This document provides information about the UCLA Clinical and Translational Science Institute (CTSI). It discusses the purpose of the National CTSA Program in providing infrastructure for clinical and translational research. It outlines various pilot programs, awards, and funding opportunities available through the UCLA CTSI, including KL2 awards, TL1 fellowships, seed grants, and team science awards. It also describes the Clinical and Translational Research Center facilities and regional consortia like UC-BRAID that enable collaboration between UC medical centers.

1. UCLA CTSI
Clinical and Translational Science Institute
NIH K Award Workshop
July 26, 2012
Steven Dubinett, MD
Director, Clinical and Translational Science Institute
Senior Associate Dean and Associate Vice Chancellor for Research
www.ctsi.ucla.edu

2. Outpatient & community based research
Inpatient
GCRC
Training in clinical and translational
team science
Regional and national consortia
linked for collaboration
Traditional
training
Individual
academic
medical centers
OLD NEW
Purpose of the
National CTSA Program
Providing an infrastructure for clinical and
translational research
Transdisciplinary team science
Individual
investigators

3. NIH CTSA Consortium

4. 4
What is translational research?
UCLA translational investigation extends
from molecules to society
Translating knowledge gained from laboratory
science into clinical practice to improve health.
The aim of translational research is to produce
new:
• therapeutics
• medical devices
• tools for diagnosing disease
• avenues for community engagement research

5. Catalyst
Grants
Rapid
Response
Team
Prototype
Grants
CTSI
Scholars
Awards
Team
Science
Awards
Novel
Methods
&
Technologies
Award
Pilots
Team
Building
Proposal
Development
Proof-­‐of-­‐Concept
Pilots
Team
Building
Proposal
Development
Proof-­‐of-­‐Concept
Overview of Pilot Programs

6. 6
Early Career Awards
Opportunity Funds Grant Amount Duration of
Award (Years)
Award Cycle Application
Due Date
KL2
Awards:
to
pursue
interdisciplinary,
mentored
research
with
training
Up
to
$125,000
in
salary
and
research
support
1 year at 75%
effort
(renewable for
up to 3 years)
July
1
Early
March
2013
TL1
Transla/onal
Science
Fellowship:
PhD
candidates
in
the
Department
of
Health
Services
in
the
UCLA
School
of
Public
Health
receive
mentored
training
to
ensure
the
translaNonal
nature
of
their
dissertaNon
projects
Annual
sNpend
plus
funding
for
health
insurance,
tuiNon/fees,
and
training-­‐related
travel
Renewable for
up to 4 years
Annual UCLA
School
of
Public
Health
applicaNon
deadline
is
December
1,
2012
TL1
Summer
Program
for
Professional
Students:
provides
professional
students
(medical,
nursing
and
dental)
early
exposure
to
interdisciplinary,
community-­‐
partnered
translaNonal
or
health
services
research
Summer
sNpend
plus
funding
for
training-­‐related
expenses
The summer
between
student’s first
and second
year (8 weeks)
June 1 Late
March
2013

7. 7
Prioritized for Early Career
Opportunity Funds Grant
Amount
Duration
of Award
(Years)
Award
Cycle
Application
Due Date
Vouchers:
for
core
services
at
CTSI
insNtuNons
Up
to
$10,000
1
Biannual
Sept.
28,
2012
Seed
Grants:
to
support
research
projects
encouraging
translaNonal
science
$1,000
to
$30,000
Up
to
1
year
Biannual
RFA
to
be
released
Fall
2012
Scholar
Awards:
seed
funds
for
junior
faculty
Criteria:
• Quality
of
the
scienNfic
proposal
• Candidate’s
potenNal
for
an
independent
translaNonal
research
career
• PotenNal
translaNonal
impact
of
the
research
and
relevance
to
the
overall
translaNonal
research
mission
of
the
UCLA
CTSI
Up
to
$30,000
Up
to
1
year
Annual
Sept.
27,
2012

8. 8
Other Collaborative
Funding Opportunities
Opportunity Funds Grant
Amount
Duration
of Award
(Years)
Award
Cycle
Application
Due Date
Team
Science
Awards:
mulNdisciplinary,
cross-­‐
insNtuNonal,
translaNonal
science
leading
to
a
proposal
under
such
team-­‐science
mechanisms
as
P01,
U54,
and
center
grants
Up
to
$200,000
1-­‐2
years
Annual
Rolling
Catalyst
Awards:
to
support
seminar
series,
team-­‐building
acNviNes
and
pilot
studies
and
other
acNviNes
to
encourage
translaNonal
team
science
$1,000
to
$25,000
Up
to
1
year
Quarterly
RFA
to
be
released
August
15,
2012

9. 9
KL2 Year 1 Awardees
Assistant Professor, CDU
“ Effects of Varenicline on Alcohol and Nicotine Consumption and
changes in Dopamine D2-like Receptor Availability in High-Alcohol
Preferring Mice”
Amira Brown, MS, PhD
Assistant Professor, Pediatric Nephrology, UCLA
“ Hepcidin and the Anemia of Chronic Kidney Disease”
Joshua Zaritsky, MD, PhD
Assistant Professor of Medicine, UCLA/VA
“ Patterns and Predictors of Poor Outcomes Following Emergency
Department Discharge in Older Adults”
Gelareh Gabayan, MD, MSHS

10. 10
KL2 Year 2 Awardees
Assistant Professor, UCLA-Harbor / LA-BioMed
“Using Research in Vancomycin-Resistant Enterococcus to Validate
an Efficient System of Quantifying Antibiotic Utilization”
James McKinnell, MD
Assistant Professor, UCLA
“Modeling of EMT/MET transitions in breast cancer stem cells”
Mary Sehl, MD, PhD
Assistant Professor, UCLA
“Development of novel therapeutic strategies to target LKB1/STK11
deficient non-small cell lung cancer”
David Shackelford, PhD

11. 11
Examples of Year 1
Team Science Awards
Stroke/cardiovascular disease in underserved minority populations:
• working with community partners, design and test
interventions to reduce risk of disease
Barbara Vickrey, MD, MPH
DMH-UCLA-USC Public Mental Health Translational Research
Consortium:
• in partnership with LA County and USC, implement best
practices within the public mental health system
Joel Braslow, MD, PhD
Overcoming acquired resistance to B-Raf targeting in melanoma
using phospho-proteomics and microfluidics:
• Building a comprehensive program for signaling discovery and
diagnostics to guide kinase inhibitor clinical trials in
melanoma
Antoni Ribas, MD

12. 12
Current Team Science Award
Partners
• AIDS Institute
• Jonsson Comprehensive Cancer Center
• Broad Stem Cell Research Center
• Cardiovascular
• Neuroscience
• Patient Safety Institute (PSI)
• Center for AIDS Research (CFAR)

13. 13
Current Seed Grant Partners
• Center for Autism Research & Treatment (CART)
• Cousins Center for Psychoneuroimmunology
• Women’s Health Center
• Resource Centers for Minority Aging Research /
Center for Health Improvement for Minority
Elders (RCMAR/CHIME)
• Pepper Center

14. Clinical and Translational Research
Center (CTRC)
Ambulatory Clinical Research Facilities
• 7 private rooms, infusion rooms, 2 procedure rooms
• >20,000 sq ft outpatient area
• Clinical and Research Sleep Center
• Interview and conference rooms
• A service center including
pharmacy and sample processing
• 23 hour capacity
First Year accomplishments
 400 ongoing research projects
 80 new protocols
 4800 out-patient
& 210 in-patient stays

15. CTSA Regional Consortia
University of California,
Los Angeles

16. 16
UC Biomedical Research Acceleration
Integration and Development (UC-BRAID)
• A committee of the CTSA PIs at UC Davis, San
Diego, San Francisco, Irvine and Los Angeles
• Initial focus on contracting, informatics and IRBs
• Drug discovery and development
• Biobanking and global consent
• Future inclusion of UCLA CTSI partner institutions

17. 17
UC Biomedical Research Acceleration
Integration and Development (UC-BRAID)