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Principles of Weight Management by R.Daniel Braun,MD Indiana U. School of Medicine
Goals of Obesity Therapy ,[object Object],[object Object],[object Object],[object Object]
Goals of Obesity Therapy ,[object Object],[object Object],[object Object]
Long Term Behavioral Rx Study   Maximum Loss   Loss last Treatment visit Perri  14% @ wk 20  13% @ wk 72 Viegener  9% @ wk 26  9% @ wk 52 Wadden  14% @ wk 52  12% @ wk 78 Wing  13% @ wk 26  10% @ wk 52
Long Term Pharmacotherapy Study   Maximum Loss   Loss last Treatment visit Andersen  15% @ wk 26  11% @ wk 52 Finer  12% @ wk 8  17% @ wk 34 14% @ wk 52 Guy-Grand  11% @ wk 34  10% @ wk 52 Weintraub  16% @ wk 34  15% @ wk 54 11% @ wk 156
Challenges in Weight Management ,[object Object],[object Object],[object Object]
Definition of Overweight ,[object Object],[object Object]
Scope of Problem ,[object Object],[object Object],[object Object]
Phenotype of Obese 1. Family is more likely to be overweight. 2. Poorer fitness than the lean, and lesser  tendency to exercise. 3. Age group at onset: infant, teen, or adult 4. Immigrants or those becoming westernized in their own natural surroundings tend to become overweight. 5. Many efforts and failures to lose weight. Many excuses for not being able to change habits or weight. 6. Overeating (binge eating) typically under stress.
Goals of Treatment ,[object Object],[object Object],[object Object],[object Object]
Benefits of Weight Loss ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Phases of Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Patient Evaluation ,[object Object],[object Object]
Treatment Decision and Selection BMI Category Health Risked based on BMI <25 Minimal 25>27 Low 27<30 Moderate 30<35 High 35<40 Very High >40 Extremely High Presence of a co-morbid condition or other risk factor jumps patient to next level of risk based on BMI. Shapeup America
Treatment Decision and Selection Health Risk Treatment Options Minimal & Low Healthful eating &/or moderate  deficit diet, Increased physical activity Lifestyle change Moderate All of above plus low calorie diet High & Very High All of above plus pharmacotherapy or very low calorie diet (VLCD) Extremely High All of above plus surgical  intervention
Goal Setting Dream Weight What you would like to weigh. Happy Weight A weight you would be happy with. Acceptable Weight Less than above but “OK” Disappointed Less than current, but more than Weight above.
Goal Setting 60 women mean age 40 years, BMI of 36.3 Current Weight 99.1 kg Dream Weight 61.4 kg  (-38%) Happy Weight 68 kg (-31%) Acceptable Weight 74 kg (-25%) Disappointed Weight 82 kg (-17%)
Goal Setting Weight Goal % Achieving Dream Weight 0% Happy Weight 9% Acceptable Weight 24% Disappointed Weight 20% Less than Disappointed 47% Foster et.al.  J Consult Clin Psychol, 1996
Induction of Weight Loss ,[object Object],[object Object],[object Object]
Maintenance of Weight Loss ,[object Object],[object Object],[object Object],[object Object]
Long-Term Weight Control ,[object Object],[object Object],[object Object]
Predictors of Weight Loss ,[object Object],[object Object],[object Object],[object Object],[object Object]
Predictors of Greater Weight Loss ,[object Object],[object Object],[object Object],[object Object]
Characteristic of Weight Loss Maintainers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Caloric Energy Balance ,[object Object],[object Object],[object Object]
Diet ,[object Object]
_diet ,[object Object],[object Object],[object Object]
Energy Deficit Calculation ,[object Object],[object Object],[object Object]
Exercise ,[object Object],[object Object],[object Object]
Behavior Modification ,[object Object],[object Object],[object Object]
Pharmacologic Management of Obesity ,[object Object]
History of Obesity Pharmacotherapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Leptin ,[object Object],[object Object],[object Object]
Sibutramine ,[object Object],[object Object]
Orlistat/Hydrolipistatin ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cholecystokinin-8 Agonists ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Initial Weight Loss Response Predicts Long Term Response ,[object Object],[object Object]
For Those Who Don’t Lose Weight ,[object Object]
For Those Who Don’t Lose Weight and There is no Cause Except Noncompliance with Diet & Exercise ,[object Object],[object Object],[object Object],[object Object]
Obesity Surgery ,[object Object],Am.J Surg  1989;157:150-155

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Principles of Weight Management

  • 1. Principles of Weight Management by R.Daniel Braun,MD Indiana U. School of Medicine
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  • 4. Long Term Behavioral Rx Study Maximum Loss Loss last Treatment visit Perri 14% @ wk 20 13% @ wk 72 Viegener 9% @ wk 26 9% @ wk 52 Wadden 14% @ wk 52 12% @ wk 78 Wing 13% @ wk 26 10% @ wk 52
  • 5. Long Term Pharmacotherapy Study Maximum Loss Loss last Treatment visit Andersen 15% @ wk 26 11% @ wk 52 Finer 12% @ wk 8 17% @ wk 34 14% @ wk 52 Guy-Grand 11% @ wk 34 10% @ wk 52 Weintraub 16% @ wk 34 15% @ wk 54 11% @ wk 156
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  • 9. Phenotype of Obese 1. Family is more likely to be overweight. 2. Poorer fitness than the lean, and lesser tendency to exercise. 3. Age group at onset: infant, teen, or adult 4. Immigrants or those becoming westernized in their own natural surroundings tend to become overweight. 5. Many efforts and failures to lose weight. Many excuses for not being able to change habits or weight. 6. Overeating (binge eating) typically under stress.
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  • 14. Treatment Decision and Selection BMI Category Health Risked based on BMI <25 Minimal 25>27 Low 27<30 Moderate 30<35 High 35<40 Very High >40 Extremely High Presence of a co-morbid condition or other risk factor jumps patient to next level of risk based on BMI. Shapeup America
  • 15. Treatment Decision and Selection Health Risk Treatment Options Minimal & Low Healthful eating &/or moderate deficit diet, Increased physical activity Lifestyle change Moderate All of above plus low calorie diet High & Very High All of above plus pharmacotherapy or very low calorie diet (VLCD) Extremely High All of above plus surgical intervention
  • 16. Goal Setting Dream Weight What you would like to weigh. Happy Weight A weight you would be happy with. Acceptable Weight Less than above but “OK” Disappointed Less than current, but more than Weight above.
  • 17. Goal Setting 60 women mean age 40 years, BMI of 36.3 Current Weight 99.1 kg Dream Weight 61.4 kg (-38%) Happy Weight 68 kg (-31%) Acceptable Weight 74 kg (-25%) Disappointed Weight 82 kg (-17%)
  • 18. Goal Setting Weight Goal % Achieving Dream Weight 0% Happy Weight 9% Acceptable Weight 24% Disappointed Weight 20% Less than Disappointed 47% Foster et.al. J Consult Clin Psychol, 1996
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