My presentation to Chemists Without Borders on September 6, 2007. I introduce the basics of the UsefulChem project and Open Notebook Science and why malaria is a particularly good target for Open Science. This includes the CombiUgi project and our collaborations with ChemSpider, Rajarshi Guha, Phil Rosenthal, Dan Zaharevitz and Tsu-Soo Tan. The final slide shows the presentation of our work on Second Life at a SciFoo Lives On session.

1. Open Notebook Science and Malaria Jean-Claude Bradley Drexel University September 6, 2007 Chemists Without Borders

4. Open and Closed Science Traditional Lab Notebook (unpublished) Traditional Journal Article Open Access Journal Article Open Notebook Science (full transparency) CLOSED OPEN

5. Where is Science headed? WE ARE HERE

6. The Robot Scientist

8. How can machines know what is important? Ask the humans

9. UsefulChem Blog

10. What chemists think is important in 2005

11. Find-A-Drug

12. Diketopiperazine Library Evolves to: on pot Ugi reaction/cyclization First iteration: Solid Support Synthesis

13. The Molecules Blog

14. The Experiments Blog

15. Comments from peers

16. The UsefulChem Wiki

17. Telling the story of the failures

18. Experiments moved to wiki

19. Experiment History

20. Experiment Edits

21. Third Party Time-Stamp on Experiment Versions

22. Monitoring experimental progress

23. How are people finding our experiments?

24. Molecules found by InChI

25. usefulchem.blogspot.com The blog as an integrative tool

26. usefulchem.wikispaces.com/Exp049 The wiki as the laboratory notebook

27. Graphical Mining of Data with JSpecView usefulchem.wikispaces.com/Exp070 (48h 7 min)

28. Processing Molecules on ChemSpider

29. The CombiUgi Project Focus on cheap starting materials and a product that precipitate easily from solution

30. Open Primary Research in Drug Design using Web2.0 tools (blogs, wikis, Second Life, mailing lists) Docking Synthesis Testing Rajarshi Guha Indiana U JC Bradley Drexel U Phil Rosenthal UCSF (malaria) Dan Zaharevitz NCI (tumors) Tsu-Soo Tan Nanyang Inst.

31. UsefulChem and Open Science in Second Life scifooliveson.wikispaces.com