1. Cluster BMT Centers for Shared Facilities (CSF) /Centers of Excellence (CeO)

3. Association of the resident’s partners (biomedical and pharmaceutical clusters)

4. Business incubators

5. Venture Capital Funds

6. Strategic industrial investors

7. Institutional Partners

9. Centers for Shared Facilities (CSF), or Centers of Excellence (CoE)

11. Service Center of support of the Cluster residents (tax, legal, customs consultants)

12. University (educational programs)

13. International traineeship

14. Internships

15. International Conferences/Roadshows2

17. CSFs provide

18. Infrastructural ground for collaboration with key-partners

19. Integration of R&D, educational and commercialisation functions

20. Effective use of Skolkovo budget by preparation the Skolkovo infrastructure for 2014 in 2011. Effective use of the time required for the city construction. Training and preparation of qualified Skolkovo own professionals on Skolkovo own equipment

21. Realisation of strategy approved by the SAC and the Board of Trustees.

22. Collaborators worldwide and in Russia have been identified

23. Existing R&D centres,

24. Universities,

25. Institutes (RAS, RAMS, NIH, EU, Japan)

26. Most of big pharmaceutical and institutional investors (RVK, ROSNANO)expressed interest in CSFs

27. Opportunity to involve Russian Ministry of Health as a major customer from 2011

28. A big time gap (half a year) between purchase, delivery, and installation of equipment in Russia. To be able to use it Q1 2012 we need to order it now.

30. 21.05.2011 Confidential 5 Basic Principles of CSF (CoE) functioning. CSF research areas should be in the BMT foresights. CSF should provide services, research and educational programmes 1) 2) CSF should provide and maintain excellence in access to modern biomedical equipment, research infrastructure, highly qualified staff, and services on the world level Infrastructure facilities, the equipment and maintenance services of CSFs are to be 100% owned by the Skolkovo Foundation or/and its wholly owned subsidiary. 3) Project companies (residents of the Skolkovo Foundation) should have a first right to use CSFs services and competencies 4) Capital expenses for major consumables and equipment are covered by the Fund. Operational budget to be provided by residents companies and external customers. 5)

32. Existing infrastructure sites (departments of the universities, scientific research centers)

33. Project companies/residents of the Skolkovo Foundation

34. Needs and expectations of key partners (industrial biotech and pharmaceutical corporations), establishing of R&D centers

35. Existing partners of BMT Cluster

36. Survey of existing infrastructure in Russia for priority areas (foresights)

37. Arrangement of a public tender. Choosing the best place /key partner for CSF

38. Identification of strategic partners (co-investors) to establish for CSF

39. Creation up to 10 CSFs

41. 22.05.2011 Transgenome and postgenome technologies Foresightes: Biomedicine and Bio-pharmaceutics Proteomics , and other omics Regenerative medicine « Preclinical and clinical studies. P4 Medicine. Cancer ) Infection diseases » « Preclinical. GLP Structural Biology MAB and other novel therapies » Registration and launch Lead optimization Preclinical Clinical - Early development Complex modeling and simulation. Biomedical Informatics Foresight Bioinformatics Directed evolution Scaling up Artificial ecosystems Foresight й Industrial biotechnologies Synthetic biology CSFs address common needs in biotech and biomedicine processing and cover the most significant areas of competence Confidential 8

42. 22.05.2011 CSFs development . First Stage 9 Confidential

43. 22.05.2011 CSFs development . Second Stage 10

44. 22.05.2011 CSFs. Training and further education programmes. 11 Confidential

45. 22.05.2011 CSF. Basic structural Principles. Sectors and open infrastructure CSF . Structural Biology. MFTI and IBC RAS Target identification for structural analysis Every SCF sector is a self sufficient entity and can operate independently. Protein Cloning. MFTI-IBC Expression and refolding. Membrane proteins(IBC) Modules in the sector have a status of a standalone laboratory/Unit Protein purification. (MFTI-IBC) Protein crystallization. Membrane proteins Structural analysis. Membrane proteins Sectors or/and laboratories could have separate locations X-RAY crystallography (MFTI) Neutron structural analysis (MFTI) NMR spectroscopy(IBC) Skolkovo owned Sectors/Laboratories are self sufficient and could be re located to Skolkovo premises in 2014 or earlier. Confocal spectroscopy (MFTI) Imaging (MFTI) Computer modelling 12 Confidential

46. CSF’sinfrastructural elements developing TODAY creates the basis for FUTURE Innovation Center “Skolkovo” создают базу для будущего Инновационного Центра 2014 2012 - 2013 2011 Concept and strategy approval Creation of CSF Biomedical Informatics. Modelling and simulation Centre Re-location and Integration to the Technopark Skolkovo Creation of joint R&Dcentre with a key partner IBMC RAMS 22.05.11 13 Pre-clinical. GLP Exterritorial Integration to the Technopark Skolkovo Creation of joint R&Dcentre with a key partner Pushchino science Centre Trans and post genomic technologies Part of CSF sectors become laboratories at the Skolkovo University IBG RAS Part of CSF sectors become exterritorial units of the Technopark Skolkovo. Structural biology. Membrane Proteins MFTI and IBC RAS Re-location and Integration to the Technopark Skolkovo and to the Skolkovo University Confidential

47. 22.05.2011 CSF.Example. Scientific Councils Skolkovo Foundation External experts Scientific collaborators of major partners(s) Scientific council of major partner(s) SAC Skolkovo BMT Cluster Scientific Expert Council Expert council of major partner(s) CSF Scientific Council Planning and management of R&D activities Educational activities CSF Development strategy Collaboration with Russian and foreign partners Example of CSF Scientific Council Composition 5 Skolkovo Fund representatives 5 Major partners representatives Independent representatives 1 Chairman - independent. Elected 14 Confidential

48. 22/05.2011 CSFs. Planned activities for 2011. Approved total budget for CFS = 1 287 353thousands RR 15 Confidential