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Nervous system 3
Neuron synapses
Neurotransmitters
Effects of drugs on synapses
One direction
No that’s not what I meant.
Nervous system 3; Synapses and Neurotransmitters
Synapse
A structure that permits a neuron (nerve cell) to
pass an electrical or chemical signal to another
cell.
Excitatory post
synaptic potential
Inhibitory post
synaptic
potential
Nervous system 3; Synapses and Neurotransmitters
Types of synapses
Nervous system 3; Synapses and Neurotransmitters
Electrical v. Chemical synapse
Types of synapses
Synapse with another neuron
Junction between two nerve cells
Neuroeffector
Neuromuscular: synapse of motor neuron
and muscle
Neuroglandular: synapse of neuron and
endocrine or exocrine gland.
Neurotransmitters
Excitatory – can cause next cell to initiate a new
impulse
– ACh (acetylcholine) – neuromuscular junction
– NE (norepinephrine)
– DA (dopamine)
Neurotransmitters
Inhibitory– can cause hyperpolarization of next
cell, reduce chance of a new impulse
– Serotonin
– GABA (gamma aminobutyric acid)
– Glycine
Nervous system 3; Synapses and Neurotransmitters
Convergence and Divergence
Nervous system 3; Synapses and Neurotransmitters
Nervous system 3; Synapses and Neurotransmitters
Synapse function
Essential for homeostasis
A problem with communication between nerves
at synapses is often the basis for disease
Examples: Parkinsons, Azheimers, depression,
anxiety, schizophrenia
Drug effects
Can increase permeability of nerve cell membrane
to Na+ makes impulses more likely
Can decrease permeability of nerve cell membrane
to Na+ makes impulses less likely
Can block / compete for receptor site binding
Aspirin, Morphine, Curare
Can inhibit secretory vesicle formation / release
Botulism / Tetanus
Nervous system 3; Synapses and Neurotransmitters

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Nervous system 3; Synapses and Neurotransmitters