3. CRITERIA FOR AUTOIMMUNE DISORDER Guidelines for classifying autoimmune disorder cause based on 3 types of evidence 3 TYPES OF EVIDENCE Direct Proof Indirect Evidence Circumstantial Evidence

4. DIRECT PROOF HOW??? - By transferring of self-reactive lymphocytes to the host. Example – self-reactive lymphocytes are transferred transplacentally from mother to the fetus. INDIRECT EVIDENCE HOW?? - (1) Reproducing the disease in the experimental animal after identify the target antigen and isolated it on animal model. This method has their disadvantage where the human disease cannot be found on experimental animal. (2) study genetically determined animal models (3) isolating T cells from the target organ

5. CIRCUMSTANTIAL EVIDENCE Autoimmunity is referred based on the clinical clues such as familial tendency, lymphocytes infiltration, MHC association, and others

10. Mechanisms Anti-idiotypic responses Failure of suppressive mechanisms Release of sequestered/ cryptic antigens Provision of T cell epitopes Cross-reactivity and molecular mimicry

14. SYSTEMIC LUPUS ERYTHEMATOSUS, SLE

24. TREATMENTS IN AUTOIMMUNE DISEASES .

27. INTRAVENOUS IMMUNE GLOBULIN (IVIg)