Es Teck Complex presentation

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Gesundheit & Medizin

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Heart Rate and sinus node depolarization

Autonomic Nervous System and Heart rate variability

SpO2 AND Photoelectrical Plethysmography SpO2 Probe Infra red/ Red 660/905 nm Photo diode SpO2% PR Vascular waves

SpO2 ANALYSIS ,[object Object],[object Object]

Analysis by Acceleration and Second derivative

Analysis of the Second derivative with age

Analysis of the second derivative and diseases : b/a

Analysis of the second derivative and diseases : d/a

Specificity and sensitivity of the b/a and d/a indicators

Specificity and sensitivity of the b/a and d/a indicators Ref. Toshiaki OTSUKA , Tomoyuki KAWADA , Masao KATSUMATA , Chikao IBUKI , and Yoshiki KUSAMA Independent Determinants of Second Derivative of the Finger Photoplethysmogram among Various Cardiovascular Risk Factors in Middle-Aged Men Hypertens Res Vol. 30, No. 12 (2007)

SpO2 and Photoelectrical Plethysmograph results

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Body Impedance Analysis (BIA) Measurement of the Resistance and Reactance in Tetra polar mode with a frequency of 50 KHz

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EIS B I A ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Impedance Components Phase Angle Xc = 1 / (2 * PI * F * C), C – Capacity [Farad] Phase Angle = Arctan (Xc / R)

Clinical application in survival in colorectal cancer The survival curves for the 2 categories of phase angle are shown. Patients with a phase angle < 5.57 had a median survival of 8.6 mo (95% CI: 4.8, 12.4; n = 26), and those with a phase angle > 5.57 had a median survival of 40.4 mo (95% CI: 21.9, 58.8; n = 26); this difference was significant ( P = 0.0001).

Impact of phase angle in liver cirrhosis

SpO2 RESULTS AND MANAGEMENT OF THE PHOTOELECTRICAL WAVE

PHOTOELECTRICAL PLETHYSMOGRAPH ANALYSIS AND RESULTS

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E.S TECK COMPLEX ,[object Object],[object Object]

Follow up of the Cerebral neurotransmitters

Chiropractor Indicators and monitoring treatment

Advices for Lifestyle and exercises and monitoring

Sport men condition Evaluation and improvement

Statistical risk analysis ,[object Object],[object Object],[object Object]

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To assess Left ventricular (LV) systolic dysfunction using 2D speckle tracking echocardiography (STE) in asymptomatic type II Diabetic patients. We acquired three LV short-axis, and three LV apical views in 100 asymptomatic diabetic patients with normal LV ejection fraction (EF) and 25 age-matched healthy volunteers. We measured end-systolic longitudinal strain (LS), radial strain (RS), and circumferential strain (CS) in 18 LV segments. There were no significant differences in LVEF between two groups. Diabetic patients had more advanced diastolic dysfunction and increased LV mass compared with controlled group. Basal, middle, and apical LSs were significantly lower in diabetic patients compared with control subjects, with 43% (43/100) of the diabetic patients showing abnormal global LS values (cut-off value: 217.2 mean 2SD in control subjects Conclusion: Detecting subclinical LV systolic dysfunction by using 2D speckle tracking echocardiography (STE) might provide useful information of the risk stratification in an asymptomatic diabetic population.

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Electrocardiography (ECG) is crucial in the medical field to assess cardiovascular diseases. ECG signal generates information, i.e., QRS complexes that imply the cardiac health of the human body. It is depicted in the form of a graph with voltage versus time interval. A distorted, inverted, lagged, small waveform implies an abnormality in a cardiac system. This study highlights the generation of an ECG signal, QRS complexes undertoned towards different diseases, event detection, and signal processing methods. It has become crucial to highlight the possibilities and advances that can be derived from an ECG signal. Throughout this study, an instance of diabetes mellitus (DM) is considered for creating concrete awareness and understanding of an ECG signal in DM. This study focuses on finding the correlation between ECG and DM. Detection of DM from ECG signal is also studied. The findings of this survey paper conclude that the correlation between DM individuals with cardiovascular complications has autonomic neuropathy, which may lead to myocardial infarction. It is also found that the QRS complex and its abnormalities are not specific to complications in DM. However, non-invasive detection of diabetes through ECG signals demonstrates future research potential.

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Introduction: Aging-associated vascular stiffening augments cardiovascular disease risk in the elderly. Research to identify targetable cellular and molecular mechanisms is of key interest as no current therapies are available to specifically target vascular stiffening. In this context, enzymes that mediate remodeling of the vascular matrix and those that promote cellular dysfunction are attractive targets. In pre-clinical models, pulse wave velocity (PWV), the gold standard measure of in vivo vascular stiffness, can be measured longitudinally and non-invasively, to make inroads towards the discovery and validation of potential targets. A novel target and model: We have identified a central role for tissue transglutaminase (TG2) in vascular stiffening during aging. TG2 is a multifunctional protein of the transglutaminase family, whose primary function is to assist in the formation of a strong and stable matrix by catalyzing crosslinking of matrix proteins. Recent studies have shown that TG2 has putative crosslinking-independent functions in aging-associated vascular stiffening and dysfunction. The crosslinking independent mechanisms of TG2 remain incompletely understood due to the lack of pre-clinical models and specific inhibitors that can selectively inhibit a single function of TG2. Thus, we developed a novel knock-in mouse, the TGM2-C277S mouse, by mutating the active site cysteine of TG2 using the CRISPR-Cas9 gene editing technology to selectively target its crosslinking function. Results and conclusion: We first validated the TGM2-C277S mouse and confirmed that this mutation removes TG2’s crosslinking function but retains its crosslinking independent functions. We next compared PWV wild type (WT), global TG2 knockout (TG2-/-), and the TGM2-C277S mice, to identify the contributions of the crosslinking-dependent and crosslinking-independent functions of TG2 to vascular aging in vivo. PWV increased significantly with age in WT mice, and to a much lower magnitude in the TGM2-C277S mice. TG2-/- mice were further protected against aging associated increase in PWV. Together, these studies show that TG2 contributes significantly to overall vascular stiffening in aging through both crosslinking dependent and crosslinking independent functions. The learning objectives are: To understand changes in pulse wave velocity (PWV) with age in mouse models To determine the specific role of tissue transglutaminase (TG2) in vascular aging To evaluate the role of vascular matrix vs. VSMCs to overall in vivo stiffness described by PWV

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