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Annex to ESF 8 of the State of Alabama Emergency Operations Plan


      Criteria for Mechanical Ventilator Triage Following Proclamation of
                     Mass-Casualty Respiratory Emergency
I.       Introduction

         A.    Purpose

               This document outlines a ventilator triage protocol intended for use
               only during a mass casualty event, proclaimed as a public health
               emergency by the Governor. It would be characterized by frequent,
               widespread cases of respiratory failure occurring in sufficient volume to
               quickly exhaust available mechanical ventilator resources. One example
               might include, not exclusively, a virulently aggressive form of pandemic
               influenza. Such pandemics have occurred in the past and could recur,
               stressing healthcare systems to their breaking points.

         B.    Scope

               This appendix covers all areas within the State of Alabama.

II.      Situation and Assumptions

         A.    Situation

               Due diligence in disaster planning requires consideration of “measures of
               last resort.” Some mass casualty disasters, such as a pandemic event, may
               necessitate that commonly accepted standards of medical care be altered to
               provide the maximum number of patients their best chance of survival.
               This would be done in support of the strategic goals of the Centers for
               Disease Control and Prevention to 1) stop, slow, or otherwise limit the
               spread of the pandemic to the United States; 2) limit the domestic spread
               of the pandemic and mitigate the disease, suffering and death; and 3)
               sustain infrastructure and mitigate impact to the economy and functioning
               of society. Assigning a proper priority for ventilator support during a
               national health crisis requires assessment of an affected individual’s level
               of premorbid function, likelihood of response to ventilator support, and
               likelihood that survival will produce a functional recovery.

         B.    Assumptions

               Disaster-related ventilator triage protocols must be evenly and fairly
               implemented if public trust is to be gained and maintained during a time of
               such extreme duress. Healthcare authorities representing the public and
               private sectors should be prepared to deliver messages that are uniform,
               realistic, and consistent. It is highly recommended that this document be
                                        Page 1 of 18
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Annex to ESF 8 of the State of Alabama Emergency Operations Plan
              considered for endorsement by the various stakeholders in mass-casualty
              disaster planning.

              Healthcare organizations incorporating this ventilator triage protocol into
              their disaster plans and attempting in good faith to follow it will be
              considered to be in compliance with the standard of care necessitated by
              the prevailing proclaimed respiratory disaster. In addition, it is highly
              recommended that hospital disaster plans/policies anticipate breakdowns
              in ventilator triage discipline, identify and confront the likely sources of
              such breakdowns, and incorporate language designed to lessen the
              probability of their occurrence.

III.   Mission

       Purpose:
       Offered as a template for inclusion in hospital disaster plan/policy following
       declaration of statewide, regional, or national public health respiratory
       emergency. [Example: Pandemic Avian Influenza]
.
       A.     Direction and Control

              This document outlines a ventilator triage protocol intended for use
              only during a mass casualty event, proclaimed as a public health
              emergency by the Governor. It would be characterized by frequent,
              widespread cases of respiratory failure occurring in sufficient volume to
              quickly exhaust available mechanical ventilator resources. One example
              might include, not exclusively, a virulently aggressive form of pandemic
              influenza. Such pandemics have occurred in the past and could recur,
              stressing healthcare systems to their breaking points.

              Should conditions become extremely grave due to widespread outbreaks
              with many people seriously affected, availability of ventilator care and
              Intensive Care Unit (ICU) care may become extremely limited in any
              locale. Under such circumstances, measures of last resort herein described
              may be employed by each hospital after thorough evaluation and
              consultation with available external sources to confirm that partner
              hospital resources, usual supplier resources, and resources obtainable
              through the collaborative efforts of the Department of Public Health
              through AIMS are all exhausted. All efforts should then be directed to
              provide aggressive treatment to those with the greatest chance of survival
              even if that requires removal of supportive care from others. This process
              is described in this document when patients are assessed and transitioned
              to Tier 2 or Tier 3 levels of care.




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   B.    Concept of Operations
         Tier 1 Trigger: Mass casualties resulting from respiratory failure
         illness of sufficient volume to quickly exhaust available mechanical
         ventilator resources. Proclamation of a state of public health
         emergency by the Governor is a necessary initial trigger. All hospitals
         will implement Tier 1 upon the Governor’s Proclamation.

         Additional supportive action: Activation of the Federal Pandemic
         Influenza Disaster Plan or other federal respiratory disaster plan.

         Tier 2 and Tier 3 Triggers: These are hospital-specific choices based
         on the hospital’s unique situation.

         Tier 2: At the discretion of the hospital when it is operating under
         Tier 1 criteria and all available resources such as ventilators and staff
         are exhausted, hospital decides to selectively withdraw ventilator
         support per guidelines in Appendix 2.

         Tier 3: At the discretion of the hospital when it is operating under
         Tier 2 criteria, persuasive outcome data compel further restriction of
         who qualifies for ventilator support. See Appendix 2.

         Criteria should be implemented in a tiered or stepwise fashion, so that as
         resources are exhausted, another stricter tier of exclusion criteria is
         implemented in an attempt to provide the best care possible to those with
         the best chance of survival (Hick, J. & O’Laughlin, D., 2006).

   C.    Operations and missions required as a result of mass casualties
         resulting from respiratory failure illness of sufficient volume to
         quickly exhaust available mechanical ventilator resources will be
         carried out during the response and recovery phases.

            1. The Response Phase – Refer to the following:

                a) “Implementation Steps Following Emergency Statewide
                   Proclamation by the Governor” algorithm (page 5);

                b) “Appendix 1 – Exclusion Criteria” (page 6);

                c) “Appendix 2 – Mechanical Ventilator Tier Criteria
                   Following Declaration of Mass-Casualty Respiratory
                   Emergency” (pages 7-9);

                d) “Appendix 3 – SOFA Triage Tool” (pages 10-11);

                                  Page 3 of 18
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Annex to ESF 8 of the State of Alabama Emergency Operations Plan
                     e) “Appendix 4 – “Initial Assessment Tool for Tier 1 and
                        Reassessment Tool for Tier 2 and Tier 3” (page 12); and

                     f) “Appendix 5 – Emergency EMS Protocol for Mass
                        Casualty Respiratory Emergency” (pages 13-16).

             2.      The Recovery Phase

                     There are usually no clear distinctions between when the Response
                     Phase ends and the Recovery Phase begins. There is typically a
                     time period as the respiratory epidemic gradually subsides and the
                     incidence of newly infected people declines during which both
                     phases are in effect simultaneously. The recovery phase begins
                     when the statewide resource assessment of ventilator use and
                     hospital admissions approaches pre-disaster levels. Functions
                     during this phase under PL 93-288 include public and individual
                     assistance, establishment of Disaster Assistance Centers, and
                     Federal disaster plans and grants. During this phase the Federal
                     Government provides relief and assistance in completion of final
                     arrangements for the casualties.

IV.   Administrative Support

      Each healthcare facility should develop internal staffs and procedures for
      administrative support.




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         Implementation Steps Following Emergency Statewide
                   Proclamation by the Governor
            Step 1
     Cancel all planned
                                                       Yes
   (Elective) surgery likely                        Proceed to
           to require                                 Step 3
      post-op ventilator
            support                                                         No
                                                      A non-medical direction hospital should
            Step 2                                  also notify the emergency physicians at the
       Alert all staff and                             medical direction hospital** that gives
        especially ED                                  orders for the ambulance services that
         physicians to                                deliver to this hospital. After notification
   implement Criteria for                                         proceed to Step 3
   Mechanical Ventilator
      Triage Following
       Proclamation of                                       Yes
       Mass-Casualty                                Begin supportive or
         Respiratory                                palliative care either
    Emergency Protocol                               in-patient or home
   for ALL incoming ED                                                                                                   Yes
       patients. Is the                                                                                              Proceed to
      facility a medical                                   No                                                          Step 4
     direction hospital?                               Proceed to
                                                     SOFA Triage
                                                          (See
                                                      Appendix 3)                    Did patient                          No
            Step 3                                     and Initial                    receive                            Begin
     Evaluate all patients                           Assessment                      ventilator                     supportive or
  admitted to the hospital                                Tool                      assistance?                        palliative
  or seen in ED with any                             (Appendix 4)                                                     care either
     respiratory illness,                                                                                            in-patient or
   whether or not related                                                                                               home
        to the declared
                                                                Yes
  emergency (respiratory
                                                      Continue with Step 3
    failure of any cause)
                                                     Follow standard clinical
  Does the patient meet
                                                       guidelines for care
     Exclusion Criteria
       (Appendix 1)?
                                                                                                   Yes
                                                                No                              Proceed to
                                                      The facility should                        Step 5*
            Step 4                                  consider implementing
        Are available                                       Tier 2
    resources adequate                                (See Appendix 2)                                      No
     to maintain Tier 1?                               Will the facility                         Continue with Step 3
                                                     implement Tier 2?                          Follow standard clinical
                                                                                                  guidelines for care

                                                           Yes                                                                 Yes
           Step 5*                         Remove patient from ventilator.                                             Continue Step 5*
      Reassess ALL                          Begin supportive or palliative                                             Reassess again at
   ventilator patients at                   care either in-patient or home                                             48 and 120 hours
     48 and 120 hours                                                                   Did patient
   Refer to Tier 2 and 3
    (See Appendix 2).                                     No                                meet                                No
  Does the patient meet                     Proceed to SOFA Triage                       criteria to                     Remove patient
    Exclusion Criteria                       (See Appendix 3) and                        continue                        from ventilator.
      (Appendix 1)?                       Reassessment Tool for Tier                     ventilator                   Begin supportive or
                                           2 and Tier 3 (Appendix 4)                    assistance?                   palliative care either
                                                                                                                       in-patient or home

*Step 5 is a last resort measure to be employed by the healthcare facility only when all other resources are exhausted by re -evaluation of the
following: suppliers, partner healthcare facilities, and public health through AIMS.
**A medical direction hospital is one whose emergency medicine physicians are certified to give orders to pre-hospital emergency medical
service personnel.

                                                              Page 5 of 18
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                                     Appendix 1
                                   Exclusion Criteria
                      This is to guide Ventilator Access in Proclaimed
                          Mass-Casualty Respiratory Emergency.

A. CARDIAC ARREST: Unwitnessed arrest, recurrent arrest, arrest unresponsive to standard
treatment. For detailed criteria refer to Cardiac under Tier 1 [See Appendix 2, (b)].

B. SEVERE TRAUMA: Especially if associated with cardiac arrest.

C. DEMENTIA: For detailed criteria refer to Neurological under Tier 1 [See Appendix 2,
(e)].

D. METASTATIC MALIGNANCY: For detailed criteria refer to Hematological and
Cancer under Tier 1 [See Appendix 2, (f)].

E. SEVERE BURN: > 60% body surface affected.

F. END STAGE ORGAN FAILURE:
      1. Pulmonary – COPD, restrictive lung disease, FEV1 (Forced Expiratory Volume in
      the first second) < 25%. For detailed criteria refer to Pulmonary under Tier 1 [See
      Appendix 2, (a)].

       2. Cardiac – including severe angina, CHF (NYHA Class III or IV). For detailed
       criteria refer to Cardiac under Tier 1 [See Appendix 2, (b)].

       3. Renal – Including anyone on or requiring dialysis. For detailed criteria refer to
       Renal under Tier 1 [See Appendix 2, (c)].

       4. Hepatic – Acute or chronic, MELD score > 20. For detailed criteria refer to
       Hepatic under Tier 1 [See Appendix 2, (d)].

       5. Neurological – Severe, irreversible neurologic event or condition with high expected
       mortality, advanced neuromuscular disease. For detailed criteria refer to Neurological
       under Tier 1 [See Appendix 2, (e)].

       6. Hematological and Cancer – Clinical or laboratory evidence of disseminated
       intravascular coagulation (DIC), leukemia or cancer. For detailed criteria refer to
       Hematological under Tier 1 [See Appendix 2, (f)].

       7. Immunological – Advanced and irreversible immunocompromise. For detailed
       criteria refer to Immunological under Tier 1 [See Appendix 2, (g)].




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                                          Appendix 2
  Mechanical Ventilator Tier Criteria Following Declaration of Mass-
                  Casualty Respiratory Emergency

Note: Nothing in this ventilator triage protocol shall preclude ventilation by hand
provided the appropriate resources are available.

                                      TIER 1
  To be implemented by all hospitals following Governor’s Proclamation of Mass-
                         Casualty Respitory Emergency

Do not offer mechanical ventilator support for patients with end stage organ failure in any
one of the following:

           a) Pulmonary:
              Respiratory failure: Refer to SOFA Triage Tool (Appendix 3) and
              Initial Assessment Tool (Appendix 4).
              adult respiratory distress syndrome; ventilatory failure; refractory
              hypoxemia; severe chronic lung disease including pulmonary fibrosis,
              cystic fibrosis; obstructive or restrictive diseases requiring continuous
              home oxygen use before onset of acute illness.

           b) Cardiac:
               CHF (NYHA Class III or IV), left ventricular dysfunction, hypotension, new
               ischemia; known congestive heart failure with ejection fraction less than
               25% or persistent ischemia/pulmonary edema unresponsive to therapy.
               The Stages of Heart Failure – NYHA Classification
               In order to determine the best course of therapy, physicians often assess
               the stage of heart failure according to the New York Heart Association
               (NYHA) functional classification system. This system relates symptoms to
               everyday activities and the patient's quality of life (Heart Failure Society
               of America, 2008).
                       Class                                            Patient Symptoms

                   Class I (Mild)      No limitation of physical activity. Ordinary physical activity does not cause undue
                                                      fatigue, palpitation, or dyspnea (shortness of breath).

                  Class II (Mild)        Slight limitation of physical activity. Comfortable at rest, but ordinary physical
                                                         activity results in fatigue, palpitation, or dyspnea.

                Class III (Moderate)   Marked limitation of physical activity. Comfortable at rest, but less than ordinary
                                                       activity causes fatigue, palpitation, or dyspnea.

                 Class IV (Severe)     Unable to carry out any physical activity without discomfort. Symptoms of cardiac
                                       insufficiency at rest. If any physical activity is undertaken, discomfort is increased.




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      c) Renal:
         hyperkalemia, diminished urine output despite adequate fluid
         resuscitation, increasing creatinine level; acute renal failure (related to
         current ilness) requiring dialysis.

      d) Hepatic:
         transaminase greater than five (5) times normal upper limit, increasing
         bilirubin or ammonia levels; cirrhosis with ascites; history of variceal
         bleeding; fixed coagulopathy or encephalopathy; acute hepatic failure with
         hyperammonemia; MELD: Model End Stage Liver Disease: a disease
         severity scoring system for adults with liver disease. The MELD score is
         based only on laboratory data in order to be as objective as possible. The
         laboratory values used are a patient's creatinine, bilirubin, and
         international normalized ratio, or INR (a measure of blood-clotting time
         (MedicineNet.com, 2008). On-line scoring tool is available from the
         Mayo Clinic located at:
         http://www.mayoclinic.org/meld/mayomodel5.html

      e) Neurological:
         altered mental status not related to volume status. Examples: metabolic or
         hypoxic source, stroke. Individuals may be excluded under Tier 1 with
         severe functional impairment produced by static or progressive
         neurological disorders and reduced likelihood for successful outcome from
         ventilator support. Functional domains include cognitive, neurological,
         and psychosocial. For example, persons with severe mental retardation,
         advanced dementia or severe traumatic brain injury may be poor
         candidates for ventilator support. The average life expectancy of persons
         with mental retardation now spans to the seventh decade and persons with
         significant neurological impairments can enjoy productive happy lives.
         Functional assessment for persons with intellectual disability, complex
         neurological problems, dementia, or mixtures of symptoms should focus
         on premorbid function in all domains of life including social, intellectual,
         professional, etc. Persons with severe or profound mental retardation,
         moderate to severe dementia, or catastrophic neurological complications
         such as persistent vegetative state are unlikely candidates for ventilator
         support. Individuals with complex neurological issues such as motor
         neuron disease, glioblastoma multiforme and others may not be
         appropriate candidates in a mass casualty situation. Children with severe
         neurological problems may not be appropriate candidates in the pediatric
         age group. Decisions should be guided by premorbid function and
         expected level of recovery rather than by diagnosis.

      f) Hematological and Cancer:
         clinical or laboratory evidence of disseminated intravascular coagulation
         (DIC), leukemia or cancer; active malignancy with poor survival potential
         (e.g., metastatic malignancy, pancreatic cancer).
                                    Page 8 of 18
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Annex to ESF 8 of the State of Alabama Emergency Operations Plan
           g) Immunological:
              Acquired Immune Deficiency Syndrome (AIDS) (presence of +HIV status
              without AIDS is not an automatic exclusion); other immunodeficiency
              syndromes at stage of disease rendering patient susceptible to
              opportunistic pathogens.

                                        TIER 2
To be implemented by individual hospital decision that, despite operating under
Tier 1 conditions, the hospital has exhausted all needed resources to maintain
Tier 1.

   1. Withdraw ventilator support and do not offer such support for patients with
      conditions listed in Tier 1.
   2. Withdraw ventilator support from those who failed to respond to mechanical
      ventilation and other support measures (e.g., antibiotics, fluids, pressors). Refer
      to SOFA Triage Tool (Appendix 3) and Reassessment Tool for Tier 2 and
      Tier 3 (Appendix 4). (Timeline may be modified based on organism-specific
      data.)

                                        TIER 3
To be implemented by individual hospital decision that, despite operating under
Tier 2 conditions, the hospital has exhausted all needed resources to maintain
Tier 2.

The hospital’s leaders within each facility, including members of the medical staff,
participating in planning activities for the facility’s Emergency Operations Plan should
develop specific directions for the Tier 3 implementation within the facility. Possibilities
include:

   1. Restriction of treatment based on disease-specific epidemiology and survival data
      for patient subgroups (may include age-based criteria).
   2. Expansion of pre-existing disease classes that will not be offered ventilatory
      support.




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                                       Appendix 3
SOFA Triage Tool:
Scoring criteria for the Sequential Organ-Failure Assessment (SOFA) score*
                                               Score
Variable               0            1             2            3            4
PaO2/FiO2,          > 400         < 400         < 300        < 200       < 100
mm Hg
Platelet            > 150         < 150         < 100        < 50         < 20
count,
x 106 /L
Bilirubin            < 1.2       1.2-1.9       2.0-5.9     6.0-11.9       >12
level, mg/dL        (< 20)       (20-32)      (33-100)    (101-203)     (> 203)
(μmol/L)
Hypotension†        None      MABP < 70       Dop < 5      Dop > 5     Dop > 15
                                                          Epi < 0.1    Epi > 0.1
                                                           Norepi       Norepi
                                                             < 0.1       > 0.1
Glasgow               15          13-14        10-12          6-9          <6
Coma score
Creatinine           <1.2        1.2-1.9       2.0-3.4      3.5-4.9        >5
level, mg/dL       (< 106)      (106-168)    (169-300)    (301-433)     (> 434)
(μmol/L)
Note: PaO2 = partial pressure of arterial oxygen; FiO2 = fraction of inspired oxygen; MABP = mean
arterial blood pressure, in mmHg;
*Adapted, from Ferriera FL, Bota DP, Bross A, et al. Serial evaluation of the SOFA score to predict
outcome in critically ill patients. JAMA 2001; 286: 1754-8. Copyright © 2001, American Medical
Association. All rights reserved.
†Dop (dopamine), epi (epinephrine) and norepi (norepinephrine) doses in μg/kg per min.

Explanation of variables:
PaO2/FiO2 indicates the level of oxygen in the patient’s blood.
Platelets are a critical component of blood clotting.
Bilirubin is measured by a blood test and indicates liver function.
Hypotension indicates low blood pressure; scores of 2, 3, and 4 indicated that blood
pressure must be maintained by the powerful medications that require ICU monitoring,
including dopamine, epinephrine, and norepinephrine.
Creatinine is measured by a blood test and indicates kidney function.




                                          Page 10 of 18
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The Glascow coma score is a standardized measure that indicates neurologic function;
low score indicates poorer function.
       Glascow Coma Scale
       Eye Opening Response
       Spontaneous--open with blinking at baseline 4 points
               To verbal stimuli, command, speech 3 points
               To pain only (not applied to face) 2 points
               No response 1 point
       Verbal Response
               Oriented 5 points
               Confused conversation, but able to answer questions 4 points
               Inappropriate words 3 points
               Incomprehensible speech 2 points
               No response 1 point
       Motor Response
               Obeys commands for movement 6 points
               Purposeful movement to painful stimulus 5 points
               Withdraws in response to pain 4 points
               Flexion in response to pain (decorticate posturing) 3 points
               Extension response in response to pain (decerebrate posturing) 2 points
               No response 1 point
       Categorization:
       Coma: No eye opening, no ability to follow commands, no word verbalizations
       (3-8)
       Head Injury Classification:
       Severe Head Injury----GCS score of 8 or less
       Moderate Head Injury----GCS score of 9 to 12
       Mild Head Injury----GCS score of 13 to 15

       Adapted from: Advanced Trauma Life Support: Course for Physicians, American
       College of Surgeons, 1993. CDC, 2008.




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                             Appendix 4
Initial Assessment Tool for Tier 1

  Triage                  Criteria                     Action or
  Code                                                 Priority
                      No respiratory failure         Begin standard treatment
GREEN                 No need for ventilator         home or inpatient non-
                      support                        ICU
                      Single Organ (Lung)            Intubate and admit to
YELLOW                failure                        ICU for aggressive
                      SOFA score < 7                 therapy
                      SOFA score 8 - 11              If resources are available,
RED                                                  intubate and admit to
                                                     ICU for aggressive
                                                     therapy. If resources are
                                                     exhausted move to
                                                     BLUE level.
                      Exclusion Criteria met         Begin supportive or
BLUE                  OR SOFA score > 11             palliative care either in-
                                                     patient or home

Reassessment Tool for Tier 2 and Tier 3 - use at 48 and 120 hours

  Triage                  Criteria                     Action or
  Code                                                 Priority
                      Able to wean off the           Discharge from ICU
GREEN                 ventilator                     (Critical Care)
                      Single Organ (Lung)            Continue aggressive
YELLOW                failure                        ventilator support.
                      SOFA score < 7
                      SOFA score 8-11                If resources are
RED                   (decreasing) and               available, continue
                      clinically improving –         ventilator care and
                      Continue aggressive            support. If resources are
                      therapy                        exhausted move to
                                                     BLUE level.
                      Exclusion Criteria met         Extubate. Discharge
BLUE                  OR SOFA score > 11             from ICU (Critical Care)
                                                     and begin palliative care.


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                                    Appendix 5

       EMERGENCY EMS PROTOCOL FOR MASS CASUALTY
               RESPIRATORY EMERGENCY
This protocol is designed to be implemented only when there is a significant respiratory
disease that has impacted the health care system to the extent that hospital beds are full,
few or no ventilators are available for new patients with respiratory failure, the
EMS/Dispatch work force is significantly depleted due to absenteeism, and the calls for
EMS support overwhelm resources to manage all calls. When the Governor proclaims a
state of emergency, the Alabama Public Health Department (ADPH) Office of EMS &
Trauma (OEMS&T) will activate this protocol to provide authorization for the
adjustment in the prehospital standard of care. Depending upon the Governor’s
proclamation, ADPH OEMS&T may activate this protocol on a regional or local basis.

                         ON-SCENE PROTOCOL
           PATIENTS WITH ACUTE FEBRILE RESPIRATORY ILLNESS

   1. Follow General Patient Care Protocol 4.1.
   2. Be sure you are using appropriate standard precautions.
          a. If Dispatch advises you of the potential for acute febrile respiratory illness
             symptoms on scene, you should don PPE for suspected cases of influenza
             prior to entering scene (disposable N-95 mask [or surgical mask if N-95
             masks are unobtainable], eye protection [shield or goggles], and
             disposable non-sterile gloves). Disposable non-sterile gown is optional
             depending on the situation (follow guidance of service medical director).
          b. If Dispatch has not identified individuals with symptoms of acute febrile
             respiratory illness on scene, you should stay more than six (6) feet away
             from patient and bystanders with symptoms and exercise appropriate
             routine respiratory droplet precautions while assessing all patients for
             suspected cases of influenza (4.c below). If patient has signs or symptoms
             of influenza or acute febrile respiratory illness, you should don the PPE
             described in a. above before coming into close contact with the patient.




                                        Page 13 of 18
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 3. If patient has critical vital signs, immediately transport to Emergency
    Department
        a. Critical Vital Signs: Adult
            If present, immediately transport to an Emergency Department
                  i. Pulse: equal or greater than 130 beats per minute
                 ii. Respiratory Rate: equal or greater than 30 breaths per minute
                iii. Systolic Blood Pressure: Less than 90 mm/Hg
                iv. Pulse Oximeter: Less than 92 on room air
                 v. Temperature: Febrile
                vi. Level of Consciousness: Responds only to Pain or is Unresponsive
               vii. Lung sounds: Rales or Wheezing

        b.    Critical Vital Signs: Pediatric:
             If present, immediately transport to Emergency Department
                        Vital Signs      Neonates         Infants        Children
                     Capillary refill: > 2 seconds      > 2 seconds    > 2 seconds
                     Resp. rate:         <30 or >45     <20 or >45     <15 or >45
                                         or increased   or increased   or increased
                                         work of        work of        work of
                                         breathing      breathing      breathing
                     Systolic Blood      < 60 mmHg      < 70 mmHg      Under age 10
                     pressure                                          < 70 + (2 X age
                                                                       in years)
                     Pulse Oximeter < 92 on room < 92 on room < 92 on room
                                         air            air            air
                     Temperature         Febrile        Febrile        Febrile
                     Level of            responds only responds only responds only
                     Consciousness       to pain or is  to pain or is  to pain or is
                                         unresponsive   unresponsive   unresponsive
                     Lung sounds         Rales or       Rales or       Rales or
                                         Wheezing       Wheezing       Wheezing

 4. If patient has normal vital signs, then evaluate for signs and symptoms of
    influenza.
        a. Normal Vital Signs Adult
                 i. Pulse: Less than 130 beats per minute
                ii. Respiratory Rate: Less than 30 breaths per minute
               iii. Systolic Blood Pressure: equal or greater than 91 mmHg
               iv. Pulse Oximeter equal or greater than 92
                v. Temperature: Afebrile
               vi. Level of Consciousness: Alert or responds to verbal stimuli
              vii. Lung sounds: Clear




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        b. Normal Vital Signs Pediatric
                  Vital Signs       Neonates             Infants          Children
                 Capillary refill: < 2 seconds          < 2 seconds      < 2 seconds
                 Unlabored          30-45               20-45            15-45
                 breathing or
                 resp. rate:
                 Systolic Blood     > 60 mmHg           > 70 mmHg        Under age 10
                 pressure                                                > 70 + (2 X age
                                                                         in years)
                   Pulse Oximeter     > 92              > 92             > 92
                   Temperature        Afebrile          Afebrile         Afebrile
                   Level of           Alert or          Alert or         Alert
                   Consciousness      responds to       responds to
                                      verbal stimuli    verbal stimuli
                   Lung sounds        Clear             Clear            Clear

        c. Signs and Symptoms of Influenza
                i. Rapid onset of symptoms
               ii. Difficulty breathing with exertion
              iii. Doctor has already diagnosed influenza
              iv. Cough
               v. Fever
              vi. Shaking Chills
             vii. Pleuritic chest pain
            viii. Sore throat (no difficulty breathing or swallowing)
              ix. Nasal congestion
               x. Runny nose
              xi. Muscle aches
             xii. Headache

 5. If patient has three (3) or more signs or symptoms of influenza, transport patient
    to alternate care facility (if available).
 6. If patient has two (2) or fewer signs or symptoms of influenza, call On-line
    Medical Direction (OLMD) to determine if patient may be left on-scene, self
    quarantine, and refer to nurse/public health hotline (insert phone number here) for
    further assistance.
 7. Endotracheal intubation should not be performed on any patient except by direct
    order of the OLMD physician (Cat. B).
 8. Because of the danger of EMS personnel becoming infected, aerosol-generating
    procedures such as advanced airway procedures, use of bag-mask, and nebulizer
    treatments should not be performed on patients with acute febrile respiratory
    illness except by direct order of the OLMD physician (Cat. B). CPAP with
    expiratory filter is still Category A.


                                    Page 15 of 18
                                 Revised 9 April 2010
Annex to ESF 8 of the State of Alabama Emergency Operations Plan
   9. If OLMD orders advanced airway procedures, use of bag-mask, or nebulizer
       treatments on a patient with acute febrile respiratory illness, EMS personnel must
       be in PPE as described in 2.a above.
   10. All patients with acute febrile respiratory illness should wear a surgical mask, if
       tolerated by the patient.
   11. Encourage good patient compartment vehicle airflow/ventilation (turn on exhaust
       fan) to reduce the concentration of aerosol accumulation when possible.

            TRANSPORT OF PATIENTS TO HEALTHCARE FACILITIES

When transporting a patient with symptoms of acute febrile respiratory illness, you
should notify the receiving healthcare facility so that appropriate infection control
precautions may be taken prior to patient arrival. Patients with febrile respiratory illness
should wear a surgical mask, if tolerated.

                             INTERFACILITY TRANSPORT

EMS personnel involved in the transfer of patients with confirmed influenza or suspected
infectious respiratory illness should use standard droplet and contact precautions for all
patient care activities. This should include wearing disposable N-95 mask, eye protection
[shield or goggles], disposable non-sterile gloves and gown. If the transported patient
can tolerate a surgical mask, its use can help to minimize the spread of infectious droplets
in the patient care compartment. Encourage good patient compartment vehicle
airflow/ventilation (turn on exhaust fan) to reduce the concentration of aerosol
accumulation when possible. Any nonessential equipment that can be removed from the
patient compartment of the ambulance before transport will hasten the time needed to
disinfect and return to service.


      CLEANING EMS TRANSPORT VEHICLES AFTER TRANSPORTING A
            SUSPECTED OR CONFIRMED INFLUENZA PATIENT

After the patient has been removed and prior to cleaning, the air within the vehicle may
be exhausted by opening the doors and windows of the vehicle while the ventilation
system is running. This should be done outdoors and away from pedestrian traffic.
Routine cleaning methods should be employed throughout the vehicle and on non-
disposable equipment.

Routine cleaning with soap or detergent and water to remove soil and organic matter,
followed by the proper use of disinfectants, are the basic components of effective
environmental management of influenza. Reducing the number of influenza virus
particles on a surface through these steps can reduce the chance of hand transfer of virus
particles. Influenza viruses are susceptible to inactivation by a number of chemical
disinfectants readily available from consumer and commercial sources.


                                        Page 16 of 18
                                     Revised 9 April 2010
Annex to ESF 8 of the State of Alabama Emergency Operations Plan

                                    References
1) Rubinson, L., Nuzzo, J., Talmor, D., et al. (2005). Augmentation of hospital critical
care capacity after bioterrorist attacks or epidemics: Recommendations of the
Working Group on Emergency Mass Critical Care. Critical Care Medicine, 33(10),
E1-E13.

2) Hick, J., O’Laughlin, D., (2006). Concept of Operations for Triage of Mechanical
Ventilation in an Epidemic. The Society for Academic Emergency Medicine. 13, 223-
229.

3) Upshur, R., Faith, K., Gibson, J., et al. (2005). Stand on Guard for Thee: Ethical
considerations in preparedness planning for pandemic influenza. University of
Toronto Joint Centre for Bioethics. Retrieved January 30, 2008, from
http://www.utoronto.ca/jcb/home/documents/pandemic.pdf

4) Environment of Care Leader. March 20, 2006 Volume 11, Number 7

5) Emergency Management Unit of the Ministry of Health and Long Term Care, (2007).
Ontario Health Plan for an Influenza Pandemic July 2007. Retrieved January 30,
2008, from
http://www.health.gov.on.ca/english/providers/program/emu/pan_flu/ohpip2/plan_full.pd
f

6) Egol, A., Fromm, R., Guntupalli, K., et al. (1999). Guidelines for ICU Admission,
Discharge, and Triage. Society of Critical Care Medicine. 27(3), 633-638.

7) Society of Critical Care. Medicine Ethics Committee. (1994). Consensus statement
on the triage of critically ill patients. Journal of the American Medical Association.
20;271(15):1200-3.

8) Health Systems Research Inc. (2005). Altered Standards of Care in Mass Casualty
Events. Agency for Healthcare Research and Quality. Retrieved January 30, 2008, from
http://www.ahrq.gov/research/altstand/altstand.pdf

9) The American Thoracic Society. ATS Board of Directors (1997). Fair Allocation of
Intensive Care Unit Resources. American Journal of Respiratory and Critical Care
Medicine. 156, 1282–1301.

10) Munson, R. (2004). The Allocation of Exotic Medical Lifesaving Therapy. In
Interventions and Reflections: Basic Issues in Medical Ethics (7th ed.), Wadsworth.

11) Christian, M., Hawryluck, L., Wax, R., et al. (2006). Development of a Triage
Protocol for Critical Care during an Influenza Pandemic. Canadian Medical
Association Journal. 175(11), 1377-81.

                                      Page 17 of 18
                                   Revised 9 April 2010
Annex to ESF 8 of the State of Alabama Emergency Operations Plan

12) Ferreira FL, Bota DP, Bross A, Melot C, Vincent JL., (2001). Serial evaluation of
the SOFA score to predict outcome in critically ill patients. Journal of the American
Medical Association. 286(14), 1754-1758.

13) Burkle, F., Hsu, E., Loehr, M., et al. (2007). Definition and Functions of Health
Unified Command and Emergency Operations Centers for Large-scale Bioevent
Disasters Within the Existing ICS. Disaster Medicine and Public Health Preparedness.
1(2), 135-141.

14) Woodson, G. (2006). Patient Triage During Pandemic Influenza. The Bird Flu
Manual.com. Retrieved January 30, 2008, from
http://www.birdflumanual.com/articles/patTriage.asp

15) Schnirring, L. (2006). Pandemic Triage Plan Addresses Tough Ventilator
Decisions. Center for Infectious Disease Research and Policy. University of Minnesota.
Retrieved January 30, 2008, from
http://www.cidrap.umn.edu/cidrap/content/influenza/panflu/news/dec0106triage.html

16) MedicineNet.com. (2008). Definition of MELD. Retrieved January 30, 2008, from
http://www.medterms.com/script/main/art.asp?articlekey=31976

17) Mayo Clinic. (2008). The MELD Model. Retrieved January 30, 2008, from
http://www.mayoclinic.org/meld/mayomodel5.html

18) Heart Failure Society of America. (2008). The Stages of Heart Failure – NYHA
Classification. Retrieved January 30, 2008, from
http://www.abouthf.org/questions_stages.htm

19) Centers for Disease Control and Prevention. National Center for Injury Prevention
and Control. (2008). Glascow Coma Scale. Retrieved January 31, 2008, from
http://www.cdc.gov/ncipc/pub-res/tbi_toolkit/physicians/gcs.htm




                                      Page 18 of 18
                                   Revised 9 April 2010

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Vent.triage

  • 1. Annex to ESF 8 of the State of Alabama Emergency Operations Plan Criteria for Mechanical Ventilator Triage Following Proclamation of Mass-Casualty Respiratory Emergency I. Introduction A. Purpose This document outlines a ventilator triage protocol intended for use only during a mass casualty event, proclaimed as a public health emergency by the Governor. It would be characterized by frequent, widespread cases of respiratory failure occurring in sufficient volume to quickly exhaust available mechanical ventilator resources. One example might include, not exclusively, a virulently aggressive form of pandemic influenza. Such pandemics have occurred in the past and could recur, stressing healthcare systems to their breaking points. B. Scope This appendix covers all areas within the State of Alabama. II. Situation and Assumptions A. Situation Due diligence in disaster planning requires consideration of “measures of last resort.” Some mass casualty disasters, such as a pandemic event, may necessitate that commonly accepted standards of medical care be altered to provide the maximum number of patients their best chance of survival. This would be done in support of the strategic goals of the Centers for Disease Control and Prevention to 1) stop, slow, or otherwise limit the spread of the pandemic to the United States; 2) limit the domestic spread of the pandemic and mitigate the disease, suffering and death; and 3) sustain infrastructure and mitigate impact to the economy and functioning of society. Assigning a proper priority for ventilator support during a national health crisis requires assessment of an affected individual’s level of premorbid function, likelihood of response to ventilator support, and likelihood that survival will produce a functional recovery. B. Assumptions Disaster-related ventilator triage protocols must be evenly and fairly implemented if public trust is to be gained and maintained during a time of such extreme duress. Healthcare authorities representing the public and private sectors should be prepared to deliver messages that are uniform, realistic, and consistent. It is highly recommended that this document be Page 1 of 18 Revised 9 April 2010
  • 2. Annex to ESF 8 of the State of Alabama Emergency Operations Plan considered for endorsement by the various stakeholders in mass-casualty disaster planning. Healthcare organizations incorporating this ventilator triage protocol into their disaster plans and attempting in good faith to follow it will be considered to be in compliance with the standard of care necessitated by the prevailing proclaimed respiratory disaster. In addition, it is highly recommended that hospital disaster plans/policies anticipate breakdowns in ventilator triage discipline, identify and confront the likely sources of such breakdowns, and incorporate language designed to lessen the probability of their occurrence. III. Mission Purpose: Offered as a template for inclusion in hospital disaster plan/policy following declaration of statewide, regional, or national public health respiratory emergency. [Example: Pandemic Avian Influenza] . A. Direction and Control This document outlines a ventilator triage protocol intended for use only during a mass casualty event, proclaimed as a public health emergency by the Governor. It would be characterized by frequent, widespread cases of respiratory failure occurring in sufficient volume to quickly exhaust available mechanical ventilator resources. One example might include, not exclusively, a virulently aggressive form of pandemic influenza. Such pandemics have occurred in the past and could recur, stressing healthcare systems to their breaking points. Should conditions become extremely grave due to widespread outbreaks with many people seriously affected, availability of ventilator care and Intensive Care Unit (ICU) care may become extremely limited in any locale. Under such circumstances, measures of last resort herein described may be employed by each hospital after thorough evaluation and consultation with available external sources to confirm that partner hospital resources, usual supplier resources, and resources obtainable through the collaborative efforts of the Department of Public Health through AIMS are all exhausted. All efforts should then be directed to provide aggressive treatment to those with the greatest chance of survival even if that requires removal of supportive care from others. This process is described in this document when patients are assessed and transitioned to Tier 2 or Tier 3 levels of care. Page 2 of 18 Revised 9 April 2010
  • 3. Annex to ESF 8 of the State of Alabama Emergency Operations Plan B. Concept of Operations Tier 1 Trigger: Mass casualties resulting from respiratory failure illness of sufficient volume to quickly exhaust available mechanical ventilator resources. Proclamation of a state of public health emergency by the Governor is a necessary initial trigger. All hospitals will implement Tier 1 upon the Governor’s Proclamation. Additional supportive action: Activation of the Federal Pandemic Influenza Disaster Plan or other federal respiratory disaster plan. Tier 2 and Tier 3 Triggers: These are hospital-specific choices based on the hospital’s unique situation. Tier 2: At the discretion of the hospital when it is operating under Tier 1 criteria and all available resources such as ventilators and staff are exhausted, hospital decides to selectively withdraw ventilator support per guidelines in Appendix 2. Tier 3: At the discretion of the hospital when it is operating under Tier 2 criteria, persuasive outcome data compel further restriction of who qualifies for ventilator support. See Appendix 2. Criteria should be implemented in a tiered or stepwise fashion, so that as resources are exhausted, another stricter tier of exclusion criteria is implemented in an attempt to provide the best care possible to those with the best chance of survival (Hick, J. & O’Laughlin, D., 2006). C. Operations and missions required as a result of mass casualties resulting from respiratory failure illness of sufficient volume to quickly exhaust available mechanical ventilator resources will be carried out during the response and recovery phases. 1. The Response Phase – Refer to the following: a) “Implementation Steps Following Emergency Statewide Proclamation by the Governor” algorithm (page 5); b) “Appendix 1 – Exclusion Criteria” (page 6); c) “Appendix 2 – Mechanical Ventilator Tier Criteria Following Declaration of Mass-Casualty Respiratory Emergency” (pages 7-9); d) “Appendix 3 – SOFA Triage Tool” (pages 10-11); Page 3 of 18 Revised 9 April 2010
  • 4. Annex to ESF 8 of the State of Alabama Emergency Operations Plan e) “Appendix 4 – “Initial Assessment Tool for Tier 1 and Reassessment Tool for Tier 2 and Tier 3” (page 12); and f) “Appendix 5 – Emergency EMS Protocol for Mass Casualty Respiratory Emergency” (pages 13-16). 2. The Recovery Phase There are usually no clear distinctions between when the Response Phase ends and the Recovery Phase begins. There is typically a time period as the respiratory epidemic gradually subsides and the incidence of newly infected people declines during which both phases are in effect simultaneously. The recovery phase begins when the statewide resource assessment of ventilator use and hospital admissions approaches pre-disaster levels. Functions during this phase under PL 93-288 include public and individual assistance, establishment of Disaster Assistance Centers, and Federal disaster plans and grants. During this phase the Federal Government provides relief and assistance in completion of final arrangements for the casualties. IV. Administrative Support Each healthcare facility should develop internal staffs and procedures for administrative support. Page 4 of 18 Revised 9 April 2010
  • 5. Annex to ESF 8 of the State of Alabama Emergency Operations Plan Implementation Steps Following Emergency Statewide Proclamation by the Governor Step 1 Cancel all planned Yes (Elective) surgery likely Proceed to to require Step 3 post-op ventilator support No A non-medical direction hospital should Step 2 also notify the emergency physicians at the Alert all staff and medical direction hospital** that gives especially ED orders for the ambulance services that physicians to deliver to this hospital. After notification implement Criteria for proceed to Step 3 Mechanical Ventilator Triage Following Proclamation of Yes Mass-Casualty Begin supportive or Respiratory palliative care either Emergency Protocol in-patient or home for ALL incoming ED Yes patients. Is the Proceed to facility a medical No Step 4 direction hospital? Proceed to SOFA Triage (See Appendix 3) Did patient No Step 3 and Initial receive Begin Evaluate all patients Assessment ventilator supportive or admitted to the hospital Tool assistance? palliative or seen in ED with any (Appendix 4) care either respiratory illness, in-patient or whether or not related home to the declared Yes emergency (respiratory Continue with Step 3 failure of any cause) Follow standard clinical Does the patient meet guidelines for care Exclusion Criteria (Appendix 1)? Yes No Proceed to The facility should Step 5* Step 4 consider implementing Are available Tier 2 resources adequate (See Appendix 2) No to maintain Tier 1? Will the facility Continue with Step 3 implement Tier 2? Follow standard clinical guidelines for care Yes Yes Step 5* Remove patient from ventilator. Continue Step 5* Reassess ALL Begin supportive or palliative Reassess again at ventilator patients at care either in-patient or home 48 and 120 hours 48 and 120 hours Did patient Refer to Tier 2 and 3 (See Appendix 2). No meet No Does the patient meet Proceed to SOFA Triage criteria to Remove patient Exclusion Criteria (See Appendix 3) and continue from ventilator. (Appendix 1)? Reassessment Tool for Tier ventilator Begin supportive or 2 and Tier 3 (Appendix 4) assistance? palliative care either in-patient or home *Step 5 is a last resort measure to be employed by the healthcare facility only when all other resources are exhausted by re -evaluation of the following: suppliers, partner healthcare facilities, and public health through AIMS. **A medical direction hospital is one whose emergency medicine physicians are certified to give orders to pre-hospital emergency medical service personnel. Page 5 of 18 Revised 9 April 2010
  • 6. Annex to ESF 8 of the State of Alabama Emergency Operations Plan Appendix 1 Exclusion Criteria This is to guide Ventilator Access in Proclaimed Mass-Casualty Respiratory Emergency. A. CARDIAC ARREST: Unwitnessed arrest, recurrent arrest, arrest unresponsive to standard treatment. For detailed criteria refer to Cardiac under Tier 1 [See Appendix 2, (b)]. B. SEVERE TRAUMA: Especially if associated with cardiac arrest. C. DEMENTIA: For detailed criteria refer to Neurological under Tier 1 [See Appendix 2, (e)]. D. METASTATIC MALIGNANCY: For detailed criteria refer to Hematological and Cancer under Tier 1 [See Appendix 2, (f)]. E. SEVERE BURN: > 60% body surface affected. F. END STAGE ORGAN FAILURE: 1. Pulmonary – COPD, restrictive lung disease, FEV1 (Forced Expiratory Volume in the first second) < 25%. For detailed criteria refer to Pulmonary under Tier 1 [See Appendix 2, (a)]. 2. Cardiac – including severe angina, CHF (NYHA Class III or IV). For detailed criteria refer to Cardiac under Tier 1 [See Appendix 2, (b)]. 3. Renal – Including anyone on or requiring dialysis. For detailed criteria refer to Renal under Tier 1 [See Appendix 2, (c)]. 4. Hepatic – Acute or chronic, MELD score > 20. For detailed criteria refer to Hepatic under Tier 1 [See Appendix 2, (d)]. 5. Neurological – Severe, irreversible neurologic event or condition with high expected mortality, advanced neuromuscular disease. For detailed criteria refer to Neurological under Tier 1 [See Appendix 2, (e)]. 6. Hematological and Cancer – Clinical or laboratory evidence of disseminated intravascular coagulation (DIC), leukemia or cancer. For detailed criteria refer to Hematological under Tier 1 [See Appendix 2, (f)]. 7. Immunological – Advanced and irreversible immunocompromise. For detailed criteria refer to Immunological under Tier 1 [See Appendix 2, (g)]. Page 6 of 18 Revised 9 April 2010
  • 7. Annex to ESF 8 of the State of Alabama Emergency Operations Plan Appendix 2 Mechanical Ventilator Tier Criteria Following Declaration of Mass- Casualty Respiratory Emergency Note: Nothing in this ventilator triage protocol shall preclude ventilation by hand provided the appropriate resources are available. TIER 1 To be implemented by all hospitals following Governor’s Proclamation of Mass- Casualty Respitory Emergency Do not offer mechanical ventilator support for patients with end stage organ failure in any one of the following: a) Pulmonary: Respiratory failure: Refer to SOFA Triage Tool (Appendix 3) and Initial Assessment Tool (Appendix 4). adult respiratory distress syndrome; ventilatory failure; refractory hypoxemia; severe chronic lung disease including pulmonary fibrosis, cystic fibrosis; obstructive or restrictive diseases requiring continuous home oxygen use before onset of acute illness. b) Cardiac: CHF (NYHA Class III or IV), left ventricular dysfunction, hypotension, new ischemia; known congestive heart failure with ejection fraction less than 25% or persistent ischemia/pulmonary edema unresponsive to therapy. The Stages of Heart Failure – NYHA Classification In order to determine the best course of therapy, physicians often assess the stage of heart failure according to the New York Heart Association (NYHA) functional classification system. This system relates symptoms to everyday activities and the patient's quality of life (Heart Failure Society of America, 2008). Class Patient Symptoms Class I (Mild) No limitation of physical activity. Ordinary physical activity does not cause undue fatigue, palpitation, or dyspnea (shortness of breath). Class II (Mild) Slight limitation of physical activity. Comfortable at rest, but ordinary physical activity results in fatigue, palpitation, or dyspnea. Class III (Moderate) Marked limitation of physical activity. Comfortable at rest, but less than ordinary activity causes fatigue, palpitation, or dyspnea. Class IV (Severe) Unable to carry out any physical activity without discomfort. Symptoms of cardiac insufficiency at rest. If any physical activity is undertaken, discomfort is increased. Page 7 of 18 Revised 9 April 2010
  • 8. Annex to ESF 8 of the State of Alabama Emergency Operations Plan c) Renal: hyperkalemia, diminished urine output despite adequate fluid resuscitation, increasing creatinine level; acute renal failure (related to current ilness) requiring dialysis. d) Hepatic: transaminase greater than five (5) times normal upper limit, increasing bilirubin or ammonia levels; cirrhosis with ascites; history of variceal bleeding; fixed coagulopathy or encephalopathy; acute hepatic failure with hyperammonemia; MELD: Model End Stage Liver Disease: a disease severity scoring system for adults with liver disease. The MELD score is based only on laboratory data in order to be as objective as possible. The laboratory values used are a patient's creatinine, bilirubin, and international normalized ratio, or INR (a measure of blood-clotting time (MedicineNet.com, 2008). On-line scoring tool is available from the Mayo Clinic located at: http://www.mayoclinic.org/meld/mayomodel5.html e) Neurological: altered mental status not related to volume status. Examples: metabolic or hypoxic source, stroke. Individuals may be excluded under Tier 1 with severe functional impairment produced by static or progressive neurological disorders and reduced likelihood for successful outcome from ventilator support. Functional domains include cognitive, neurological, and psychosocial. For example, persons with severe mental retardation, advanced dementia or severe traumatic brain injury may be poor candidates for ventilator support. The average life expectancy of persons with mental retardation now spans to the seventh decade and persons with significant neurological impairments can enjoy productive happy lives. Functional assessment for persons with intellectual disability, complex neurological problems, dementia, or mixtures of symptoms should focus on premorbid function in all domains of life including social, intellectual, professional, etc. Persons with severe or profound mental retardation, moderate to severe dementia, or catastrophic neurological complications such as persistent vegetative state are unlikely candidates for ventilator support. Individuals with complex neurological issues such as motor neuron disease, glioblastoma multiforme and others may not be appropriate candidates in a mass casualty situation. Children with severe neurological problems may not be appropriate candidates in the pediatric age group. Decisions should be guided by premorbid function and expected level of recovery rather than by diagnosis. f) Hematological and Cancer: clinical or laboratory evidence of disseminated intravascular coagulation (DIC), leukemia or cancer; active malignancy with poor survival potential (e.g., metastatic malignancy, pancreatic cancer). Page 8 of 18 Revised 9 April 2010
  • 9. Annex to ESF 8 of the State of Alabama Emergency Operations Plan g) Immunological: Acquired Immune Deficiency Syndrome (AIDS) (presence of +HIV status without AIDS is not an automatic exclusion); other immunodeficiency syndromes at stage of disease rendering patient susceptible to opportunistic pathogens. TIER 2 To be implemented by individual hospital decision that, despite operating under Tier 1 conditions, the hospital has exhausted all needed resources to maintain Tier 1. 1. Withdraw ventilator support and do not offer such support for patients with conditions listed in Tier 1. 2. Withdraw ventilator support from those who failed to respond to mechanical ventilation and other support measures (e.g., antibiotics, fluids, pressors). Refer to SOFA Triage Tool (Appendix 3) and Reassessment Tool for Tier 2 and Tier 3 (Appendix 4). (Timeline may be modified based on organism-specific data.) TIER 3 To be implemented by individual hospital decision that, despite operating under Tier 2 conditions, the hospital has exhausted all needed resources to maintain Tier 2. The hospital’s leaders within each facility, including members of the medical staff, participating in planning activities for the facility’s Emergency Operations Plan should develop specific directions for the Tier 3 implementation within the facility. Possibilities include: 1. Restriction of treatment based on disease-specific epidemiology and survival data for patient subgroups (may include age-based criteria). 2. Expansion of pre-existing disease classes that will not be offered ventilatory support. Page 9 of 18 Revised 9 April 2010
  • 10. Annex to ESF 8 of the State of Alabama Emergency Operations Plan Appendix 3 SOFA Triage Tool: Scoring criteria for the Sequential Organ-Failure Assessment (SOFA) score* Score Variable 0 1 2 3 4 PaO2/FiO2, > 400 < 400 < 300 < 200 < 100 mm Hg Platelet > 150 < 150 < 100 < 50 < 20 count, x 106 /L Bilirubin < 1.2 1.2-1.9 2.0-5.9 6.0-11.9 >12 level, mg/dL (< 20) (20-32) (33-100) (101-203) (> 203) (μmol/L) Hypotension† None MABP < 70 Dop < 5 Dop > 5 Dop > 15 Epi < 0.1 Epi > 0.1 Norepi Norepi < 0.1 > 0.1 Glasgow 15 13-14 10-12 6-9 <6 Coma score Creatinine <1.2 1.2-1.9 2.0-3.4 3.5-4.9 >5 level, mg/dL (< 106) (106-168) (169-300) (301-433) (> 434) (μmol/L) Note: PaO2 = partial pressure of arterial oxygen; FiO2 = fraction of inspired oxygen; MABP = mean arterial blood pressure, in mmHg; *Adapted, from Ferriera FL, Bota DP, Bross A, et al. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001; 286: 1754-8. Copyright © 2001, American Medical Association. All rights reserved. †Dop (dopamine), epi (epinephrine) and norepi (norepinephrine) doses in μg/kg per min. Explanation of variables: PaO2/FiO2 indicates the level of oxygen in the patient’s blood. Platelets are a critical component of blood clotting. Bilirubin is measured by a blood test and indicates liver function. Hypotension indicates low blood pressure; scores of 2, 3, and 4 indicated that blood pressure must be maintained by the powerful medications that require ICU monitoring, including dopamine, epinephrine, and norepinephrine. Creatinine is measured by a blood test and indicates kidney function. Page 10 of 18 Revised 9 April 2010
  • 11. Annex to ESF 8 of the State of Alabama Emergency Operations Plan The Glascow coma score is a standardized measure that indicates neurologic function; low score indicates poorer function. Glascow Coma Scale Eye Opening Response Spontaneous--open with blinking at baseline 4 points To verbal stimuli, command, speech 3 points To pain only (not applied to face) 2 points No response 1 point Verbal Response Oriented 5 points Confused conversation, but able to answer questions 4 points Inappropriate words 3 points Incomprehensible speech 2 points No response 1 point Motor Response Obeys commands for movement 6 points Purposeful movement to painful stimulus 5 points Withdraws in response to pain 4 points Flexion in response to pain (decorticate posturing) 3 points Extension response in response to pain (decerebrate posturing) 2 points No response 1 point Categorization: Coma: No eye opening, no ability to follow commands, no word verbalizations (3-8) Head Injury Classification: Severe Head Injury----GCS score of 8 or less Moderate Head Injury----GCS score of 9 to 12 Mild Head Injury----GCS score of 13 to 15 Adapted from: Advanced Trauma Life Support: Course for Physicians, American College of Surgeons, 1993. CDC, 2008. Page 11 of 18 Revised 9 April 2010
  • 12. Annex to ESF 8 of the State of Alabama Emergency Operations Plan Appendix 4 Initial Assessment Tool for Tier 1 Triage Criteria Action or Code Priority No respiratory failure Begin standard treatment GREEN No need for ventilator home or inpatient non- support ICU Single Organ (Lung) Intubate and admit to YELLOW failure ICU for aggressive SOFA score < 7 therapy SOFA score 8 - 11 If resources are available, RED intubate and admit to ICU for aggressive therapy. If resources are exhausted move to BLUE level. Exclusion Criteria met Begin supportive or BLUE OR SOFA score > 11 palliative care either in- patient or home Reassessment Tool for Tier 2 and Tier 3 - use at 48 and 120 hours Triage Criteria Action or Code Priority Able to wean off the Discharge from ICU GREEN ventilator (Critical Care) Single Organ (Lung) Continue aggressive YELLOW failure ventilator support. SOFA score < 7 SOFA score 8-11 If resources are RED (decreasing) and available, continue clinically improving – ventilator care and Continue aggressive support. If resources are therapy exhausted move to BLUE level. Exclusion Criteria met Extubate. Discharge BLUE OR SOFA score > 11 from ICU (Critical Care) and begin palliative care. Page 12 of 18 Revised 9 April 2010
  • 13. Annex to ESF 8 of the State of Alabama Emergency Operations Plan Appendix 5 EMERGENCY EMS PROTOCOL FOR MASS CASUALTY RESPIRATORY EMERGENCY This protocol is designed to be implemented only when there is a significant respiratory disease that has impacted the health care system to the extent that hospital beds are full, few or no ventilators are available for new patients with respiratory failure, the EMS/Dispatch work force is significantly depleted due to absenteeism, and the calls for EMS support overwhelm resources to manage all calls. When the Governor proclaims a state of emergency, the Alabama Public Health Department (ADPH) Office of EMS & Trauma (OEMS&T) will activate this protocol to provide authorization for the adjustment in the prehospital standard of care. Depending upon the Governor’s proclamation, ADPH OEMS&T may activate this protocol on a regional or local basis. ON-SCENE PROTOCOL PATIENTS WITH ACUTE FEBRILE RESPIRATORY ILLNESS 1. Follow General Patient Care Protocol 4.1. 2. Be sure you are using appropriate standard precautions. a. If Dispatch advises you of the potential for acute febrile respiratory illness symptoms on scene, you should don PPE for suspected cases of influenza prior to entering scene (disposable N-95 mask [or surgical mask if N-95 masks are unobtainable], eye protection [shield or goggles], and disposable non-sterile gloves). Disposable non-sterile gown is optional depending on the situation (follow guidance of service medical director). b. If Dispatch has not identified individuals with symptoms of acute febrile respiratory illness on scene, you should stay more than six (6) feet away from patient and bystanders with symptoms and exercise appropriate routine respiratory droplet precautions while assessing all patients for suspected cases of influenza (4.c below). If patient has signs or symptoms of influenza or acute febrile respiratory illness, you should don the PPE described in a. above before coming into close contact with the patient. Page 13 of 18 Revised 9 April 2010
  • 14. Annex to ESF 8 of the State of Alabama Emergency Operations Plan 3. If patient has critical vital signs, immediately transport to Emergency Department a. Critical Vital Signs: Adult If present, immediately transport to an Emergency Department i. Pulse: equal or greater than 130 beats per minute ii. Respiratory Rate: equal or greater than 30 breaths per minute iii. Systolic Blood Pressure: Less than 90 mm/Hg iv. Pulse Oximeter: Less than 92 on room air v. Temperature: Febrile vi. Level of Consciousness: Responds only to Pain or is Unresponsive vii. Lung sounds: Rales or Wheezing b. Critical Vital Signs: Pediatric: If present, immediately transport to Emergency Department Vital Signs Neonates Infants Children Capillary refill: > 2 seconds > 2 seconds > 2 seconds Resp. rate: <30 or >45 <20 or >45 <15 or >45 or increased or increased or increased work of work of work of breathing breathing breathing Systolic Blood < 60 mmHg < 70 mmHg Under age 10 pressure < 70 + (2 X age in years) Pulse Oximeter < 92 on room < 92 on room < 92 on room air air air Temperature Febrile Febrile Febrile Level of responds only responds only responds only Consciousness to pain or is to pain or is to pain or is unresponsive unresponsive unresponsive Lung sounds Rales or Rales or Rales or Wheezing Wheezing Wheezing 4. If patient has normal vital signs, then evaluate for signs and symptoms of influenza. a. Normal Vital Signs Adult i. Pulse: Less than 130 beats per minute ii. Respiratory Rate: Less than 30 breaths per minute iii. Systolic Blood Pressure: equal or greater than 91 mmHg iv. Pulse Oximeter equal or greater than 92 v. Temperature: Afebrile vi. Level of Consciousness: Alert or responds to verbal stimuli vii. Lung sounds: Clear Page 14 of 18 Revised 9 April 2010
  • 15. Annex to ESF 8 of the State of Alabama Emergency Operations Plan b. Normal Vital Signs Pediatric Vital Signs Neonates Infants Children Capillary refill: < 2 seconds < 2 seconds < 2 seconds Unlabored 30-45 20-45 15-45 breathing or resp. rate: Systolic Blood > 60 mmHg > 70 mmHg Under age 10 pressure > 70 + (2 X age in years) Pulse Oximeter > 92 > 92 > 92 Temperature Afebrile Afebrile Afebrile Level of Alert or Alert or Alert Consciousness responds to responds to verbal stimuli verbal stimuli Lung sounds Clear Clear Clear c. Signs and Symptoms of Influenza i. Rapid onset of symptoms ii. Difficulty breathing with exertion iii. Doctor has already diagnosed influenza iv. Cough v. Fever vi. Shaking Chills vii. Pleuritic chest pain viii. Sore throat (no difficulty breathing or swallowing) ix. Nasal congestion x. Runny nose xi. Muscle aches xii. Headache 5. If patient has three (3) or more signs or symptoms of influenza, transport patient to alternate care facility (if available). 6. If patient has two (2) or fewer signs or symptoms of influenza, call On-line Medical Direction (OLMD) to determine if patient may be left on-scene, self quarantine, and refer to nurse/public health hotline (insert phone number here) for further assistance. 7. Endotracheal intubation should not be performed on any patient except by direct order of the OLMD physician (Cat. B). 8. Because of the danger of EMS personnel becoming infected, aerosol-generating procedures such as advanced airway procedures, use of bag-mask, and nebulizer treatments should not be performed on patients with acute febrile respiratory illness except by direct order of the OLMD physician (Cat. B). CPAP with expiratory filter is still Category A. Page 15 of 18 Revised 9 April 2010
  • 16. Annex to ESF 8 of the State of Alabama Emergency Operations Plan 9. If OLMD orders advanced airway procedures, use of bag-mask, or nebulizer treatments on a patient with acute febrile respiratory illness, EMS personnel must be in PPE as described in 2.a above. 10. All patients with acute febrile respiratory illness should wear a surgical mask, if tolerated by the patient. 11. Encourage good patient compartment vehicle airflow/ventilation (turn on exhaust fan) to reduce the concentration of aerosol accumulation when possible. TRANSPORT OF PATIENTS TO HEALTHCARE FACILITIES When transporting a patient with symptoms of acute febrile respiratory illness, you should notify the receiving healthcare facility so that appropriate infection control precautions may be taken prior to patient arrival. Patients with febrile respiratory illness should wear a surgical mask, if tolerated. INTERFACILITY TRANSPORT EMS personnel involved in the transfer of patients with confirmed influenza or suspected infectious respiratory illness should use standard droplet and contact precautions for all patient care activities. This should include wearing disposable N-95 mask, eye protection [shield or goggles], disposable non-sterile gloves and gown. If the transported patient can tolerate a surgical mask, its use can help to minimize the spread of infectious droplets in the patient care compartment. Encourage good patient compartment vehicle airflow/ventilation (turn on exhaust fan) to reduce the concentration of aerosol accumulation when possible. Any nonessential equipment that can be removed from the patient compartment of the ambulance before transport will hasten the time needed to disinfect and return to service. CLEANING EMS TRANSPORT VEHICLES AFTER TRANSPORTING A SUSPECTED OR CONFIRMED INFLUENZA PATIENT After the patient has been removed and prior to cleaning, the air within the vehicle may be exhausted by opening the doors and windows of the vehicle while the ventilation system is running. This should be done outdoors and away from pedestrian traffic. Routine cleaning methods should be employed throughout the vehicle and on non- disposable equipment. Routine cleaning with soap or detergent and water to remove soil and organic matter, followed by the proper use of disinfectants, are the basic components of effective environmental management of influenza. Reducing the number of influenza virus particles on a surface through these steps can reduce the chance of hand transfer of virus particles. Influenza viruses are susceptible to inactivation by a number of chemical disinfectants readily available from consumer and commercial sources. Page 16 of 18 Revised 9 April 2010
  • 17. Annex to ESF 8 of the State of Alabama Emergency Operations Plan References 1) Rubinson, L., Nuzzo, J., Talmor, D., et al. (2005). Augmentation of hospital critical care capacity after bioterrorist attacks or epidemics: Recommendations of the Working Group on Emergency Mass Critical Care. Critical Care Medicine, 33(10), E1-E13. 2) Hick, J., O’Laughlin, D., (2006). Concept of Operations for Triage of Mechanical Ventilation in an Epidemic. The Society for Academic Emergency Medicine. 13, 223- 229. 3) Upshur, R., Faith, K., Gibson, J., et al. (2005). Stand on Guard for Thee: Ethical considerations in preparedness planning for pandemic influenza. University of Toronto Joint Centre for Bioethics. Retrieved January 30, 2008, from http://www.utoronto.ca/jcb/home/documents/pandemic.pdf 4) Environment of Care Leader. March 20, 2006 Volume 11, Number 7 5) Emergency Management Unit of the Ministry of Health and Long Term Care, (2007). Ontario Health Plan for an Influenza Pandemic July 2007. Retrieved January 30, 2008, from http://www.health.gov.on.ca/english/providers/program/emu/pan_flu/ohpip2/plan_full.pd f 6) Egol, A., Fromm, R., Guntupalli, K., et al. (1999). Guidelines for ICU Admission, Discharge, and Triage. Society of Critical Care Medicine. 27(3), 633-638. 7) Society of Critical Care. Medicine Ethics Committee. (1994). Consensus statement on the triage of critically ill patients. Journal of the American Medical Association. 20;271(15):1200-3. 8) Health Systems Research Inc. (2005). Altered Standards of Care in Mass Casualty Events. Agency for Healthcare Research and Quality. Retrieved January 30, 2008, from http://www.ahrq.gov/research/altstand/altstand.pdf 9) The American Thoracic Society. ATS Board of Directors (1997). Fair Allocation of Intensive Care Unit Resources. American Journal of Respiratory and Critical Care Medicine. 156, 1282–1301. 10) Munson, R. (2004). The Allocation of Exotic Medical Lifesaving Therapy. In Interventions and Reflections: Basic Issues in Medical Ethics (7th ed.), Wadsworth. 11) Christian, M., Hawryluck, L., Wax, R., et al. (2006). Development of a Triage Protocol for Critical Care during an Influenza Pandemic. Canadian Medical Association Journal. 175(11), 1377-81. Page 17 of 18 Revised 9 April 2010
  • 18. Annex to ESF 8 of the State of Alabama Emergency Operations Plan 12) Ferreira FL, Bota DP, Bross A, Melot C, Vincent JL., (2001). Serial evaluation of the SOFA score to predict outcome in critically ill patients. Journal of the American Medical Association. 286(14), 1754-1758. 13) Burkle, F., Hsu, E., Loehr, M., et al. (2007). Definition and Functions of Health Unified Command and Emergency Operations Centers for Large-scale Bioevent Disasters Within the Existing ICS. Disaster Medicine and Public Health Preparedness. 1(2), 135-141. 14) Woodson, G. (2006). Patient Triage During Pandemic Influenza. The Bird Flu Manual.com. Retrieved January 30, 2008, from http://www.birdflumanual.com/articles/patTriage.asp 15) Schnirring, L. (2006). Pandemic Triage Plan Addresses Tough Ventilator Decisions. Center for Infectious Disease Research and Policy. University of Minnesota. Retrieved January 30, 2008, from http://www.cidrap.umn.edu/cidrap/content/influenza/panflu/news/dec0106triage.html 16) MedicineNet.com. (2008). Definition of MELD. Retrieved January 30, 2008, from http://www.medterms.com/script/main/art.asp?articlekey=31976 17) Mayo Clinic. (2008). The MELD Model. Retrieved January 30, 2008, from http://www.mayoclinic.org/meld/mayomodel5.html 18) Heart Failure Society of America. (2008). The Stages of Heart Failure – NYHA Classification. Retrieved January 30, 2008, from http://www.abouthf.org/questions_stages.htm 19) Centers for Disease Control and Prevention. National Center for Injury Prevention and Control. (2008). Glascow Coma Scale. Retrieved January 31, 2008, from http://www.cdc.gov/ncipc/pub-res/tbi_toolkit/physicians/gcs.htm Page 18 of 18 Revised 9 April 2010