The document discusses various classes of analgesics and anti-inflammatory drugs used to treat pain and inflammation. It covers the mechanisms of action and examples of opioid analgesics like morphine, codeine, and fentanyl; non-opioid analgesics like acetaminophen; and nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen, indomethacin, and naproxen. It also discusses the selective COX-2 inhibitor Vioxx, which was later voluntarily withdrawn due to evidence linking it to increased cardiovascular risk.

1. Analgesics and Anti-inflammatories Pharmacology 49.222 Bill Diehl-Jones RN, PhD Faculty of Nursing and Department of Zoology

2. Major Drug Classifications

6. A Few Word About Prostglandins Arachidonic Acid Prostaglandins Leukotrienes Lipoxygenase Cyclooxygenase Phospholipase A2 Cell Membrane (What’s the significance? We’ll talk later …)

12. Morphine, Meperidine, Methadone and Fentanyl are STRONG Opioid Agonists What does that mean?

16. Clinical Pearls on Narcotics

20. And Now, NSAIDs ….

22. Where do NSAIDs Work? Arachidonic Acid Prostaglandins Leukotrienes Lipoxygenase Cyclooxygenase Phospholipase A2 Cell Membrane Steroids works here: NSAIDs

24. Clinical Pearls on NSAIDS

30. And now, a word about VIOXX