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DNA repair and prostate cancer
- 1. Genetic Variants of DNA Repair genes and Prostate Cancer: Department of Epidemiology and Biostatistics George Washington University July 2003 A Population-Based Case-Control Study in China Jamie D. Ritchey
- 3. The Male urinary and reproductive system
- 4. International Patterns Hsing, Tsao, and Devesa, International Journal of Cancer, 2000. African American men Chinese men in China
- 7. Single Nucleotide Polymorphisms (SNPs) Greenhut, Kerrigan, and Kelly, http://press2.nci.nih.gov/sciencebehind/snps_cancer/snps_cancer/snps_ , 2003. Change in shape Altered Cancer Risk SNP: Decreased DNA repair capacity Genomic instability Oncogene activation Inactivate Tumor suppressors Loss of heterozygosity
- 10. Environmental Factors (Diet) + SNP of DNA repair genes = latent effects increasing prostate cancer risk ? Greenhut, Kerrigan, and Kelly, http://press2.nci.nih.gov/sciencebehind/snps_ cancer/snps_cancer/snps_ , 2003.
- 13. Shanghai Prostate Cancer Study Study Design 268 Prostate cancer cases Interview 191 Cases Genotyped 305 controls Genotyped 495 Population Controls 243 cases interviewed 472 controls interviewed 200 cases provided 20 ml fasting blood 330 controls provided 20 ml of fasting blood
- 14. Genotyping Blood Buffy coat Purified DNA MALDI-TOF/hME assays XRCC1_399, XRCC3_241, ERCC2_751, MGMT_84, MGMT_143 191 Cases Genotyped 305 controls Genotyped
- 16. RESULTS
- 17. Selected demographic characteristics Characteristic Cases (n=162) Controls (n=251) Age < 69 70-75 > 76 Education None Elementary-high College/ above Other Stage Localized Regional Remote Unknown/unstaged PSA % 19 22 20 N 78 89 84 % 15 12 12 N 61 50 51 12 76 12 ~1 29 191 30 1 9 76 15 0 14 124 24 0 - - - - - - - - 38 31 30 1 61 50 48 2
- 19. Genetic Markers and other Factors: Combined Effects XRCC1_399 Waist to Hip Ratio Insulin Resistance Age-Adjusted
- 20. Genetic Markers and other Factors: Combined Effects MGMT_84 Waist to hip Ratio Insulin Resistance Age-Adjusted
- 21. Genetic Markers and other Factors: Combined Effects XRCC1_399 Total Preserved Food Age-adjusted
- 22. Genetic Markers and other Factors: Combined Effects MGMT_84 Total Preserved Food
- 23. Genetic Markers and other Factors: Combined Effects XRCC1_399 Allium Vegetable intake
- 24. Genetic Markers and other Factors: Combined Effects MGMT_84 Allium Vegetable intake
Editor's Notes
- Good morning. I will be talking about DNA repair variants and prostate cancer, presenting results from a recent population-based case-control study in Shanghai, China in which I investigated the data for the GWU Special project requirement.