yr almost identical to MATCH dropout, and VA multisite dropout
  4. Social learning, stress and coping, and behavioral economic theories all pertain to ongoing mutual-help organization participation that can aid long term recovery…
  5. Men may use AA more than women to help them buffer socially-relevant relapse risks. Women appear to benefit in similar ways, but more work is needed to understand the additional ways women derive recovery benefit from AA. The pattern of findings underscores some gender-based differences that may have broader implications for the addiction treatment and recovery field. For women between the ages of 30 and 50, a focus on finding alternative ways to cope with negative affect may yield recovery benefits, while among men in the same life-stage, a relatively greater focus on coping with high risk social situations may yield recovery related benefits.
  6. TSF implemented in various ways:
  7. TSF implemented in various ways:
  8. TSF implemented in various ways:
  9. TSF implemented in various ways: