1. Hipersensitif tipe I

2. POLLEN

3. NORMAL

5. HIPERSENSITIF TIPE II

7. HIPERSENSITIFITAS TIPE IV

9. AIDS MECHANISM

15. CD4 cell activity increase Cytotoxic T Cells promed B cell activity Auto-antibodies Cytokines (delayed hyper- sensitivity re- action) Ag/Ab+complement CELL DESTRUCTION

16. ORGAN SPESIFIK Antibody or cell mediated reaction to Target organ Associated disease Thyroid cells and hormone or TSH receptor Thytroid Primary myxoedema,Hashimoto’s disease (autoimmune thyroiditis), Thyrotoxikosis (Graves’ disease) Parietal cells intrinsic factor/intrinsic factor B12 complex Stomach Pernicious anemia

17. SAMBUNGAN Red blood cells Red blood cells Haemolytic anemia Pancreatic islet beta cells Pancreas Type I diabetes Adrenal cortical cell, ACTH receptor Adrenal Addison’s disease Parathyroid cells Parathyroid Prymary hypoparathyroidism Acetylcholline receptor Voluntary muscle Myasthemia gravis

18. NON-ORGAN SPECIFIC Antibody to Target organ Associated Disease Mitochondria Liver Primary biliary cirrosis Smooth muscle Nuclear constituents IgG Many other body protein Liver Autoimmune chronic hepatis Skin and muscle The connective tissue disease, Dermatomyositis, Rhematoid arthritis, Systemic lupus erythematosus (SLE), Progressive systemic sclerosis Skin, kidney,endocardium, blood vessels, joints

22. HASHIMOTO DISEASE

23. APPLIED IMMUNOLOGY I .Immunohistochemical Identification

25. Immunohistochemical

26. Immunohistochemical

27. Immunoflorescent

28. TISSUE TRANSPLANTATION Antigen presenting Cell in graft Present “foreign” HLA antigen Cell mediated immunity Cytokines Rejevtion Host T cell Spesific T cell immune Respons to HLA antigen Cytotoxic T cells Attack graff cell (particularly vascular endothelium