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PRP Art & science

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Platelet Rich Plasma Art & science Islam Kassem,BDS,MSc,FDS RCS Consultant oral & maxillofacial Surgeon ikassem@dr.com
Angle Face Left New technology of injection your own blood to get a Youthful Look . . ikassem@dr.com
Why Are Celebrities Injecting Their Faces With Blood? ikassem@dr.com
ikassem@dr.com
Platelet?  Anuclear piece of cytoplasm  Include hemostasis, α-granule,lysosomal granule, dense granules ikassem@dr.com
 At least 7 different growth factors that stimulate bone & soft tissue healing  PDGF aa,bb,ab  TGF b1,b2  VEGF  EGF ikassem@dr.com
Days of operation ikassem@dr.com
7 days later  PLT exhausted after 7 days  Macrophage by low oxygen tension, acidity, lactate concentration  Secrete same growth factors  Activated until it is down regulated by the restoration of normal oxygen tension ikassem@dr.com
Day 3rd ikassem@dr.com
17days  Graft is completely permeated by new capillaries  Initial osteoid formation  Osteoclast resorb osteoid and BMP released  New bone formation and maturation ikassem@dr.com
Days 14 ikassem@dr.com
The mechanism of growth factor effects on cells Inactive state ikassem@dr.com
Activation activation ikassem@dr.com
Clinical effects of PRP on bone regeneration Platelet RBC Normal blood PRP ikassem@dr.com
Trabecular areaNative mandible Autogenous BG ikassem@dr.com
Clinical effects of PRP on soft tissue healing  Split thickness skin graft donor site healing ikassem@dr.com
6 days Thrombin side : 5% epithelization 95% granulation tissue PRP side ; 95% epithelization 5% granulation tissue ikassem@dr.com
6 months Thrombin side : scarring hypo and hyper- pigmentation area PRP side ;less scarring Much less pigmentation change ikassem@dr.com
Patient discomfort  Patient discomfort decrease ikassem@dr.com
Epithelization ikassem@dr.com
6days ↔ ↔ ikassem@dr.com
1 months ikassem@dr.com
Contraindications  Pre-existing coagulation defect : thrombocytopenia, hypofibrinogenia…  Hypersensitivity to bovine thrombin ikassem@dr.com
Clinical steps ikassem@dr.com
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Clinical application ikassem@dr.com
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Ridge preservation ikassem@dr.com
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Glomerular Filtration and determinants of glomerular filtration .pptxGlomerular Filtration and determinants of glomerular filtration .pptx
Glomerular Filtration and determinants of glomerular filtration .pptx
 

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