Erectile Dysfunction And Tadalafil

DR B. K. IYER MEDICAL ADVISOR SHELYS PHARMACEUTICALS, TANZANIA Erectile dysfunction! A growing problem

Definition & Classification of ED ,[object Object],[object Object],[object Object],[object Object]

Is ED common? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Causes of ED ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

History, examination and investigations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Distinguishing psychogenic and organic ED Droupy S et al. (2006) How, why and when should urologists evaluate male sexual function? Nat Clin Pract Urol 3: 84 – 94 doi:10.1038/ ncpuro406

Treatment or referral ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

WITH FOCUS ON TADALAFIL PDE5 inhibitors

PDE-5 inhibitors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PDE-5 Inhibitors ,[object Object],[object Object],[object Object],[object Object],[object Object]

MOA of PDE5 5 inhibitors ,[object Object]

Comparison of sildenafil, vardenafil, tadalafil ,[object Object],[object Object],[object Object],[object Object]

Comparison of sildenafil, vardenafil, tadalafil PDE5 inhibitor Duration Sildenafil 12 hours Vardenafil 4-5 hours Tadalafil 36 hours Vardenafil, however, is the most potent (lowest maximal concentration) and binds to PDE5 more rapidly than the others, thus it has a potential time of onset of 10 minutes.

Tadalafil ,[object Object],[object Object],[object Object],[object Object],[object Object]

Tadalafil ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Tadalafil ,[object Object],[object Object],[object Object],[object Object]

Studies on Tadalafil on ED in Diabetic men ,[object Object],[object Object],[object Object],[object Object]

Tadalafil – performance on IIEF5 parameters Overall baseline Placebo, n-122 Tadalafil, n-126

Tadalafil - performance on dosage increase

Daily Tadalafil prevents ED in Diabetic men ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Medscape J Med. 2008; 10(5): 127 by George D. Lundberg.

CLASS EFFECT OR MOLECULE EFFECT? Bonus effects of Tadalafil

Tadalafil and metabolic syndrome ,[object Object],Diabetes Care May 2009 vol. 32 no. 5 857-859 by Kevin D. Hill et al. ,[object Object],[object Object]

Tadalafil and cardiovascular medicine ,[object Object],The Korean Journal of Internal Medicine : 22:37-39, 2007, Use of Tadalafil for treating PAH Secondary to COPD by Hyun-Sook Kim et al . ,[object Object],[object Object],[object Object],[object Object]

Tadalafil and PAH and beyond ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Curr Pharm Des. 2009;15(30):3521-39. PDE5 inhibitors in non-urological conditions by Vlachopoulos C, et al. Curr Pharm Des. 2009;15(30):3540-51. Phosphodiesterase-5 inhibitors: future perspectives by Konstantinos G et al

Problems with PDE5 inhibitors ,[object Object],[object Object],[object Object],Curr Pharm Des. 2009;15(30):3476-85. Phosphodiesterase type 5 inhibitors: unmet needs by Hatzimouratidis K, Hatzichristou DG..

Problems of ED in patients with heart disease ,[object Object],[object Object],[object Object],[object Object],[object Object]

Erectile Dysfunction And Tadalafil

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Erectile Dysfunction And Tadalafil