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Genetics mendelian.ppt
1. Genetics
â˘âŻ Gregor Mendel
â⯠Documented a particulate mechanism of
inheritance through his experiments with
garden peas
PowerPoint Lectures for
Biology, Seventh Edition
Neil Campbell and Jane Reece
Figure 14.1
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Copyright Š 2005 Pearson Education, Inc. publishing as Benjamin Cummings
1
2. â˘âŻ Mendel used the scientific approach to identify
two laws of inheritance
â˘âŻ Mendel discovered the basic principles of
heredity
â˘âŻ Crossing pea plants
1
APPLICATION By crossing (mating) two true-breeding
varieties of an organism, scientists can study patterns of
inheritance. In this example, Mendel crossed pea plants
that varied in flower color.
TECHNIQUE
Removed stamens
from purple flower
2 Transferred sperm-
bearing pollen from
stamens of white
flower to eggbearing carpel of
purple flower
Parental
generation
(P)
â⯠By breeding garden peas in carefully planned
experiments
3 Pollinated carpel
Stamens
Carpel (male)
(female)
matured into pod
4 Planted seeds
from pod
When pollen from a white flower fertilizes
TECHNIQUE
RESULTS
eggs of a purple flower, the first-generation hybrids all have purple
flowers. The result is the same for the reciprocal cross, the transfer First
generation
of pollen from purple flowers to white flowers.
offspring
(F1)
5 Examined
offspring:
all purple
flowers
Figure 14.2
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Copyright Š 2005 Pearson Education, Inc. publishing as Benjamin Cummings
2
3. â˘âŻ Some genetic vocabulary
â⯠Character: a heritable feature, such as flower
color
â⯠Trait: a variant of a character, such as purple
or white flowers
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â˘âŻ In a typical breeding experiment
â⯠Mendel mated two contrasting, true-breeding
varieties, a process called hybridization
â˘âŻ The true-breeding parents
â⯠Are called the P generation
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3
4. The Law of Segregation
â˘âŻ The hybrid offspring of the P generation
â⯠Are called the F1 generation
â˘âŻ When F1 individuals self-pollinate
â⯠The F2 generation is produced
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â˘âŻ When Mendel crossed contrasting, truebreeding white and purple flowered pea plants
â⯠All of the offspring were purple
â˘âŻ When Mendel crossed the F1 plants
â⯠Many of the plants had purple flowers, but
some had white flowers
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4
5. â˘âŻ Mendel discovered
â˘âŻ Mendel reasoned that
â⯠A ratio of about three to one, purple to white flowers,
in the F2 generation
EXPERIMENT True-breeding purple-flowered pea plants and
white-flowered pea plants were crossed (symbolized by Ă). The
resulting F1 hybrids were allowed to self-pollinate or were crosspollinated with other F1 hybrids. Flower color was then observed
in the F2 generation.
P Generation
(true-breeding
parents)
Ă
Purple
flowers
White
flowers
â⯠In the F1 plants, only the purple flower factor
was affecting flower color in these hybrids
â⯠Purple flower color was dominant, and white
flower color was recessive
F1 Generation
(hybrids)
All plants had
purple flowers
RESULTS Both purple-flowered plants and whiteflowered plants appeared in the F2 generation. In Mendelâs
experiment, 705 plants had purple flowers, and 224 had white
flowers, a ratio of about 3 purple : 1 white.
F2 Generation
Figure 14.3
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Copyright Š 2005 Pearson Education, Inc. publishing as Benjamin Cummings
5
6. Mendelâs Model
â˘âŻ Mendel observed the same pattern
â⯠In many other pea plant characters
â˘âŻ Mendel developed a hypothesis
â⯠To explain the 3:1 inheritance pattern that he
observed among the F2 offspring
â˘âŻ Four related concepts make up this model
Table 14.1
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Copyright Š 2005 Pearson Education, Inc. publishing as Benjamin Cummings
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7. â˘âŻ First, alternative versions of genes
â˘âŻ Second, for each character
â⯠Account for variations in inherited characters,
which are now called alleles
â⯠A genetic locus is actually represented twice
Allele for purple flowers
Locus for flower-color gene
Figure 14.4
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â⯠An organism inherits two alleles, one from
each parent
Homologous
pair of
chromosomes
Allele for white flowers
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7
8. â˘âŻ Third, if the two alleles at a locus differ
â⯠Then one, the dominant allele, determines the
organismâs appearance
â⯠The other allele, the recessive allele, has no
noticeable effect on the organismâs
appearance
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â˘âŻ Fourth, the law of segregation
â⯠The two alleles for a heritable character
separate (segregate) during gamete formation
and end up in different gametes
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9. â˘âŻ Does Mendelâs segregation model account for
the 3:1 ratio he observed in the F2 generation
of his numerous crosses?
â˘âŻ Mendelâs law of segregation, probability and
the Punnett square
Each true-breeding plant of the
parental generation has identical
alleles, PP or pp.
Gametes (circles) each contain only
one allele for the flower-color gene.
In this case, every gamete produced
by one parent has the same allele.
â⯠We can answer this question using a Punnett
square
P Generation
Ă
Appearance:
Purple flowers White flowers
Genetic makeup:
PP
pp
Gametes:
p
P
Union of the parental gametes
produces F1 hybrids having a Pp
combination. Because the purpleflower allele is dominant, all
these hybrids have purple flowers.
F1 Generation
When the hybrid plants produce
gametes, the two alleles segregate,
half the gametes receiving the P
allele and the other half the p allele.
Gametes:
This box, a Punnett square, shows
all possible combinations of alleles
in offspring that result from an
F1 Ă F1 (Pp Ă Pp) cross. Each square
represents an equally probable product
of fertilization. For example, the bottom
left box shows the genetic combination
resulting from a p egg fertilized by
a P sperm.
Appearance:
Genetic makeup:
Purple flowers
Pp
1/ p
2
1/
2 P
F1 sperm
P
p
PP
Pp
F2 Generation
P
F1 eggs
p
pp
Pp
Figure 14.5
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Random combination of the gametes
results in the 3:1 ratio that Mendel
observed in the F2 generation.
3
:1
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10. Useful Genetic Vocabulary
â˘âŻ An organism that is homozygous for a
particular gene
â⯠Has a pair of identical alleles for that gene
â⯠Exhibits true-breeding
â˘âŻ An organismâs phenotype
â⯠Is its physical appearance
â˘âŻ An organismâs genotype
â⯠Is its genetic makeup
â˘âŻ An organism that is heterozygous for a
particular gene
â⯠Has a pair of alleles that are different for that
gene
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Copyright Š 2005 Pearson Education, Inc. publishing as Benjamin Cummings
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11. The Testcross
â˘âŻ Phenotype versus genotype
Phenotype
Purple
3
Purple
â˘âŻ In pea plants with purple flowers
Genotype
PP
(homozygous)
â⯠The genotype is not immediately obvious
1
Pp
(heterozygous)
2
Pp
(heterozygous)
Purple
1
Figure 14.6
White
pp
(homozygous)
Ratio 3:1
Ratio 1:2:1
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12. â˘âŻ A testcross
â⯠Allows us to determine the genotype of an
organism with the dominant phenotype, but
unknown genotype
â⯠Crosses an individual with the dominant
phenotype with an individual that is
homozygous recessive for a trait
â˘âŻ The testcross
APPLICATION An organism that exhibits a dominant trait,
such as purple flowers in pea plants, can be either homozygous for
the dominant allele or heterozygous. To determine the organismâs
genotype, geneticists can perform a testcross.
Ă
Dominant phenotype,
unknown genotype:
PP or Pp?
Recessive phenotype,
known genotype:
pp
If PP,
then all offspring
purple:
TECHNIQUE In a testcross, the individual with the
unknown genotype is crossed with a homozygous individual
expressing the recessive trait (white flowers in this example).
By observing the phenotypes of the offspring resulting from this
cross, we can deduce the genotype of the purple-flowered
parent.
If Pp,
then 1â2 offspring purple
and 1â2 offspring white:
p
p
p
p
Pp
Pp
pp
pp
RESULTS
P
Pp
P
Pp
P
p
Pp
Pp
Figure 14.7
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13. The Law of Independent Assortment
â˘âŻ Mendel derived the law of segregation
â⯠By following a single trait
â˘âŻ The F1 offspring produced in this cross
â⯠Were monohybrids, heterozygous for one
character
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â˘âŻ Mendel identified his second law of inheritance
â⯠By following two characters at the same time
â˘âŻ Crossing two, true-breeding parents differing in
two characters
â⯠Produces dihybrids in the F1 generation,
heterozygous for both characters
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14. â˘âŻ How are two characters transmitted from
parents to offspring?
â⯠As a package?
â⯠Independently?
â˘âŻ A dihybrid cross
â⯠Illustrates the inheritance of two characters
â˘âŻ Produces four phenotypes in the F2 generation
EXPERIMENT Two true-breeding pea plantsâ
one with yellow-round seeds and the other with
green-wrinkled seedsâwere crossed, producing
dihybrid F1 plants. Self-pollination of the F1 dihybrids,
which are heterozygous for both characters,
produced the F2 generation. The two hypotheses
predict different phenotypic ratios. Note that yellow
color (Y) and round shape (R) are dominant.
P Generation
YYRR
yyrr
Gametes
F1 Generation
YR
Ă
Hypothesis of
dependent
assortment
yr
YyRr
Hypothesis of
independent
assortment
Sperm
RESULTS
1â YR
2
CONCLUSION The results support the hypothesis of
independent assortment. The alleles for seed color and seed
shape sort into gametes independently of each other.
Sperm
yr
1â
2
Eggs
1
F2 Generation â2YR YYRR YyRr
(predicted
offspring)
1 â yr
2
YyRr yyrr
3â
4
1â
4
1â
4
Yr
1 â yR
4
1â
4
Phenotypic ratio 3:1
YR
1 â Yr
4
1 â yR
4
Eggs
1 â YR
4
1â
4
yr
9â
16
1â
4
yr
YYRR YYRr YyRR YyRr
YYrr
YYrr
YyRr
Yyrr
YyRR YyRr yyRR yyRr
YyRr
3â
16
Yyrr
yyRr
3â
16
yyrr
1â
16
Phenotypic ratio 9:3:3:1
Figure 14.8
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108
101
32
Phenotypic ratio approximately 9:3:3:1
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15. â˘âŻ Using the information from a dihybrid cross,
Mendel developed the law of independent
assortment
â⯠Each pair of alleles segregates independently
during gamete formation
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â˘âŻ The laws of probability govern Mendelian
inheritance
â˘âŻ Mendelâs laws of segregation and independent
assortment
â⯠Reflect the rules of probability
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16. The Multiplication and Addition Rules Applied to
Monohybrid Crosses
â˘âŻ The multiplication rule
â˘âŻ Probability in a monohybrid cross
â⯠Can be determined using this rule
â⯠States that the probability that two or more
independent events will occur together is the
product of their individual probabilities
Rr
Rr
Ă
Ă
Segregation of
alleles into eggs
Segregation of
alleles into sperm
Sperm
R
1â
2
R
R
1â
2
r
Figure 14.9
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1â
4
1â
4
r
r
R
R
Eggs
1â
2
r
1â
2
R
1â
4
r
r
1â
4
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17. â˘âŻ The rule of addition
â⯠States that the probability that any one of two
or more exclusive events will occur is
calculated by adding together their individual
probabilities
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Solving Complex Genetics Problems with the Rules
of Probability
â˘âŻ We can apply the rules of probability
â⯠To predict the outcome of crosses involving
multiple characters
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18. â˘âŻ A dihybrid or other multicharacter cross
â⯠Is equivalent to two or more independent
monohybrid crosses occurring simultaneously
â˘âŻ In calculating the chances for various
genotypes from such crosses
â˘âŻ Inheritance patterns are often more complex
than predicted by simple Mendelian genetics
â˘âŻ The relationship between genotype and
phenotype is rarely simple
â⯠Each character first is considered separately
and then the individual probabilities are
multiplied together
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19. Extending Mendelian Genetics for a Single Gene
The Spectrum of Dominance
â˘âŻ The inheritance of characters by a single gene
â˘âŻ Complete dominance
â⯠May deviate from simple Mendelian patterns
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â⯠Occurs when the phenotypes of the
heterozygote and dominant homozygote are
identical
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20. â˘âŻ In codominance
â⯠Two dominant alleles affect the phenotype in
separate, distinguishable ways
â˘âŻ In incomplete dominance
â⯠The phenotype of F1 hybrids is somewhere between
the phenotypes of the two parental varieties
P Generation
Red
C RC R
â˘âŻ The human blood group MN
White
CWCW
Ă
Gametes CR
CW
â⯠Is an example of codominance
Pink
C RC W
F1 Generation
Gametes
Eggs
F2 Generation
Figure 14.10
CR
1â
2
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1â
2
Cw
1â
2
1â
2
CR
1â
2
CR
CR 1â2 CR
Sperm
CR CR CR CW
CR CW CW CW
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21. Multiple Alleles
â˘âŻ The Relation Between Dominance and
Phenotype
â˘âŻ Most genes exist in populations
â⯠In more than two allelic forms
â˘âŻ Dominant and recessive alleles
â⯠Do not really âinteractâ
â⯠Lead to synthesis of different proteins that
produce a phenotype
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22. â˘âŻ The ABO blood group in humans
â⯠Is determined by multiple alleles
pleiotropy- single gene controls more than one
character
eg. one gene affects corolla, anther, calyx, leaf
and capsule of tobacco
Table 14.2
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23. Epistasis
â˘âŻ In epistasis
Epistasis â Cucurbita pepo
â⯠A gene at one locus alters the phenotypic
expression of a gene at a second locus
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24. Extending Mendelian Genetics for Two or More Genes
â˘âŻ An example of epistasis
BbCc
â˘âŻ Some traits
Ă
â⯠May be determined by two or more genes
BbCc
Sperm
1â
4
BC
1â
4
bC
1â
4
Bc
1â
4
bc
Eggs
1â
4
BC
BBCC
BbCC
BBCc
BbCc
1â
4
bC
BbCC
bbCC
BbCc
bbCc
1â
4
Bc
BBCc
BbCc
BBcc
1â
4
bc
BbCc
bbCc
Bbcc
9â
16
3â
16
Bbcc
bbcc
4â
16
Figure 14.11
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25. Polygenic Inheritance
Polygenic inheritance
â˘âŻ Many human characters
â⯠Vary in the population along a continuum and
are called quantitative characters
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26. â˘âŻ Quantitative variation usually indicates
polygenic inheritance
â⯠An additive effect of two or more genes on a
single phenotype
AaBbCc
Ă
AaBbCc
aabbcc Aabbcc AaBbcc AaBbCc AABbCc AABBCc AABBCC
Fraction of progeny
20â
64
15â
64
Figure 14.12
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6â
64
1â
64
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27. Linked genes- genes are on the same
chromosome
â˘âŻ Eukaryotic cells store hereditary information in
the nucleus
â˘âŻ Nucleid acids- DNA
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â˘âŻ Transfer of nucleic acids Ă ď transfer of
hereditary traits
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28. DNA STRUCTURE
Chargaffâs rule
â˘âŻ Polymer of nucleotide
â˘âŻ nucleotide
â⯠Sugar + phophate
group + nitrogen
containing bases
â˘âŻ Nitrogen containing bases
â⯠PURINE- G and A
PYRIMIDINE- C and U
(RNA) or T (DNA)
ÂĄďĄâŻ
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A= T; G=C
Equal proportion of purines and pyrimidines
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ÂĄďĄâŻ
28
29. DNA
DNA REPLICATION
â˘âŻ Double helix structure
â˘âŻ During S-phase
â˘âŻ Anti parallel
â˘âŻ Semi-conservative
ÂĄďĄâŻ
2 chains of nucleotides held by
H-bond
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30. DNA polymerase
Okazaki
â˘âŻ Need primers (RNA)
â⯠Will be replaced later
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â˘âŻ Synthesis is
discontinuous
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31. THE CENTRAL DOGMA TRACES
THE FLOW OF GENE-ENCODED
INFORMATION
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32. Central Dogma
â˘âŻ Most hereditary traits
reflect the action of
enzymes
â˘âŻ Info for the structure of
an enzyme Ă ď DNA
â˘âŻ GENE
â⯠Specific region in the
DNA that codes for
an enzyme
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33. The Products of Gene Expression: A Developing Story
Basic Principles of Transcription and Translation
â˘âŻ As researchers learned more about proteins
â˘âŻ Transcription
â⯠The made minor revision to the one geneâone
enzyme hypothesis
â˘âŻ Genes code for polypeptide chains or for RNA
molecules
â⯠Is the synthesis of RNA under the direction of
DNA
â⯠Produces messenger RNA (mRNA)
â˘âŻ Translation
â⯠Is the actual synthesis of a polypeptide, which
occurs under the direction of mRNA
â⯠Occurs on ribosomes
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34. â˘âŻ In eukaryotes
â˘âŻ In prokaryotes
â⯠Transcription and translation occur together
â⯠RNA transcripts are modified before becoming true
mRNA
Nuclear
envelope
TRANSCRIPTION
DNA
DNA
TRANSCRIPTION
mRNA
Ribosome
Pre-mRNA
RNA PROCESSING
TRANSLATION
mRNA
Polypeptide
Ribosome
(a) Prokaryotic cell. In a cell lacking a nucleus, mRNA
produced by transcription is immediately translated
without additional processing.
Figure 17.3a
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TRANSLATION
Polypeptide
Figure 17.3b
(b) Eukaryotic cell. The nucleus provides a separate
compartment for transcription. The original RNA
transcript, called pre-mRNA, is processed in various
ways before leaving the nucleus as mRNA.
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35. TRANSCRIPTION
Heterogeneous nuclear RNA (hnRNA)
â˘âŻ DNA sequence in the
gene is transcribed into an
RNA sequence
â˘âŻ RNA polymerase
â˘âŻ promoter
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36. Ribonucleic acid (RNA)
Codons
â˘âŻ Messenger RNA (mRNA)
â˘âŻ DNA encodes for sequence of a.a. in proteins
â⯠Transcripts of gene used to direct a.a.
assembly into proteins
â˘âŻ Ribosomal RNA (rRNA)
â˘âŻ DNA Ă ď mRNA transcripts
â˘âŻ Ribosomes read sequence in increments of 3
nucleotides Ă ď CODON
â⯠Combine with proteins to make up the
ribosomes
â˘âŻ Transfer RNA (tRNA)
â⯠Transport a.a. to ribosomes
â˘âŻ GATTACA A A
(DNA)
â˘âŻ CUAAUGU U U (mRNA)
â˘âŻ CUA-AUG-UUU
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37. TRANSLATION
â˘âŻ The ribosome has three binding sites for tRNA
â˘âŻ mRNA transcript is translated into a.a.
â⯠The P site
â˘âŻ mRNA binds with rRNA in ribosomes
â⯠The A site
â˘âŻ One codon is exposed at a time
â⯠The E site
P site (Peptidyl-tRNA
binding site)
A site (AminoacyltRNA binding site)
E site
(Exit site)
Large
subunit
E
mRNA
binding site
Figure 17.16b
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P
A
Small
subunit
(b) Schematic model showing binding sites. A ribosome has an mRNA
binding site and three tRNA binding sites, known as the A, P, and E sites.
This schematic ribosome will appear in later diagrams.
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38. tRNA
The GENETIC code
â˘âŻ Carries a
particular a.a.
â˘âŻ Anticodon
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39. Translocation
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40. Termination
â˘âŻ When nonsense codon is exposed
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41. â˘âŻ The norm of reaction
â⯠Is the phenotypic range of a particular
genotype that is influenced by the environment
Figure 14.13
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42. Integrating a Mendelian View of Heredity and Variation
â˘âŻ Multifactorial characters
â⯠Are those that are influenced by both genetic
and environmental factors
â˘âŻ An organismâs phenotype
â⯠Includes its physical appearance, internal
anatomy, physiology, and behavior
â⯠Reflects its overall genotype and unique
environmental history
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