The document discusses several key topics related to scaling up health systems and achieving universal access: 1. Evidence is important for implementing sustainable change, but the right questions must be asked and appropriate models/assumptions used. 2. Much of the variation in health outcomes between countries is due to differences in technological progress, not income levels. More research is needed to address developing country needs. 3. Scaling up health systems is an experiment in itself. Different types of evidence are needed from individual, institutional, and systems-level research on scaling up programs. 4. Research and innovation systems must work together across sectors and levels to develop and disseminate new health technologies, processes and knowledge globally.