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AXIOM Innovations
      The Magazine for Interventional Radiology, Cardiology and Surgery




      Issue Number 14 | November 2011




Treatment of
Endoleaks
Using syngo iGuide
Page 26


New Hope
for Stenotic
Patients
Aortic Valve
Implantation
Page 38


Endovascular
Surgery with
3D Imaging
New Imaging
Possibilities
Page 42




                                        Low Dose - High Principles
                                        Saving Dose with CARE and syngo DynaCT
Editorial




               “Keeping image quality
                high and radiation
                dose low is one of the
                key drivers in the
                development of our
                imaging portfolio.”
                    Dr. Heinrich Kolem,
                    CEO of the Angiography & Interventional X-Ray Business Unit (AX)
                    at Siemens Healthcare




2 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
Editorial




Dear Reader,



                                                                                                      Dr. Heinrich Kolem
                                                                                                      CEO AX Division




Earlier this year, I had the opportunity to        patients. They are also key drivers for            possibility especially for high-risk
attend the Cardiovascular and Interven-            our development. We know that our                  patients who cannot undergo open sur-
tional Radiological Society of Europe’s            customers carry a lot of responsibility            gery. New innovative applications such
(CIRSE) annual conference in Munich.               for each individual patient they treat.            as syngo Aortic ValveGuide* help sur-
The CIRSE is one of the most renowned              In return, it is our responsibility to offer       geons and cardiologists replace calcified
conferences for interventional imag-               reliable systems to support our cus-               aortic heart valves with more guidance
ing. There were approximately 6,000                tomers worldwide. We are constantly                and a new automated workflow.
attendees eager to learn about the lat-            exploring new possibilities to reduce
est technologies and advances in their             dose without compromising image qual-              Looking back on a very exciting year
clinical field. I was very pleased to see          ity. The title of this issue reflects that         for Siemens Healthcare, I am proud
how many visitors were interested in               line of thought, “Low Dose - High Prin-            to present to you this issue of AXIOM
our products and solutions. For the first          ciples.” Our dose saving initiative with           Innovations. You can read more about
time, we showcased how “The Future is              CARE (Combined Applications to Reduce              CARE technology, new functionalities in
Flexible” with the Artis zeego, our multi-         Exposure) and CLEAR (an imaging tech-              endovascular and thoracic surgery, and
axis C-arm system based on robotic                 nology to enhance visualization with               many other innovative topics. Enjoy!
technology. We introduced the Hybrid IR            X-ray) not only reduces radiation dose
concept which offers new opportunities             for patients and staff, but also boosts
for interventional radiologists looking            image quality to an outstanding level.
to expand to more complex cases. In
order to meet current and future imag-             A growing trend in the market for inter-
ing needs, Artis zeego allows a variety            ventional cardiology and hybrid surgery            Dr. Heinrich Kolem
of working heights and delivers large              is the minimally invasive replacement
volume image results.                              of valves. With demographic changes in
                                                   our society and a growing percentage of
Improving clinical workflow and                    elderly patients, new treatment meth-
radiation dose reduction are of great              ods will evolve. Minimally invasive pro-
importance to our customers and their              cedures are an exciting new treatment




* The syngo Aortic ValveGuide is pending 510(k) clearance, and is not yet commercially available in the United States.




                                                                   AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine   3
Content




                                                                                                 26
                                                      16                                         Enhanced Endoleak

   Content                                            Radiation Reduction
                                                      is Key in Pediatrics
                                                                                                 Treatment Through
                                                                                                 Improved Navigation




                                 10 A long-term commitment                   3    Editorial
                                    to reduce radiation dose
                                    Siemens has long been a leader in
                                    addressing the need to provide opti-
                                    mal images at the lowest possible        6    News
                                    radiation dose following the ALARA
                                    principle. Many institutions world-
                                    wide working with Siemens angio-
                                    graphy systems use the CARE              10   Cover Story
                                    applications in their daily routine
                                    when imaging patients of all ages.            Low Dose, High Principles:
                                    It is most importatnt to them to              Cardiac CARE for All
                                    keep radiation dose low, especially           A Report from Fundación
                                    for children and also their own staff.        Cardioinfantil in Colombia

                                                                                  A Pediatric Radiologist's Approach
                                                                                  to Radiation Reduction
                                                                                  Interview with Dr. Anne Marie
                                                                                  Cahill, Children's Hospital of
                                                                                  Philadelphia

                                                                                  Treatment of Complex Head and
                                Cover                                             Neck Malformation in an Infant
                                                                                  Clinical Case
                                Imaging of temporal
                                mandibular joint with
                                reduced radiation dose.                           CAREposition
                                Courtesy of Anne                                  An Evaluation of Radiation-Free
                                Marie Cahill, M.D.,
                                Department of
                                                                                  Positioning
                                Interventional
                                Radiology,
                                Children´s Hospital
                                of Philadelphia,                             61   Imprint
                                Pennsylvania, USA




4 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
Content




                 32                                           42
                 syngo Neuro PBV IR Helps During              Advanced Technology Revolutionizes
                 Revascularization Treatment                  Endovascular Surgery




   Angiography                         38 Minimally Invasive Aortic Valve         54 An Innovative Setting –
                                          Implantation Offers New Hope to            Hybrid Room 3D Imaging Delivers
26 Endoleak Treatment:                    Stenotic Patients                          Groundbreaking Care
   Enhanced Visualization Meets           Interview with Dr. Antonio Dager           St. Joseph Hospital in California
   Enhanced Navigation                    at Angiographia de Occidente in            chooses an interdisciplinary
   syngo iGuide facilitates better        Colombia                                   approach to maximize patient care
   Workflow

30 Quantitative Evidences of              Surgery                                      Customer Care
   Hemodynamic Improvement of
   Brain Arteriovenous Malformation    42 3D Imaging Brings a New Vision          58 Upcoming Congresses &
   after Surgical Intervention            to Endovascular Surgery                    Workshops
   Clinical case                          Interview with Dr. Alan Lumsden,
                                          Director of the Methodist Hospital      60 Subscription & Information
32 Revascularization Treatment            DeBakey Heart and Vascular Center
   of Acute Cerebral Stenosis             in Houston
   Clinical case
                                       48 Accuracy Far Beyond Conventional
                                          Pneumological Practice
   Cardiology                             Dr. Hohenforst-Schmidt pioneers
                                          new navigation techniques in
34 Overlay of MRI Images                  pneumology
   in Pulmonary Vein Isolation
   A clinical evaluation               48 Navigation in the Lung
   by Prof. Rukshen Weerasooriya          Clinical Case

36 Accurate Placement                  50 Heart Valve Replacement –
   of Aortic Valves                       Significant Changes Thanks to
   Clinical case                          Hybrid Surgery
                                          Dr. Tatsuhiro Komiya talks about
                                          new surgical procedures




                                                   AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine   5
News




Less Radiation During
Catheter Interventions
Siemens’ Artis zee® angiography system has
recently integrated the MediGuide Technology
from St. Jude Medical, a medical positioning
system that visualizes the position of a catheter
without radiation.
Like a GPS system, the MediGuide Technology
locates the catheter during cardiac interventions
and projects its precise position in real time on
a previously acquired fluoroscopy image of the
patient. During electrophysiological interventions,
a miniaturized sensor integrated into the catheter
can be located by receiving electromagnetic posi-
tioning signals from the MediGuide transmitters,
which are incorporated into the detector housing
of the Artis zee system. The MediGuide Technology
then calculates the respective position and orien-
tation of the catheter and displays it in real time
on fluoroscopic images of the patient that were
recorded earlier. The technology also compensates
for patient movement caused by respiration and
heart motion.
The MediGuide Technology provides significant
benefits especially during complex electrophysi-
ological procedures. The electrophysiologist no
longer has to take fluoroscopic images of the
patient each time the catheter is re-positioned.
As a result, less radiation and less contrast agent
use is expected.
The Heart Center Leipzig, Germany, has already
performed the first interventions with Artis
zee and the MediGuide Technology. “The low-
radiation, precise localization of the catheter tip
onto the pre-recorded fluoroscopy image is a most
impressive function, because the system is able to
compensate the motion from the heart beat and
breathing,” said Professor Dr. Gerhard Hindricks,
Director of the Rhythmology Department. “For my
team and me, this is clearly the future in electro-
physiology.”



                                                                            Localization of the catheter supported by MediGuide Technology
                                                                                                        and EnSite Velocity Mapping System.




6 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
News




Integrated FFR Calculation Saves
Space and Time
The measurement of fractional
flow reserve (FFR) helps to deter-
mine the hemodynamic signifi-
cance of a coronary stenosis and
to guide balloon and stent place-
ment. FFR is being measured by
comparing the blood pressures
distal (behind) and proximal (in
front) to a lesion. Once this ratio
reaches 0.75 or below, a stenosis
is considered hemodynamically
significant and a stent placement
is recommended.
The FAME study published
in 2009 (N Engl J Med 2009;
360:213-224) evaluated FFR-
guided CAD treatment and
clearly found an increase in
patient survival of 30 % while at
the same time treatment costs
decreased by 30 %.
St Jude Medical and Volcano
offer FFR measurement solu-
tions in the cath lab that now
have been fully integrated with
the Siemens AXIOM Sensis XP
recording system, which offers
simple plug&play connectivity
and makes using an external
workstation obsolete.
For getting the new FFR mea-
surement capabilities, AXIOM
Sensis XP software must be
upgraded to the latest software
version due for release at the
end of 2011. The FFR option can
already be ordered today and will
become available with the new
software version.
All systems in the field currently
running software version VC10
will be upgraded free of charge to
VC11 starting in spring 2012.                                AXIOM Sensis XP running VC11 software and FFR option.




                                      AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine   7
News




A New Era: Hybrid Operating Rooms
in the American Hospital
                                                As one of the most modern hospitals           where TAVI (Transcatheter Aortic Valve
                                                not only in Turkey but the entire region,     Implantation) procedures have recently
                                                the American Hospital in Istanbul             begun to be performed with the use
                                                continues its leading role in hybrid          of the Artis zeego system and Siemens
                                                operating room practices with the             syngo DynaCT Cardiac software,
                                                recently installed Siemens Artis zeego        procedures can be completed more
                                                multi-axis robotic angiography system.        rapidly and reliably with the comfort
                                                Thanks to the Artis zeego system,             introduced by Artis zeego and the wide
                                                both advanced hybrid practices and            movement capability of the C-arm.
                                                standardized cardiologic procedures can       The American Hospital is currently able
                                                be performed. In the new procedure            to perform interventional procedures,
                                                room that has an angiography                  thanks to the hybrid system it has
                                                operating table that tilts in four            recently acquired, as well as ongoing
                                                different directions, a laminar flow          medical, technical and technological
                                                unit and anesthesia device pendants,          developments. Operating in Istanbul,
                                                the latest technological innovations,         Turkey since 1920, the American
                                                such as a 56" Artis zee Large Display,        Hospital offers the latest technologies
                                                an integrated Intravascular Ultrasound        to aid the hundreds of millions of
                                                (IVUS), an integrated hemodynamic             people in the region as a hospital held
Dr. Genco Yücel, Department of Cardiology,      recording system (Siemens AXIOM               in high regard not only in Turkey but in
in front of the department’s new Artis zeego.   Sensis XP), etc., are used. At the center     neighboring countries as well.




Hybrid OR With Trumpf Table Opened
at Clinical Center Ludwigsburg
Since 2010, Siemens optionally delivers Artis zeego or Artis
zee ceiling with the TruSystem 7500 OR table by Trumpf.
In May 2011 another hybrid operating room with Trumpf´s
OR table and Siemens Artis zeego went live at the clinical
center Ludwigsburg, Germany – meanwhile this is the sixth
installation worldwide that combines an Artis system with a
Trumpf OR table. The room at the clinical center Ludwigsburg
is located in a brand new building as part of a 35 million euro
project to build one of the most modern surgical centers in
Germany with altogether 9 fully digital connected operating
rooms. With this new hybrid OR, patients will benefit from
fewer shifts during the procedures, less radiation because of
faster and fewer acquisitions, and fewer complications since
the success of the intervention can be verified right in the OR
at the end of the procedure.
Siemens is also going to offer a similar integration of the
Artis zeego and Artis zee ceiling with Maquet OR tables in            View of the new hybrid operating room in Ludwigsburg with the Trumpf
early 2013.                                                           TruSystem 7500 OR table and Siemens Artis zeego.




8 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
News




Siemens Integrates
Maquet’s Magnus OR Table
for Hybrid ORs
1                                                                         2




Fig. 1: Siemens Artis zeego with Maquet’s Magnus table with breakable    Fig. 2: Maquet also offers a radiolucent table top for artifact-free imaging
top supports complex procedures in advanced positions.                   in endovascular procedures.


The versatile Magnus OR table* from              and neurosurgery. The Artis zeego is              First clinical user tests of the integrated
Maquet will be available together with           the only robotic C-arm-system on the              solution with Artis zeego are anticipated
Artis zeego and Artis zee ceiling. With the      market that can adapt to the complete             to start in May 2012; general availability
existing family of Artis tables, Trumpf’s        height adjustment of the table. The               is planned for December 2012. The inte-
TruSystem 7500 tables and the Magnus             multi-axis robotic system also follows            gration with Artis zee ceiling is sched-
table to follow, Siemens can provide             the movements of the operating table.             uled to be available in spring 2013.
three fully integrated table systems. This       It flexibly adjusts to even complicated           Of course Siemens will continue to
means synchronized C-arm and OR table            positions of the segmented table top.             offer the tried-and-true family of fully
movements, 2D and 3D imaging, all with           This flexibility also allows free access          integrated Artis zee tables. They are
a single integrated operation module.            from any side, with a comfortable space           available in three different versions: the
And the right table for surgical require-        for the anesthetist and his equipment.            standard table, table with tilt, and the
ments in the hybrid OR.                          If open procedures without imaging                OR table with tilt and cradle. The carbon
The key benefit of the new solution is           equipment are performed, Artis zeego’s            table tops allow for high-end imaging,
the multidisciplinary use of the hybrid          multiple park positions allow for maxi-           including 3D. The Artis table family is
OR – which means it will allow for both          mum space in the OR field.                        the solution of choice for cardiac and
interventional imaging and for open              Equipped with an additional floating              vascular procedures providing an exten-
procedures where extremely flexible              carbon table top, the integrated solu-            sive longitudinal travel range, full body
patient positioning may be required.             tion enables full cath lab functionality.         coverage and a free floating radiolucent
The Magnus OR table is fitted with               The table top provides 360° radio-                table top.
exchangeable table tops – a fully radio-         translucency for superb X-ray images,
lucent carbon top (Fig. 2) as well as a          including 3D. A transport system
highly flexible, segmented table top             ensures the easy exchange of the table
(Fig. 1). The latter allows surgeons the         tops. The patient can be prepared and
most appropriate patient positioning,            positioned on the table top in the              * WIP. The information about this product is preliminary.
                                                                                                   The product is under development and not commercially
including complicated positions,                 induction area ensuring ahead of time             available in the U.S., and its future availability cannot
occurring especially in orthopedics              maximum efficiency for the OR.                    be ensured.




                                                                 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine                9
Cover Story CARE




Low Dose,
High Principles:
Cardiac CARE for All




10 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
CARE Cover Story




                     At Fundación Cardioinfantil in
                     Bogotá, Colombia, no one is
                     turned away for lack of ability
                     to pay. Using the most
                     advanced equipment from
                     Siemens, the hospital’s
                     dedicated staff is making
                     interventional imaging safer
                     for everyone, especially those
                     who need it most: their
                     youngest, weakest patients.
                     By Chris Kraul




AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine   11
Cover Story CARE




                                             Any day now, Nelsy, a five-year-old          because her mother and brother have
                                             Colombian girl, will undergo an angio-       died and her father is worried that he
                                             plasty at Bogotá’s Fundación Cardio-         will lose her as well,” says Ronderos.
                                             infantil hospital that will save her life.   By coming to Fundación Cardioinfantil
                                             Pale, underweight and short of breath,       in Bogotá for treatment, Nelsy will
                                             Nelsy was screened in late May by the        receive another benefit that could be
                                             clinic’s outreach team in the southwest-     just as consequential to her long-term
                                             ern city of Pasto and found to have per-     health. Her procedure will be performed
                                             sistent ductus arteriosis, a congenital      using Siemens’ state-of-the-art “low
                                             condition that, without a procedure to       dose” interventional imaging technol-
                                             close the ductus, would have proved          ogy. The hospital has four Siemens Artis
                                             fatal by her mid-teens.                      systems that – with their advanced
                                             Nelsy, whose mother and ten-year old         software and imaging innovations – can
                                             brother both died of heart disease, will     dramatically cut the radiation exposure
                                             be brought to Bogotá free of charge          of patients like Nelsy, compared with
                                             from her home 300 miles away, a poor         what they would have received a few
                                             fishing village on Colombia’s southwest-     years ago.
                                             ern Pacific coast. She and her father will   Each system is bundled with Siemens’
                                             be put up in the clinic’s housing and,       proprietary CARE (Combined Applica-
                                             despite the fact that they have no way       tions to Reduce Exposure) applica-
                                             to pay the hospital bills, Nelsy will be     tions that can help to decrease typical
“The Siemens                                 given the kind of care that has made         exposure in catheterization labs. It does

 engineers have                              Fundación Cardioinfantil a private,
                                             nonprofit institution, a beacon of car-
                                                                                          that by providing a broad range of dose
                                                                                          saving applications, enhanced monitor-
 helped a lot in                             diovascular treatment in Latin America.
                                             The hospital draws paying patients from
                                                                                          ing and reporting of the radiation being
                                                                                          generated and a flexibility of use that
 giving individual                           throughout the Caribbean and Cen-            allows doctors at Fundacion Cardioin-
                                             tral America, and from as far away as        fantil to tailor treatment to a patient’s
 training to our                             Florida and Peru. It also takes on scores    specific age, weight and diagnosis.

 personnel with                              of pro bono “social” cases per year, like
                                             Nelsy’s, mainly from Colombia but it
                                                                                          “The advances that we are seeing in
                                                                                          Siemens’ imaging are allowing us to be
 the goal of                                 accepts desperately poor patients from
                                             Ecuador and Venezuela as well.
                                                                                          more precise with our procedures with
                                                                                          less risk of complications and failures,”
 minimizing the                              Making the Safety Factor a
                                                                                          said Dr. Ronderos. Additionally he states
                                                                                          the better the imaging, the less time he
 radiation used in                           High Priority                                spends diagnosing the condition and
                                             The procedure in the hospital’s heart        placing coils, stents and heart valves.
 a given exam                                catheterization lab to close the ductus      That reduces the patient’s and the medi-
 and to devise                               will only take 45 minutes. But it will
                                             save Nelsy from probable death by
                                                                                          cal staff’s exposure to radiation, he said.
                                                                                          That lessened exposure is important
 additional                                  pneumonia in the coming years and            for the operator as well as the patient.
                                             give her a good chance of leading a          Medical staff who administer the pro-
 measures of                                 long, healthy life, says Miguel Ronde-       cedures are concerned about their own
                                             ros, MD, a cardiologist who trained at       risk as well.
 radiological                                University of Alabama-Birmingham and         Making angiography safer has been a
 protection.”                                who was part of the outreach team that
                                             diagnosed Nelsy. He will also perform
                                                                                          Siemens objective since the company
                                                                                          entered the medical equipment field
                                             the angioplasty.                             in the early 1960s, and especially
Miguel Ronderos, M.D.,                       “We immediately classified Nelsy as          since a low dose application initiative
Department of Cardiology, Fundación          a medical emergency, because she is          was launched in 1994. Since then,
Cardioinfantil, Bogotá, Colombia
                                             in heart failure right now. But she is       the company has achieved a series of
                                             also what we call a social emergency,        breakthroughs, all with the goal of


 12 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
CARE Cover Story




A Vision of Improved Healthcare Access
Fundación Cardioinfantil’s history began in        brigades – teams of a half-dozen doctors and
1971 when two Colombian doctors, brothers          nurses – to seek out sick children in remote,
Reinaldo and Camilo Cabrera, returned home         poverty-stricken areas of the country. Now,
from completing their medical training at the      about eight times a year, the brigades hold
Texas Heart Institute in Houston determined        two-day cardiovascular clinics at partner
to address the inequalities of their country’s     hospitals from one end of the country to the
healthcare. High on their list of concerns was     other where young patients in need gather.
the incidence of congenital heart defects,         Two months prior to each visit, the founda-
affecting one in every 100 babies. In devel-       tion’s community relations department starts
oped countries, such defects are easily            getting the word out via radio announce-
diagnosed and treated, but they too often          ments and posters that any family who has
proved to be death sentences in Colombia.          a child with possible heart problems will be
Poverty and difficult geography make access        examined for free. It was in one such brigade
to quality medical care an impossible dream        visit held at Pasto’s Hospital Los Angeles in
for much of the population.                        May that Ronderos diagnosed Nelsy, one
With the help of ex-president Carlos Lleras        of 400 young people who lined up for an
Restrepo, the new physicians opened the pre-       examination, and put her on the list of kids
decessor of today’s foundation in a corner of      to be brought to Bogotá. She and her father
Bogotá’s Misericordia Hospital, a charity clinic   traveled eight hours by boat and four hours
for children, specifically to offer cardiovascu-   by bus to get to the examination site.
lar care to poor youth in the urban area. They     Fundación Cardioinfantil’s staff examine
relied on donations of services, equipment,        about 4,000 poor young people per year
cash and eventually land from the city of          during these outreach clinics. Of those,
Bogotá, where the current 300-bed hospital         250 children and adolescents, or about
is situated.                                       20 percent of all the children examined,
As it grew, the clinic broadened its mission to    are subsequently brought to the hospital
include children who could pay for treatment       for heart surgery or angiography at the
as part of a scheme by which paying patients       bustling Bogotá hospital, free of charge.
helped subsidize care for the poor. Later, as      For their service to Colombia, the Cabrera
the clinic’s reputation for quality care spread,   brothers were decorated in July 2010 by
adult heart patients were admitted, also to        then-president Alvaro Uribe with the Order
help subsidize treatment for poor children.        of Boyaca, the highest national honor
Adults now comprise about 70 percent of the        attainable by a Colombian civilian. One of the
caseload.                                          doctors, Reinaldo Cabrera, died in November
In 1986, the Cabrera brothers decided to pro-      2010, but his brother Camilo continues to
vide care to young patients for whom a trip to     be active and currently is the director of the
Bogotá for life-saving treatment was impos-        foundation.
sible. The hospital began organizing outreach




                                 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine   13
Cover Story CARE




  Combined Applications to Reduce Exposure:
  An Integrated Answer to Dose Reduction                                             the imaging and visibility of devices.
  CAREvision: pulsed fluoroscopy application that provides extremely                 Over the last five years, Siemens syngo
  low frequencies to meet individual dose-saving targets. Pulses can                 DynaCT has made soft tissue imaging
  drop from a range of 30 p/s to only 0.5 p/s. At 7.5 p/s, a 75 % dose               possible, enabling physicians to get
  reduction is achieved.                                                             additional soft tissue information in
                                                                                     the interventional suite and thus get a
  CAREfilter: a variable CU-filter (0.1 mm – 0.9 mm) is automatically set            better understanding of the structure of
  according to the current transparency of the object/C-arm angulation,              the vessels and organs they are dealing
  without any necessary interaction from the user. Dose reduction: up                with.
  to 50 %.                                                                           Dr. Dario Echeverri, who heads Funda-
  CAREposition: positioning without repeated fluoroscopy. The feature                cion Cardioinfantil’s catheterization lab
  is especially needed during long-lasting neurointerventions that can               and who is also the current president
  take several hours as the provider can control patient positioning                 of the Latin American Society of Inter-
  without the need for additional fluoroscopy.                                       ventionist Cardiology, said the CARE
                                                                                     application “CAREguard” is especially
  CAREprofile: radiation-free adjustment of collimators as well                      valuable because it tracks radiation skin
  as radiation-free semitransparent filter parameter setting. Dose                   dose thresholds of patients and medical
  reduction: Up to 9 %.                                                              staff and sounds a warning if they are
  CAREguard: a new real-time application that monitors skin dose                     exceeded.
  exposure and allows for effective skin dose control. Three separate                “It allows us to do a continuous follow-
  thresholds can be defined with warning indicators that alert                       up of the radiation dispersed by the
  for length of exposure time. The feature reduces exposure for                      machines and helps us reduce exposure
  radiologists, technicians, and patients.                                           to patients and MDs, nurses and techni-
                                                                                     cians working in the lab,” Echeverri said.
  Low Dose Acquisition: additional low dose protocols that can be
                                                                                     Cognizant of the importance of low
  accessed hands free, directly from a footswitch. These tools can
                                                                                     dose imaging, Siemens sends a free
  reduce radiation dose by 67 %.
                                                                                     update of the latest software VC14
  Low Dose syngo DynaCT: an optional feature, offers CT-like 3D                      including all CARE (Combined Applica-
  imaging for radiosensitive patients and others. As an example, 5 sec               tions to Reduce Exposure) and CLEAR
  protocol can be done at 0.1 µGy/frame instead of 0.36 µGy/frame,                   (image quality) features to all customers
  which results in a 72 % reduction.                                                 of its Artis zee angiography systems
                                                                                     around the world.
  CAREreport: a structured dose report that contains all patient                     Siemens’ advances now enable doctors
  demographics, procedure, and dose information. Using commercially                  to reduce the number of times a typical
  available programs or in-house software, this information can be                   heart patient has to undergo imaging
  filtered for further processing, such as dose analysis.                            exams. A decade ago, Nelsy might have
                                                                                     had to undergo three different proce-
                                                                                     dures during her stay at Cardioinfantil:
                                                                                     one to diagnose, a second to treat her
limiting dosage while enhancing image       quality images are now captured at       disease, and a third to confirm success.
quality. Improved safety is doubly criti-   7.5 frames per second, down from 30      But the likelihood now is that a single
cal because of the expanding range of       frames previously, making possible a     procedure will suffice.
diagnoses and treatments for which          75 percent reduction in radiation dur-   “Nowadays, we must be much more
angiography is now used, going far          ing the procedure. CAREreport offers a   careful with our exams in arriving at a
beyond its original cardiovascular appli-   running account of radiation dispersed   diagnosis,” Dr. Ronderos said. “Each day
cation to include neuro and abdominal       along with the patient’s demographics,   we are more aware of the importance to
interventions and surgeries.                procedure and dose information.          health of the cumulative dose of radia-
The low dose equipment is achieving                                                  tion over the course of a lifetime and,
that goal with a variety of innovations.    A Two-Way Flow of Information            with the Siemens technology we have,
Proprietary technology pulses radia-        But there is more than that to low       combined with our understanding and
tion instead of emitting continuous         dose. Efficiency gains from powerful     quality of the imaging, we can minimize
fluoroscopy. With CAREvision, high          new Siemens software have improved       exposure in a given exam.”


14 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
CARE Cover Story




Fewer procedures also mean a patient         says Echeverri, because he, Ronderos
receives fewer injections of contrast        and other medical staff operate the
agent, which if overused can damage          machines themselves without specially
kidneys.                                     trained technicians.
As one of a dozen Siemens “reference         “We want the relationship with Siemens
sites” at leading hospitals in Latin         to go far beyond buying and selling
America and the Caribbean, Fundación         equipment. We want Siemens to help us
Cardioinfantil has become a key prov-        in an integral way with training, market-
ing ground for Siemens’ low dose             ing and advice, a friend who will help
imaging initiative in the region. The        distinguish the foundation. The Low
clinic also has become an incubator for      Dose Workshop with Siemens was very
more intensive relationships between         encouraging, and it produced concrete
Siemens product managers and the             results,” says Echeverri.
medical professionals who use the            In exchange for going the extra mile,
company’s equipment. The company             Siemens is allowed to bring prospec-
and its clinical customers see such close    tive clients to Cardioinfantil to see
relationships as a necessity, given the      the systems in action, and even bring
high stakes in cardiovascular care: the      in doctors and nurses from foreign
life-saving benefits of cutting-edge ther-   countries to receive training on the
apies as well as the potential hazards of    machines. Siemens also gets important
the imaging devices.                         feedback that is incorporated into the
“Over the last year, a real two-way flow     systems’ software and design. A bonus
of information with Siemens has begun,       for Siemens is its association with one              “CAREguard
so that we can receive not just the
low dose technology but training and
                                             of Colombia’s most admired institutions
                                             for its mission of delivering lifesaving
                                                                                                   allows us to do
advice, and we want that to continue,”
says cardiologist Echeverri. “By the same
                                             cardiovascular care to poor children and
                                             young people who otherwise might die
                                                                                                   continuous
token, we offer suggestions on design        prematurely.                                          follow-up of the
improvements to better protect the           Attesting to Fundación Cardioinfan-
patients and people who work in the          til’s high standards is its cooperation               radiation
room.” Those suggestions have included
smaller tables to accommodate child
                                             arrangement with the Cleveland Clinic,
                                             which sends medical staff to Bogotá
                                                                                                   dispersed by the
patients and design changes for protec-
tive clothing.
                                             once a year to conduct professional
                                             seminars.
                                                                                                   machines and
The advances of the Artis zee system         “Most companies just want to sell                     helps us reduce
give Dr. Echeverri added flexibility in      machines and there is usually a discon-
devising different protocols “according      nect between the sales and technical                  exposure to
to the patient and his or her condition,     staff of these companies. Siemens is
instead of using the same program for        changing that trend. Together we are                  patients and
all patients. This is new with the latest
software of our Artis zee.” Adds Dr.
                                             constantly refining the proper use of
                                             the machines,” Dr. Ronderos concluded.
                                                                                                   MDs, nurses and
Ronderos: “The Siemens engineers have        “We have come to a nice arrangement.”                 technicians
helped a lot in giving individual train-
ing to our personnel with the goal of        Chris Kraul is a freelance writer based in Bogotá,    working in the
minimizing the radiation used in a given     Colombia, covering stories a wide range of top-
exam and to devise additional measures       ics. A reporter for the Los Angeles Times for 22      lab.”
                                             years, he was most recently the Latin American
of radiological protection.”                 Bureau Chief at the newspaper’s Bogotá office.
In February, Siemens brought in experts                                                            Dario Echeverri, M.D.,
to the clinic from Germany to lead a                                                               Department of Cardiology, Fundación
dose and radiation workshop on safe                                                                Cardioinfantil, Bogotá, Colombia
                                              Contact
operation of the angiography sys-
                                              vera.juennemann@siemens.com
tems. That was an important gesture,


                                                            AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine      15
Cover Story CARE




A Pediatric Radiologist’s
Approach to Radiation
Reduction

Siemens has long been a leader in addressing the need
to provide optimal images at the lowest possible radiation
dose. AXIOM Innovations’ Robert L. Bard discussed
radiation dose savings and their clinical application in
pediatric patients with Anne Marie Cahill, MD, of the
Children’s Hospital of Philadelphia.
By Robert L. Bard




There is considerable concern among         are paramount for Cahill because she        grams automatically using the lowest
both medical professionals and the pub-     frequently deals with complex cases.        possible radiation dose while providing
lic these days about radiation exposure,    Furthermore, radiation exposure is          the best possible images, but clinicians
in part due to the growing use of imag-     especially important for her because she    still have the ability to increase the
ing equipment in both diagnostic and        is treating children.                       dose if there is an area of interest that
interventional medicine. Anne Marie         Siemens products have long been             requires further investigation. For exam-
Cahill, MD, Director of Interventional      designed to help clinicians obtain qual-    ple, Cahill commonly evaluates patients
Radiology at the Children’s Hospital        ity images while following the ALARA        with vascular anomalies where she first
of Philadelphia, has worked with the        principle. Siemens addresses the ALARA      selects a low dose 3D program, syngo
Siemens’ product development group          principle with its Combined Applica-        DynaCT, to deliver the lowest necessary
to find new ways of imaging with lower      tions to Reduce Exposure, or “CARE”         dose of radiation to image the vascula-
radiation doses and at the same time        package. CARE is available throughout       ture. However, if she notices a section
achieving the best possible images. This    the Siemens line of imaging products        of blood vessel that is not imaged well
principle is commonly referred to as the    and addresses several aspects of the        or appears to be abnormal during the
“ALARA” principle: as low as reasonably     imaging process, including the docu-        initial scan, she has the freedom and
achievable.                                 mentation and monitoring of radiation       ability to interrupt the standardized
While clinicians must be aware of acute     exposure of both patients and clinicians.   program and she can concentrate the
radiation exposure from any individual      A primary feature of CARE is the ability    imaging on that particular area and
procedure, they must be even more           to standardize radiation doses at the       investigate any potential abnormalities.
diligent in managing chronic radiation      lowest possible level for each and every    Siemens CAREguard is available with
doses for their patients who receive        procedure or image. CARE permits the        all Artis zee angiography systems,
either multiple procedures acutely or       interventional radiologist to choose        providing skin dose control software
chronic procedures in a long-term evalu-    programs in advance so that ALARA can       that helps limit and document radia-
ation of their condition. These concerns    be achieved. Study-specific imaging pro-    tion levels. With CAREguard, radiation


16 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
CARE Cover Story




AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine   17
Cover Story CARE




doses are constantly measured and             has experienced three major benefits of      only are fewer images necessary using
the user can set the parameters to site-      the Siemens products in their ability to     Overlay Reference, but the images are
specific values. If pre-defined skin dose     image at the lowest possible radiation       obtained at a lower radiation level.
levels are exceeded, an audible warn-         doses: Store Fluoro, Overlay Reference,      Therefore, radiation is decreased as
ing sounds, and a skin dose indicator         and Low Dose syngo DynaCT.                   compared to traditional applications that
flashes on the live display. A warning        Store Fluoro enables the user to store a     relied upon traditional fluoroscopy.
pop-up is also prominently displayed on       regular fluoro scene during a procedure      During common vascular imaging, radia-
the touchscreen of the system’s table-        for documentation instead of doing a         tion dose is decreased because, as Cahill
side control, which is located within the     new acquisition. Cahill explains that this   states, “We can do an angiogram and
interventional radiologist’s view during      functionality allows her to decrease the     save a specific image and then overlay
the procedure. Radiation exposure lev-        number of acquisitions she requires as       that image onto the live fluoro. Later
els can be generated with CAREreport,         compared to previous clinical methods.       that image can be used to track smaller
and they can also be archived in the          She can save images on the display           arteries. This process saves radiation
PACS system along with the procedural         monitor instead of obtaining further         because we do not perform roadmaps
images. Cahill and her colleagues regu-       images and exposing the patient – and        (comprehensive tracking of blood flow
larly take advantage of this feature by       staff – to additional levels of radiation.   through the vasculature) as much as we
providing patients with radiation infor-      Prior to having this capability, it would    used to.”
mation when reviewing clinical results.       have been necessary for her to acquire
                                              additional images to assure she had all      C-arm CT and Joint Injections
Clinical Applications                         of the information she needed before         The Children’s Hospital of Philadelphia
for Low-Dose Imaging                          the patient left the interventional          also uses syngo DynaCT to reduce radia-
Cahill has worked closely with Siemens        radiology suite.                             tion exposure in patients who require
in developing C-arm CT protocols that         Similar to Store Fluoro, Overlay Refer-      imaging where the radiation dose is a
provide 3D information in the inter-          ence can decrease the number of              particular concern. C-arm computed
ventional radiation suite at very low         images acquired as compared to previ-        tomography permits joint injections
radiation doses. She reports that she         ous clinical imaging methods. Not            with the use of CT and fluoroscopy and




AVM nidus extending from T6 to L1 supplied by a left intercostal artery

1                                               2                                          3




1 Conventional intercostal artery angiogram    2 VRT (Volume Rendering Technique)          3 Embedded MPR Image of AVM nidus




18 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
CARE Cover Story




                                                                                                 “Store Fluoro allows
                                                                                                  us to decrease the
omits an additional dose of radiation        latter is used to determine the relation-
                                                                                                  number of acquired
from traditional CT. Cahill references her   ship of the airway to the treated lesion             images. With the
research using C-arm CT, which shows         to help decide if the patient's breathing
that radiation doses can be significantly    tube can be safely removed post proce-
                                                                                                  Store Fluoro
decreased when treating and evaluat-         dure. In vascular malformation therapy               functionality we can
ing patients with temporal mandibular        this helps clinicians determine whether
joint (TMJ) disorder. She explains that      the breathing tube can be safely
                                                                                                  save images on the
radiation savings are largely obtained by    removed from patients who are asleep                 display monitor
reducing the need to acquire traditional     under general anesthesia.
computed tomography examinations             In addition, vascular anomalies are                  instead of obtaining
following interventional treatments.         treated using Low Dose syngo DynaCT                  further images and
TMJ disorder commonly requires               as well, and the radiation savings – also
patients to receive repeated injections      about 50 percent of conventional CT – is             exposing the patient,
once or twice a year, and the radiation      largely obtained once again by omitting              and staff, to
dose savings adds up during the course       a post-procedural traditional CT. One of
of treatment. Pediatric TMJ patients are     the major advantages of treating vascu-              additional levels of
one specific group where imaging with        lar anomalies in this fashion is that the            radiation.”
the ALARA principle is crucial because       success of the sclerotherapy procedure
of the repeated radiation exposure of a      can be evaluated immediately after the
vulnerable area, the jaw, because of its     procedure by the same interventional                Anne Marie Cahill, M.D., Department
                                                                                                 of Interventional Radiology, Children’s
proximity to the eyes and thyroid.           radiologist at the same location, which
                                                                                                 Hospital of Philadelphia, PA, USA
Joint injections are a common applica-       is an efficient use of hospital resources
tion of C-arm CT because of the ability      and an excellent means to improve
to image at very low dose. Dr. Cahill        patient satisfaction to their clinical care.
estimates based on phantom studies           The importance of dose savings –
about a 50 percent reduction when            especially in young patients – will
compared to conventional CT and a            only increase with the growth of
further radiation dose reduction of 6%       non-invasive imaging and radiologic
from a manufacturer setting. This dose       interventions. Siemens has addressed
reduction is possible due to the inher-      the need to provide high-quality images
ent high contrast of bone and needle         at the lowest possible radiation dose
in CT imaging. The benefit of such a         with its CARE package, which provides
significant dose savings also applies to     a clear indication of the radiation levels
the treatment of children with juvenile      used for every image or procedure. This
arthritis, who are sometimes as young        ALARA approach improves the account-
as two or three years old and, as in TMJ     ability of the interventional radiologist,
cases, require multiple injections dur-      interventional cardiologist, and admin-
ing the course of their treatment. The       istrators while promoting a healthy
importance of reducing the amount of         environment for patients and staff.
acute and chronic radiation is quite evi-
dent in these delicate patients.             Robert L. Bard is a freelance medical writer cer-
Other areas where significant radiation      tified by the American Medical Writer’s Associa-
                                             tion who also conducts clinical research at the
savings are achieved include procedures      University of Michigan’s Division of Cardiovas-
where syngo DynaCT is used to guide          cular Medicine.
the needle during bone biopsies and
to assess the airway and lesion during
                                              Contact
vascular malformation therapy, whereby
                                              heike.theessen@siemens.com
the intermittent imaging used in the


                                                           AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine         19
Cover Story CARE




Treatment of Complex Head and Neck
Lymphatic Malformation in an Infant
Supported by syngo DynaCT
Courtesy of Anne Marie Cahill, M.D., Deddeh Ballah, B.A.
Department of Interventional Radiology, Children’s Hospital of Philadelphia, PA, USA




                                                      Children's Hospital of Philadelphia
                                                      – Founded in 1855 as the nation's
                                                      first hospital devoted exclusively
                                                      to caring for children, it has been
                                                      the birthplace of many firsts in pe-
                                                      diatric medicine. In interventional
                                                      radiology employees are working
                                                      hand in hand to provide best
                                                      possible care for their patients.




Patient history                             course of 24 months. Doxycycline is an           sible dose while preserving diagnostic
At 40 weeks in utero the male fetus         antibiotic that causes inflammation of           information. With the inherent contrast
was diagnosed with a large neck mass        the lymphatic malformation epithelium            provided by the sclerotherapy agent we
on prenatal ultrasound. Prenatal MR         that eventually leads to scarring and            are able to reduce the dose provided
imaging was performed demonstrat-           regression of the lesion. The second             by our typical syngo DynaCT to 6 % of
ing a 5.7 cm by 2.7 cm left neck mass.      and third sclerotherapy procedures used          the manufacturer setting and 50 % of
The patient was delivered at CHOP           Low Dose syngo DynaCT imaging to                 conventional CT.
via Caesarean section for concern of        confirm sclerotherapy distribution in the        In the future, syngo DynaCT can be
airway compromise. The baby boy             lesion. The syngo DynaCT was acquired            used to direct procedures. By identifying
required routine resuscitation and was      with a dose value of 0.7 mGy.                    areas of the lesions that lack sclero-
transferred uneventfully to the neonatal                                                     therapy agent after injection, additional
intensive care unit.                        Comments                                         injections may be performed during
                                            syngo DynaCT is used to confirm sclero-          treatment potentially reducing the num-
Diagnosis                                   therapy agent distribution and deter-            ber of future sessions.
On the third day of life, a neck MRI with   mine proximity to the airway in patients
and without gadolinium contrast was         with complex head and neck lymphatic
performed on the neonate, showing a         malformations. Intraprocedural syngo
                                                                                             Pediatr Radiol. 2011 Apr;41(4):
T2 hyperintense, multicystic lesion with    DynaCT images can provide information
                                                                                              476-82. Epub 2010 Nov 16.
evidence of hemorrhage that extended        regarding the volume of lesion treated
to the posterior neck and deeper            and the necessity for further treatment           Results:
                                                                                              The manufacturer's default setting gave an equivalent
structures of the neck, including the       sessions. It enables us to create image
                                                                                              CTDI of 4.8 mGy. Optimizing the dose settings and
prevertebral and retropharyngeal space,     reconstructions in three planes on a              adding copper filtration reduced the radiation dose by
confirming a macrocystic lymphatic          separate workstation allowing us to               94 %. This represents a 50 % reduction from conven-
                                                                                              tional CT.
malformation.                               compare the extent of the lesion treated
                                            to the pre-treatment lesion in those
Treatment                                   three planes on MRI.
                                                                                              Contact
This patient underwent three doxycy-        Since this is essentially a CT scan it is
                                                                                              heike.theessen@siemens.com
cline sclerotherapy procedures over the     imperative to achieve the lowest pos-


20 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
CARE Cover Story




1
                            1 Axial T2 weighted MR image demonstrating
                           the macrocystic lymphatic malformation left neck.




2
                            2 Correlating axial syngo DynaCT image
                           demonstrating the distribution of the
                           sclerotherapy agent throughout the lesion
                           when compared to the MRI. Note the close
                           proximity of the sclerotherapy agent and
                           lesion to the airway guiding post-procedure
                           therapy, resulting in the patient remaining
                           intubated post-procedure.




    AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine    21
Cover Story CARE




Evaluation of CAREposition:
Radiation-Free Positioning with
CAREposition Results in a Decrease
in Screening Times


Brendan Erskine, and Elissa Marshall from the Department of
Radiology, The Alfred, Melbourne, Australia have conducted a
study on the potential of CAREposition to reduce the fluoroscopic
screening time during various diagnostic procedures. The study
was presented as a paper: “Evaluation of Siemens CAREposition,
Radiation-Free Positioning For Angiography and Fluoroscopy” at
the ASMIRRT 2011 conference.
by Brendan Erskine and Elissa Marshall




Introduction                                 savings, not to investigate dose minimi-   Other techniques for reducing screening
CAREposition is a Siemens functionality      zation. While a reduction in screening     time,
that enables accurate repositioning of       time will result in lower patient dose,
the patient under visual control without     ultimately dose is a product of many       • Last Image Hold (LIH) holds the last
radiation exposure. Guidance is pro-         factors, beyond the scope of this study,     fluoroscopic image on the viewing
vided by a centrally positioned crosshair    such as:                                     monitor and incorporates radiation-
marking the central beam while the                                                        free collimation and wedge filter
collimated field of view (FOV) is visually   •   Patient habitus                          placement
displayed as a white outlined rectan-        •   Object-to-image distance
gular box. This is displayed on the last     •   Source-to-object distance              • ‘Fluoro Store’ or ‘Fluoro Loop’ per-
image hold and adjusts automatically         •   Field of view                            mit the operator to review and
to changes in position of the table and      •   Exposure factors (kV, mA)                save the last fluoroscopic imaging
C-arm as well as changes in FOV.             •   Exposure time                            sequence. While not directly reduc-
                                             •   Detector quantum efficiency (DQE)        ing the screening time, this software
Background                                   •   Pulsed fluoroscopy                       functionality may indirectly reduce
CAREposition functionality is aimed          •   Adaptive dose filtration by the          screening time and patient dose by
purely at reducing fluoroscopic screen-          application of copper/aluminum           allowing the storage of fluoroscopic
ing time and therefore the primary               prefiltration                            sequences instead of formal (higher
focus of this study was to quantify these                                                 dose) angiographic sequences


22 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
CARE Cover Story




                            Table 1: Screening Times Pre & Post CAREposition


                            30:00
Mean Screening Time (min)




                            25:00


                            20:00


                            15:00
                                                                                                                                  pre CAREposition
                                                                                                                                  post CAREposition
                            10:00


                            05:00


                            00:00

    Aorto-femoral Angiography                                                       ERCP
    Femoral Angiography                                                             PICC Line Insertion
    AV Fistulography                                                                Gastrografin Swallow
    AV Fistula – Interventional                                                     Defecating Proctography
    Tunneled Line Insertion                                                         Pain Management
    Jugular Vonoplasty                                                              Video Swallow


                                                                          Erskine Brendan and Marshall Elissa, Dept. of Radiology, The Alfred, Melbourne, Australia




• Some fluoroscopic systems especially                   as the difficulty of laser visualization          Methods
  mobile image intensifiers (I.I.) incor-                in brightly lit rooms and refraction              Screening times from procedures per-
  porate the use of I.I. mounted laser                   of the laser through plastic I.I. cov-            formed on all angiographic and fluoro-
  guidance to assist positioning without                 ers. Also, accurate positioning of the            scopic machines were obtained over a
  the need for radiation. This relatively                laser is made more difficult on heavily           six month period. At the trial midpoint,
  cheap method of image guidance                         draped patients.                                  three multipurpose fluoroscopic/angio-
  suffers from many drawbacks such                                                                         graphic machines were enabled with


                                                                   AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine                     23
Cover Story CARE




Table 2: Screening time measurements during diagnostic and interventional procedures

  Procedure                                                Case Numbers                    PRE CAREposition                 POST CAREposition

  Endoscopic retrograde
                                                           94                              04:52                            03:42
  pancreato-cholangiography (ERCP)
  Gastrografin Swallow                                     65                              01:18                            01:24
  Video Swallow                                            50                              03:24                            03:20
  Defecating proctography                                  39                              01:46                            01:27
  Peripherally Inserted Central Catheter (PICC)            656                             00:45                            00:45
  Tunnelled catheter insertion
                                                           103                             01:28                            01:00
  (Hickmans, Permcath, Portocath)
  Pain management injections
                                                           126                             00:47                            00:47
  (Epidural, Facet joint, Medial branch block)
  Aorto-femoral angiography – Diagnostic                   27                              03:26                            03:11
  Femoral angiography – Diagnostic                         25                              01:30                            01:11
  Arterio-venous (AV) fistulography –
                                                           19                              01:06                            00:49
  Diagnostic
  Arterio-venous (AV) fistulography –
                                                           22                              14:50                            14:02
  Interventional
  Jugular venoplasty – Interventional                      47                              27:09                            20:11

                                                                 Erskine Brendan and Marshall Elissa, Dept. of Radiology, The Alfred, Melbourne, Australia




CAREposition software licensing:            interventional) will always lead to a                 certainly provided more accurate
                                            wide spread of results. To obtain the                 results.
• Siemens AXIOM Artis MP                    most accurate data, only procedures
  (fluoroscopy)                             (diagnostic or interventional) with                   Discussion
• Siemens AXIOM Artis MP                    standardized imaging and relatively                   […] CAREposition appeared most
  (angiography)                             high case numbers were chosen. These                  beneficial in the scenario of sequen-
• Siemens AXIOM Artis dMP                   procedures along with results are dem-                tial diagnostic imaging of peripheral
  (fluoroscopy/angiography)                 onstrated in Table 1.                                 vasculature, whereby accurate overlap
                                                                                                  between acquisitions could be achieved
All machines employed remote (pedes-        Study limitations                                     with minimal fluoroscopy. Aorto-femoral
tal) C-arm/table controls ran exclusively   Since we are primarily a teaching insti-              diagnostic angiographic studies saw a
by the radiographer. Our main angio-        tution, it is likely that even without the            7 % reduction in screening time (3:26
graphic machine, a Siemens Artis zee        use of CAREposition we might have                     to 3:11 min), with single leg diagnostic
biplane, had CAREposition licensing         observed a small reduction in screen-                 studies demonstrating a 21 % reduction
from installation and was therefore         ing times given increasing experience                 (1:30 to 1:11 min). A similar result was
excluded from the trial.                    of both medical and allied staff. Also,               demonstrated for diagnostic AV fistulog-
Although data from approximately            despite the six month trial encompass-                raphy, where a 26 % reduction (1:06 to
2,200 procedures were obtained,             ing approximately 2,200 fluoroscopic/                 0:49 min) was observed. Several exam-
the variability of fluoroscopic and         angiographic procedures, a greater                    ples for procedures are listed in Table 2.
angiographic procedures (particularly       period of data collection would have                  When operators gain confidence in the


24 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
CARE Cover Story




1a                                                      1b                                          1c




 1 Utilization of CAREposition during three angiographic procedures:
a Trans-jugular liver biopsy
b Cerebral angiography
c Femoral angiography




accuracy of CAREposition functionality,           ing time was demonstrated, however,           lization of CAREposition has resulted in a
huge reductions in screening time could           noting our case numbers were small.           modest decrease in screening times for
be achieved. Such was highlighted when            A much larger result was demonstrated         a range of diagnostic procedures with
reliance exclusively on CAREposition for          in jugular venoplasty procedures. This        greatest benefit being demonstrated
guidance of angiographic positioning in           interventional procedure was chosen           when used in sequential diagnostic
three peripheral diagnostic studies com-          because it provided the largest subject       imaging of peripheral vasculature.
prising 19 separate acquisitions, were            group of all the interventional proce-
achieved with totals of only 4, 6 and 8           dures and involved standardized imag-         Thanks to the following angiographers for their
seconds fluoroscopy time […]                      ing of both internal jugular veins and        assistance in compiling procedural data: Jane
                                                                                                Chow, Karen Patel, Alix Fell, Wayne Chan, Neal
[…] screening times in interventional             azygos system with subsequent angio-          Russell, Lisa Broadley.
procedures are heavily dependent on               plasty of stenosed vessels, providing us
both the patient pathology and the                with a more accurate reflection of the
skill of the clinician. Although difficult        benefits of CAREposition.
to quantify, CAREposition appeared
extremely useful in complex and chal-             Conclusion
lenging interventional procedures                 CAREposition provides radiation-free flu-
especially when multiple working                  oroscopic and angiographic positioning
projections were employed. In the                 with the use of graphic markers overlaid
                                                                                                  Contact
angiographic intervention of AV fistulas          on the fluoroscopic last image hold.
                                                                                                  vera.juennemann@siemens.com
only a small reduction (5 %) in screen-           Our study has demonstrated that the uti-


                                                                AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine     25
Angiography syngo iGuide




Endoleak Treatment:
Enhanced Visualization
Meets Enhanced Navigation




Diagnostic CT scan showes an Endoleak Type II.   The CT images are fused with the   syngo iGuide allows you to place target and
                                                 syngo DynaCT dataset.              skin entry point on the CT image, which is
                                                                                    overlaid onto the syngo DynaCT.




              1                                                    2                                   3
syngo iGuide integrated needle guidance                                                The endovascular repair of abdominal
                                                                                       aortic aneurysms (EVAR) with stent
enables vascular surgeons and                                                          grafts has surged in popularity over
interventional radiologists to efficiently,                                             the past decade, dramatically reduc-
                                                                                       ing the amount of recovery time for
precisely, and effectively treat type II                                               patients in comparison with open repair.
endoleaks, one of the most vexing                                                      However, approximately one-third1 of
                                                                                       patients who undergo EVAR will have
complications following endovascular                                                   an endoleak, a condition in which
abdominal aortic aneurysm repair.                                                      blood flows outside the lumen of the
                                                                                       endograft but within the aneurysm sac,
By Sameh Fahmy, MS                                                                     potentially increasing the risk of rupture.
                                                                                       In type II endoleaks, aortic branches that


26 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
syngo iGuide Angiography




syngo iGuide
provides a
bull's eye
view and pro-
gression
views for
optimal nee-                              After reaching the target a catheter will be   A DSA scene shows clearly all endoleak related
dle tracking.                             placed in the endoleak.                        vessels. The feeding vessels will be embolized
                                                                                         with various coils and Cordis Trufill n-Butyl
                                                                                         Cyanoacrylate glue.




                4                                                  5                                        6
have been excluded by the endograft,      pital DeBakey Heart and Vascular Center        syngo DynaCT, the solution frees up
such as the lumbar arteries and the       in Houston, Texas, USA, and Professor of       the hospital’s computed tomography
inferior mesenteric artery, perfuse the   Cardiovascular Surgery at Weill Cornell        (CT) scanners for routine diagnostic
aneurysm sac via retrograde blood flow.   Medical College of Cornell University.         imaging and enhances workflow by
Type II endoleaks are the most common     In July 2010, Lumsden and his collea-          eliminating the need to transfer the
endoleak and can have multiple feeding    gues began using syngo iGuide inte-            patient during the procedure. “The most
and draining vessels that make their      grated needle guidance, a software             important thing for us is that the aneu-
treatment challenging. “Sometimes         solution that enables physicians to per-       rysm stops growing,” says Lumsden,
when we get referred to these patients,   form needle procedures more precisely          who uses the multi-axis Artis zeego.
they may have had three or four trans-    and efficiently using the Artis zee family     “And in the majority of patients that
femoral attempts at blocking the en-      of C-arm systems. Because the planning         we have treated with syngo iGuide, the
doleak off,” says Alan Lumsden, MD,       of the procedure is accomplished using         aneurysm has stopped growing and the
Medical Director of the Methodist Hos-    cross-sectional images acquired with           endoleak has gone away.”


                                                        AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine       27
Angiography syngo iGuide




                                             Interventional radiologists such as         much shorter amount of time. Detailed
                                             David Lacey, MD, at Iowa Methodist          anatomical information is obtained with
                                             Medical Center in Des Moines, Iowa          syngo DynaCT, and the images are fused
                                             report similar promising results. “I’m      with a diagnostic CT that was obtained
                                             more apt to be able to select small ves-    earlier. To define the needle path, physi-
                                             sels and embolize them, and our results     cians mark the needle target point in
                                             have been very good,” says Lacey, who       the CT dataset and then mark the loca-
                                             in 2008 became one of the first users of    tion of the skin entry point. By scrolling
                                             syngo iGuide in the USA.                    through the multiplanar reformations,
                                                                                         physicians can follow the needle path
                                             Saving Time                                 easily and verify that there are no vital
                                             and Streamlining Workflow                    structures, such as the inferior vena
                                             The two most common approaches              cava, in the way of the planned path.
                                             for treating type II endoleaks are the      syngo iGuide automatically proposes
                                             transarterial approach, often via trans-    two needle progression views, in which
                                             femoral access, and direct translumbar      the planned path is graphically overlaid
                                             puncture. The success rate of the tran-     onto the fluoroscopic image. The needle
                                             sarterial approach is low, with up to 80    is advanced under fluoro guidance, and
                                             percent recurrence rate due to the com-     an additional syngo DynaCT run is per-
                                             plexity of endoleaks and the potentially    formed in slab mode to check the final
                                             circuitous route.2                          position of the needle. Once the needle
                                             “The transfemoral approach has been         position is verified, the physicians per-
                                             tried and largely has failed,” Lumsden      form the embolization.
                                             says. “The idea behind the translum-        Lacey estimates that the use of syngo
                                             bar procedure is that instead of going      iGuide reduces the time it takes to per-
                                             through multiple feeding branches, you      form the procedure by an hour, while
                                             go right where they all come together       Lumsden notes that it may save even
                                             and work into those feeding branches        more time in particularly complicated
                                             from inside that. The access in trying to   cases. “The last one we did probably
 “In the majority of                         go transfemoral or transmesenteric is       took an hour,” Lumsden says. “Before, it
  patients that we                           very long and torturous; some catheters     probably took two to three hours.”
                                             can’t even get to them.”                    In addition to the measurable reduc-
  have treated with                          Lacey explains that before Iowa Meth-       tion in time associated with the use of
  syngo iGuide, the                          odist Medical Center began using syngo      syngo iGuide, the elimination of patient
                                             iGuide with its ceiling-mounted Artis       transfer from the CT has the theoretical
  aneurysm has                               zee, he and his colleagues would use a      advantage of maintaining sterility, since
  stopped growing                            translumbar approach and advance the        physicians no longer have to transfer a
                                             needle into the endoleak cavity using CT    patient with a wire extending from the
  and the endoleak                           fluoroscopy. After confirming that the      aneurysm sac, out the patient’s back,
  has gone away.”                            needle was in position by the pulsatile     and to the outside world.
                                             return of blood, the physicians would       A CT scanner can be used for many
                                             exchange the needle over a guidewire,       diagnostic scans in the time it takes to
   Alan B. Lumsden, M.D., Medical Director   secure the wire with tape, and then         complete a single needle procedure, so
   Methodist DeBakey Heart and Vascular
                                             transfer the patient to the interven-       the elimination of the CT scanner for
   Center, The Methodist Hospital,
   Houston, TX, USA                          tional radiology angio suite. The patient   needle guidance also has clear finan-
                                             would then be re-prepped before physi-      cial benefits. Lacey points out that the
                                             cians used the guidewire to advance a       increasing use of interventions such as
                                             catheter under fluoroscopic guidance        CT biopsies and CT ablations has put
                                             into the endoleak cavity, where coils       additional scheduling demands on the
                                             and glue are used for the embolization.     scanners at Iowa Methodist Medical
                                             With the installation of syngo iGuide,      Center, making any technology that
                                             however, the entire procedure is per-       reduces demand for the CT scanners
                                             formed in the angio suite – and in a        especially welcome.


28 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
syngo iGuide Angiography




                                           Lacey points out several components of       these feeding vessels.”
                                           syngo iGuide that he says reflect a level    The physicians say the power of the
                                           of refinement not seen in similar needle     technology is evident by the ease with
                                           guidance systems. The ability to obtain      which it handles challenging cases.
                                           a control scan after the needle has been     Lacey points out that he often encoun-
                                           placed helps ensure accuracy by auto-        ters aneurysm sacs that measure less
                                           matically correcting for patient motion      than a centimeter. The difficulty of
                                           or even the deformation of tissues           accessing them is compounded in larger
“The 3D overlay lets                       caused by the pressure of the needle on      patients, who in many cases require a
                                           the skin. The Artis zee ceiling-mounted      20-centimeter needle. “That’s a long
 you look at any an-                       system he uses is equipped with an           way to go to get an accurate placement
 gle to figure out                          integrated laser crosshair that precisely    with a needle, but it turns out to be
                                           marks the skin entry point. This reduces     pretty easy to do with this system,” he
 how to best navigate                      radiation dose by eliminating the need       says. “I’m always impressed that I can hit
 the otherwise un-                         for fluoroscopy to match the needle tip      that target, often in just one pass, using
                                           with the path in the bulls-eye view and      this system.”
 predictable pathway                       improves ease of use. After acquiring        The physicians say that long-term
 into this lesion.”                        the initial syngo DynaCT scan to define      follow-up and several additional cases
                                           small structures, Lacey uses syngo           will be required to quantify improved
                                           DynaCT in low-dose mode to further           patient outcomes using syngo iGuide,
 David L. Lacey, M.D., Department of Ra-   minimize radiation to the patient.           but the early results are certainly prom-
 diology, Iowa Methodist Medical Center,
                                           Once the endoleak site has been              ising. Lacey says the success in treating
 Des Moines, Iowa, USA
                                           accessed, Lacey uses an additional tool      type II endoleaks at Iowa Methodist
                                           known as syngo iPilot to overlay a 3D        Medical Center has already led to refer-
                                           syngo DynaCT angiography image on            rals. In one recent case, the referring
                                           the live fluoro as he navigates the cath-    physician tried and failed to treat the
                                           eter. “The 3D overlay lets you look at any   patient using conventional tools and
                                           angle to figure out how to best navigate     sent the patient to Iowa Methodist,
                                           the otherwise unpredictable pathway          nearly four hours away.
                                           into this lesion,” Lacey says. “It allows    Lacey adds that syngo iGuide is so easy
                                           you to very quickly and easily pick off      to use that it can give physicians who
                                           the supplying vessels and really helps       lack significant experience or confi-
                                           you address the full extent of the leak.”    dence with needle procedures the abil-
                                                                                        ity to successfully perform procedures,
                                           Handling Challenging Cases                   including type II endoleak repairs, that
                                           with Ease                                    they might otherwise find challenging.
                                           Lumsden says that using conventional         Using syngo iGuide is so simple, he
                                           techniques, most physicians are quite        says, “It’s kind of like cheating.”
                                           happy just to get the needle into the
                                           aneurysm sac. The precision that syngo       Sameh Fahmy, MS, is an award-winning free-
                                           iGuide enables, however, allows physi-       lance medical and technology journalist based
                                                                                        in Athens, Georgia, U.S.
                                           cians to enter the aneurysm sac at a
                                           location that maximizes their likelihood      1 Baum RA, et. al. Endoleaks after Endovascular
                                                                                           Repair of Abdominal Aortic Aneurysms J Vasc Inerv
                                           of embolizing the vessels that are feed-
                                                                                           Radiol 2003; 14:1111-1117
                                           ing the endoleak.                             2 Baum et al. Treatment of type 2 endoleaks after
                                           “If you have two lumbar arteries that are       endovascular repair of abdominal aortic aneu-
                                                                                           rysms: comparison of transarterial and translumbar
                                           feeding into the aneurysm and we enter          techniques. J VascSurg 2002; 35:23–29.
                                           right alongside one of them, we can’t
                                           bend the catheters around to get to it,”
                                           Lumsden explains. “So one of the things
                                           we’re looking at is trying to choose
                                                                                         Contact
                                           the trajectory that will give us the best
                                                                                         heike.theessen@siemens.com
                                           opportunity to catheterize and block off


                                                       AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine            29
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Ax kundenmagazin 14

  • 1. AXIOM Innovations The Magazine for Interventional Radiology, Cardiology and Surgery Issue Number 14 | November 2011 Treatment of Endoleaks Using syngo iGuide Page 26 New Hope for Stenotic Patients Aortic Valve Implantation Page 38 Endovascular Surgery with 3D Imaging New Imaging Possibilities Page 42 Low Dose - High Principles Saving Dose with CARE and syngo DynaCT
  • 2. Editorial “Keeping image quality high and radiation dose low is one of the key drivers in the development of our imaging portfolio.” Dr. Heinrich Kolem, CEO of the Angiography & Interventional X-Ray Business Unit (AX) at Siemens Healthcare 2 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 3. Editorial Dear Reader, Dr. Heinrich Kolem CEO AX Division Earlier this year, I had the opportunity to patients. They are also key drivers for possibility especially for high-risk attend the Cardiovascular and Interven- our development. We know that our patients who cannot undergo open sur- tional Radiological Society of Europe’s customers carry a lot of responsibility gery. New innovative applications such (CIRSE) annual conference in Munich. for each individual patient they treat. as syngo Aortic ValveGuide* help sur- The CIRSE is one of the most renowned In return, it is our responsibility to offer geons and cardiologists replace calcified conferences for interventional imag- reliable systems to support our cus- aortic heart valves with more guidance ing. There were approximately 6,000 tomers worldwide. We are constantly and a new automated workflow. attendees eager to learn about the lat- exploring new possibilities to reduce est technologies and advances in their dose without compromising image qual- Looking back on a very exciting year clinical field. I was very pleased to see ity. The title of this issue reflects that for Siemens Healthcare, I am proud how many visitors were interested in line of thought, “Low Dose - High Prin- to present to you this issue of AXIOM our products and solutions. For the first ciples.” Our dose saving initiative with Innovations. You can read more about time, we showcased how “The Future is CARE (Combined Applications to Reduce CARE technology, new functionalities in Flexible” with the Artis zeego, our multi- Exposure) and CLEAR (an imaging tech- endovascular and thoracic surgery, and axis C-arm system based on robotic nology to enhance visualization with many other innovative topics. Enjoy! technology. We introduced the Hybrid IR X-ray) not only reduces radiation dose concept which offers new opportunities for patients and staff, but also boosts for interventional radiologists looking image quality to an outstanding level. to expand to more complex cases. In order to meet current and future imag- A growing trend in the market for inter- ing needs, Artis zeego allows a variety ventional cardiology and hybrid surgery Dr. Heinrich Kolem of working heights and delivers large is the minimally invasive replacement volume image results. of valves. With demographic changes in our society and a growing percentage of Improving clinical workflow and elderly patients, new treatment meth- radiation dose reduction are of great ods will evolve. Minimally invasive pro- importance to our customers and their cedures are an exciting new treatment * The syngo Aortic ValveGuide is pending 510(k) clearance, and is not yet commercially available in the United States. AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 3
  • 4. Content 26 16 Enhanced Endoleak Content Radiation Reduction is Key in Pediatrics Treatment Through Improved Navigation 10 A long-term commitment 3 Editorial to reduce radiation dose Siemens has long been a leader in addressing the need to provide opti- mal images at the lowest possible 6 News radiation dose following the ALARA principle. Many institutions world- wide working with Siemens angio- graphy systems use the CARE 10 Cover Story applications in their daily routine when imaging patients of all ages. Low Dose, High Principles: It is most importatnt to them to Cardiac CARE for All keep radiation dose low, especially A Report from Fundación for children and also their own staff. Cardioinfantil in Colombia A Pediatric Radiologist's Approach to Radiation Reduction Interview with Dr. Anne Marie Cahill, Children's Hospital of Philadelphia Treatment of Complex Head and Cover Neck Malformation in an Infant Clinical Case Imaging of temporal mandibular joint with reduced radiation dose. CAREposition Courtesy of Anne An Evaluation of Radiation-Free Marie Cahill, M.D., Department of Positioning Interventional Radiology, Children´s Hospital of Philadelphia, 61 Imprint Pennsylvania, USA 4 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 5. Content 32 42 syngo Neuro PBV IR Helps During Advanced Technology Revolutionizes Revascularization Treatment Endovascular Surgery Angiography 38 Minimally Invasive Aortic Valve 54 An Innovative Setting – Implantation Offers New Hope to Hybrid Room 3D Imaging Delivers 26 Endoleak Treatment: Stenotic Patients Groundbreaking Care Enhanced Visualization Meets Interview with Dr. Antonio Dager St. Joseph Hospital in California Enhanced Navigation at Angiographia de Occidente in chooses an interdisciplinary syngo iGuide facilitates better Colombia approach to maximize patient care Workflow 30 Quantitative Evidences of Surgery Customer Care Hemodynamic Improvement of Brain Arteriovenous Malformation 42 3D Imaging Brings a New Vision 58 Upcoming Congresses & after Surgical Intervention to Endovascular Surgery Workshops Clinical case Interview with Dr. Alan Lumsden, Director of the Methodist Hospital 60 Subscription & Information 32 Revascularization Treatment DeBakey Heart and Vascular Center of Acute Cerebral Stenosis in Houston Clinical case 48 Accuracy Far Beyond Conventional Pneumological Practice Cardiology Dr. Hohenforst-Schmidt pioneers new navigation techniques in 34 Overlay of MRI Images pneumology in Pulmonary Vein Isolation A clinical evaluation 48 Navigation in the Lung by Prof. Rukshen Weerasooriya Clinical Case 36 Accurate Placement 50 Heart Valve Replacement – of Aortic Valves Significant Changes Thanks to Clinical case Hybrid Surgery Dr. Tatsuhiro Komiya talks about new surgical procedures AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 5
  • 6. News Less Radiation During Catheter Interventions Siemens’ Artis zee® angiography system has recently integrated the MediGuide Technology from St. Jude Medical, a medical positioning system that visualizes the position of a catheter without radiation. Like a GPS system, the MediGuide Technology locates the catheter during cardiac interventions and projects its precise position in real time on a previously acquired fluoroscopy image of the patient. During electrophysiological interventions, a miniaturized sensor integrated into the catheter can be located by receiving electromagnetic posi- tioning signals from the MediGuide transmitters, which are incorporated into the detector housing of the Artis zee system. The MediGuide Technology then calculates the respective position and orien- tation of the catheter and displays it in real time on fluoroscopic images of the patient that were recorded earlier. The technology also compensates for patient movement caused by respiration and heart motion. The MediGuide Technology provides significant benefits especially during complex electrophysi- ological procedures. The electrophysiologist no longer has to take fluoroscopic images of the patient each time the catheter is re-positioned. As a result, less radiation and less contrast agent use is expected. The Heart Center Leipzig, Germany, has already performed the first interventions with Artis zee and the MediGuide Technology. “The low- radiation, precise localization of the catheter tip onto the pre-recorded fluoroscopy image is a most impressive function, because the system is able to compensate the motion from the heart beat and breathing,” said Professor Dr. Gerhard Hindricks, Director of the Rhythmology Department. “For my team and me, this is clearly the future in electro- physiology.” Localization of the catheter supported by MediGuide Technology and EnSite Velocity Mapping System. 6 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 7. News Integrated FFR Calculation Saves Space and Time The measurement of fractional flow reserve (FFR) helps to deter- mine the hemodynamic signifi- cance of a coronary stenosis and to guide balloon and stent place- ment. FFR is being measured by comparing the blood pressures distal (behind) and proximal (in front) to a lesion. Once this ratio reaches 0.75 or below, a stenosis is considered hemodynamically significant and a stent placement is recommended. The FAME study published in 2009 (N Engl J Med 2009; 360:213-224) evaluated FFR- guided CAD treatment and clearly found an increase in patient survival of 30 % while at the same time treatment costs decreased by 30 %. St Jude Medical and Volcano offer FFR measurement solu- tions in the cath lab that now have been fully integrated with the Siemens AXIOM Sensis XP recording system, which offers simple plug&play connectivity and makes using an external workstation obsolete. For getting the new FFR mea- surement capabilities, AXIOM Sensis XP software must be upgraded to the latest software version due for release at the end of 2011. The FFR option can already be ordered today and will become available with the new software version. All systems in the field currently running software version VC10 will be upgraded free of charge to VC11 starting in spring 2012. AXIOM Sensis XP running VC11 software and FFR option. AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 7
  • 8. News A New Era: Hybrid Operating Rooms in the American Hospital As one of the most modern hospitals where TAVI (Transcatheter Aortic Valve not only in Turkey but the entire region, Implantation) procedures have recently the American Hospital in Istanbul begun to be performed with the use continues its leading role in hybrid of the Artis zeego system and Siemens operating room practices with the syngo DynaCT Cardiac software, recently installed Siemens Artis zeego procedures can be completed more multi-axis robotic angiography system. rapidly and reliably with the comfort Thanks to the Artis zeego system, introduced by Artis zeego and the wide both advanced hybrid practices and movement capability of the C-arm. standardized cardiologic procedures can The American Hospital is currently able be performed. In the new procedure to perform interventional procedures, room that has an angiography thanks to the hybrid system it has operating table that tilts in four recently acquired, as well as ongoing different directions, a laminar flow medical, technical and technological unit and anesthesia device pendants, developments. Operating in Istanbul, the latest technological innovations, Turkey since 1920, the American such as a 56" Artis zee Large Display, Hospital offers the latest technologies an integrated Intravascular Ultrasound to aid the hundreds of millions of (IVUS), an integrated hemodynamic people in the region as a hospital held Dr. Genco Yücel, Department of Cardiology, recording system (Siemens AXIOM in high regard not only in Turkey but in in front of the department’s new Artis zeego. Sensis XP), etc., are used. At the center neighboring countries as well. Hybrid OR With Trumpf Table Opened at Clinical Center Ludwigsburg Since 2010, Siemens optionally delivers Artis zeego or Artis zee ceiling with the TruSystem 7500 OR table by Trumpf. In May 2011 another hybrid operating room with Trumpf´s OR table and Siemens Artis zeego went live at the clinical center Ludwigsburg, Germany – meanwhile this is the sixth installation worldwide that combines an Artis system with a Trumpf OR table. The room at the clinical center Ludwigsburg is located in a brand new building as part of a 35 million euro project to build one of the most modern surgical centers in Germany with altogether 9 fully digital connected operating rooms. With this new hybrid OR, patients will benefit from fewer shifts during the procedures, less radiation because of faster and fewer acquisitions, and fewer complications since the success of the intervention can be verified right in the OR at the end of the procedure. Siemens is also going to offer a similar integration of the Artis zeego and Artis zee ceiling with Maquet OR tables in View of the new hybrid operating room in Ludwigsburg with the Trumpf early 2013. TruSystem 7500 OR table and Siemens Artis zeego. 8 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 9. News Siemens Integrates Maquet’s Magnus OR Table for Hybrid ORs 1 2 Fig. 1: Siemens Artis zeego with Maquet’s Magnus table with breakable Fig. 2: Maquet also offers a radiolucent table top for artifact-free imaging top supports complex procedures in advanced positions. in endovascular procedures. The versatile Magnus OR table* from and neurosurgery. The Artis zeego is First clinical user tests of the integrated Maquet will be available together with the only robotic C-arm-system on the solution with Artis zeego are anticipated Artis zeego and Artis zee ceiling. With the market that can adapt to the complete to start in May 2012; general availability existing family of Artis tables, Trumpf’s height adjustment of the table. The is planned for December 2012. The inte- TruSystem 7500 tables and the Magnus multi-axis robotic system also follows gration with Artis zee ceiling is sched- table to follow, Siemens can provide the movements of the operating table. uled to be available in spring 2013. three fully integrated table systems. This It flexibly adjusts to even complicated Of course Siemens will continue to means synchronized C-arm and OR table positions of the segmented table top. offer the tried-and-true family of fully movements, 2D and 3D imaging, all with This flexibility also allows free access integrated Artis zee tables. They are a single integrated operation module. from any side, with a comfortable space available in three different versions: the And the right table for surgical require- for the anesthetist and his equipment. standard table, table with tilt, and the ments in the hybrid OR. If open procedures without imaging OR table with tilt and cradle. The carbon The key benefit of the new solution is equipment are performed, Artis zeego’s table tops allow for high-end imaging, the multidisciplinary use of the hybrid multiple park positions allow for maxi- including 3D. The Artis table family is OR – which means it will allow for both mum space in the OR field. the solution of choice for cardiac and interventional imaging and for open Equipped with an additional floating vascular procedures providing an exten- procedures where extremely flexible carbon table top, the integrated solu- sive longitudinal travel range, full body patient positioning may be required. tion enables full cath lab functionality. coverage and a free floating radiolucent The Magnus OR table is fitted with The table top provides 360° radio- table top. exchangeable table tops – a fully radio- translucency for superb X-ray images, lucent carbon top (Fig. 2) as well as a including 3D. A transport system highly flexible, segmented table top ensures the easy exchange of the table (Fig. 1). The latter allows surgeons the tops. The patient can be prepared and most appropriate patient positioning, positioned on the table top in the * WIP. The information about this product is preliminary. The product is under development and not commercially including complicated positions, induction area ensuring ahead of time available in the U.S., and its future availability cannot occurring especially in orthopedics maximum efficiency for the OR. be ensured. AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 9
  • 10. Cover Story CARE Low Dose, High Principles: Cardiac CARE for All 10 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 11. CARE Cover Story At Fundación Cardioinfantil in Bogotá, Colombia, no one is turned away for lack of ability to pay. Using the most advanced equipment from Siemens, the hospital’s dedicated staff is making interventional imaging safer for everyone, especially those who need it most: their youngest, weakest patients. By Chris Kraul AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 11
  • 12. Cover Story CARE Any day now, Nelsy, a five-year-old because her mother and brother have Colombian girl, will undergo an angio- died and her father is worried that he plasty at Bogotá’s Fundación Cardio- will lose her as well,” says Ronderos. infantil hospital that will save her life. By coming to Fundación Cardioinfantil Pale, underweight and short of breath, in Bogotá for treatment, Nelsy will Nelsy was screened in late May by the receive another benefit that could be clinic’s outreach team in the southwest- just as consequential to her long-term ern city of Pasto and found to have per- health. Her procedure will be performed sistent ductus arteriosis, a congenital using Siemens’ state-of-the-art “low condition that, without a procedure to dose” interventional imaging technol- close the ductus, would have proved ogy. The hospital has four Siemens Artis fatal by her mid-teens. systems that – with their advanced Nelsy, whose mother and ten-year old software and imaging innovations – can brother both died of heart disease, will dramatically cut the radiation exposure be brought to Bogotá free of charge of patients like Nelsy, compared with from her home 300 miles away, a poor what they would have received a few fishing village on Colombia’s southwest- years ago. ern Pacific coast. She and her father will Each system is bundled with Siemens’ be put up in the clinic’s housing and, proprietary CARE (Combined Applica- despite the fact that they have no way tions to Reduce Exposure) applica- to pay the hospital bills, Nelsy will be tions that can help to decrease typical “The Siemens given the kind of care that has made exposure in catheterization labs. It does engineers have Fundación Cardioinfantil a private, nonprofit institution, a beacon of car- that by providing a broad range of dose saving applications, enhanced monitor- helped a lot in diovascular treatment in Latin America. The hospital draws paying patients from ing and reporting of the radiation being generated and a flexibility of use that giving individual throughout the Caribbean and Cen- allows doctors at Fundacion Cardioin- tral America, and from as far away as fantil to tailor treatment to a patient’s training to our Florida and Peru. It also takes on scores specific age, weight and diagnosis. personnel with of pro bono “social” cases per year, like Nelsy’s, mainly from Colombia but it “The advances that we are seeing in Siemens’ imaging are allowing us to be the goal of accepts desperately poor patients from Ecuador and Venezuela as well. more precise with our procedures with less risk of complications and failures,” minimizing the Making the Safety Factor a said Dr. Ronderos. Additionally he states the better the imaging, the less time he radiation used in High Priority spends diagnosing the condition and The procedure in the hospital’s heart placing coils, stents and heart valves. a given exam catheterization lab to close the ductus That reduces the patient’s and the medi- and to devise will only take 45 minutes. But it will save Nelsy from probable death by cal staff’s exposure to radiation, he said. That lessened exposure is important additional pneumonia in the coming years and for the operator as well as the patient. give her a good chance of leading a Medical staff who administer the pro- measures of long, healthy life, says Miguel Ronde- cedures are concerned about their own ros, MD, a cardiologist who trained at risk as well. radiological University of Alabama-Birmingham and Making angiography safer has been a protection.” who was part of the outreach team that diagnosed Nelsy. He will also perform Siemens objective since the company entered the medical equipment field the angioplasty. in the early 1960s, and especially Miguel Ronderos, M.D., “We immediately classified Nelsy as since a low dose application initiative Department of Cardiology, Fundación a medical emergency, because she is was launched in 1994. Since then, Cardioinfantil, Bogotá, Colombia in heart failure right now. But she is the company has achieved a series of also what we call a social emergency, breakthroughs, all with the goal of 12 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 13. CARE Cover Story A Vision of Improved Healthcare Access Fundación Cardioinfantil’s history began in brigades – teams of a half-dozen doctors and 1971 when two Colombian doctors, brothers nurses – to seek out sick children in remote, Reinaldo and Camilo Cabrera, returned home poverty-stricken areas of the country. Now, from completing their medical training at the about eight times a year, the brigades hold Texas Heart Institute in Houston determined two-day cardiovascular clinics at partner to address the inequalities of their country’s hospitals from one end of the country to the healthcare. High on their list of concerns was other where young patients in need gather. the incidence of congenital heart defects, Two months prior to each visit, the founda- affecting one in every 100 babies. In devel- tion’s community relations department starts oped countries, such defects are easily getting the word out via radio announce- diagnosed and treated, but they too often ments and posters that any family who has proved to be death sentences in Colombia. a child with possible heart problems will be Poverty and difficult geography make access examined for free. It was in one such brigade to quality medical care an impossible dream visit held at Pasto’s Hospital Los Angeles in for much of the population. May that Ronderos diagnosed Nelsy, one With the help of ex-president Carlos Lleras of 400 young people who lined up for an Restrepo, the new physicians opened the pre- examination, and put her on the list of kids decessor of today’s foundation in a corner of to be brought to Bogotá. She and her father Bogotá’s Misericordia Hospital, a charity clinic traveled eight hours by boat and four hours for children, specifically to offer cardiovascu- by bus to get to the examination site. lar care to poor youth in the urban area. They Fundación Cardioinfantil’s staff examine relied on donations of services, equipment, about 4,000 poor young people per year cash and eventually land from the city of during these outreach clinics. Of those, Bogotá, where the current 300-bed hospital 250 children and adolescents, or about is situated. 20 percent of all the children examined, As it grew, the clinic broadened its mission to are subsequently brought to the hospital include children who could pay for treatment for heart surgery or angiography at the as part of a scheme by which paying patients bustling Bogotá hospital, free of charge. helped subsidize care for the poor. Later, as For their service to Colombia, the Cabrera the clinic’s reputation for quality care spread, brothers were decorated in July 2010 by adult heart patients were admitted, also to then-president Alvaro Uribe with the Order help subsidize treatment for poor children. of Boyaca, the highest national honor Adults now comprise about 70 percent of the attainable by a Colombian civilian. One of the caseload. doctors, Reinaldo Cabrera, died in November In 1986, the Cabrera brothers decided to pro- 2010, but his brother Camilo continues to vide care to young patients for whom a trip to be active and currently is the director of the Bogotá for life-saving treatment was impos- foundation. sible. The hospital began organizing outreach AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 13
  • 14. Cover Story CARE Combined Applications to Reduce Exposure: An Integrated Answer to Dose Reduction the imaging and visibility of devices. CAREvision: pulsed fluoroscopy application that provides extremely Over the last five years, Siemens syngo low frequencies to meet individual dose-saving targets. Pulses can DynaCT has made soft tissue imaging drop from a range of 30 p/s to only 0.5 p/s. At 7.5 p/s, a 75 % dose possible, enabling physicians to get reduction is achieved. additional soft tissue information in the interventional suite and thus get a CAREfilter: a variable CU-filter (0.1 mm – 0.9 mm) is automatically set better understanding of the structure of according to the current transparency of the object/C-arm angulation, the vessels and organs they are dealing without any necessary interaction from the user. Dose reduction: up with. to 50 %. Dr. Dario Echeverri, who heads Funda- CAREposition: positioning without repeated fluoroscopy. The feature cion Cardioinfantil’s catheterization lab is especially needed during long-lasting neurointerventions that can and who is also the current president take several hours as the provider can control patient positioning of the Latin American Society of Inter- without the need for additional fluoroscopy. ventionist Cardiology, said the CARE application “CAREguard” is especially CAREprofile: radiation-free adjustment of collimators as well valuable because it tracks radiation skin as radiation-free semitransparent filter parameter setting. Dose dose thresholds of patients and medical reduction: Up to 9 %. staff and sounds a warning if they are CAREguard: a new real-time application that monitors skin dose exceeded. exposure and allows for effective skin dose control. Three separate “It allows us to do a continuous follow- thresholds can be defined with warning indicators that alert up of the radiation dispersed by the for length of exposure time. The feature reduces exposure for machines and helps us reduce exposure radiologists, technicians, and patients. to patients and MDs, nurses and techni- cians working in the lab,” Echeverri said. Low Dose Acquisition: additional low dose protocols that can be Cognizant of the importance of low accessed hands free, directly from a footswitch. These tools can dose imaging, Siemens sends a free reduce radiation dose by 67 %. update of the latest software VC14 Low Dose syngo DynaCT: an optional feature, offers CT-like 3D including all CARE (Combined Applica- imaging for radiosensitive patients and others. As an example, 5 sec tions to Reduce Exposure) and CLEAR protocol can be done at 0.1 µGy/frame instead of 0.36 µGy/frame, (image quality) features to all customers which results in a 72 % reduction. of its Artis zee angiography systems around the world. CAREreport: a structured dose report that contains all patient Siemens’ advances now enable doctors demographics, procedure, and dose information. Using commercially to reduce the number of times a typical available programs or in-house software, this information can be heart patient has to undergo imaging filtered for further processing, such as dose analysis. exams. A decade ago, Nelsy might have had to undergo three different proce- dures during her stay at Cardioinfantil: one to diagnose, a second to treat her limiting dosage while enhancing image quality images are now captured at disease, and a third to confirm success. quality. Improved safety is doubly criti- 7.5 frames per second, down from 30 But the likelihood now is that a single cal because of the expanding range of frames previously, making possible a procedure will suffice. diagnoses and treatments for which 75 percent reduction in radiation dur- “Nowadays, we must be much more angiography is now used, going far ing the procedure. CAREreport offers a careful with our exams in arriving at a beyond its original cardiovascular appli- running account of radiation dispersed diagnosis,” Dr. Ronderos said. “Each day cation to include neuro and abdominal along with the patient’s demographics, we are more aware of the importance to interventions and surgeries. procedure and dose information. health of the cumulative dose of radia- The low dose equipment is achieving tion over the course of a lifetime and, that goal with a variety of innovations. A Two-Way Flow of Information with the Siemens technology we have, Proprietary technology pulses radia- But there is more than that to low combined with our understanding and tion instead of emitting continuous dose. Efficiency gains from powerful quality of the imaging, we can minimize fluoroscopy. With CAREvision, high new Siemens software have improved exposure in a given exam.” 14 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 15. CARE Cover Story Fewer procedures also mean a patient says Echeverri, because he, Ronderos receives fewer injections of contrast and other medical staff operate the agent, which if overused can damage machines themselves without specially kidneys. trained technicians. As one of a dozen Siemens “reference “We want the relationship with Siemens sites” at leading hospitals in Latin to go far beyond buying and selling America and the Caribbean, Fundación equipment. We want Siemens to help us Cardioinfantil has become a key prov- in an integral way with training, market- ing ground for Siemens’ low dose ing and advice, a friend who will help imaging initiative in the region. The distinguish the foundation. The Low clinic also has become an incubator for Dose Workshop with Siemens was very more intensive relationships between encouraging, and it produced concrete Siemens product managers and the results,” says Echeverri. medical professionals who use the In exchange for going the extra mile, company’s equipment. The company Siemens is allowed to bring prospec- and its clinical customers see such close tive clients to Cardioinfantil to see relationships as a necessity, given the the systems in action, and even bring high stakes in cardiovascular care: the in doctors and nurses from foreign life-saving benefits of cutting-edge ther- countries to receive training on the apies as well as the potential hazards of machines. Siemens also gets important the imaging devices. feedback that is incorporated into the “Over the last year, a real two-way flow systems’ software and design. A bonus of information with Siemens has begun, for Siemens is its association with one “CAREguard so that we can receive not just the low dose technology but training and of Colombia’s most admired institutions for its mission of delivering lifesaving allows us to do advice, and we want that to continue,” says cardiologist Echeverri. “By the same cardiovascular care to poor children and young people who otherwise might die continuous token, we offer suggestions on design prematurely. follow-up of the improvements to better protect the Attesting to Fundación Cardioinfan- patients and people who work in the til’s high standards is its cooperation radiation room.” Those suggestions have included smaller tables to accommodate child arrangement with the Cleveland Clinic, which sends medical staff to Bogotá dispersed by the patients and design changes for protec- tive clothing. once a year to conduct professional seminars. machines and The advances of the Artis zee system “Most companies just want to sell helps us reduce give Dr. Echeverri added flexibility in machines and there is usually a discon- devising different protocols “according nect between the sales and technical exposure to to the patient and his or her condition, staff of these companies. Siemens is instead of using the same program for changing that trend. Together we are patients and all patients. This is new with the latest software of our Artis zee.” Adds Dr. constantly refining the proper use of the machines,” Dr. Ronderos concluded. MDs, nurses and Ronderos: “The Siemens engineers have “We have come to a nice arrangement.” technicians helped a lot in giving individual train- ing to our personnel with the goal of Chris Kraul is a freelance writer based in Bogotá, working in the minimizing the radiation used in a given Colombia, covering stories a wide range of top- exam and to devise additional measures ics. A reporter for the Los Angeles Times for 22 lab.” years, he was most recently the Latin American of radiological protection.” Bureau Chief at the newspaper’s Bogotá office. In February, Siemens brought in experts Dario Echeverri, M.D., to the clinic from Germany to lead a Department of Cardiology, Fundación dose and radiation workshop on safe Cardioinfantil, Bogotá, Colombia Contact operation of the angiography sys- vera.juennemann@siemens.com tems. That was an important gesture, AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 15
  • 16. Cover Story CARE A Pediatric Radiologist’s Approach to Radiation Reduction Siemens has long been a leader in addressing the need to provide optimal images at the lowest possible radiation dose. AXIOM Innovations’ Robert L. Bard discussed radiation dose savings and their clinical application in pediatric patients with Anne Marie Cahill, MD, of the Children’s Hospital of Philadelphia. By Robert L. Bard There is considerable concern among are paramount for Cahill because she grams automatically using the lowest both medical professionals and the pub- frequently deals with complex cases. possible radiation dose while providing lic these days about radiation exposure, Furthermore, radiation exposure is the best possible images, but clinicians in part due to the growing use of imag- especially important for her because she still have the ability to increase the ing equipment in both diagnostic and is treating children. dose if there is an area of interest that interventional medicine. Anne Marie Siemens products have long been requires further investigation. For exam- Cahill, MD, Director of Interventional designed to help clinicians obtain qual- ple, Cahill commonly evaluates patients Radiology at the Children’s Hospital ity images while following the ALARA with vascular anomalies where she first of Philadelphia, has worked with the principle. Siemens addresses the ALARA selects a low dose 3D program, syngo Siemens’ product development group principle with its Combined Applica- DynaCT, to deliver the lowest necessary to find new ways of imaging with lower tions to Reduce Exposure, or “CARE” dose of radiation to image the vascula- radiation doses and at the same time package. CARE is available throughout ture. However, if she notices a section achieving the best possible images. This the Siemens line of imaging products of blood vessel that is not imaged well principle is commonly referred to as the and addresses several aspects of the or appears to be abnormal during the “ALARA” principle: as low as reasonably imaging process, including the docu- initial scan, she has the freedom and achievable. mentation and monitoring of radiation ability to interrupt the standardized While clinicians must be aware of acute exposure of both patients and clinicians. program and she can concentrate the radiation exposure from any individual A primary feature of CARE is the ability imaging on that particular area and procedure, they must be even more to standardize radiation doses at the investigate any potential abnormalities. diligent in managing chronic radiation lowest possible level for each and every Siemens CAREguard is available with doses for their patients who receive procedure or image. CARE permits the all Artis zee angiography systems, either multiple procedures acutely or interventional radiologist to choose providing skin dose control software chronic procedures in a long-term evalu- programs in advance so that ALARA can that helps limit and document radia- ation of their condition. These concerns be achieved. Study-specific imaging pro- tion levels. With CAREguard, radiation 16 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 17. CARE Cover Story AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 17
  • 18. Cover Story CARE doses are constantly measured and has experienced three major benefits of only are fewer images necessary using the user can set the parameters to site- the Siemens products in their ability to Overlay Reference, but the images are specific values. If pre-defined skin dose image at the lowest possible radiation obtained at a lower radiation level. levels are exceeded, an audible warn- doses: Store Fluoro, Overlay Reference, Therefore, radiation is decreased as ing sounds, and a skin dose indicator and Low Dose syngo DynaCT. compared to traditional applications that flashes on the live display. A warning Store Fluoro enables the user to store a relied upon traditional fluoroscopy. pop-up is also prominently displayed on regular fluoro scene during a procedure During common vascular imaging, radia- the touchscreen of the system’s table- for documentation instead of doing a tion dose is decreased because, as Cahill side control, which is located within the new acquisition. Cahill explains that this states, “We can do an angiogram and interventional radiologist’s view during functionality allows her to decrease the save a specific image and then overlay the procedure. Radiation exposure lev- number of acquisitions she requires as that image onto the live fluoro. Later els can be generated with CAREreport, compared to previous clinical methods. that image can be used to track smaller and they can also be archived in the She can save images on the display arteries. This process saves radiation PACS system along with the procedural monitor instead of obtaining further because we do not perform roadmaps images. Cahill and her colleagues regu- images and exposing the patient – and (comprehensive tracking of blood flow larly take advantage of this feature by staff – to additional levels of radiation. through the vasculature) as much as we providing patients with radiation infor- Prior to having this capability, it would used to.” mation when reviewing clinical results. have been necessary for her to acquire additional images to assure she had all C-arm CT and Joint Injections Clinical Applications of the information she needed before The Children’s Hospital of Philadelphia for Low-Dose Imaging the patient left the interventional also uses syngo DynaCT to reduce radia- Cahill has worked closely with Siemens radiology suite. tion exposure in patients who require in developing C-arm CT protocols that Similar to Store Fluoro, Overlay Refer- imaging where the radiation dose is a provide 3D information in the inter- ence can decrease the number of particular concern. C-arm computed ventional radiation suite at very low images acquired as compared to previ- tomography permits joint injections radiation doses. She reports that she ous clinical imaging methods. Not with the use of CT and fluoroscopy and AVM nidus extending from T6 to L1 supplied by a left intercostal artery 1 2 3 1 Conventional intercostal artery angiogram 2 VRT (Volume Rendering Technique) 3 Embedded MPR Image of AVM nidus 18 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 19. CARE Cover Story “Store Fluoro allows us to decrease the omits an additional dose of radiation latter is used to determine the relation- number of acquired from traditional CT. Cahill references her ship of the airway to the treated lesion images. With the research using C-arm CT, which shows to help decide if the patient's breathing that radiation doses can be significantly tube can be safely removed post proce- Store Fluoro decreased when treating and evaluat- dure. In vascular malformation therapy functionality we can ing patients with temporal mandibular this helps clinicians determine whether joint (TMJ) disorder. She explains that the breathing tube can be safely save images on the radiation savings are largely obtained by removed from patients who are asleep display monitor reducing the need to acquire traditional under general anesthesia. computed tomography examinations In addition, vascular anomalies are instead of obtaining following interventional treatments. treated using Low Dose syngo DynaCT further images and TMJ disorder commonly requires as well, and the radiation savings – also patients to receive repeated injections about 50 percent of conventional CT – is exposing the patient, once or twice a year, and the radiation largely obtained once again by omitting and staff, to dose savings adds up during the course a post-procedural traditional CT. One of of treatment. Pediatric TMJ patients are the major advantages of treating vascu- additional levels of one specific group where imaging with lar anomalies in this fashion is that the radiation.” the ALARA principle is crucial because success of the sclerotherapy procedure of the repeated radiation exposure of a can be evaluated immediately after the vulnerable area, the jaw, because of its procedure by the same interventional Anne Marie Cahill, M.D., Department of Interventional Radiology, Children’s proximity to the eyes and thyroid. radiologist at the same location, which Hospital of Philadelphia, PA, USA Joint injections are a common applica- is an efficient use of hospital resources tion of C-arm CT because of the ability and an excellent means to improve to image at very low dose. Dr. Cahill patient satisfaction to their clinical care. estimates based on phantom studies The importance of dose savings – about a 50 percent reduction when especially in young patients – will compared to conventional CT and a only increase with the growth of further radiation dose reduction of 6% non-invasive imaging and radiologic from a manufacturer setting. This dose interventions. Siemens has addressed reduction is possible due to the inher- the need to provide high-quality images ent high contrast of bone and needle at the lowest possible radiation dose in CT imaging. The benefit of such a with its CARE package, which provides significant dose savings also applies to a clear indication of the radiation levels the treatment of children with juvenile used for every image or procedure. This arthritis, who are sometimes as young ALARA approach improves the account- as two or three years old and, as in TMJ ability of the interventional radiologist, cases, require multiple injections dur- interventional cardiologist, and admin- ing the course of their treatment. The istrators while promoting a healthy importance of reducing the amount of environment for patients and staff. acute and chronic radiation is quite evi- dent in these delicate patients. Robert L. Bard is a freelance medical writer cer- Other areas where significant radiation tified by the American Medical Writer’s Associa- tion who also conducts clinical research at the savings are achieved include procedures University of Michigan’s Division of Cardiovas- where syngo DynaCT is used to guide cular Medicine. the needle during bone biopsies and to assess the airway and lesion during Contact vascular malformation therapy, whereby heike.theessen@siemens.com the intermittent imaging used in the AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 19
  • 20. Cover Story CARE Treatment of Complex Head and Neck Lymphatic Malformation in an Infant Supported by syngo DynaCT Courtesy of Anne Marie Cahill, M.D., Deddeh Ballah, B.A. Department of Interventional Radiology, Children’s Hospital of Philadelphia, PA, USA Children's Hospital of Philadelphia – Founded in 1855 as the nation's first hospital devoted exclusively to caring for children, it has been the birthplace of many firsts in pe- diatric medicine. In interventional radiology employees are working hand in hand to provide best possible care for their patients. Patient history course of 24 months. Doxycycline is an sible dose while preserving diagnostic At 40 weeks in utero the male fetus antibiotic that causes inflammation of information. With the inherent contrast was diagnosed with a large neck mass the lymphatic malformation epithelium provided by the sclerotherapy agent we on prenatal ultrasound. Prenatal MR that eventually leads to scarring and are able to reduce the dose provided imaging was performed demonstrat- regression of the lesion. The second by our typical syngo DynaCT to 6 % of ing a 5.7 cm by 2.7 cm left neck mass. and third sclerotherapy procedures used the manufacturer setting and 50 % of The patient was delivered at CHOP Low Dose syngo DynaCT imaging to conventional CT. via Caesarean section for concern of confirm sclerotherapy distribution in the In the future, syngo DynaCT can be airway compromise. The baby boy lesion. The syngo DynaCT was acquired used to direct procedures. By identifying required routine resuscitation and was with a dose value of 0.7 mGy. areas of the lesions that lack sclero- transferred uneventfully to the neonatal therapy agent after injection, additional intensive care unit. Comments injections may be performed during syngo DynaCT is used to confirm sclero- treatment potentially reducing the num- Diagnosis therapy agent distribution and deter- ber of future sessions. On the third day of life, a neck MRI with mine proximity to the airway in patients and without gadolinium contrast was with complex head and neck lymphatic performed on the neonate, showing a malformations. Intraprocedural syngo Pediatr Radiol. 2011 Apr;41(4): T2 hyperintense, multicystic lesion with DynaCT images can provide information 476-82. Epub 2010 Nov 16. evidence of hemorrhage that extended regarding the volume of lesion treated to the posterior neck and deeper and the necessity for further treatment Results: The manufacturer's default setting gave an equivalent structures of the neck, including the sessions. It enables us to create image CTDI of 4.8 mGy. Optimizing the dose settings and prevertebral and retropharyngeal space, reconstructions in three planes on a adding copper filtration reduced the radiation dose by confirming a macrocystic lymphatic separate workstation allowing us to 94 %. This represents a 50 % reduction from conven- tional CT. malformation. compare the extent of the lesion treated to the pre-treatment lesion in those Treatment three planes on MRI. Contact This patient underwent three doxycy- Since this is essentially a CT scan it is heike.theessen@siemens.com cline sclerotherapy procedures over the imperative to achieve the lowest pos- 20 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 21. CARE Cover Story 1 1 Axial T2 weighted MR image demonstrating the macrocystic lymphatic malformation left neck. 2 2 Correlating axial syngo DynaCT image demonstrating the distribution of the sclerotherapy agent throughout the lesion when compared to the MRI. Note the close proximity of the sclerotherapy agent and lesion to the airway guiding post-procedure therapy, resulting in the patient remaining intubated post-procedure. AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 21
  • 22. Cover Story CARE Evaluation of CAREposition: Radiation-Free Positioning with CAREposition Results in a Decrease in Screening Times Brendan Erskine, and Elissa Marshall from the Department of Radiology, The Alfred, Melbourne, Australia have conducted a study on the potential of CAREposition to reduce the fluoroscopic screening time during various diagnostic procedures. The study was presented as a paper: “Evaluation of Siemens CAREposition, Radiation-Free Positioning For Angiography and Fluoroscopy” at the ASMIRRT 2011 conference. by Brendan Erskine and Elissa Marshall Introduction savings, not to investigate dose minimi- Other techniques for reducing screening CAREposition is a Siemens functionality zation. While a reduction in screening time, that enables accurate repositioning of time will result in lower patient dose, the patient under visual control without ultimately dose is a product of many • Last Image Hold (LIH) holds the last radiation exposure. Guidance is pro- factors, beyond the scope of this study, fluoroscopic image on the viewing vided by a centrally positioned crosshair such as: monitor and incorporates radiation- marking the central beam while the free collimation and wedge filter collimated field of view (FOV) is visually • Patient habitus placement displayed as a white outlined rectan- • Object-to-image distance gular box. This is displayed on the last • Source-to-object distance • ‘Fluoro Store’ or ‘Fluoro Loop’ per- image hold and adjusts automatically • Field of view mit the operator to review and to changes in position of the table and • Exposure factors (kV, mA) save the last fluoroscopic imaging C-arm as well as changes in FOV. • Exposure time sequence. While not directly reduc- • Detector quantum efficiency (DQE) ing the screening time, this software Background • Pulsed fluoroscopy functionality may indirectly reduce CAREposition functionality is aimed • Adaptive dose filtration by the screening time and patient dose by purely at reducing fluoroscopic screen- application of copper/aluminum allowing the storage of fluoroscopic ing time and therefore the primary prefiltration sequences instead of formal (higher focus of this study was to quantify these dose) angiographic sequences 22 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 23. CARE Cover Story Table 1: Screening Times Pre & Post CAREposition 30:00 Mean Screening Time (min) 25:00 20:00 15:00 pre CAREposition post CAREposition 10:00 05:00 00:00 Aorto-femoral Angiography ERCP Femoral Angiography PICC Line Insertion AV Fistulography Gastrografin Swallow AV Fistula – Interventional Defecating Proctography Tunneled Line Insertion Pain Management Jugular Vonoplasty Video Swallow Erskine Brendan and Marshall Elissa, Dept. of Radiology, The Alfred, Melbourne, Australia • Some fluoroscopic systems especially as the difficulty of laser visualization Methods mobile image intensifiers (I.I.) incor- in brightly lit rooms and refraction Screening times from procedures per- porate the use of I.I. mounted laser of the laser through plastic I.I. cov- formed on all angiographic and fluoro- guidance to assist positioning without ers. Also, accurate positioning of the scopic machines were obtained over a the need for radiation. This relatively laser is made more difficult on heavily six month period. At the trial midpoint, cheap method of image guidance draped patients. three multipurpose fluoroscopic/angio- suffers from many drawbacks such graphic machines were enabled with AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 23
  • 24. Cover Story CARE Table 2: Screening time measurements during diagnostic and interventional procedures Procedure Case Numbers PRE CAREposition POST CAREposition Endoscopic retrograde 94 04:52 03:42 pancreato-cholangiography (ERCP) Gastrografin Swallow 65 01:18 01:24 Video Swallow 50 03:24 03:20 Defecating proctography 39 01:46 01:27 Peripherally Inserted Central Catheter (PICC) 656 00:45 00:45 Tunnelled catheter insertion 103 01:28 01:00 (Hickmans, Permcath, Portocath) Pain management injections 126 00:47 00:47 (Epidural, Facet joint, Medial branch block) Aorto-femoral angiography – Diagnostic 27 03:26 03:11 Femoral angiography – Diagnostic 25 01:30 01:11 Arterio-venous (AV) fistulography – 19 01:06 00:49 Diagnostic Arterio-venous (AV) fistulography – 22 14:50 14:02 Interventional Jugular venoplasty – Interventional 47 27:09 20:11 Erskine Brendan and Marshall Elissa, Dept. of Radiology, The Alfred, Melbourne, Australia CAREposition software licensing: interventional) will always lead to a certainly provided more accurate wide spread of results. To obtain the results. • Siemens AXIOM Artis MP most accurate data, only procedures (fluoroscopy) (diagnostic or interventional) with Discussion • Siemens AXIOM Artis MP standardized imaging and relatively […] CAREposition appeared most (angiography) high case numbers were chosen. These beneficial in the scenario of sequen- • Siemens AXIOM Artis dMP procedures along with results are dem- tial diagnostic imaging of peripheral (fluoroscopy/angiography) onstrated in Table 1. vasculature, whereby accurate overlap between acquisitions could be achieved All machines employed remote (pedes- Study limitations with minimal fluoroscopy. Aorto-femoral tal) C-arm/table controls ran exclusively Since we are primarily a teaching insti- diagnostic angiographic studies saw a by the radiographer. Our main angio- tution, it is likely that even without the 7 % reduction in screening time (3:26 graphic machine, a Siemens Artis zee use of CAREposition we might have to 3:11 min), with single leg diagnostic biplane, had CAREposition licensing observed a small reduction in screen- studies demonstrating a 21 % reduction from installation and was therefore ing times given increasing experience (1:30 to 1:11 min). A similar result was excluded from the trial. of both medical and allied staff. Also, demonstrated for diagnostic AV fistulog- Although data from approximately despite the six month trial encompass- raphy, where a 26 % reduction (1:06 to 2,200 procedures were obtained, ing approximately 2,200 fluoroscopic/ 0:49 min) was observed. Several exam- the variability of fluoroscopic and angiographic procedures, a greater ples for procedures are listed in Table 2. angiographic procedures (particularly period of data collection would have When operators gain confidence in the 24 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 25. CARE Cover Story 1a 1b 1c 1 Utilization of CAREposition during three angiographic procedures: a Trans-jugular liver biopsy b Cerebral angiography c Femoral angiography accuracy of CAREposition functionality, ing time was demonstrated, however, lization of CAREposition has resulted in a huge reductions in screening time could noting our case numbers were small. modest decrease in screening times for be achieved. Such was highlighted when A much larger result was demonstrated a range of diagnostic procedures with reliance exclusively on CAREposition for in jugular venoplasty procedures. This greatest benefit being demonstrated guidance of angiographic positioning in interventional procedure was chosen when used in sequential diagnostic three peripheral diagnostic studies com- because it provided the largest subject imaging of peripheral vasculature. prising 19 separate acquisitions, were group of all the interventional proce- achieved with totals of only 4, 6 and 8 dures and involved standardized imag- Thanks to the following angiographers for their seconds fluoroscopy time […] ing of both internal jugular veins and assistance in compiling procedural data: Jane Chow, Karen Patel, Alix Fell, Wayne Chan, Neal […] screening times in interventional azygos system with subsequent angio- Russell, Lisa Broadley. procedures are heavily dependent on plasty of stenosed vessels, providing us both the patient pathology and the with a more accurate reflection of the skill of the clinician. Although difficult benefits of CAREposition. to quantify, CAREposition appeared extremely useful in complex and chal- Conclusion lenging interventional procedures CAREposition provides radiation-free flu- especially when multiple working oroscopic and angiographic positioning projections were employed. In the with the use of graphic markers overlaid Contact angiographic intervention of AV fistulas on the fluoroscopic last image hold. vera.juennemann@siemens.com only a small reduction (5 %) in screen- Our study has demonstrated that the uti- AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 25
  • 26. Angiography syngo iGuide Endoleak Treatment: Enhanced Visualization Meets Enhanced Navigation Diagnostic CT scan showes an Endoleak Type II. The CT images are fused with the syngo iGuide allows you to place target and syngo DynaCT dataset. skin entry point on the CT image, which is overlaid onto the syngo DynaCT. 1 2 3 syngo iGuide integrated needle guidance The endovascular repair of abdominal aortic aneurysms (EVAR) with stent enables vascular surgeons and grafts has surged in popularity over interventional radiologists to efficiently, the past decade, dramatically reduc- ing the amount of recovery time for precisely, and effectively treat type II patients in comparison with open repair. endoleaks, one of the most vexing However, approximately one-third1 of patients who undergo EVAR will have complications following endovascular an endoleak, a condition in which abdominal aortic aneurysm repair. blood flows outside the lumen of the endograft but within the aneurysm sac, By Sameh Fahmy, MS potentially increasing the risk of rupture. In type II endoleaks, aortic branches that 26 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 27. syngo iGuide Angiography syngo iGuide provides a bull's eye view and pro- gression views for optimal nee- After reaching the target a catheter will be A DSA scene shows clearly all endoleak related dle tracking. placed in the endoleak. vessels. The feeding vessels will be embolized with various coils and Cordis Trufill n-Butyl Cyanoacrylate glue. 4 5 6 have been excluded by the endograft, pital DeBakey Heart and Vascular Center syngo DynaCT, the solution frees up such as the lumbar arteries and the in Houston, Texas, USA, and Professor of the hospital’s computed tomography inferior mesenteric artery, perfuse the Cardiovascular Surgery at Weill Cornell (CT) scanners for routine diagnostic aneurysm sac via retrograde blood flow. Medical College of Cornell University. imaging and enhances workflow by Type II endoleaks are the most common In July 2010, Lumsden and his collea- eliminating the need to transfer the endoleak and can have multiple feeding gues began using syngo iGuide inte- patient during the procedure. “The most and draining vessels that make their grated needle guidance, a software important thing for us is that the aneu- treatment challenging. “Sometimes solution that enables physicians to per- rysm stops growing,” says Lumsden, when we get referred to these patients, form needle procedures more precisely who uses the multi-axis Artis zeego. they may have had three or four trans- and efficiently using the Artis zee family “And in the majority of patients that femoral attempts at blocking the en- of C-arm systems. Because the planning we have treated with syngo iGuide, the doleak off,” says Alan Lumsden, MD, of the procedure is accomplished using aneurysm has stopped growing and the Medical Director of the Methodist Hos- cross-sectional images acquired with endoleak has gone away.” AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 27
  • 28. Angiography syngo iGuide Interventional radiologists such as much shorter amount of time. Detailed David Lacey, MD, at Iowa Methodist anatomical information is obtained with Medical Center in Des Moines, Iowa syngo DynaCT, and the images are fused report similar promising results. “I’m with a diagnostic CT that was obtained more apt to be able to select small ves- earlier. To define the needle path, physi- sels and embolize them, and our results cians mark the needle target point in have been very good,” says Lacey, who the CT dataset and then mark the loca- in 2008 became one of the first users of tion of the skin entry point. By scrolling syngo iGuide in the USA. through the multiplanar reformations, physicians can follow the needle path Saving Time easily and verify that there are no vital and Streamlining Workflow structures, such as the inferior vena The two most common approaches cava, in the way of the planned path. for treating type II endoleaks are the syngo iGuide automatically proposes transarterial approach, often via trans- two needle progression views, in which femoral access, and direct translumbar the planned path is graphically overlaid puncture. The success rate of the tran- onto the fluoroscopic image. The needle sarterial approach is low, with up to 80 is advanced under fluoro guidance, and percent recurrence rate due to the com- an additional syngo DynaCT run is per- plexity of endoleaks and the potentially formed in slab mode to check the final circuitous route.2 position of the needle. Once the needle “The transfemoral approach has been position is verified, the physicians per- tried and largely has failed,” Lumsden form the embolization. says. “The idea behind the translum- Lacey estimates that the use of syngo bar procedure is that instead of going iGuide reduces the time it takes to per- through multiple feeding branches, you form the procedure by an hour, while go right where they all come together Lumsden notes that it may save even and work into those feeding branches more time in particularly complicated from inside that. The access in trying to cases. “The last one we did probably “In the majority of go transfemoral or transmesenteric is took an hour,” Lumsden says. “Before, it patients that we very long and torturous; some catheters probably took two to three hours.” can’t even get to them.” In addition to the measurable reduc- have treated with Lacey explains that before Iowa Meth- tion in time associated with the use of syngo iGuide, the odist Medical Center began using syngo syngo iGuide, the elimination of patient iGuide with its ceiling-mounted Artis transfer from the CT has the theoretical aneurysm has zee, he and his colleagues would use a advantage of maintaining sterility, since stopped growing translumbar approach and advance the physicians no longer have to transfer a needle into the endoleak cavity using CT patient with a wire extending from the and the endoleak fluoroscopy. After confirming that the aneurysm sac, out the patient’s back, has gone away.” needle was in position by the pulsatile and to the outside world. return of blood, the physicians would A CT scanner can be used for many exchange the needle over a guidewire, diagnostic scans in the time it takes to Alan B. Lumsden, M.D., Medical Director secure the wire with tape, and then complete a single needle procedure, so Methodist DeBakey Heart and Vascular transfer the patient to the interven- the elimination of the CT scanner for Center, The Methodist Hospital, Houston, TX, USA tional radiology angio suite. The patient needle guidance also has clear finan- would then be re-prepped before physi- cial benefits. Lacey points out that the cians used the guidewire to advance a increasing use of interventions such as catheter under fluoroscopic guidance CT biopsies and CT ablations has put into the endoleak cavity, where coils additional scheduling demands on the and glue are used for the embolization. scanners at Iowa Methodist Medical With the installation of syngo iGuide, Center, making any technology that however, the entire procedure is per- reduces demand for the CT scanners formed in the angio suite – and in a especially welcome. 28 AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine
  • 29. syngo iGuide Angiography Lacey points out several components of these feeding vessels.” syngo iGuide that he says reflect a level The physicians say the power of the of refinement not seen in similar needle technology is evident by the ease with guidance systems. The ability to obtain which it handles challenging cases. a control scan after the needle has been Lacey points out that he often encoun- placed helps ensure accuracy by auto- ters aneurysm sacs that measure less matically correcting for patient motion than a centimeter. The difficulty of or even the deformation of tissues accessing them is compounded in larger “The 3D overlay lets caused by the pressure of the needle on patients, who in many cases require a the skin. The Artis zee ceiling-mounted 20-centimeter needle. “That’s a long you look at any an- system he uses is equipped with an way to go to get an accurate placement gle to figure out integrated laser crosshair that precisely with a needle, but it turns out to be marks the skin entry point. This reduces pretty easy to do with this system,” he how to best navigate radiation dose by eliminating the need says. “I’m always impressed that I can hit the otherwise un- for fluoroscopy to match the needle tip that target, often in just one pass, using with the path in the bulls-eye view and this system.” predictable pathway improves ease of use. After acquiring The physicians say that long-term into this lesion.” the initial syngo DynaCT scan to define follow-up and several additional cases small structures, Lacey uses syngo will be required to quantify improved DynaCT in low-dose mode to further patient outcomes using syngo iGuide, David L. Lacey, M.D., Department of Ra- minimize radiation to the patient. but the early results are certainly prom- diology, Iowa Methodist Medical Center, Once the endoleak site has been ising. Lacey says the success in treating Des Moines, Iowa, USA accessed, Lacey uses an additional tool type II endoleaks at Iowa Methodist known as syngo iPilot to overlay a 3D Medical Center has already led to refer- syngo DynaCT angiography image on rals. In one recent case, the referring the live fluoro as he navigates the cath- physician tried and failed to treat the eter. “The 3D overlay lets you look at any patient using conventional tools and angle to figure out how to best navigate sent the patient to Iowa Methodist, the otherwise unpredictable pathway nearly four hours away. into this lesion,” Lacey says. “It allows Lacey adds that syngo iGuide is so easy you to very quickly and easily pick off to use that it can give physicians who the supplying vessels and really helps lack significant experience or confi- you address the full extent of the leak.” dence with needle procedures the abil- ity to successfully perform procedures, Handling Challenging Cases including type II endoleak repairs, that with Ease they might otherwise find challenging. Lumsden says that using conventional Using syngo iGuide is so simple, he techniques, most physicians are quite says, “It’s kind of like cheating.” happy just to get the needle into the aneurysm sac. The precision that syngo Sameh Fahmy, MS, is an award-winning free- iGuide enables, however, allows physi- lance medical and technology journalist based in Athens, Georgia, U.S. cians to enter the aneurysm sac at a location that maximizes their likelihood 1 Baum RA, et. al. Endoleaks after Endovascular Repair of Abdominal Aortic Aneurysms J Vasc Inerv of embolizing the vessels that are feed- Radiol 2003; 14:1111-1117 ing the endoleak. 2 Baum et al. Treatment of type 2 endoleaks after “If you have two lumbar arteries that are endovascular repair of abdominal aortic aneu- rysms: comparison of transarterial and translumbar feeding into the aneurysm and we enter techniques. J VascSurg 2002; 35:23–29. right alongside one of them, we can’t bend the catheters around to get to it,” Lumsden explains. “So one of the things we’re looking at is trying to choose Contact the trajectory that will give us the best heike.theessen@siemens.com opportunity to catheterize and block off AXIOM Innovations · November 2011 · www.siemens.com/healthcare-magazine 29