By: Mark H. Meissner, MD
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2. Mark H. Meissner, MD
Professor of Surgery
University of Washington School of Medicine
Seattle, WA
Outcomes of Venous
Interventions in C5-6 Disease
3. Chronic Venous Insufficiency
5% prevalence (US) of CEAP class 4 - 6
6 - 7 million people with skin changes
400,000 - 500,000 people with ulcers
90% require medical treatment
Direct medical costs of $600 - $2000
> $10,000 if not healed within 12 weeks
Treatment options
Medical
Compression
Pharmacologic adjuncts
Wound care adjuncts
Surgical
Superficial venous surgery
Perforator interruption
Valvular reconstruction
Iliac stenting
C5
C6
5. Observational study of 119 patients
34% bed rest followed by ECS
66% ambulatory treatment with ECS
Complete Healing
Compliant 97%
Noncompliant 55%
Recurrence (5 yr life table)
Compliant - 29%
Noncompliant - 100%
Compression for Venous Leg Ulcers
Mayberry, Surgery 1991
7. Surgery for C5-6 Disease
The ESCHAR Trial - Barwell JR, Lancet 2004
Prospective randomized trial
High ligation, stripping, phlebectomy
Multilayer compression bandaging
500 patients with CEAP 5 and 6 disease
Endpoints
24 week ulcer healing (NS)
Compression - 65%
Surgery + Compression - 65%
12 month ulcer recurrence (p < .0001)
Compression - 28%
Surgery + Compression - 12%
Ulcer healing
Freedom from recurrence
8. IPV Interruption & Ulcer Recurrence
O’Donnell TO, J Vasc Surg 2008
Systematic review of RCTs for venous ulceration (C6)
Compression vs perforator surgery (2 trials)
Compression vs superficial surgery (2 trials)
Author N
Trial
Intervention
Zamboni 47
Superficial
Surgery
ESCHAR 428
Superficial
Surgery
Van Gent 196
Perforator
Surgery
Stacey 41
Perforator
Surgery
Risk Ratio (95% CI)
0.50.20.10.050.02 1 2 5 10 20 50
Favors Surgery Favors Compression
9. The Problem of Perforator “Incompetence”
Perforator reflux often resolves with correction of superficial
reflux
Perforator incompetence unlikely to be the primary cause of
recurrent / residual varicosities
Perforator interruption does not reduce recurrent ulceration
Current studies have often taken non-specific approach
Ability to distinguish important perforators is limited
Unknown role for identification and interruption of critical
perforators in future
Available Evidence Suggests…
But…
10. Defining Important Perforators
Gloviczki et al, J Vasc Surg 2011
> 3.5 mm diameter
Outward flow > 0.5 sec
Localized in the area of a healed or
active ulcer
Think “Pathologic”
NOT
“Incompetent”
Perforators