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Using Big Data to Shift from Evidence-
   based Practice to Practice-based
              Evidence
            Christopher Longhurst, MD, MS
   Associate Professor of Clinical Pediatrics, Stanford University
   Chief Medical Information Officer, Packard Children’s Hospital
Packard Children’s Hospital at Stanford
•   Opened in 1991
•   Mission: To provide extraordinary family-centered care
•   311 bed pediatric/obstetric tertiary-care facility
•   Hospital stats (FY 2010)
     • 4500 Deliveries
     • 13k Discharges
     • 140k Clinic visits
Pediatrics, December 2005
Pediatrics, May 2010
New England Journal of Medicine, Nov 2011
Hype Cycle
“Big Data” Signals in Biomedicine & Healthcare
Physiologic signals (remote monitoring, quantified self)
Images (radiology, pathology, dermatology, ophthalmology)
Omics (genomics, microbiomics, proteonomics)
Social data (network analysis, crowdsourced)
EMR data (structured and unstructured)
Physiologic Data – Stanford
Science Translational Medicine, 2010
Physiologic Data – Silicon Valley
Images – Stanford
AMIA Annu Symp Proc, 2008
Images – Silicon Valley
Omics – Stanford
Lancet, May 2010
Omics – Silicon Valley
Social Data – Silicon Valley




Full disclosure: I serve on
the medical advisory
board for Doximity.
AHRQ, 2007




“Information technology must be deployed
and reengineered to overcome growing
problems associated with information
overload. Finally, and most importantly,
patients will have to be engaged on
multiple levels to become ‘coproducers’
in a safer practice of medical diagnosis.”
EMR Data - Stanford
AMIA Proceedings, 2009
Finding Labs and Events that Predict Harm
True Positive Rate
and False Positive
Rate

Best performing labs
and events
  Best sensitivity: urea nitrogen
  Best specificity: feeding tube
  response
  Best overall: indirect bilirubin




 1
8
IEEE Intelligent Systems, April 2009




“The first lesson of web-scale learning is
to use available large-scale data rather
than hoping for annotated data that isn’t
available.”
Science Translational Medicine, Nov 2010
2012 IOM Report on “Learning Healthcare System”
Pediatrics, May 2011




Visit http://CRIT.stanford.edu
to join a learning collaborative
EMR-Enabled Checklist
Preliminary Results
RN in involvement on      Added approximately 1
rounds increased from     minute to each patient’s
56% to 79% of             rounds
encounters                  mean 76 seconds
Care change made in 1/3     median 56 seconds
of patient encounters
Compliance w/ CABSI Prevention Bundle
   100%
                                                *        *
    90%
    80%
    70%                    *
    60%
    50%
    40%
    30%
    20%
    10%
    0%
          Insertion     Line      Dressing    Cap      Port
           Bundle     Necessity   Change     Change   Change
BMJ, Feb 2013




“Systems more likely to succeed
provided advice for patients in addition
to practitioners (OR 2.77).”
Journal of Quality and Patient Safety, Aug 2012
Journal of Participatory Medicine, Dec 2012
New England Journal of Medicine, Dec 2012




“Clinical decision support algorithms will be derived entirely
from data, not expert opinion, market incentives, or
committee consensus. The huge amount of data available
will make it possible to draw inferences from observations
that will not be encumbered by unknown confounding.”
How do we ensure that the healthcare system
 learns from every patient, at every visit, every
                     time?
Christopher Longhurst, MD
clonghurst@lpch.org

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iHT2 Health IT Summit San Francisco 2013 - Christopher Longhurst, MD, CMIO, Lucile Packard Children's Hospital, Case Study "Using Big Data to Shift from Evidence-based Practice to Practice-based Evidence"

  • 1. Using Big Data to Shift from Evidence- based Practice to Practice-based Evidence Christopher Longhurst, MD, MS Associate Professor of Clinical Pediatrics, Stanford University Chief Medical Information Officer, Packard Children’s Hospital
  • 2. Packard Children’s Hospital at Stanford • Opened in 1991 • Mission: To provide extraordinary family-centered care • 311 bed pediatric/obstetric tertiary-care facility • Hospital stats (FY 2010) • 4500 Deliveries • 13k Discharges • 140k Clinic visits
  • 5. New England Journal of Medicine, Nov 2011
  • 6.
  • 8. “Big Data” Signals in Biomedicine & Healthcare Physiologic signals (remote monitoring, quantified self) Images (radiology, pathology, dermatology, ophthalmology) Omics (genomics, microbiomics, proteonomics) Social data (network analysis, crowdsourced) EMR data (structured and unstructured)
  • 9. Physiologic Data – Stanford Science Translational Medicine, 2010
  • 10. Physiologic Data – Silicon Valley
  • 11. Images – Stanford AMIA Annu Symp Proc, 2008
  • 15. Social Data – Silicon Valley Full disclosure: I serve on the medical advisory board for Doximity.
  • 16. AHRQ, 2007 “Information technology must be deployed and reengineered to overcome growing problems associated with information overload. Finally, and most importantly, patients will have to be engaged on multiple levels to become ‘coproducers’ in a safer practice of medical diagnosis.”
  • 17. EMR Data - Stanford AMIA Proceedings, 2009
  • 18. Finding Labs and Events that Predict Harm True Positive Rate and False Positive Rate Best performing labs and events Best sensitivity: urea nitrogen Best specificity: feeding tube response Best overall: indirect bilirubin 1 8
  • 19. IEEE Intelligent Systems, April 2009 “The first lesson of web-scale learning is to use available large-scale data rather than hoping for annotated data that isn’t available.”
  • 21. 2012 IOM Report on “Learning Healthcare System”
  • 22. Pediatrics, May 2011 Visit http://CRIT.stanford.edu to join a learning collaborative
  • 23.
  • 25. Preliminary Results RN in involvement on Added approximately 1 rounds increased from minute to each patient’s 56% to 79% of rounds encounters mean 76 seconds Care change made in 1/3 median 56 seconds of patient encounters
  • 26. Compliance w/ CABSI Prevention Bundle 100% * * 90% 80% 70% * 60% 50% 40% 30% 20% 10% 0% Insertion Line Dressing Cap Port Bundle Necessity Change Change Change
  • 27. BMJ, Feb 2013 “Systems more likely to succeed provided advice for patients in addition to practitioners (OR 2.77).”
  • 28. Journal of Quality and Patient Safety, Aug 2012
  • 29. Journal of Participatory Medicine, Dec 2012
  • 30. New England Journal of Medicine, Dec 2012 “Clinical decision support algorithms will be derived entirely from data, not expert opinion, market incentives, or committee consensus. The huge amount of data available will make it possible to draw inferences from observations that will not be encumbered by unknown confounding.”
  • 31. How do we ensure that the healthcare system learns from every patient, at every visit, every time?