Description of the work done at the Bioinformatics Core Service of the Institute for Plant Molecular and Cell Biology (Instituto de Biología Molecular y Celular de Plantas, IBMCP,www.ibmcp.upv.es). The IBMCP is a research center of the Polytechnic University of Valencia (Universidad Politécnica de Valencia, UPV, www.upv.es) and the Spanish Research Council (Consejo Superior de Investigaciones Científicas, CSIC, www.csic.es) of Spain.

1. M
D
S
A
Q
P
A
R
N
V
A
V
RT SVDY FGH GPS MRS NMK ACDE FGH SGYP TAC MDT DEE GHQ GYPN HGY KACD GQR GPS MRS GYP ACD
H
C
H
M
K
M
HQ
K
S
P
F
H
M
I
M
FG FMGP PNM EEF KFG HGY IMDT PNM EDER FGH VDG DTA NMK DERS HMR YPNM EEF EEF KFG MRS PNMK EF
M
M
M
EE RSGY ACD YPN MRS VDG SHGY ACD PNMK GPS DGI GYP CDE MKFG SHG DPQD ACD YPN FGH HGY PQDE C
D Q
H
H
K
G HQRT SVD KFG GPS HMR PNMK SGY EEFM PSV MRS MKA YPN GHMR PSV HQRT SVD PNM MRS SVD QRTA
P
G
P
FM FG
G
R
G
G
P
M
H
Y
D
G
Y
F
H
FM
PN
GH
K EFMG YPN DEE MKF SHG FMGQ TAC EEFM KFG HGY QRS NMK RTIM MKF EFMG RSG MKF IMG KFG MGQR
M E
G
M
Q
N D
R
N
R
P
M
C
S
N
D
E
E
Q
F
PN
MG
RT
C GQRS RTA VDY GHM CDE FGHQ TAC DYPN HMR EEF SGY FGH MGPS ACD YPNM GYP GHQ PSN DEE PQDE
A M
Q
G
S
K F
R
K
A
K
Q
S
D
F
V
G
K
F
D
KF
QR
MG
E KFGH MGP PNM MDT PNM FGHQ GPS NMKF MPQ FMG PNM GHE YPNM QRS MGQR NMK HEF VDP PSV TACD
F
M
P
DE NM
M
G
Y
F
G
Y
E
G
P
F
K
G
R
GI
GY
PS
P CDEE RSG SVD SHG PNM DEEF SGY VDGI QDE GSH NMK RSH EEFM DEE SHGY MKF IMG TIM GHQ AGAA
Y A
R
P
R
Q
P
N
R
Q
Y
M
F
HG M K
MG FMGP GHM SHG KAC MGQ MGPS SVD PSVD SGY FGH PQD VDP SVDG GYP HQRT GHQ NMK GAA GGT
F
N
M
D
G
F
R
F
YP QDEE DEE NMK HMR YPN DEEF EEF IMGP FMG MGQ NMK PSV MGPS MGP GQRS KFG NMK GYP AGC TGGG AA
C
E
M
D
F
T
G
G
A
P
F
P
P
T
M
Q
I
G
FG
YP
SH
VD QRTA VDY NMK RSH VDP RTAC HQR TACE DEE RSG TIM QRT ACEE EEF GYPN HGY HMR GCT CGG AAGC C
M
R
A
GH MGPS GYP FGH GPS GHQ MKFG GHM DTAC MGQ GHQ FGH HMT TACD GSH VDGS KFG TCA AAA GGA GGGT
F F
C
M
K
E MQRS NMK RTI MKF YPN NMKF GIM DEEF MKF PNM KFG IMD PSVD GPS YPNM GGG AAT AGC TGG ATCG
P
N
C
DE PN
D
M
G
G
G
Q
Y
T
Q
D
P
G
G
SN
NM
TA
Y RSGY FGH MGP GSH SGY GPSV VDP HGYP SHG GYP SVD EFM DEEF PSV ACAT AGC AGC CGG TAA AAGC
G Q
K
G
A
S G
S
G
R
E
C
F
S
A
S
T
M
C
A
VD
GP
AT
M YPNM GHE GPS MGQ EEF IMGP VDG PSVD GQR EFM KCD MTA EEFM KFG CGGA TCA AAG AAG GTC CAAA
F G
F
M
A
F
M
G
S
M
D
H
G
EE SH
MK EEFM DEE TAC QRT MGP EFMG EEF ACDE YPN KFG ACD YPN TAAG GGG GGTT ATC GGG GGT CTG
N D
G
K
G
H
C
G
A
VD SGYP AC DTA HQR KFG DEEF CDE TACD QRT QRS PNM PNM QRSG AGC GGTG GGG GCT GGT TGG AGCG 00
T
H
T
A
A
0
M
Y
G
M
G
T
R
D
G
C
G
A
FG
GY
CG
GQ FGHM DGI NMK YPN NMK GHMT GIM MKFG EFM QRS SHG EFM GTCA ATC CGGG CGC GAT CGG GCT 1101 1
V
E
G
D
G
0
P
E
A
P
G
A
K
N
A
F
G
1
HG
MR
AT
NM MGPS HGY DGS SGY NMK GPSV GYP TACD EFM FGH PQD GGG GCTA CAA CTAA CTA AAG CAA 101 0101 0
S
E
G
H
T
0
P
T
0
V
K
T
F
D
G
M
A
1
QR
VD
AG
EE GHMR GPS FMG SGY EEF HMRS GIM TACD PNM GPS GGG CAA CTAA AAA CAAA AGC CTA 001 110 1101 1
M
Y
A
D
C
1
D
T
0
E
M
G
F
D
T
1
G
G
QR
TC
00
MK DEEF CDE FMG TAC MKF GPSV GIM QRSG RTI AGA TAA AAA TAAG TAA AAGA AAA 001 101 101 1000 1
A
Q
C
D
C
1
N
G
0
E
A
1
C
G
A
M
C
1
QR
GC
11
TA IMDT CDE FGH GYP EEF GPSV EFM KFGH GTT AAA GCG AAG GCTG CGG GGGT 110 110 111 111 1011 0
G
A
0
E
G
1
D
A
1
K
C
0
G
M
G
M
C
0
RS
AA
10
VD IMDT PNM EDE FGH EEF DPQD YPN TGGG AAG GCT GTC AAG CTAA GTG 0111 101 010 010 001 0111 1
S G
K
G
1
D SHGY ACD PNM ACD PSV GSHG GGG GTCA AAA GGG GCT AAG ACGG 100 0101 101 010 100 101 0101
T
A
0
K
C
0
SV MR
C
0
G
A
0
NM RSGY HQR TIM SVD AAA GGGG GGT GGGT CAA GTC CAA 011 0100 110 1011 010 101 111 000
H YP
G
G
1
G
1
C
0
1
R
G
1
Q
C
0
FG HG
T
1
GP
AT
00
MG NMKF GHQ EFM AAT GGG GTGG AAA CTAA GGG CTA 010 111 0111 111 1101 010 010 110 111
S EF
T
1
1
MR DE
YP NMKF CDE AGC ATC CGG AATC AAG GGGT AAG 111 010 101 0111 001 0111 111 101 101 11
G
C
G
1
0
K
G
1
TA MRSH GYP PNM GAA TAA AGAT GCT GTCA AAC GCG 010 000 1010 101 1010 011 010 010 101 0101 1
H
A
1
A
0
1
C
0
0
Y
A
0
H
G
0
A
1
1
CG
01
00
FG VDGS RSG AAG AAG GCT GGAA GGG AATC CTA 000 001 010 1101 011 0001 101 010 011 010 1000 1
Q
G
T
1
0
A
1
1
T
1
0
S
T
1 101 Forment, septiembre 2012
C
0
0
CA
11
01
GP EFMG AGC AAT GAA AAG CGGG AGC CAAA 100 010 111 101 1110 111 1Javier 011 111 101 101 1010 1
0 1
M
A
1
0
A
0
A
1
0
T
1
1
T
0
1
Bioinformatics Core Services:
a bridge between biologists and software developers

2. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
E
T
M
EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
“Bioinformatics Core Services” boom.

3. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
E
T
M
EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
“Bioinformatics Core Services” boom.

4. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
E
T
M
EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
“Bioinformatics Core Services” boom.

5. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
E
T
M
EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
“Bioinformatics Core Services” boom.

6. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
E
T
M
EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
“Bioinformatics Core Services” mission.

7. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
E
T
M
EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
“Bioinformatics Core Services” mission.

8. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
E
T
M
EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
“Bioinformatics Core Services” mission.

9. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
F
S
E
Q
Y
P
P
D
R
TA GP
N
G
RT SGY GH PSV
MG
EF
GY- GPSV FMG GHQinfrastructure PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
computer DER MKF FMG G K MR D FM H Y
T
T
F
P
T
P
EF GQ
FM CDEE MKF DE
PN DEE EFM PNM GH MPQ DEE DGS RSG NMK IMG HQR GHM GIMD FMG ACD
M DEE A
N
C
F
G
E
P
GY
V
E
EF AC
DT HGYP MKA QRS TAC ACD SVDY NMK DGIM DPQ GPS MGQ SGY HQRT MKF NMKF SVD CDE HMT KA
M S
T
R
F
G
N
P
V
QR VDGI MR GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
E
H SH
G
S
F
M
E
C
N
E
M
S
R
H
F
G
CE
YP
DE NMKF KFG DEE
GP MKFG MRdata managementMGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
C P
M
- A
C
S
M
PN KFGH MDT HGY YPN MKA DEEF ACD FGHQ FGH DGI DPQ GSH GPSV EEF QRTA MGQ GQR GHM SVD TCGG
Y M
I
K
F
D N
T
D
C
N
D
P
S
V
M
H
K
Q
M
A
HG
SV
KF
P SVDG HMR MRS GYP VDP GHQR PNM YPNM GPS MGP PSV EEF DTAC KFG CDEE EEF PNM IMG AAG AAAG
G
M
D
G Y GP
M
C
Y
S
D
T
H
I
Y
G
A
F
M
C
SH
MG
RT
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
V
A
RT MGPS S
PN MKFG QanalysisVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY - data
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N- software development
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
S
D
P
D
F
F
A RSGY bioinformatics consultation DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
AC ACDE VDY NMK GIM NMK FMGP C
-T
A
1
T
MK GQ
A
A
0
QR QRT GPS GYP SVD GYP DEE DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
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1
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V - bioinformatics training
A
0
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1
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0
G
T
0
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0
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C
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“Bioinformatics Core” services provided.

10. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY- GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
Excel F DE M F
T
M
R
T
G
F
H
P
D
T
K
P
EF GQ
FM CDEE MK DE
PN DEE EFM PNM GHM MPQ DEEF DGS RSGY NMK IMG HQR GHM GIMD FMG ACD
M DEE A
N
C
F
G
E
P
GY
V
E
EF AC
DT HGYP MKA QRS TAC ACD SVDY NMK DGIM DPQ GPS MGQ SGY HQRT MKF NMKF SVD CDE HMT KA
M S
T
R
F
G
N
P
V
QR VDGI MR GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
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Q
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N
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M
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H
D
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M
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C
G
G
P
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F
G
M
P
F
G
SH
PS
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I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
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Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
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C
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FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
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M
G
S
T
G
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A
G
D
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C
G
T
A
PS
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SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
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A
A
0
E
G
C
E
G
A
P
G
D
C
G
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FG
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G
G
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1
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P
T
P
P
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P
A
G
A
1
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CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
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G
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G
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S
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D
T
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C
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MG
QR
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M C
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C
0
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A
1
T
C
T
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A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
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FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
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T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
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CG
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SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
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A
0
A
T
1
Q
T
0
G
T
0
H
A
0
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1
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GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
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G
0
1
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A
0
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A
1
G
1
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1
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CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
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AA
11
Regular computer skills of experimental researchers.

11. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY- GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
BLASTF DE M F
T
M
R
T
G
F
H
P
D
T
K
P
EF GQ
FM CDEE MK DE
PN DEE EFM PNM GHM MPQ DEEF DGS RSGY NMK IMG HQR GHM GIMD FMG ACD
M DEE A
N
C
F
G
E
P
GY
V
E
EF AC
DT HGYP MKA QRS TAC ACD SVDY NMK DGIM DPQ GPS MGQ SGY HQRT MKF NMKF SVD CDE HMT KA
M S
T
R
F
G
N
P
V
QR VDGI MR GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
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G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
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CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
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A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
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CT
11
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EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
Regular computer skills of experimental researchers.

12. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY- GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
CLUSTAL DE M F
T
M
R
T
G
F
H
P
D
T
K
P
EF GQ
FM CDEE MKF DE
PN DEE EFM PNM GHM MPQ DEEF DGS RSGY NMK IMG HQR GHM GIMD FMG ACD
M DEE A
N
C
F
G
E
P
GY
V
E
EF AC
DT HGYP MKA QRS TAC ACD SVDY NMK DGIM DPQ GPS MGQ SGY HQRT MKF NMKF SVD CDE HMT KA
M S
T
R
F
G
N
P
V
QR VDGI MR GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
Regular computer skills of experimental researchers.

13. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY- GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
VectorNTI DE M F
T
M
R
T
G
F
H
P
D
T
K
P
EF GQ
FM CDEE MKF DE
PN DEE EFM PNM GHM MPQ DEEF DGS RSGY NMK IMG HQR GHM GIMD FMG ACD
M DEE A
N
C
F
G
E
P
GY
V
E
EF AC
DT HGYP MKA QRS TAC ACD SVDY NMK DGIM DPQ GPS MGQ SGY HQRT MKF NMKF SVD CDE HMT KA
M S
T
R
F
G
N
P
V
QR VDGI MR GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
Regular computer skills of experimental researchers.

14. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
N
Y
DY NMKF GIM RSG ACgeneratingGmore thanP1TB RS GYP MsequencingDdata D MGP EFM
experiments D YPNMK MTAC VD I DGIMD RSHG Y NMK GQ ofS raw KFG FGHE RSHGY Q EE PSV P F E G
C
TA GPSV YP SVD GQ QRT SG
H
N
G
M
E
M
P
S
K
D
R
G
G
M RSG GP EFM GH ER MKFG MGP GPSV FGH RSH EEF MGQ HGYP PNM FGHM SVD TIM ACE TAC PSVD
M
K
P
EF GQ
F
Y
D
F
D
E
M PQD
R
M
K
N
S
G
KF
MT
M DEEF ACD PNM CDE GYP CDEE EEF YPNM FGH M+ DEE VDG QRSG PNM TIMG GHQ FGH GIM EFM TACD
M Q
A
D
T
K
F
EF AC
D
Y
S
S
E
MD SHGY NMK GQR RTA TAC PSVD PNM VDGI VDP MGP FMG RSG GHQR NMK PNMK PSV KCD GHM MKA
T GI
G
P
S
Y PS
P
R
Q
N
M
F
M
R
Y
QR VD
G
F
HQ
EE
KF
HM SHGY EEF KFG GHQ EFM QRSG Mtemporary ACD FMG NMK SHGY RSG EEFM YPN PNM GYP EEF
G IMGP CEE files
S FG
F
E
H
GP MK
MR TACD PNM NMK CDE FMG DEEF QRT HMTA MDT QDE GYP VDG FMGQ ACD QRSG SGY MRS PQD GG
H
N
A
D
Y
I
R
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
+S V H
D N
G
M
E
R
C
G
G
P
R
S
F
G
M
P
F
G
SH
P
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
processed data H
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RS VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM +EF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
E M
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PN DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
RAM memory-hungry software C
S
G
G
E
M
G
S
T
G
E
A
G
D
E
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
=N
T
T
Q QRTA GYP GHM SVD VDG HMRS GYP EFMG GYP GYP GYP TAA AATC AAA AAAG TAA AGC GAT 011 0101
G H
S
C
G
M G
C
1
F MGP PS FG
H
A
E
C
0
T
RS
AA
SH
SH
F EDER NMKBIG COMPUTERSDNEEDED:GQ AAG TGC AGCG GGT AAAG TCA GTT 010 100 1111
F FMG MK HMR AC HMR VDGS M
K D
P
G
M C
T
G
N
C
0
EE E
F
G
G
G
G
A
0
CA
01
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
A
1
T
T
MK GQ
A
A
0
SV YPN
PN EEF TAC
TA C RAM
QR QRTA GPSeveralVD GYhard-disk TGGG CGB AA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
D G + 32
G GPS TB CD
M
G
1
M
C
S
G
0
S
T
1
H
1
EF KF
C
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
Modern Biology requirements: hardware (I).

15. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
F
P
M
F
PS DE
K
G
Y
P
Very high D RSHGY PNMK GQ S GYPN
DY NMKF GIM RSG ACD PNM MTAC DGI GIMprocessingRtime MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
M
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
E
T
EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK weeks D/ months)SGY NMKF MGP HQRT HMT IMD MGP CD
(days / FGHMR MPQ DEEFM DGSH R
E
M
Y
F
N
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MK GIM PQ PSV MGQ GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
S
E
N
E
H
S
G
EE MKF FG EEF QR FMG TIM + CE TAC EF PNM SH sequence YP
GP MKFG MRS ACD 300,000,000MsequencesMTA 1/10 second per MGQR CDE RSG GYP RSH PQDE G
G EE
G
N NMK CD F
D QDE GY VD
R
P
S
PN KFGH MDT HGY YP MKA DEE ACD FGHQ FGH DGI DP GSH GPS EEF QRTA MGQ GQR GHM SVD TCGG
=M V D M
Y M
I
F
D N
T
D
C
N
P
S
M
H
K NMK SV
Q
A
HG
S
KF
P SVDG HMR MRS GYP VDP GHQR PNM YP10 GP60 GP60 SV24 F DTAC KFG CDEE EEF PNM IMG AAG AAAG
E = 347.22 days
P/ E
300,000,000
G Y GP
FG FGH RSH GPS KF HGY RSG / EFM /RTIM /FMG ACD IM PNM DTA ACD SGY QRT GTT GC AGC
K
M
M
G
A
M
E
H
EF YPNM NMK FGH TIM PSN VDGS MGQ ACDE GHQ CDE HMT SVD SHGY GIM IMDT GQR KFG GGG CAA TCAA G
P
F
M
F
D
C
G
P
T
K
K
M
D
T
G
S
R
G
QR
FG
TG
SV RSGY PNM FGH EFM MGP CDEE HQR PNMK PNM NMK FMG GHM GPSV SVD DEEF YPN GGG GGG GGG CAAA A
Y
Y
G
P
A
F
G
F
K
P
C
Q
Q
A KFG GY
M
T
GH
EE
GG
NM QRSG PNM MKF DEE MDT AffordableSsolution: computing G VDP DGSH AAA GGT GGT TAA GGTC A
H QR G SGY ACD NMK EEF EFM clusters
M GS
N
P
G
C
MG SHGY YPN MTA DGI GYP SVD FMG MGQR QRT SGY GHD CDE MGPS PSV AATC TCG ATC AGC GGG GCTA
F G
G
H
A
E
G
G
A
T
H
R
G
H
F
T
P
I
A
SV
KF
AA
VD GQRS KFG MGP MRS FMG ACDE DEE MKFG EDE PNM QRT QRT EEFM AGC TAAG TAA CGG GGG GAA GGGG
D
C
M
PS FM
C
A
0
E
H
G
F
Y
G
N
C
D
T
T
GH
GH
AC
E GYPN DEE MKF CDE IMD MDTA GYP MKAC RSG MKF KFG MKC CGGA AAG AAAG TAA CAA AGC GGG 1110
A
M
A
C
Q
C
0
DE R S
H
A
G
N
C
TA GYPN HMT SVD DGI MRS GYPN FMG GYPN YPN GYP AAG ATC AAAG AAG TAAT GCT GAT 111 101
Q QR
G
G
A
E
A
H
A
0
P
S
A
S
H
C
H
G
M G GH
SV
CT
10
ER NMKF FMG MGP KFG MRS ACDE MRS DGSH GQR AAG GCT GCG GGTC AAG TCAA TTA 010 000 111
F ED
M
1
T
MK CD
YP CDEE EEF YPN FGH MDT KFGH PSV EEFM TCA CGC TAA GGG CGGA GGG GGGG 101 110 101 11
G
A
K
C
0
D
G
1
MK GQRS RTA TAC SVD PNM VDGI PNM EFMG ACD GGG AAG AAG CGGT AAG GTGG GTG 010 010 001 1000 0
Q
T
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Modern Biology requirements: hardware (II).

16. G
V
S
S
G
M
F
Q
G
F
F
Q
F
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D
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PS DE
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11
Modern Biology requirements: network accessibility.

17. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
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F
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GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
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PS DE
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Modern Biology requirements: operating system

18. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
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F
P
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QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C GG
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA Tversus CAA TCG CTA GGGT GGG 1101 010 000 110 010
G GCTA
M GH
M
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
Modern Biology requirements: software

19. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS - FASTA format M
E
T
M
EF GQ
FM CDEE MKF DED PN EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
Modern Biology requirements: direct data manipulation

20. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS - GenBank format
E
T
M
EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
Modern Biology requirements: direct data manipulation

21. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS - EMBL format M
E
T
M
EF GQ
FM CDEE MKF DED PN EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
Modern Biology requirements: direct data manipulation

22. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS - fastq format
E
T
M
EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
T
C
T
MK GQ
N
A
N
A
0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
H
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
Modern Biology requirements: direct data manipulation

23. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS - Perl
E
T
M
EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
G
M
E
R
C
G
G
P
V
R
S
F
G
M
P
F
G
SH
PS
MK
YP PSVD GHM HMR HGY SVD FGHQ YPN GYPN MGP IMG GPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
S
A
M
G
N
P
SV RS
V
-NPythonF GP E Q
HM
GG
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
FG
FG
AA
EE SGYP CDE NMK ACD GIM IMDT HGY NMKA QRS NMK MKF NMK GCGG AAA GAAA CTA TCA AAG CGG 1111 0
D R
A
G
G
S
C
1
D
P
T
P
P
A
P
A
G
A
1
MT
PN
CT
GQ HQRT SGY FGH PSV SVD GHMR HGY EEFM HGY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
M G
R
S
G
S
G
1
P
G
0
K
S
A
D
T
F
C
0
MG
QR
TA
KF DEDE PNM EEF FMG NMK GHMR TAC GHMR VDG FMG AAA CTG AAGC GGG GAAA GTC GGT 101 010 0111
M C
E
C
0
A RSGY ACD CDE DYP MKF GIMD MKF MGPS DEE GGT GCG GCT GTGG GCG GGGG GGG 011 011 101 0011
V
A
1
C
T
MK GQ
N
A
N
A
0
-T R
QR R TA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
M
G
1
M
C
S
G
0
S
T
1
HQ
G
1
EF KF
C
C
GP
AA
11
FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
M MK
N
N
A
0
M
G
0
YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
G
0
G
0
1
G
A
0
I
A
1
G
1
T
1
1
KF
CT
11
Javier 010
EF MGPS QRT PNM AGC GGG GAAA GGG GATC AGC AAG CTA 110 1100 010 0010 Forment, 1 100 02012 1010
0septiembre 10
H I
G
1
1
1
C
1
Y
A
00 10
A
1
G
1
1
TA
TG
GH
AA
11
Modern Biology requirements: programming skills

24. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
R
Q
V
F
Y
S
E
Q
Y
P
P
D
R
TA GP
H
N
G
RT
MG
EF
GY GPSV FMG GHQ RSG KFG MGPS PSV FGHM SHG EEF GQR GYP PNMK GHM SVDP IMG ACE ACD SVD
M RS
E
T
M
EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
E
M
Y
D
F
N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
N
M
A
S
K
Q
G
C
H
D
N
T
S
H
R
F
G
NM
PS
VD
QR VDGI MRS GYP FMG GHQ HQRT MGP SGYP PSV GPS EFM DEE MGQR KFG GYPN GYP FMG NMK MKF YPNM F
H
G
S
F
M
E
F
C
N
E
H
M
S
R
H
G
F
G
EE
CE
YP
GP MKFG MRS ACD NMK MKF CDEE MGQ EEFM RTI MTA DTA DEE GYPN DGS MGQR CDE RSG GYP RSH PQDE G
H
A
Q
F
V
G
N
Q
M
T
H
Q
N
D
F
A
H
D
YP
IM
RS
YP MKFG IMD SHG GYP NMK QDEE TAC KFGH KFG VDG VDP DGS MGPS DEE HQRT FMG MGQ FGH PSV ATCG C
D N
S
G
M PS
E
R
C
G
G
P
V
R
F
G
M
P
F
G
SH
MK
G IMGP G programs:
YP PSVD - HM HMR HGY SVD FGHQ YPN GYPN UniversityPS DEE MDTA MKF ACDE DEE YPN TIM TAA CAAA C
G progressively included in M
G G
S
M
R
M NMKF KFG HMR MGP NMK GSHG QRS DEEF QRT EEF TAC DGI GYPN MDT DTAC RSG GHQ GGT AAG AAAG
I
M
G
M
H
Q
EF YP
G
I
S
V
A
PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
D GY
H
K
G
M
E
E
S
A
F
M
G
N
N
P
SV RS
Q
V
HM
GG
GP
YP MKFG GHE EFM ACD FGH GYPN GYP YPNM EEF KFG MGP GPS PQDE HGY ACGG GGG TGG TCA CAA
Q SG
T
F
A
NM QR
PN NMKF CDE IMD NMK GSH GQRS RSG TACD PNM DEE EFM SVD VDGS CAA GGGT GGG CTA GGT AA
Y
G
E
G
P
- use of Linux
Y
C
A
FM GSHG GYP HMT VDG HGY PSVD EFM FMGQ HQR RSG FGH ACD IMGP GPS TAAT ATC GAT AAG TGG AGCT G
S
G
G
E
M
G
S
T
G
E
A
G
D
E
C
G
T
A
PS
MK
GA
SV MGQR MKF FMG HMR EFM TACD CDE NMKF DED YPN HQR HQR DEEF AAG CTAA CTA GCG CGG GGA TGGG 0
P F
C
G
N
A
A
0
E
G
C
E
G
A
P
G
D
C
G
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G
G
S YP
C
1
D
P
T
P
P
A
A
G
A
1
MT
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GQ HQRT SGY - GH PSV SVD GHMR language GY HGY SGY CTA TAAT GAA CAAA CTA AAG AGA 101 0010
G EEFM H
M G
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M C
T
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0
E
F
G
G
G
G
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0
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CA
01
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V
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MK GQ
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0
QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
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1
M
C
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G
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T
1
H
G
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M MK
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0
G
0
YP YPN KAC EEF CD GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
M
T
1
M
T
1
S
A
1
D
G
1
G
A
A
F
A
1
TA
CG
10
SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
A
0
A
T
1
Q
T
0
G
T
0
H
A
0
C
A
1
FM
GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
0
TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
V
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0
G
0
1
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0
I
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1
G
1
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Biologists must have computer skills...

25. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
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D
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H
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MG
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M RS
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T
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EF GQ
FM CDEE MKF DED PNM EEF EFMG NMK GHMR PQD EEF GSH SGY NMKF MGP HQRT HMT IMD MGP CD
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M
Y
D
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N
M
G
EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M - reusability ofRhardware and softwareG
N
M
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H
G
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M
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C
N
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H
M
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R
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PN MKFG QRT MGP SVD EFM RTAC KFG MKCD FGH GPS RSH VDG DGIM FMG NMKF TGG GTC GTC ACG
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V and cost-effective R
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K D
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T
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G
G
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V
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QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH
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S
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G
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FG DEEF GQR EFM MQR MTA VDGI CGG CAAA GGG GCT AAG GAT CAAA 110 0010 100 011 000 101
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0
M
G
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YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
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T
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1
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D
G
1
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F
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V
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1
Q
T
0
G
T
0
H
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0
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1
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GG
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C
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TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
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H I
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1
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… or use centralized core services.

26. G
V
S
S
G
M
F
Q
G
F
F
Q
F
P
H
K
F
P
T
E
GH EEFM QRS FMG EEF KFG EDER NMK MGPS DEE HQR NMK PNM NMKF FMG GHMR NMK ACD FMG DEE DYP
F D
D
P
E
G
C
P
P
E
M
Y
C
MK AC
FM CDEE TAC YPN ACD SGY DEEF DTA MKFG HGY RSG GYP CDE NMKF HGY PNMK QDE RTA PSV RS
E
K
K
S
G
D
S
P
NM PQDE RTA GIM SHG PNM MGQR TAC DGIM YPN VDG MGQ GQR QRTA GYP HMRS HGY SVD GHQ EFM PNMQ R
Q
G
S
M
S
Q
Y
M
E
D
S
P
D
V
G
F
H
Y
MR
EF
KF
SV KFGH PSV FGH SHG DEE KFGH GPS MRSH MGP CDE EEF KFG EDER MKF GHMR IMG SNM ACD RSG EFMG S
R
D
K
NM EFMG NMK GHM TAC PNM EEFM FGH DEEF DTA TAC PNM ACD GYPN MKF HQRT MGP PNM MGQ QDE SVDG
D
Y
F
P
M
F
PS DE
K
G
N
Y
K
P
DY NMKF GIM RSG ACD PNM MTAC DGI GIMD SHG PNM QRS GYP MKFG GHE SHGY DEE SVD MGP EFM
C SV
D
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Q
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Q
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P
P
D
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H
N
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RT
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T
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FM someMKF Daway M EEF EFMG NMK GHMR requirementsGY NMKF MGP HQRT HMT IMD MGP CD
DE N far ED YPN from day-to-day MPQD EEF DGS S
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F
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EF ACDE DTA GYP KAC RSG TACD CDE VDYP MKF GIM PQD PSV MGQR GYP QRTI KFG MKF VDG DEE HMTA A
M
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H
F
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NM MGQ QR RTA PS YPN SVD
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M
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N
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moreR TIMG PSNM DGSH MGQR ACDE thanC F H S
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PS FMG NMK EFM GHM EEF DTAC ACD PNMK CDE GYP GHQ GHQ CDEE AAA GCTA GCT AGC ACG CGG GTGG 00
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QR QRTA GPS GYP SVD GYP DEEF DTA TGGG CTA CAA TCG CTA GGGT GGG 1101 010 000 110 010
M GH - more interested in more academically profitable work
M
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G
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YP YPN KAC EEF CDE GYP MGQR GPS AGAT AAG GTG GAA AGC GCTA AAT 1010 111 011 101 100 1100 11
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SH GYPN DPQ HQR GQR DEE DEEF GCT AAGC ACG AAG TCA CAA AAGC AAG 1011 011 110 010 111 0010 01
V
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0
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T
1
Q
T
0
G
T
0
H
A
0
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1
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GG
00
RS MGPS MKF DEE VDP RTA AGAA GTC ATCA AGC GGG TAA CGG AAGC 101 1010 101 010 101 110 0101 1
S
C
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TI GPSN DPQ MGP GHQ GAA GGGG CTA TCAA GGT AAG AAG TCA 0110 110 1011 001 101 010 111 1010
R M
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1
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H I
G
1
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11
Collaboration with bioinformatics research groups.