2. OVER VIEW
INTRODUCTION
SPECIAL FEATURES
GENERAL PROPERTIES
FORMULATION
METHOD OF PREPARATION
EVALUATION TESTS
ADVANTAGES & DISADVANTAGES
CONCLUSION
3. INTRODUCTION
These are the drug delivery systems
which fastly disintegrate in mouth with
H2O.
It was first developed in 1970’s
alternative to tablets & capsules.
It consists of very thin oral strip which is
placed on tongue & upon hydration it
fastly releases drug into oral cavity.
4. Thin elegant film
Available in various sizes & shapes
Unobstrusive
Excellent mucoadhesion
Rapid release
5. GENERAL PROPERTIES
Thickness ranges from 1-10mm & it’s surface area is
1-20 cm².
Its low dry tack allows for ease of handling &
application.
Its rapid hydration rate facilitates fast softening &
absorption.
2mm thickness of film will take 5-10sec to start its
disintegration.
6.
7. FORMULATION
DRUG
WATER SOLUBLE POLYMER
SUPER DISINTEGRANTS
PLASTISIZER
SURFACTANTS
FLAVOURS
COLOURS
SWEETENING AGENTS
SALIVA STIMIULATING AGENTS
8. SOLVENT CASTING*
SEMI-SOLID CASTING
HOT MELT EXTRUSION
SOLID DISPERSION EXTRUSION
ROLLING METHOD
10. Convenient dosing
No water needed
No risk of chocking
Taste masking
Enhanced stability
First pass metabolism can be avoided
11. Easily fragile & brittle.
Special package for protection during storage &
transportation.
12. These are having several advantages
over conventional dosage forms like
ODT, TABLETS, CAPSULES ,IV etc., so
they are of great importance during the
emergency cases such as allergic
reations & asthamatic attacks.