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Oncosexology for Iceland 28-01-2011 Woet  L.  Gianotten MD-psychotherapist consultant in oncosexologythe Netherlands 2002
Financial disclosure I have been connected to Bayer Schering Pharma for presentation / teaching in the areas of:						 		Multiple  Sclerosis & sexuality 		Hemophilia & sexuality
1. IntroductionSexuality / gender / disease / general approach   2.  The sexual aftermath of cancer & treatment 3.  Various oncosexology treatment (approaches)
Prevalence numbers in cancer (Dutch estimates) %% of total adult population (> 20 yrs) ± 4.0% Cancer diagnosis survivors ± 0.2% recovery treatment palliative † ± 0.1% terminal
Total   ±4.3%
Oncology professionals (& other medical prof’s) Talking sex? Very Scared:What to ask?  How to deal with that? Patients Talkingsex? Veryscared to start! > 85% willnever  start thatdiscussion In  62%  of womenwithgynaecologiccancerthe topic had not been addressed! Sadovsky R et al. Cancer & sexualproblems. J SexMed2010;7:349–73.
A change in approach and  a change in consequences ! Differentiation Disease Disease bio-       psycho-        social       causes Sexualdisfunction a pro-active responsibility!  sexual         sexual function	      identity            sexual        relationship
Differentiation Sexualfunction Sexuallidentity Sexualrelationship sexual activity
before her bowel cancer  after the intervention
Gender differences
Default Need for contact.Always relating & trying to be nice. testosterone At birth these differences are already measurable Need for autonomyand disconnecting T acts on the genitals and on the brain  L Brizendine:  ‘The female brain’,  2006  L Brizendine:  ‘The male brain’, 2010
That is not better, That is not worse ! Typical female-male differences        MaleMore orientedon ‘SEX’  genital orgasm penetration       Female More orientedon relating 	contact sensuality More assertive Bad antennae   More submissive Rather sensitive More feelings of sexu of ´sexual guilt´
girls / women are more ‘people-oriented’   boys / men are more ‘thing-oriented’
In case of cancer? Women: more busy‘restoring the relation’ with partner Men: more busy ´restoring  function´ Problemswitherection / orgasm Problemswithdesire Problemswith‘disfigurement’
Male and worries? Male and (diagnosis of) prostate cancer ± 25% of the men went to see their doctor because his wife told him to do so. ± 10% of the men didn’t tell his wife about the visit to the doctor!  Shame!
Female and worries? Femalefeelguiltyaboutnothavingdesire. There is a big differencebetween‘nodesire’  and  ‘nodesire’ My desire has completely disappeared since my disease / treatment I don’t like sex at all. I hate him! Guilt!
A common trap for the male attitude When his function fails (no erection, no orgasm) ,[object Object],41% of wives of USA men with erectile dysfunctionexperienced that  he stopped all intimacy Carroll & Bagley; J Sex Mar Ther 1990;16:70-8.
Sexual function (for oncosexology)
The basics of sexual function excitement arousal orgasm desire
Usual female pattern:First contact & committment.Then evt. arousal. Then desire can develop and evt. continue to orgasm Man and woman are different Usual  male pattern:First desire. Then continuation(more or less linear)Then ‘black hole’(refractory period) Sexualdesire
Needed for desire: Enough testosteron Good enoughneurotransmitter balance: Dopamin, prolactin, etc Sexual desire
T / androgen levelsover the male life 40 30 20 10 0 nmol/L Testicular testosterone Adrenal  testosterone  Puberty
T / androgen levelsover the female life 4 3 2 1 0 nmol/L Ovarian testosterone Adrenal  testosterone  Puberty Menopause
Androgens for the womanNeeded for:     ●  sexual desire,●  ability to get aroused ●  ability & strength of orgasm●  assertiveness●  physical strength (not being tired)●  general wellbeing●  good mood (T acts as an antidepressant)    bone mass    muscle mass   SHBG 4 3 2 1 0 nmol/L Ovarian testosterone Adrenal  testosterone  Puberty Menopause
Why?   Why do people have sex? Why is discussingsexuality important?
Why do people have sex? Relation (love, intimacy, etc) ,[object Object]
Recreation (fun, adventure, lust, etc)
Habit / custom,[object Object]
Physical: musclerelaxationvaginal  / cervicalstimulationincreases the pain threshold 				 		(byendorphines) safest  ‘sleep medication’ decreasesvaginalatrophy   massage and orgasmincreaseoxytocin-level 					(and as suchincreasemutual trust)
More reasons why we have to discuss sexuality   Becauseformanypatients (and partners) sexuality and intimacyare important aspects of QoL. Because our treatment interventions cause so much harm!
 Discuss sexuality with all patients?
It is our responsibility to take care that eventual problems will get attention.  ,[object Object]
 Being single
 Gay / lesbian
 Culture
 Etc Should not be arguments to not give attention
[object Object],Performance-driven        (relatively more Excitement-driven           male sexuality) Intimacy-driven sexuality  (relatively more female sexuality) Young age                                    Senior age
Gay men and cancer? Cancer causes Different sexMore risk for STD 	HIV 	HPV 	HBV		HCV		 more Kaposi sarcomamore oral cancermore anal cancer (??)more penis cancer more liver cancer  Different lifestyleLess overweight 	More alcohol consumption 	More recreational drugs  + / - other cancer?
Lesbian women and cancer :   causes Different sexLess risk for HPV  Be aware:  even in ‘pure lesbians’       HPV was found 1 Less cervix cancer More ovarian cancer Different reproductive historyLess oral contraception 	Less pregnancies 	Less lactation  More endometrium ca. More breast cancer Different lifestyleMore smoking 	More overweight 	More alcohol consumption 	Less healthy diet More bowel cancer 1 Bailey JV, Kavanagh J, Owen C, et al.    Lesbians and cervical screening.    Br J Gen Pract. 2000; 50 (455): 481-2.
Discuss sexuality in the palliative phase- terminal phase? “Those last months we had sexveryfrequently. In spite of the cancerhe was myhero.We bothenjoyedthatsoverymuch!”Widow (74 yrs) of man whodied of livercancer
“Intimacy is a casualty in the battle against cancer!” Focus on   cancer & sexuality? or Focus on   treatment & sexuality?
Fourexamples of treatmentinfluence: ,[object Object]
	Prostate cancer
Ovariancancer
Blood / lymphcancer,[object Object]
Breast  cancer:  (sexual) treatment  consequences
‘Presumedorganconfined’ Spread outside the prostate Prostate cancer Diagnosis Staging (T/N/M) Where? Life expectancy? ADT AndrogendeprivationTr. ‘Short’ ‘Long’ WW In case of failure(PSA increase) Whencastrationresistencydevelops: Surgery Brachytherapy Chemotherapy, (docetaxel, etc.) ExtBeam RT
ADT WW Surgery Brachytherapy Chemotherapy ExtBeam RT
[object Object],Healthy situation Adrenal gland 50% of the androgens 50% of the androgens
Androgen (testosteron) supply 4 3 2 1 0 nmol/L Ovarian testosterone Adrenal testosterone  Menopause Puberty
[object Object],Adrenal gland
Ovarian cancer No estrogen!Acute menopausal troubles 4 3 2 1 0 nmol / L Possible androgen deprivation symptoms Ovarian testosterone Adrenal testosterone
[object Object],Chemotherapie Adrenal gland

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2011 01-28 reykjavik onco lecture

  • 1. Oncosexology for Iceland 28-01-2011 Woet L. Gianotten MD-psychotherapist consultant in oncosexologythe Netherlands 2002
  • 2. Financial disclosure I have been connected to Bayer Schering Pharma for presentation / teaching in the areas of: Multiple Sclerosis & sexuality Hemophilia & sexuality
  • 3. 1. IntroductionSexuality / gender / disease / general approach 2. The sexual aftermath of cancer & treatment 3. Various oncosexology treatment (approaches)
  • 4. Prevalence numbers in cancer (Dutch estimates) %% of total adult population (> 20 yrs) ± 4.0% Cancer diagnosis survivors ± 0.2% recovery treatment palliative † ± 0.1% terminal
  • 5. Total ±4.3%
  • 6. Oncology professionals (& other medical prof’s) Talking sex? Very Scared:What to ask? How to deal with that? Patients Talkingsex? Veryscared to start! > 85% willnever start thatdiscussion In 62% of womenwithgynaecologiccancerthe topic had not been addressed! Sadovsky R et al. Cancer & sexualproblems. J SexMed2010;7:349–73.
  • 7. A change in approach and a change in consequences ! Differentiation Disease Disease bio- psycho- social causes Sexualdisfunction a pro-active responsibility! sexual sexual function identity sexual relationship
  • 8. Differentiation Sexualfunction Sexuallidentity Sexualrelationship sexual activity
  • 9. before her bowel cancer after the intervention
  • 11. Default Need for contact.Always relating & trying to be nice. testosterone At birth these differences are already measurable Need for autonomyand disconnecting T acts on the genitals and on the brain L Brizendine: ‘The female brain’, 2006 L Brizendine: ‘The male brain’, 2010
  • 12. That is not better, That is not worse ! Typical female-male differences MaleMore orientedon ‘SEX’ genital orgasm penetration Female More orientedon relating contact sensuality More assertive Bad antennae More submissive Rather sensitive More feelings of sexu of ´sexual guilt´
  • 13. girls / women are more ‘people-oriented’ boys / men are more ‘thing-oriented’
  • 14. In case of cancer? Women: more busy‘restoring the relation’ with partner Men: more busy ´restoring function´ Problemswitherection / orgasm Problemswithdesire Problemswith‘disfigurement’
  • 15. Male and worries? Male and (diagnosis of) prostate cancer ± 25% of the men went to see their doctor because his wife told him to do so. ± 10% of the men didn’t tell his wife about the visit to the doctor! Shame!
  • 16. Female and worries? Femalefeelguiltyaboutnothavingdesire. There is a big differencebetween‘nodesire’ and ‘nodesire’ My desire has completely disappeared since my disease / treatment I don’t like sex at all. I hate him! Guilt!
  • 17.
  • 18. Sexual function (for oncosexology)
  • 19. The basics of sexual function excitement arousal orgasm desire
  • 20. Usual female pattern:First contact & committment.Then evt. arousal. Then desire can develop and evt. continue to orgasm Man and woman are different Usual male pattern:First desire. Then continuation(more or less linear)Then ‘black hole’(refractory period) Sexualdesire
  • 21. Needed for desire: Enough testosteron Good enoughneurotransmitter balance: Dopamin, prolactin, etc Sexual desire
  • 22. T / androgen levelsover the male life 40 30 20 10 0 nmol/L Testicular testosterone Adrenal testosterone Puberty
  • 23. T / androgen levelsover the female life 4 3 2 1 0 nmol/L Ovarian testosterone Adrenal testosterone Puberty Menopause
  • 24. Androgens for the womanNeeded for: ● sexual desire,● ability to get aroused ● ability & strength of orgasm● assertiveness● physical strength (not being tired)● general wellbeing● good mood (T acts as an antidepressant) bone mass muscle mass SHBG 4 3 2 1 0 nmol/L Ovarian testosterone Adrenal testosterone Puberty Menopause
  • 25. Why? Why do people have sex? Why is discussingsexuality important?
  • 26.
  • 28.
  • 29. Physical: musclerelaxationvaginal / cervicalstimulationincreases the pain threshold (byendorphines) safest ‘sleep medication’ decreasesvaginalatrophy  massage and orgasmincreaseoxytocin-level (and as suchincreasemutual trust)
  • 30. More reasons why we have to discuss sexuality Becauseformanypatients (and partners) sexuality and intimacyare important aspects of QoL. Because our treatment interventions cause so much harm!
  • 31. Discuss sexuality with all patients?
  • 32.
  • 34. Gay / lesbian
  • 36. Etc Should not be arguments to not give attention
  • 37.
  • 38. Gay men and cancer? Cancer causes Different sexMore risk for STD HIV HPV HBV HCV more Kaposi sarcomamore oral cancermore anal cancer (??)more penis cancer more liver cancer Different lifestyleLess overweight More alcohol consumption More recreational drugs + / - other cancer?
  • 39. Lesbian women and cancer : causes Different sexLess risk for HPV Be aware: even in ‘pure lesbians’ HPV was found 1 Less cervix cancer More ovarian cancer Different reproductive historyLess oral contraception Less pregnancies Less lactation More endometrium ca. More breast cancer Different lifestyleMore smoking More overweight More alcohol consumption Less healthy diet More bowel cancer 1 Bailey JV, Kavanagh J, Owen C, et al. Lesbians and cervical screening. Br J Gen Pract. 2000; 50 (455): 481-2.
  • 40. Discuss sexuality in the palliative phase- terminal phase? “Those last months we had sexveryfrequently. In spite of the cancerhe was myhero.We bothenjoyedthatsoverymuch!”Widow (74 yrs) of man whodied of livercancer
  • 41. “Intimacy is a casualty in the battle against cancer!” Focus on cancer & sexuality? or Focus on treatment & sexuality?
  • 42.
  • 45.
  • 46. Breast cancer: (sexual) treatment consequences
  • 47.
  • 48.
  • 49. ‘Presumedorganconfined’ Spread outside the prostate Prostate cancer Diagnosis Staging (T/N/M) Where? Life expectancy? ADT AndrogendeprivationTr. ‘Short’ ‘Long’ WW In case of failure(PSA increase) Whencastrationresistencydevelops: Surgery Brachytherapy Chemotherapy, (docetaxel, etc.) ExtBeam RT
  • 50. ADT WW Surgery Brachytherapy Chemotherapy ExtBeam RT
  • 51.
  • 52. Androgen (testosteron) supply 4 3 2 1 0 nmol/L Ovarian testosterone Adrenal testosterone Menopause Puberty
  • 53.
  • 54. Ovarian cancer No estrogen!Acute menopausal troubles 4 3 2 1 0 nmol / L Possible androgen deprivation symptoms Ovarian testosterone Adrenal testosterone
  • 55.
  • 56. 4 3 2 1 0 nmol / L the full range of androgen deficiency Ovarian testosterone Adrenal testosterone
  • 57.
  • 58. Unmet needs Here liesour faithfulSexlife 10 Jan 197821 March 2006
  • 59.
  • 62. Tools and toys
  • 66. Restoring / dealingwith male/femaleinteraction
  • 67.
  • 68. 2010 Cancer & Sexuality editors John P. Mulhall Irwin Goldstein Luca Incrocci Ray Rosen Contains > 50 chapter > 60 authors Springer : March ? 2007 2011 2010 2007
  • 69. Thankyou ! @ .com woet gianotten