Opioid Analgesics Receptors, Ligands, Effects

OPIOID ANALGESICS Dennis Paul, Ph.D. MEB 7154

Opioid Receptor Subtypes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Endogenous Opioids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Opioid receptors, endogenous ligands and function: Mu receptors Mu 1 : B-endorphin, endomorphin enkephalin Mu 2 : B-endorphin, endomorphin Kappa receptors Kappa 1 : dynorphins Kappa 2 & 3 : dynorphins , unknown Delta receptors Delta 1 : enkephalins , dynorphins Delta 2 : enkephalins

Cloned Opioid Receptors ,[object Object],[object Object],[object Object]

In vivo assays: ,[object Object],[object Object],[object Object]

Analgesic Assays ,[object Object],[object Object],[object Object],[object Object]

Reinforcing Properties ,[object Object],[object Object]

Stimulus Properties ,[object Object],[object Object]

II Opioid Agonists ,[object Object],[object Object],[object Object],[object Object]

Desirable properties of morphine as an analgesic ,[object Object],[object Object],[object Object]

Undesirable properties of morphine as an analgesic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Tolerance ,[object Object],[object Object],[object Object],[object Object]

Multiple sites of action ,[object Object],[object Object],[object Object]

Metabolism of morphine ,[object Object],[object Object],[object Object]

Heroin ,[object Object],[object Object],[object Object]

Hydromorphone (Dilaudid) ,[object Object],[object Object],[object Object]

Oxymorphone (Numorphan) ,[object Object]

Codeine ,[object Object],[object Object],[object Object],[object Object]

Oxycodone ,[object Object],[object Object],[object Object]

Hydrocodone and Dihydrocodeine ,[object Object]

Mixtures containing Codeine ,[object Object],[object Object]

Synthetic compounds ,[object Object],[object Object],[object Object],[object Object],[object Object]

Meperidine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Fentanyl ,[object Object],[object Object],[object Object],[object Object],[object Object]

Fentanyl derivatives ,[object Object],[object Object],[object Object]

Methadone ,[object Object],[object Object],[object Object],[object Object]

LAAM ,[object Object],[object Object]

Propoxyphene ,[object Object],[object Object],[object Object],[object Object]

Opioid Antagonists ,[object Object],[object Object],[object Object]

Signs of Overdose ,[object Object],[object Object],[object Object],[object Object],[object Object]

Naloxone ,[object Object],[object Object]

Naltrexone ,[object Object],[object Object],[object Object],[object Object]

Nalmefene ,[object Object],[object Object],[object Object]

Mixed agonist-antagonists ,[object Object],[object Object],[object Object],[object Object]

Nalorphine and Cyclazocine ,[object Object],[object Object],[object Object],[object Object]

Pentazocine ,[object Object],[object Object],[object Object]

Butorphanol ,[object Object],[object Object],[object Object],[object Object]

Nalbuphine ,[object Object],[object Object],[object Object],[object Object]

Partial agonist: Buprenorphine ,[object Object],[object Object],[object Object],[object Object]

Tramadol ,[object Object],[object Object],[object Object],[object Object]

Dependence and Withdrawal ,[object Object],[object Object],[object Object],[object Object],[object Object]

Other factors that influence the effectiveness of opioid treatment ,[object Object],[object Object],[object Object]

Salvinorin A ,[object Object],[object Object],[object Object]

Opioid Analgesics Receptors, Ligands, Effects

Empfohlen

Empfohlen

Weitere ähnliche Inhalte

Was ist angesagt?

Was ist angesagt? (20)

Andere mochten auch

Andere mochten auch (20)

Ähnlich wie Opioid Analgesics Receptors, Ligands, Effects

Ähnlich wie Opioid Analgesics Receptors, Ligands, Effects (20)

Mehr von jamal53

Mehr von jamal53 (8)

Kürzlich hochgeladen

Kürzlich hochgeladen (20)

Opioid Analgesics Receptors, Ligands, Effects